Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PLAGL2	55	1	56	4470.061
#2	PBX1	51	4	55	1433.783
#3	ASCL2	50	8	58	771.548
#4	ZEB2	44	3	47	75.771
#5	CDX2	42	4	46	3460.102
#6	SATB2	41	7	48	629.118
#7	TAF4	40	1	41	29.056
#8	CITED2	40	9	49	2409.291
#9	BCL6	40	10	50	1999.311
#10	ZEB1	40	7	47	1090.158
#11	GLI3	39	3	42	280.725
#12	CEBPA	38	2	40	51.944
#13	TRPS1	37	5	42	90.562
#14	NR1I2	37	6	43	289.522
#15	MITF	36	2	38	624.003
#16	PRRX1	36	6	42	188.003
#17	ZFPM2	36	4	40	67.778
#18	GTF2IRD1	35	5	40	125.395
#19	PURA	35	7	42	1904.266
#20	HIF1A	35	12	47	1410.663
#21	AFF4	34	2	36	3127.017
#22	NR3C1	34	8	42	2772.445
#23	KLF3	34	6	40	353.76
#24	GABPA	33	4	37	78.009
#25	PEG3	33	7	40	134.475
#26	NFYB	32	7	39	758.859
#27	TAF13	32	14	46	8972.824
#28	TSHZ3	32	5	37	2543.367
#29	KLF9	32	7	39	1624.463
#30	ESRRA	32	10	42	1033.951
#31	MEIS1	31	7	38	177.907
#32	FLI1	31	4	35	16031.509
#33	ELK3	31	10	41	341.316
#34	MTA2	31	3	34	649.024
#35	CREB3L1	31	10	41	1205.25
#36	SP1	31	1	32	28.416
#37	AEBP1	30	3	33	281.973
#38	ATF2	30	1	31	15.248
#39	CREB1	29	6	35	171.083
#40	STAT2	29	9	38	4215.015
#41	ATF1	29	5	34	572.597
#42	ZHX1	28	9	37	846.734
#43	RCOR1	28	10	38	2962.697
#44	GLIS2	28	9	37	1774.791
#45	FOXM1	27	4	31	607.518
#46	SMAD2	27	11	38	7576.766
#47	RUNX1T1	27	9	36	821.112
#48	MAF	26	7	33	6050.295
#49	GABPB1	26	6	32	282.992
#50	MEIS2	26	15	41	1781.916
#51	OVOL1	26	6	32	305.702
#52	ZNF281	26	13	39	3718.281
#53	ELF2	26	11	37	867.397
#54	MEF2A	26	12	38	1086.637
#55	ARID3A	26	4	30	67.323
#56	TFCP2	25	10	35	7319.435
#57	JUN	25	12	37	3278.906
#58	FUBP1	25	7	32	1006.95
#59	CBFB	25	3	28	37.115
#60	GATAD1	24	10	34	1889.661
#61	UHRF1	24	6	30	898.042
#62	ETV6	24	9	33	3562.889
#63	ZNF217	24	10	34	2159.642
#64	ETS1	24	15	39	1140.093
#65	SNAI2	24	8	32	126.231
#66	FOXA2	24	10	34	951.878
#67	TCF12	24	4	28	2897.811
#68	LASS6	23	8	31	312.862
#69	AHCTF1	23	8	31	6004.92
#70	FOXA3	23	5	28	637.126
#71	E2F3	23	13	36	2169.564
#72	ATOH1	23	4	27	1937.712
#73	ZKSCAN1	22	7	29	842.577
#74	ZNF165	22	14	36	1986.262
#75	NFIB	22	9	31	852.597
#76	C5orf41	22	11	33	827.012
#77	CNOT8	22	7	29	476.474
#78	EBF1	22	8	30	1436.056
#79	ZNF75D	21	10	31	1131.218
#80	TGIF2	21	6	27	754.921
#81	TEAD3	21	13	34	2254.244
#82	HMG20B	21	7	28	332.159
#83	ZNF131	21	2	23	241.995
#84	SMAD4	21	13	34	850.721
#85	CUX1	21	6	27	1950.038
#86	NFATC1	21	14	35	2152.517
#87	STRN3	21	12	33	1559.29
#88	MAX	21	7	28	2288.243
#89	C1orf85	21	12	33	659.273
#90	ZNF91	21	11	32	1498.335
#91	MEF2C	20	9	29	306.624
#92	AHR	20	15	35	1526.422
#93	GATAD2B	20	12	32	1118.06
#94	PHF1	20	12	32	1660.002
#95	TWIST1	20	7	27	176.019
#96	ARNT	20	14	34	6046.168
#97	ZBTB38	20	10	30	1440.192
#98	TEAD4	20	9	29	3778.984
#99	ELF1	20	9	29	2815.911
#100	TBX1	20	3	23	406.256
#101	HNF4G	19	8	27	155.732
#102	FOXN3	19	8	27	857.625
#103	NOLC1	19	13	32	2381.956
#104	ARNTL2	19	19	38	2636.679
#105	USF1	19	7	26	1071.114
#106	EHF	19	14	33	2836.999
#107	ZNF238	19	11	30	352.114
#108	TWIST2	19	8	27	205.131
#109	HCLS1	19	3	22	28.486
#110	ETV1	19	13	32	1927.118
#111	RB1	19	8	27	172.245
#112	TFAP2A	19	17	36	4730.541
#113	SPDEF	18	10	28	986.537
#114	TCFL5	18	10	28	856.145
#115	LMO4	18	14	32	1647.83
#116	CBFA2T2	18	13	31	2146.57
#117	ERG	18	9	27	1308.515
#118	E2F7	18	7	25	1540.22
#119	SCAND1	18	11	29	1114.692
#120	C11orf9	18	9	27	298.038
#121	HMGA1	18	12	30	1218.283
#122	PBX2	17	13	30	1784.989
#123	TCF3	17	8	25	1861.851
#124	BTG2	17	8	25	1491.795
#125	TAF5	17	7	24	427.286
#126	E2F5	17	10	27	648.105
#127	MYCL1	17	11	28	1721.195
#128	FOXJ3	17	6	23	309.649
#129	YEATS4	17	16	33	2274.303
#130	NOTCH1	17	6	23	3039.866
#131	ZNF639	17	17	34	3788.188
#132	CREB3L4	17	5	22	1041.405
#133	TFAM	17	12	29	659.146
#134	GTF2I	17	10	27	1483.277
#135	KDM5A	17	10	27	1900.751
#136	HSF2	17	12	29	465.499
#137	IRF1	17	7	24	8605.349
#138	HNF4A	17	11	28	992.416
#139	NFIC	17	11	28	1550.013
#140	ZNF148	17	14	31	1841.88
#141	TRIM22	17	14	31	3005.368
#142	MEOX2	17	7	24	676.86
#143	STAT1	16	5	21	6864.92
#144	SIX4	16	14	30	2123.359
#145	NR4A3	16	10	26	2206.067
#146	MAFB	16	13	29	862.666
#147	CBFA2T3	16	11	27	1807.115
#148	HHEX	16	16	32	1220.777
#149	MYC	16	12	28	682.892
#150	GATAD2A	16	12	28	543.534
#151	FOXF1	16	9	25	2517.413
#152	HIF3A	16	7	23	1914.56
#153	FOSL2	16	10	26	823.949
#154	HEYL	16	10	26	858.081
#155	TSHZ2	16	10	26	274.91
#156	JUNB	15	7	22	295.828
#157	NR2C1	15	13	28	3424.619
#158	HNF1B	15	9	24	458.79
#159	KLF2	15	12	27	616.75
#160	HSF1	15	8	23	1368.065
#161	MNT	15	4	19	260.721
#162	ZSCAN21	15	9	24	4656.446
#163	ZFP36L2	15	13	28	2851.482
#164	TFEC	15	8	23	14499.647
#165	TCF7	15	13	28	899.265
#166	ELK1	15	12	27	3920.546
#167	MYBL2	15	11	26	419.647
#168	ZRANB2	15	9	24	479.781
#169	SOX4	15	16	31	802.831
#170	BACH1	15	19	34	2897.336
#171	ESR1	15	6	21	2215.032
#172	CREM	15	9	24	944.623
#173	CSRNP3	15	19	34	5370.518
#174	SREBF1	15	11	26	1183.514
#175	RCAN1	14	14	28	559.061
#176	ZNF323	14	18	32	4017.195
#177	VTN	14	11	25	1701.03
#178	NFE2L3	14	17	31	1371.576
#179	SCML1	14	14	28	860.046
#180	NKX2-3	14	7	21	582.046
#181	HIC1	14	16	30	989.632
#182	EGR2	14	11	25	770.511
#183	E2F8	14	11	25	560.249
#184	RXRB	14	11	25	658.974
#185	TFCP2L1	14	18	32	1535.021
#186	DDIT3	14	13	27	1787.159
#187	ZNF207	14	7	21	405.05
#188	NR4A2	14	8	22	2347.469
#189	ZNF92	14	13	27	914.012
#190	TFDP1	14	9	23	1674.548
#191	IKZF1	14	6	20	16224.355
#192	BLZF1	14	14	28	1071.894
#193	ARID4A	14	14	28	1498.401
#194	HDAC1	14	10	24	858.113
#195	FOXO3	14	19	33	1860.104
#196	EGR1	14	14	28	2003.385
#197	EGR3	14	6	20	667.949
#198	PTTG1	14	8	22	749.14
#199	MECOM	14	11	25	2664.454
#200	TCF4	14	13	27	2658.54
#201	ZNF3	13	4	17	84.802
#202	ETV5	13	14	27	417.272
#203	ZNF167	13	11	24	966.356
#204	NR4A1	13	1	14	176.255
#205	NR2F2	13	15	28	698.004
#206	BHLHE40	13	11	24	2100.273
#207	CREBZF	13	21	34	1720.159
#208	GAS7	13	7	20	514.527
#209	RORA	13	6	19	288.15
#210	TCF7L2	13	13	26	3171.777
#211	ISX	13	9	22	3069.513
#212	HMGB2	13	9	22	1379.892
#213	TEAD1	13	14	27	930.464
#214	FBXW7	13	17	30	1216.823
#215	RUNX1	13	10	23	1797.83
#216	TFE3	13	10	23	455.719
#217	CDKN2A	13	16	29	1339.792
#218	ELF4	13	12	25	998.57
#219	TCEAL1	13	16	29	3216.125
#220	ADNP	13	16	29	895.146
#221	ZSCAN16	12	14	26	1966.955
#222	MEIS3P1	12	11	23	1632.483
#223	ZNF81	12	2	14	125.04
#224	NKX2-1	12	12	24	5039.205
#225	FOXD1	12	18	30	1872.855
#226	MAFF	12	14	26	1354.731
#227	HLF	12	9	21	1422.738
#228	HOXA10	12	6	18	722.725
#229	ZNF236	12	14	26	823.885
#230	MAFK	12	16	28	2574.776
#231	ZNF41	12	12	24	783.129
#232	SCML2	12	13	25	1071.669
#233	IRF7	12	13	25	10200.76
#234	SMAD9	12	18	30	3035.455
#235	GBX2	12	7	19	479.29
#236	HOXA9	11	8	19	756.531
#237	ZNF277	11	15	26	288.294
#238	BATF2	11	11	22	5924.607
#239	KLF7	11	16	27	1874.241
#240	BTAF1	11	8	19	1024.272
#241	CNOT7	11	16	27	874.656
#242	KLF12	11	18	29	2110.387
#243	TBX3	11	18	29	844.082
#244	PROX1	11	15	26	1184.172
#245	XBP1	11	6	17	302.381
#246	MLXIPL	11	12	23	1029.987
#247	TAF12	11	17	28	1760.775
#248	SOX6	11	13	24	1522.369
#249	PBX3	11	8	19	211.807
#250	TFDP2	11	16	27	1548.977
#251	MNX1	11	15	26	1174.739
#252	CSRNP1	11	6	17	185.487
#253	EPAS1	11	12	23	1082.819
#254	RBCK1	10	21	31	1095.93
#255	CTNNB1	10	14	24	624.613
#256	RUNX2	10	16	26	274.748
#257	ATF3	10	9	19	1235.975
#258	PPARG	10	10	20	779.135
#259	TGIF1	10	9	19	455.508
#260	TULP4	10	11	21	991.799
#261	FOXO1	10	18	28	2223.886
#262	IRF6	10	16	26	2497.102
#263	ZNF367	10	6	16	368.931
#264	ISL1	10	18	28	2752.914
#265	FOXF2	10	8	18	472.886
#266	SLC26A3	10	15	25	533.506
#267	HOXA1	10	15	25	1511.902
#268	SUPT4H1	10	9	19	829.901
#269	DMRT1	10	8	18	4599.018
#270	HEY1	10	15	25	1148.001
#271	PLSCR1	10	10	20	3139.985
#272	PHTF1	10	11	21	624.438
#273	FOXK1	10	11	21	1425.022
#274	SP3	10	13	23	2365.477
#275	BACH2	10	12	22	189.991
#276	GCFC1	10	20	30	2388.267
#277	MGA	10	10	20	435.855
#278	ETV4	9	18	27	1662.625
#279	HOXA5	9	8	17	594.879
#280	NFIL3	9	10	19	299.284
#281	HOXD10	9	10	19	894.459
#282	STAT4	9	16	25	797.074
#283	LZTS1	9	9	18	25.718
#284	HOXB2	9	17	26	1266.212
#285	HOXB9	9	11	20	1629.214
#286	ENO1	9	14	23	1639.268
#287	SOX9	9	17	26	2722.581
#288	NR2F6	9	17	26	754.087
#289	ZNF24	9	12	21	754.382
#290	SIX2	9	21	30	2023.025
#291	ZSCAN18	9	20	29	638.32
#292	TARDBP	9	12	21	635.927
#293	ZNF138	9	10	19	2632.317
#294	ZFHX3	9	21	30	1544.119
#295	ELF3	9	19	28	951.032
#296	ZNF117	9	21	30	930.676
#297	TAF4B	9	24	33	2558.175
#298	ZNF483	9	8	17	278.362
#299	THRB	9	23	32	1967.456
#300	ARNT2	9	13	22	963.057
#301	ETS2	9	15	24	522.91
#302	SLC2A4RG	9	15	24	2114.257
#303	GATA6	9	19	28	740.985
#304	FOXP1	9	16	25	1743.051
#305	HOXA7	9	6	15	811.337
#306	KLF4	8	16	24	1044.16
#307	REL	8	15	23	1335.099
#308	CEBPB	8	20	28	1242.26
#309	MXD1	8	17	25	644.63
#310	NFIX	8	25	33	1939.21
#311	SUPT6H	8	12	20	477.245
#312	KLF6	8	14	22	1835.72
#313	HOXB8	8	17	25	2209.36
#314	SIN3A	8	16	24	1103.627
#315	HOPX	8	11	19	156.554
#316	VDR	8	14	22	908.396
#317	RERE	8	10	18	768.69
#318	GLI2	8	13	21	359.078
#319	HOXA3	8	15	23	496.18
#320	ESRRG	8	11	19	1437.947
#321	HOXD11	8	10	18	1010.479
#322	NFATC2	8	11	19	521.299
#323	IRX3	8	22	30	2047.85
#324	NFAT5	8	16	24	1491.757
#325	ZNF232	8	19	27	2335.957
#326	NKX3-2	8	7	15	204.63
#327	NR1H3	8	12	20	1674.189
#328	ZNF93	8	20	28	581.293
#329	SOX13	8	17	25	2447.104
#330	ZIC2	8	19	27	1394.331
#331	ZFP36L1	8	20	28	881.096
#332	PRDM1	8	21	29	1988.751
#333	JUND	8	16	24	715.955
#334	SIX1	8	14	22	2025.464
#335	KLF10	7	16	23	2756.835
#336	IRF8	7	21	28	627.824
#337	PLAG1	7	22	29	1163.961
#338	IRF9	7	9	16	477.104
#339	GTF2H3	7	12	19	313.456
#340	HDAC2	7	14	21	305.293
#341	ZNF37A	7	14	21	1164.928
#342	MSRB2	7	21	28	813.872
#343	RUNX3	7	18	25	6174.695
#344	PPARA	7	18	25	3000.33
#345	RFX5	7	13	20	2136.691
#346	NR1D2	7	16	23	530.348
#347	MMP14	7	13	20	299.946
#348	CEBPD	7	21	28	656.362
#349	FOSL1	7	18	25	1168.935
#350	ZNF134	7	16	23	1237.073
#351	TSC22D3	7	14	21	495.969
#352	NFXL1	7	17	24	2453.013
#353	LEF1	7	17	24	1272.181
#354	HOXA11	7	12	19	690.027
#355	GLIS3	7	15	22	269.949
#356	HMGB1	7	11	18	790.56
#357	RFXAP	7	20	27	750.926
#358	ZNF33B	7	29	36	1221.646
#359	BHLHE41	7	17	24	199.975
#360	ZC3H8	7	14	21	427.47
#361	HMBOX1	7	18	25	2289.089
#362	TSC22D1	7	22	29	1857.036
#363	HMGA2	7	18	25	3265.061
#364	ARNTL	7	16	23	342.965
#365	TCF21	7	11	18	108.951
#366	SOX12	7	18	25	1240.628
#367	CLOCK	6	15	21	931.824
#368	PA2G4	6	10	16	745.634
#369	MLLT10	6	23	29	2240.95
#370	ATF6	6	20	26	791.19
#371	TEAD2	6	16	22	632.024
#372	TSHZ1	6	21	27	604.191
#373	HOXD8	6	19	25	1857.968
#374	KDM5B	6	15	21	1172.378
#375	SALL1	6	14	20	3285.372
#376	HOXD13	6	11	17	1071.061
#377	MTA1	6	20	26	1468.175
#378	TSC22D2	6	17	23	3971.001
#379	ZNF643	6	16	22	384.527
#380	ARX	6	18	24	2850.499
#381	HOXA2	6	15	21	636.514
#382	BATF	6	13	19	950.501
#383	SOLH	6	15	21	777.195
#384	MEOX1	6	20	26	485.435
#385	LCOR	6	21	27	1216.164
#386	KLF11	6	15	21	1265.891
#387	ZNF83	6	21	27	352.779
#388	SLC30A9	6	27	33	908.421
#389	FOSB	6	7	13	379.151
#390	WNT5A	6	12	18	756.297
#391	ST18	6	17	23	1241.506
#392	TP63	6	11	17	421.584
#393	FOS	6	11	17	936.099
#394	ZNF140	6	16	22	246.268
#395	HOXB3	6	14	20	537.163
#396	FOXC1	6	22	28	1351.501
#397	HOXB6	6	11	17	438.082
#398	MSX2	6	18	24	2191.768
#399	ADNP2	6	21	27	359.116
#400	FOXQ1	6	21	27	1818.017
#401	ETV7	5	10	15	2224.177
#402	DMRT2	5	29	34	1364.819
#403	ZHX2	5	19	24	1721.048
#404	IRX2	5	18	23	1230.157
#405	KCNH8	5	15	20	1174.241
#406	TFAP2C	5	21	26	1545.032
#407	NCOR1	5	18	23	667.28
#408	ZNF175	5	17	22	1103.249
#409	GRHL3	5	19	24	456.725
#410	HES1	5	20	25	3252.309
#411	FOXP2	5	16	21	624.878
#412	NR3C2	5	21	26	874.064
#413	EGR4	5	15	20	3276.542
#414	PITX2	5	14	19	430.161
#415	SMAD1	5	15	20	694.317
#416	RORC	5	20	25	458.018
#417	SATB1	5	23	28	1033.615
#418	NR1H4	5	17	22	1834.697
#419	PURB	5	20	25	648.64
#420	NFIA	5	16	21	1754.539
#421	C2orf3	5	13	18	504.306
#422	CREBL2	5	22	27	2179.984
#423	NEUROD1	5	19	24	1356.581
#424	SIM2	5	20	25	1647.397
#425	ZIC1	5	8	13	390.42
#426	SOX7	5	13	18	351.399
#427	ELK4	5	16	21	1254.861
#428	NFATC3	5	17	22	688.136
#429	HAND1	5	11	16	401.737
#430	NFX1	5	26	31	1454.996
#431	DLX6	5	15	20	588.897
#432	HES6	4	18	22	1241.47
#433	TRIM25	4	23	27	887.958
#434	NFYA	4	23	27	1311.489
#435	SPEN	4	13	17	391.025
#436	ZFP90	4	16	20	1487.637
#437	ZNF274	4	15	19	1314.345
#438	KLF5	4	19	23	1119.527
#439	EN2	4	18	22	602.57
#440	MYNN	4	15	19	154.728
#441	BCL11B	4	24	28	1130.821
#442	ONECUT2	4	21	25	2281.304
#443	NFE2L2	4	18	22	550.728
#444	SIX3	4	12	16	586.229
#445	TFEB	4	17	21	406.592
#446	ZNF268	4	21	25	595.903
#447	SREBF2	4	15	19	278.842
#448	SP4	4	20	24	3209.232
#449	ZXDA	4	15	19	1893.571
#450	RARA	4	16	20	1078.336
#451	SMAD5	4	17	21	2500.868
#452	HIRA	4	15	19	381.972
#453	MKX	3	12	15	169.943
#454	PITX1	3	13	16	648.219
#455	MSX1	3	22	25	694.994
#456	SOX1	3	16	19	2003.054
#457	HOXB13	3	20	23	1006.089
#458	HOXB5	3	15	18	2203.307
#459	NR2F1	3	18	21	417.162
#460	TRIM29	3	22	25	411.642
#461	EOMES	3	11	14	117.301
#462	HR	3	14	17	266.776
#463	TP53	3	27	30	899.666
#464	SOX8	3	16	19	332.424
#465	ELF5	3	25	28	1333.433
#466	PCGF2	3	11	14	147.063
#467	GRHL2	3	18	21	337.064
#468	MESP1	3	17	20	1002.837
#469	SMAD6	3	17	20	601.672
#470	SOX11	3	14	17	1030.965
#471	TRERF1	3	23	26	593.366
#472	POU2F3	2	19	21	707.621
#473	YY1	2	14	16	181.118
#474	FOXC2	2	17	19	300.357
#475	HOXA13	2	18	20	424.52
#476	PAX6	2	11	13	585.788
#477	NR5A2	2	15	17	123.79
#478	CREB5	2	23	25	420.083
#479	CREB3L2	2	20	22	989.5
#480	IRF2	2	23	25	344.432
#481	SCAND3	2	17	19	583.016
#482	IRF5	2	22	24	196.06
#483	FOXA1	2	16	18	576.032
#484	MYCN	2	22	24	259.684
#485	IRX5	2	15	17	377.662
#486	GTF2H2	2	15	17	595.406
#487	ZNF45	2	21	23	299.712
#488	JDP2	1	22	23	140.927
#489	ZNF397	1	20	21	77.054
#490	L3MBTL4	1	19	20	353.002
#491	ZNF85	1	17	18	1135.06
#492	HOXB7	1	10	11	59.657
#493	FOXG1	1	14	15	535.949
#494	ZNF256	1	19	20	101.398
#495	CITED1	1	19	20	107.751
#496	NPAS2	1	27	28	1219.15
#497	ATF7	1	14	15	33.46
#498	CTBP1	0	25	25	0
#499	WT1	0	22	22	0
#500	SOX2	0	20	20	0