Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	THRB	167	3	170	26.002
#2	LHX3	157	0	157	0
#3	ETV1	155	3	158	547.348
#4	RUNX1T1	150	2	152	1848.141
#5	TFCP2L1	122	6	128	58.187
#6	ATF1	119	6	125	180.81
#7	KLF15	112	7	119	387.876
#8	ZNF192	110	9	119	1090.271
#9	NEUROD2	110	5	115	78.48
#10	HMGA2	109	10	119	10485.439
#11	ZNF45	95	10	105	3167.267
#12	POU4F2	93	7	100	105.339
#13	NPAT	90	9	99	290.161
#14	TBX21	88	10	98	553.162
#15	NFATC3	84	8	92	231.818
#16	TAF12	84	11	95	538.548
#17	NFYB	83	10	93	196.193
#18	AFF1	78	12	90	348.005
#19	SMAD6	76	10	86	318.751
#20	REL	74	11	85	118.146
#21	NFIC	69	9	78	112.366
#22	SIX6	68	12	80	346.156
#23	PHOX2B	65	17	82	1357.755
#24	FLI1	65	10	75	264.457
#25	KLF6	64	13	77	539.343
#26	PPBPL2	64	12	76	313.842
#27	NFYA	60	16	76	360.762
#28	SP4	57	18	75	1029.575
#29	MAX	55	8	63	144.04
#30	ARNTL	55	18	73	3296.454
#31	ETV5	54	14	68	587.872
#32	MGA	54	15	69	2577.735
#33	SPIB	54	17	71	384.18
#34	MEIS2	54	2	56	25.412
#35	MEF2C	54	14	68	1002.184
#36	MECOM	53	17	70	253.638
#37	NFYC	53	9	62	292.194
#38	CREB3L1	51	14	65	374.632
#39	TCF4	51	2	53	776.428
#40	CLOCK	51	9	60	64.917
#41	TBR1	49	14	63	201.646
#42	ASCL2	48	18	66	361.332
#43	PHTF1	48	16	64	3000.858
#44	NFAT5	48	14	62	1810.438
#45	HOXD13	47	19	66	447.282
#46	RXRG	47	20	67	739.212
#47	HDAC2	46	11	57	354.104
#48	SNAI2	46	3	49	211.301
#49	YEATS4	46	11	57	9779.848
#50	DLX4	45	22	67	1733.215
#51	BLZF1	44	14	58	17097.603
#52	ZNF165	44	15	59	2802.589
#53	C11orf9	44	19	63	1325.094
#54	MEOX2	42	11	53	1365.663
#55	TSHZ2	42	17	59	388.508
#56	FOXN3	41	13	54	1102.964
#57	ADNP2	41	12	53	473.173
#58	RORA	40	12	52	837.094
#59	MAF	40	13	53	179.307
#60	CREM	40	14	54	2073.211
#61	HAND1	39	17	56	5001.645
#62	BHLHE41	39	8	47	690.584
#63	TWIST1	38	5	43	1208.212
#64	ZNF155	38	15	53	1228.882
#65	ZEB1	38	24	62	7921.535
#66	E2F3	37	18	55	2143.176
#67	MAFB	37	14	51	1247.279
#68	SUPT6H	36	6	42	186.181
#69	ENO1	36	17	53	3439.763
#70	GABPA	36	14	50	1518.157
#71	SOX10	35	9	44	2576.085
#72	MYCN	35	21	56	1380.551
#73	ZFP36L2	34	19	53	808.095
#74	HNF1B	34	19	53	3888.625
#75	HSF1	34	21	55	2925.323
#76	FOXO1	34	22	56	12520.604
#77	GATA3	33	13	46	2604.847
#78	HIF1A	33	13	46	4720.113
#79	HMGB1	33	8	41	106.572
#80	PKNOX2	32	19	51	339.746
#81	TP63	32	16	48	571.851
#82	PBX1	32	19	51	2839.701
#83	NR2F1	32	10	42	4128.845
#84	NR2E1	32	24	56	4839.76
#85	HOXA5	31	8	39	1391.874
#86	AR	31	14	45	1340.112
#87	HOXA11	30	17	47	323.422
#88	MEOX1	30	8	38	314.723
#89	RXRA	30	22	52	3286.173
#90	BNC1	30	22	52	365.555
#91	RXRB	30	20	50	1637.599
#92	MBD1	30	12	42	958.65
#93	ZNF202	30	20	50	492.285
#94	AHR	29	11	40	399.968
#95	JUND	29	9	38	496.6
#96	HOXA9	29	26	55	2066.763
#97	NFIX	29	17	46	142.261
#98	TP53	28	12	40	96.719
#99	SMAD1	28	13	41	2787.997
#100	ZNF500	28	18	46	5406.213
#101	NR3C1	28	14	42	2535.976
#102	TBX19	28	19	47	732.774
#103	FOXN2	27	12	39	99.469
#104	ISL1	27	18	45	176.012
#105	T	27	21	48	705.662
#106	NFX1	27	11	38	1360.78
#107	NR2E3	27	28	55	5540.179
#108	TADA3	27	18	45	3510.804
#109	AEBP1	26	8	34	714.208
#110	ZKSCAN1	26	15	41	714.864
#111	TFEC	26	22	48	1083.117
#112	NR2C1	26	19	45	457.747
#113	NR2F6	25	23	48	247.912
#114	NRL	25	11	36	49.39
#115	LHX6	25	11	36	1791.642
#116	HMGB2	25	12	37	944.539
#117	ALS2CR8	25	18	43	2561.75
#118	KLF5	25	21	46	1166.779
#119	ZNF446	24	23	47	6656.913
#120	ZNF277	24	13	37	15073.491
#121	GATA6	24	21	45	454.929
#122	ELF4	24	18	42	630.577
#123	JUN	24	15	39	745.071
#124	HOXC11	24	15	39	629.224
#125	PRRX2	24	19	43	1269.575
#126	SOX21	24	15	39	469.63
#127	EGR1	23	8	31	387.829
#128	MAFK	23	20	43	440.335
#129	MMP14	23	13	36	2579.951
#130	NPAS1	23	19	42	248.485
#131	HEY1	23	20	43	1931.392
#132	ELK4	23	20	43	1062.967
#133	NR2F2	23	16	39	1774.051
#134	CITED2	23	16	39	218.355
#135	ZEB2	23	12	35	1885.309
#136	TRPS1	23	19	42	1152.772
#137	RUNX3	22	20	42	825.845
#138	CBFA2T2	22	21	43	1466.455
#139	VENTX	22	19	41	90.348
#140	OLIG2	22	24	46	648.44
#141	SIX2	22	21	43	1795.808
#142	ZNF83	22	14	36	1535.745
#143	POU5F1B	22	23	45	891.621
#144	RUNX2	22	14	36	53.786
#145	TFAP2A	21	14	35	1527.743
#146	ZNF434	21	18	39	483.513
#147	ZNF174	21	24	45	542.994
#148	TCF7L2	21	19	40	2331.475
#149	SRY	21	19	40	112.02
#150	WNT5A	21	18	39	702.919
#151	SPDEF	21	11	32	2298.886
#152	TCF12	21	19	40	2913.969
#153	NFIB	21	18	39	590.187
#154	SOX15	21	26	47	2190.194
#155	HOXC10	20	12	32	1463.236
#156	MYOG	20	20	40	1002.845
#157	RARA	20	13	33	125.863
#158	ZNF132	20	22	42	2368.178
#159	ZNF323	20	20	40	372.688
#160	BRD8	20	20	40	666.586
#161	FOSB	20	6	26	162.707
#162	PEG3	20	24	44	2899.28
#163	HOXA1	20	24	44	2200.815
#164	TFEB	20	17	37	945.283
#165	ZFP36L1	20	21	41	484.634
#166	ZXDC	20	21	41	1912.213
#167	TBX3	20	27	47	2377.799
#168	TRIM29	20	10	30	201.944
#169	NKX6-1	20	24	44	772.741
#170	HOXC5	19	21	40	1620.391
#171	GCM1	19	25	44	429.341
#172	RUNX1	19	18	37	188.016
#173	FOXM1	19	17	36	544.229
#174	NPAS2	19	18	37	1014.91
#175	STRN3	19	20	39	697.555
#176	NR3C2	19	15	34	4926.524
#177	PPARG	19	17	36	279.36
#178	FOS	19	10	29	1379.073
#179	MYBL2	19	16	35	639.99
#180	ZBTB48	19	26	45	3144.955
#181	TRIM25	18	22	40	436.564
#182	STAT1	18	20	38	515.683
#183	FOSL2	18	18	36	1413.657
#184	LHX1	18	25	43	735.114
#185	GATA1	18	16	34	153.409
#186	ZNF238	18	20	38	1725.048
#187	EHF	18	21	39	1393.901
#188	HMGA1	18	23	41	182.277
#189	IRX5	18	18	36	3396.578
#190	TFAP2C	18	18	36	302.626
#191	ERF	18	26	44	3427.339
#192	ZNF117	18	20	38	967.735
#193	MLLT10	18	18	36	609.713
#194	NEUROD1	18	25	43	3968.844
#195	ECSIT	18	25	43	1245.731
#196	EN1	18	16	34	4419.849
#197	NKX3-2	17	21	38	543.059
#198	NANOG	17	24	41	2421.393
#199	HOXA7	17	18	35	948.899
#200	TP73	17	20	37	1025.338
#201	TEAD4	17	20	37	3404.445
#202	E2F5	17	19	36	337.279
#203	HOPX	17	10	27	368.386
#204	HNF4A	17	16	33	130.147
#205	ESRRG	17	20	37	1782.089
#206	MAFF	17	16	33	316.973
#207	PAX4	17	18	35	376.91
#208	KLF4	16	17	33	1437.641
#209	POU3F4	16	24	40	747.133
#210	CSDA	16	17	33	211.231
#211	ELK3	16	15	31	5139.646
#212	HOXA4	16	20	36	981.802
#213	E2F1	16	19	35	627.813
#214	PLSCR1	16	10	26	129.023
#215	HLF	16	15	31	874.225
#216	NFKB2	16	19	35	182.404
#217	GATA2	16	21	37	1957.009
#218	MYC	16	12	28	521.59
#219	ARNT2	16	28	44	1899.153
#220	MYT1L	15	33	48	14174.174
#221	HOXD4	15	22	37	776.702
#222	FOSL1	15	20	35	434.404
#223	HINFP	15	19	34	1863.339
#224	IKZF3	15	19	34	85.312
#225	HOXA10	15	28	43	2282.628
#226	ONECUT1	15	23	38	1611.395
#227	CEBPD	15	23	38	333.773
#228	NR4A2	15	27	42	1148.831
#229	PBX3	15	22	37	1443.322
#230	ZNF140	15	23	38	1664.975
#231	MYF5	15	19	34	288.712
#232	HOXD11	15	18	33	183.97
#233	HEY2	15	19	34	657.172
#234	ZGPAT	15	19	34	527.271
#235	SOX11	15	18	33	1332.429
#236	HSF4	14	21	35	623.654
#237	TAL1	14	26	40	812.211
#238	MSRB2	14	27	41	2529.597
#239	CDKN2A	14	29	43	1698.981
#240	HOXB2	14	22	36	5525.902
#241	SOX4	14	27	41	952.959
#242	SIM1	14	27	41	2278.365
#243	ZFP37	14	24	38	600.321
#244	SMAD9	14	22	36	1281.067
#245	HES1	14	16	30	131.99
#246	LMO4	14	20	34	715.753
#247	SRF	14	20	34	644.022
#248	ZIC3	14	20	34	82.743
#249	CEBPE	14	22	36	1951.804
#250	GBX2	14	27	41	1917.667
#251	HOXB13	14	29	43	804.881
#252	FUBP1	14	21	35	647.038
#253	ZSCAN18	14	21	35	761.322
#254	ESR1	14	24	38	1839.458
#255	ARNTL2	14	18	32	1470.378
#256	ATF6	14	16	30	174.202
#257	CBFB	14	16	30	589.791
#258	KLF9	14	16	30	1202.952
#259	ALX3	14	24	38	263.301
#260	EGR2	14	8	22	131.721
#261	GAS7	13	13	26	862.132
#262	SOX5	13	25	38	1467.626
#263	HOXD1	13	23	36	954.252
#264	TLX1	13	27	40	1596.36
#265	SREBF1	13	21	34	1134.565
#266	HIC1	13	21	34	522.368
#267	HOXC8	13	19	32	731.366
#268	THRA	13	22	35	864.024
#269	MYT1	13	28	41	1758.876
#270	HMX1	13	19	32	79.111
#271	PITX2	13	31	44	2934.548
#272	MYF6	13	24	37	5616.722
#273	NEUROG1	13	23	36	93.555
#274	MYCL1	13	24	37	1383.435
#275	HCFC1	13	23	36	1749.946
#276	SALL1	13	26	39	863.903
#277	MZF1	13	19	32	365.854
#278	ST18	12	34	46	3043.612
#279	TFAP4	12	20	32	1303.244
#280	HNF1A	12	25	37	361.024
#281	SP1	12	23	35	1153.644
#282	TADA2A	12	28	40	1974.235
#283	PHOX2A	12	20	32	526.927
#284	ZNF154	12	20	32	548.214
#285	RFXAP	12	33	45	1085.262
#286	KLF1	12	25	37	578.192
#287	MTA2	12	19	31	256.512
#288	NR0B1	12	32	44	1091.277
#289	HOXB9	12	29	41	1710.792
#290	FOXP3	12	24	36	545.503
#291	MLL	12	20	32	496.74
#292	KLF12	12	19	31	341.189
#293	HSF2	12	31	43	4070.408
#294	FOXF1	12	20	32	1210.745
#295	NR5A1	11	20	31	774.897
#296	GABPB1	11	17	28	895.811
#297	SCML1	11	20	31	604.77
#298	PPARA	11	23	34	2109.325
#299	VTN	11	24	35	1295.184
#300	ZFHX3	11	26	37	333.928
#301	EN2	11	19	30	94.202
#302	PDX1	11	23	34	555.079
#303	RARG	11	24	35	278.483
#304	TLX2	11	21	32	134.254
#305	NKX3-1	11	22	33	2086.463
#306	ARNT	11	18	29	144.628
#307	ZNF643	11	24	35	1066.727
#308	CREBBP	11	20	31	488.082
#309	HOXD9	11	22	33	754.943
#310	SOX9	11	19	30	630.825
#311	TAF1B	11	17	28	571.183
#312	MLXIPL	11	21	32	2426.689
#313	RBPJL	11	27	38	674.328
#314	MYOD1	11	25	36	2057.818
#315	BACH1	11	25	36	1821.154
#316	USF2	11	14	25	5275.219
#317	ESRRA	10	20	30	292.941
#318	ESRRB	10	29	39	1234.562
#319	LMX1B	10	22	32	489.711
#320	NR4A1	10	10	20	637.808
#321	NR1I2	10	19	29	864.427
#322	E2F8	10	21	31	956.32
#323	TCEAL1	10	21	31	954.128
#324	ZSCAN12	10	22	32	2033.165
#325	HOXD3	10	27	37	1180.766
#326	TFAP2B	10	22	32	584.142
#327	TBX6	10	27	37	1113.333
#328	PROX1	10	23	33	848.101
#329	GATA4	10	24	34	1033.388
#330	FOXE3	10	19	29	1607.606
#331	DMRT1	10	19	29	864.523
#332	RFX3	10	23	33	1852.95
#333	ATF3	10	11	21	354.822
#334	IRF5	10	31	41	1208.4
#335	STAT6	10	23	33	624.59
#336	SMAD3	10	19	29	196.424
#337	PLAG1	10	22	32	206.048
#338	IRX4	10	22	32	1310.665
#339	MXD1	9	31	40	699.848
#340	CRX	9	22	31	1582.867
#341	EMX1	9	21	30	384.163
#342	PKNOX1	9	29	38	537.638
#343	CREB5	9	31	40	1751.964
#344	TCF21	9	21	30	1602.921
#345	HOXA2	9	24	33	399.949
#346	ONECUT2	9	16	25	936.428
#347	MSC	9	29	38	1250.183
#348	POU4F1	9	29	38	581.919
#349	EGR4	9	25	34	218.431
#350	KDM5B	9	30	39	1427.08
#351	HESX1	9	23	32	1075.304
#352	TCF15	9	25	34	557.105
#353	TBX4	9	22	31	2432.377
#354	HMG20B	9	18	27	507.222
#355	FOXI1	9	25	34	284.84
#356	CITED1	9	23	32	589.918
#357	PAX8	9	27	36	861.912
#358	ZNF268	9	13	22	4586.724
#359	CUX2	9	29	38	1275.673
#360	NR5A2	9	26	35	439.277
#361	FOXD1	9	30	39	654.708
#362	WT1	9	28	37	737.923
#363	TEF	9	23	32	463.881
#364	SOX18	9	22	31	451.969
#365	NR4A3	9	24	33	1893.813
#366	TCF7	8	25	33	954.95
#367	PITX1	8	31	39	642.701
#368	POU3F3	8	30	38	1027.636
#369	DLX2	8	34	42	2297.004
#370	ZNF135	8	26	34	838.557
#371	NKX2-8	8	27	35	597.251
#372	NKX2-1	8	25	33	180.112
#373	MNX1	8	31	39	1363.865
#374	VSX1	8	21	29	1339.023
#375	PGR	8	33	41	678.747
#376	GLI2	8	31	39	778.673
#377	POU3F1	8	28	36	552.354
#378	ZNF167	8	29	37	1192.042
#379	RERE	8	25	33	1841.444
#380	PRDM1	8	20	28	246.992
#381	IKZF1	8	27	35	1774.055
#382	LEF1	8	32	40	1233.708
#383	SIM2	8	29	37	667.717
#384	SOX2	8	30	38	4045.664
#385	ESR2	8	21	29	840.438
#386	PAX6	8	26	34	399.758
#387	SLC26A3	8	34	42	1586.524
#388	ERG	8	22	30	1248.374
#389	HOXB6	8	30	38	816.495
#390	ZNF444	8	22	30	723.924
#391	FOXO4	8	24	32	334.187
#392	RORB	8	22	30	431.038
#393	DLX6	7	23	30	151.401
#394	POU3F2	7	32	39	360.838
#395	ZNF134	7	21	28	355.942
#396	NR1I3	7	27	34	1088.39
#397	ZSCAN2	7	26	33	512.228
#398	ETV4	7	25	32	1217.741
#399	NR1H4	7	25	32	582.528
#400	REST	7	34	41	2350.516
#401	ZNF236	7	25	32	765.374
#402	POU2F2	7	25	32	359.923
#403	MEF2D	7	22	29	713.175
#404	FOXD3	7	27	34	710.684
#405	CSRNP3	7	32	39	905.274
#406	NFATC4	7	23	30	505.286
#407	HNF4G	7	19	26	252.172
#408	TSC22D2	7	29	36	1961.181
#409	OVOL1	7	22	29	785.129
#410	HOXC13	7	22	29	700.291
#411	SOX30	7	32	39	910.373
#412	ZNF287	7	22	29	397.115
#413	ELF5	7	19	26	181.003
#414	ZNF80	7	30	37	601.079
#415	TAF13	7	20	27	526.539
#416	ZIC1	7	30	37	1305.787
#417	TFDP2	7	19	26	251.194
#418	FOXC2	7	27	34	771.54
#419	TFDP3	7	30	37	971.631
#420	FOXD2	6	30	36	982.985
#421	ZNF91	6	23	29	1951.384
#422	CTBP1	6	23	29	433.789
#423	GSC2	6	25	31	569.353
#424	PAX5	6	26	32	2754.657
#425	ELK1	6	16	22	979.405
#426	POU1F1	6	24	30	1202.124
#427	SCAND2	6	35	41	966.943
#428	C2orf3	6	26	32	641.589
#429	HAND2	6	25	31	1136.875
#430	NFATC1	6	34	40	978.051
#431	BUD31	6	23	29	503.091
#432	EGR3	6	11	17	506.387
#433	STAT2	6	30	36	1040.795
#434	RCAN1	6	26	32	446.187
#435	PRDM2	6	23	29	347.395
#436	NKX2-5	6	20	26	449.034
#437	SCRT1	6	26	32	1466.629
#438	YY1	6	23	29	231.435
#439	E2F2	6	27	33	1647.707
#440	ATF6B	5	25	30	402.301
#441	BATF3	5	25	30	605.493
#442	HOXB1	5	25	30	785.735
#443	IRF4	5	33	38	560.049
#444	SATB2	5	31	36	1214.488
#445	TBX5	5	26	31	378.877
#446	POU2F3	5	30	35	534.861
#447	MSX2	5	33	38	491.743
#448	LZTS1	5	25	30	404.241
#449	HR	5	27	32	1111.637
#450	POU6F2	5	26	31	695.719
#451	TLX3	5	20	25	161.662
#452	ARID3A	5	24	29	710.161
#453	FOXJ1	5	36	41	586.616
#454	FOXH1	5	30	35	513.768
#455	TSC22D3	5	28	33	828.789
#456	HIF3A	5	32	37	605.878
#457	DBP	5	27	32	1131.509
#458	FOXG1	5	29	34	659.774
#459	NR6A1	4	34	38	645.3
#460	ZNF41	4	28	32	363.153
#461	TBX2	4	21	25	929.625
#462	RB1	4	24	28	343.48
#463	FOXL2	4	26	30	1102.292
#464	FOXA2	4	22	26	496.013
#465	FOXE1	4	29	33	676.453
#466	PPARD	4	22	26	288.678
#467	ATF5	4	25	29	2361.322
#468	SPI1	4	24	28	1278.792
#469	FOXB1	4	20	24	279.192
#470	PHF1	4	26	30	1072.045
#471	SIX1	3	29	32	1562.263
#472	SNAPC5	3	25	28	152.721
#473	PTH	3	31	34	487.722
#474	ASCL1	3	35	38	461.897
#475	ETV2	3	31	34	224.321
#476	RARB	3	29	32	201.789
#477	E2F4	3	31	34	427.298
#478	POU6F1	3	26	29	753.467
#479	FOXO3	3	26	29	250.051
#480	SNAPC4	3	27	30	525.012
#481	ATOH1	3	29	32	163.524
#482	POU4F3	3	32	35	2002.138
#483	TBX1	3	35	38	349.754
#484	HOXA3	3	22	25	455.238
#485	HOXB7	3	20	23	231.178
#486	NFE2	3	36	39	366.427
#487	VDR	3	27	30	1053.362
#488	ZNF639	3	32	35	276.962
#489	ZHX3	3	29	32	718.108
#490	ZNF3	3	25	28	207.838
#491	TCF3	3	33	36	353.789
#492	HOXB3	2	27	29	343.749
#493	ZNF81	2	26	28	427.626
#494	BARX1	2	32	34	290.018
#495	LHX2	2	25	27	224
#496	CREBZF	2	25	27	71.308
#497	ZNF157	2	37	39	245.731
#498	PAX3	1	33	34	80.172
#499	SIX3	1	33	34	860.995
#500	HOXB8	1	28	29	92.417