Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ARNTL2	61	0	61	0
#2	TCF4	42	2	44	3187.464
#3	PBX1	38	6	44	4849.486
#4	NFE2L3	33	4	37	182.729
#5	PTTG1	31	4	35	243.229
#6	NR3C2	31	5	36	908.427
#7	PKNOX2	30	2	32	243.746
#8	LASS6	29	9	38	4130.058
#9	NFE2L1	29	3	32	131.776
#10	KLF15	29	3	32	292.083
#11	RBPJL	28	6	34	946.525
#12	RUNX1T1	27	5	32	366.07
#13	KLF11	27	5	32	889.286
#14	USF2	27	6	33	534.024
#15	LEF1	27	8	35	1443.423
#16	IKZF1	27	4	31	714.249
#17	ELF4	27	5	32	1617.505
#18	CBFA2T3	26	13	39	3409.12
#19	ERG	26	4	30	205.523
#20	HNF1A	26	4	30	802.738
#21	RUNX2	25	2	27	230.089
#22	ZNF444	24	3	27	1041.209
#23	KLF7	24	6	30	495.69
#24	TSHZ2	23	4	27	478.276
#25	HOXB7	23	9	32	2849.025
#26	HOXA3	23	11	34	1869.631
#27	ZXDC	23	7	30	374.417
#28	RUNX1	23	9	32	2627.443
#29	ZEB2	23	10	33	1300.913
#30	VDR	22	8	30	1387.655
#31	XBP1	22	6	28	569.245
#32	KLF2	22	7	29	1693.479
#33	HCLS1	21	6	27	867.515
#34	MAF	21	8	29	725.934
#35	UHRF1	21	6	27	2344.112
#36	ZNF189	20	8	28	1360.505
#37	MEIS1	20	8	28	936.005
#38	PRRX1	20	6	26	599.817
#39	FLI1	20	6	26	675.788
#40	KLF5	20	7	27	941.976
#41	AEBP1	20	6	26	958.182
#42	MXD1	20	8	28	2515.554
#43	MMP14	20	7	27	2441.132
#44	IRF7	20	9	29	1135.999
#45	PAX8	20	6	26	786.198
#46	PRDM1	20	8	28	2278.172
#47	RFXAP	20	9	29	3414.032
#48	CREB3L4	19	12	31	2483.141
#49	GATA4	19	10	29	1690.431
#50	E2F8	19	9	28	1152.011
#51	MAFB	19	7	26	257.562
#52	ZFPM2	19	5	24	215.441
#53	NFKB2	19	6	25	1180.297
#54	NEUROD1	19	5	24	1910.032
#55	ESR1	19	7	26	964.476
#56	PROX1	18	12	30	2033.188
#57	FOSL2	18	4	22	2056.924
#58	FOXM1	18	6	24	945.262
#59	KLF12	18	6	24	169.714
#60	GAS7	18	6	24	1393.469
#61	FOXF2	18	8	26	8386.126
#62	HOXB3	18	6	24	1857.779
#63	NR1H2	18	9	27	2454.291
#64	ETV6	18	7	25	1561.308
#65	SOX6	18	10	28	3053.827
#66	SPDEF	17	12	29	6180.601
#67	HOPX	17	3	20	127.066
#68	HOXB2	17	6	23	252.826
#69	NFYA	17	5	22	313.658
#70	PEG3	17	6	23	1055.041
#71	BCL3	17	10	27	3537.866
#72	FOXL1	17	9	26	3590.721
#73	CBFB	16	9	25	1614.987
#74	KDM5B	16	10	26	1465.009
#75	ELF3	16	7	23	2966.76
#76	RARB	16	11	27	1258.639
#77	PHF1	16	6	22	2587.807
#78	ST18	16	4	20	788.246
#79	EHF	16	10	26	873.75
#80	MEF2C	16	6	22	251.101
#81	ECSIT	15	8	23	1418.68
#82	ZGPAT	15	9	24	877.683
#83	CEBPB	15	9	24	2570.997
#84	BHLHE40	15	8	23	989.893
#85	BTG2	15	11	26	723.756
#86	NR5A2	15	10	25	1985.753
#87	RUNX3	15	11	26	2723.328
#88	SOLH	15	6	21	1845.283
#89	IRF1	15	9	24	1995.624
#90	ESRRG	15	9	24	493.816
#91	ZSCAN18	15	8	23	2891.181
#92	STAT6	15	9	24	2706.381
#93	TEF	14	11	25	636.961
#94	TFDP2	14	12	26	3648.849
#95	RFX5	14	8	22	2795.028
#96	C2orf3	14	8	22	4446.421
#97	FOXP2	14	10	24	1857.853
#98	ZNF91	14	10	24	4976.016
#99	WT1	14	9	23	895.387
#100	TFAP2A	14	7	21	1500.734
#101	TFDP1	14	7	21	2574.801
#102	PLSCR1	14	6	20	1296.501
#103	SOX15	14	6	20	1293.051
#104	E2F3	14	10	24	1195.641
#105	HOXA2	14	7	21	311.616
#106	AHR	14	10	24	1355.316
#107	RELB	14	7	21	1811.996
#108	NFIA	14	9	23	3084.455
#109	FOXP4	13	9	22	3463.534
#110	PBX3	13	7	20	729.388
#111	PITX1	13	9	22	5064.003
#112	STAT1	13	9	22	1549.32
#113	CSRNP3	13	11	24	906.866
#114	ENO1	13	10	23	651.317
#115	MAFF	13	10	23	3032.43
#116	VAV1	13	8	21	3591.368
#117	HEY1	13	9	22	4478.024
#118	RORA	13	8	21	3073.92
#119	TFE3	13	7	20	933.89
#120	YY1	13	12	25	4627.121
#121	MSX1	12	5	17	1544.6
#122	C11orf9	12	8	20	1628.898
#123	KLF9	12	9	21	725.492
#124	TAF10	12	12	24	3561.712
#125	HMGA1	12	11	23	2735.319
#126	HMG20B	12	8	20	1999.598
#127	NPAS1	12	11	23	4648.209
#128	SOX4	12	6	18	860.159
#129	ETS1	12	11	23	708.276
#130	SALL2	12	8	20	611.491
#131	CITED2	12	7	19	396.3
#132	E2F7	12	5	17	246.941
#133	MTA1	12	4	16	1334.571
#134	ELK1	12	10	22	1888.585
#135	ZNF193	11	8	19	1310.85
#136	SRF	11	8	19	5319.771
#137	GRHL2	11	7	18	3429.134
#138	POU2F3	11	10	21	2748.089
#139	EBF1	11	10	21	2723.84
#140	IRF6	11	13	24	2434.402
#141	FOSL1	11	13	24	2700.938
#142	ZNF33A	11	8	19	1831.058
#143	NR2F6	11	10	21	2777.854
#144	CREB1	11	7	18	477.47
#145	RARA	11	10	21	3805.38
#146	ZNF238	11	5	16	1482.033
#147	ZKSCAN5	11	10	21	2139.52
#148	EOMES	11	7	18	432.667
#149	GTF2H4	11	11	22	2028.556
#150	RELA	11	10	21	1494.518
#151	SATB1	11	10	21	1681.917
#152	TADA3	11	11	22	6422.929
#153	FOXQ1	11	15	26	1873.579
#154	HNF1B	11	10	21	5185.381
#155	ZHX3	11	7	18	88.173
#156	ZKSCAN1	11	7	18	1144.593
#157	TSHZ1	11	10	21	939.544
#158	ZNF93	11	8	19	3972.55
#159	ATF3	11	4	15	1588.677
#160	IRF9	10	6	16	972.502
#161	KLF6	10	8	18	1310.977
#162	ZEB1	10	6	16	619.471
#163	TEAD2	10	9	19	3765.063
#164	ZNF85	10	13	23	1615.282
#165	RCOR1	10	5	15	2172.924
#166	MYCL1	10	9	19	5019.411
#167	GLIS2	10	8	18	937.314
#168	CREB3	10	12	22	1589.318
#169	STAT2	10	11	21	1998.061
#170	HIC1	10	8	18	294.797
#171	GTF2IRD1	10	11	21	1025.383
#172	BATF3	10	8	18	1971.026
#173	TWIST1	10	9	19	3205.357
#174	TSC22D3	10	9	19	135.213
#175	EVX1	10	5	15	985.666
#176	TULP4	9	8	17	3006.198
#177	MYBL2	9	7	16	546.654
#178	TCF12	9	9	18	3101.876
#179	ZNF496	9	13	22	1669.834
#180	ZNF397	9	9	18	3145.589
#181	THRA	9	11	20	2082.222
#182	E2F5	9	8	17	2400.965
#183	BACH2	9	9	18	3613.245
#184	TAF5	9	10	19	2793.676
#185	IRF8	9	9	18	931.338
#186	FOXO1	9	5	14	2937.141
#187	THRB	9	11	20	308.61
#188	HMGA2	9	9	18	4496.769
#189	SOX13	9	6	15	995.808
#190	CEBPD	9	11	20	593.083
#191	PRDM2	9	8	17	415.603
#192	PRRX2	9	4	13	509.763
#193	MITF	9	8	17	282.177
#194	SMAD9	9	8	17	1011.405
#195	TSHZ3	9	12	21	4749.86
#196	TEAD3	8	9	17	441.116
#197	SIX1	8	17	25	2171.15
#198	GATA6	8	13	21	5123.374
#199	ETV7	8	7	15	411.912
#200	TP53	8	7	15	760.36
#201	TRIM28	8	6	14	1086.834
#202	TRIM22	8	10	18	3015.972
#203	ZIC2	8	10	18	2139.221
#204	ETS2	8	8	16	1330.336
#205	BATF	8	14	22	1885.448
#206	MYT1L	8	7	15	2644.632
#207	SIX5	8	7	15	1458.993
#208	CREB3L1	8	8	16	2021.71
#209	GATA3	8	10	18	319.964
#210	SATB2	8	7	15	626.606
#211	CREM	8	10	18	982.317
#212	ZNF133	8	6	14	1239.518
#213	NR2F2	8	11	19	4763.588
#214	TFEC	8	14	22	3065.403
#215	HR	8	14	22	3492.918
#216	HES1	8	9	17	2076.899
#217	MSX2	8	8	16	3793.073
#218	PAX6	8	10	18	1243.755
#219	RXRB	8	9	17	860.903
#220	TP63	8	4	12	1592.345
#221	PPARG	8	13	21	3308.502
#222	ZBTB25	8	6	14	1408.384
#223	PPARD	8	9	17	527.574
#224	SMAD3	8	17	25	6852.76
#225	GTF2I	8	4	12	1422.785
#226	GLI2	8	10	18	1966.922
#227	NFIX	8	8	16	3312.928
#228	NR3C1	8	13	21	2641.777
#229	HHEX	8	13	21	1264.81
#230	HOXB5	8	8	16	358.755
#231	FOXN3	8	10	18	2338.93
#232	HMGB2	8	7	15	1395.293
#233	RB1	8	11	19	1152.187
#234	ELK3	8	9	17	768.509
#235	RARG	8	11	19	1755.189
#236	EGR1	8	6	14	1001.076
#237	MEOX2	7	10	17	1446.748
#238	NFATC1	7	10	17	1821.976
#239	HOXD4	7	5	12	1682.717
#240	HEYL	7	11	18	1554.871
#241	MSRB2	7	10	17	1584.788
#242	GATAD1	7	15	22	3162.288
#243	LMO4	7	13	20	2498.087
#244	NR0B1	7	9	16	1529.075
#245	SMAD5	7	14	21	4052.584
#246	GLI3	7	8	15	2706.506
#247	LHX6	7	7	14	819.839
#248	C1orf85	7	8	15	759.076
#249	FOXA3	7	12	19	1381.984
#250	MAX	7	8	15	1091.192
#251	MYPOP	7	11	18	1734.075
#252	ZBTB38	7	9	16	382.34
#253	PPARA	7	14	21	7180.437
#254	ZNF274	7	10	17	873.524
#255	ATF7	7	6	13	500.872
#256	E2F6	7	8	15	2032.116
#257	SLC2A4RG	7	9	16	745.216
#258	HES6	7	10	17	1639.436
#259	MLLT10	7	15	22	3811.111
#260	TEAD4	7	15	22	1951.965
#261	NR1D2	7	10	17	764.202
#262	HNF4G	7	11	18	3132.522
#263	GABPB1	7	13	20	648.58
#264	JUND	7	10	17	976.227
#265	JUNB	7	10	17	318.01
#266	NFAT5	7	7	14	524.957
#267	C12orf28	7	11	18	6463.318
#268	SOX9	7	5	12	284.591
#269	SIX2	7	8	15	3087.711
#270	ZNF281	7	13	20	1597.438
#271	ATF4	7	10	17	2514.668
#272	SCMH1	7	11	18	744.193
#273	ZNF71	7	7	14	833.798
#274	TRIM29	6	14	20	1322.263
#275	NR4A3	6	7	13	806.984
#276	ISL1	6	10	16	1051.162
#277	SIM1	6	13	19	1456.371
#278	KLF4	6	10	16	1016.481
#279	EGR2	6	9	15	521.779
#280	ONECUT1	6	5	11	143.549
#281	TCF21	6	14	20	1804.623
#282	NR4A1	6	7	13	551.708
#283	FOXF1	6	7	13	436.296
#284	ZNF83	6	16	22	1281.163
#285	HOXB6	6	12	18	3044.631
#286	ISX	6	5	11	2390.717
#287	GLIS3	6	15	21	1262.52
#288	NR2F1	6	15	21	811.762
#289	BATF2	6	11	17	1392.17
#290	HOXC9	6	11	17	1316.907
#291	TBX2	6	4	10	397.033
#292	CBL	6	8	14	917.881
#293	GATA2	6	10	16	459.64
#294	ZNF236	6	10	16	1309.536
#295	FOXO3	6	11	17	1131.136
#296	NANOGNB	6	9	15	1694.399
#297	ZFHX4	6	6	12	1002.4
#298	HNF4A	6	12	18	1166.69
#299	ETV4	6	9	15	1176.673
#300	NFIL3	6	11	17	823.123
#301	ZC3H8	6	8	14	1433.054
#302	SIN3A	6	6	12	906.165
#303	KLF3	6	9	15	3312.061
#304	MEF2A	6	8	14	715.477
#305	BCL6	6	9	15	1616.783
#306	ELK4	6	9	15	609.066
#307	CREBBP	6	8	14	1532.378
#308	PURB	6	13	19	1130.423
#309	GATAD2B	6	11	17	1702.104
#310	MGA	6	11	17	1723.338
#311	NFYB	6	6	12	891.071
#312	TAF12	6	7	13	773.074
#313	MSC	6	8	14	1055.152
#314	MESP1	6	9	15	1439.613
#315	TBX1	6	7	13	220.519
#316	ZFHX3	6	7	13	632.187
#317	ONECUT3	6	7	13	744.702
#318	MSL3	6	8	14	1254.19
#319	MLX	5	12	17	884.549
#320	NR1I2	5	20	25	3295.886
#321	TGIF1	5	11	16	1508.68
#322	CREB3L3	5	3	8	1392.535
#323	MEIS3	5	9	14	255.162
#324	HOXB8	5	7	12	291.944
#325	KLF10	5	8	13	315.25
#326	CSRNP1	5	7	12	419.175
#327	SCAND3	5	10	15	1910.236
#328	ZNF323	5	4	9	177.566
#329	TARDBP	5	9	14	1029.595
#330	KLF16	5	7	12	847.424
#331	FOXD1	5	11	16	391.663
#332	NFYC	5	12	17	1943.45
#333	ARX	5	7	12	1786.661
#334	SPI1	5	9	14	648.857
#335	VTN	5	10	15	2083.988
#336	NFATC2	5	9	14	1646.872
#337	ZNF167	5	9	14	3213.157
#338	YEATS4	5	8	13	692.074
#339	SP1	5	10	15	1674.009
#340	SNAI2	5	10	15	382.243
#341	SMAD4	5	10	15	786.71
#342	NFATC3	5	9	14	1189.938
#343	STAT4	5	11	16	453.94
#344	HOXD8	5	13	18	3690.747
#345	SREBF2	5	11	16	949.241
#346	BHLHE41	5	13	18	9509.172
#347	MLL	5	12	17	1516.662
#348	SOX11	5	16	21	1395.863
#349	TRPS1	5	10	15	4997.365
#350	IRX2	5	6	11	509.305
#351	FOS	5	9	14	3154.011
#352	WNT5A	5	16	21	1574.014
#353	SOX8	5	12	17	3309.632
#354	TAF5L	5	10	15	1305.311
#355	KDM5A	5	11	16	1273.588
#356	RXRA	4	15	19	5584.168
#357	FOXO6	4	7	11	1093.041
#358	SP140	4	6	10	369.236
#359	ZNF256	4	12	16	1543.283
#360	HMBOX1	4	10	14	1287.929
#361	ZNF33B	4	7	11	581.085
#362	KCNH8	4	13	17	2728.25
#363	CEBPA	4	10	14	887.494
#364	HOXD1	4	7	11	1478.153
#365	TCF7L2	4	13	17	916.688
#366	ATF2	4	7	11	1005.996
#367	CTNNB1	4	7	11	2157.425
#368	TSC22D1	4	7	11	410.521
#369	SPEN	4	9	13	995.711
#370	TFCP2L1	4	9	13	2013.28
#371	PGR	4	9	13	394.638
#372	ZNF207	4	14	18	1079.358
#373	PBX4	4	9	13	421.387
#374	ZSCAN2	4	7	11	333.666
#375	PLAGL2	4	6	10	728.802
#376	CSDA	4	8	12	1188.073
#377	HOXC4	4	9	13	488.129
#378	HOXD10	4	4	8	941.007
#379	ETV1	4	10	14	227.703
#380	ZIC1	4	6	10	1849.568
#381	ZFPM1	4	11	15	2106.602
#382	TFEB	4	12	16	3586.723
#383	FOSB	4	15	19	1199.44
#384	POU2F2	4	11	15	581.502
#385	HOXA13	4	12	16	532.259
#386	TFAM	4	11	15	914.334
#387	CNOT7	4	10	14	1765.075
#388	SPIB	4	13	17	1131.527
#389	BCL11B	4	9	13	151.685
#390	HIF1A	4	10	14	667.65
#391	ONECUT2	4	8	12	157.83
#392	SIM2	4	11	15	498.799
#393	NR4A2	4	8	12	1325.755
#394	SOX2	4	7	11	487.381
#395	NFIC	4	16	20	3264.155
#396	PLAG1	4	9	13	1248.957
#397	TWIST2	4	7	11	251.57
#398	FOXS1	4	13	17	2875.454
#399	ZKSCAN4	4	11	15	810.573
#400	DBP	4	7	11	453.876
#401	TRERF1	3	8	11	117.041
#402	ZSCAN16	3	6	9	753.518
#403	ZFP36L2	3	11	14	827.051
#404	MECOM	3	9	12	310.524
#405	ZFP36L1	3	9	12	1193.313
#406	HOXA5	3	11	14	2906.215
#407	CCRN4L	3	9	12	771.417
#408	SIX4	3	13	16	1635.231
#409	HLF	3	14	17	972.641
#410	NPAS2	3	13	16	1368.201
#411	REL	3	5	8	269.082
#412	ZNF367	3	10	13	995.368
#413	AFF4	3	10	13	994.835
#414	GTF2H2	3	11	14	607.856
#415	RCAN1	3	10	13	1019.315
#416	RBCK1	3	12	15	1459.185
#417	RORC	3	11	14	2340.822
#418	SLC26A3	3	7	10	1590.765
#419	HOXB9	3	9	12	414.943
#420	NR1H3	3	11	14	895.001
#421	OVOL1	3	11	14	584.001
#422	ZFP42	3	4	7	895.141
#423	HOXA1	3	8	11	1114.334
#424	LZTS1	3	11	14	258.826
#425	MEOX1	3	14	17	1551.833
#426	ARNT	3	8	11	1576.151
#427	MNX1	3	14	17	523.853
#428	IRX5	3	9	12	337.761
#429	MYC	3	11	14	99.623
#430	NANOG	3	9	12	251.353
#431	ARNTL	3	12	15	2132.176
#432	MEIS2	3	10	13	482.262
#433	HAND1	3	9	12	2709.116
#434	MAFK	3	12	15	1118.037
#435	SOX7	2	11	13	341.731
#436	L3MBTL4	2	9	11	221.109
#437	ZNF135	2	9	11	266.853
#438	NKX3-2	2	8	10	798.59
#439	ZNF165	2	13	15	1601.559
#440	JDP2	2	9	11	407.38
#441	ELF5	2	4	6	278.425
#442	TBX3	2	10	12	113.406
#443	STAT3	2	11	13	1228.041
#444	SMAD6	2	13	15	206.179
#445	CREBL2	2	10	12	411.266
#446	FOXC1	2	16	18	1585.919
#447	EGR3	2	10	12	1351.843
#448	SIX3	2	9	11	530.722
#449	TBX15	2	9	11	89.094
#450	PITX2	2	11	13	2205.519
#451	CDKN2A	2	14	16	938.592
#452	JUN	2	9	11	47.056
#453	ASCL1	2	6	8	967.763
#454	TFAP2C	2	8	10	163.917
#455	HEY2	2	8	10	1730.303
#456	ZNF628	2	10	12	450.668
#457	FOXA2	2	12	14	364.006
#458	DDIT3	2	12	14	299.963
#459	ATF5	1	7	8	1411.318
#460	ZNF117	1	9	10	84.226
#461	ZNF148	1	12	13	439.955
#462	IRF4	1	9	10	123.605
#463	FOXC2	1	11	12	295.89
#464	MLXIPL	1	12	13	606.716
#465	SALL1	1	7	8	275.645
#466	PGBD1	1	8	9	428.897
#467	NKX3-1	1	10	11	109.448
#468	SLC30A9	1	13	14	273.292
#469	HOXC10	1	11	12	128.203
#470	TCF19	1	13	14	94.802
#471	ZHX2	1	10	11	138.595
#472	NFIB	1	8	9	41.027
#473	NKX2-3	1	10	11	122.777
#474	FOXA1	1	8	9	278.066
#475	ZNF268	1	9	10	267.171
#476	ZNF215	1	7	8	83.652
#477	ARNT2	1	11	12	1504.938
#478	IRX3	1	9	10	448.915
#479	TSC22D4	1	8	9	474.507
#480	HOXA10	1	14	15	100.028
#481	FEV	1	6	7	38.594
#482	GATA5	1	8	9	810.528
#483	POU5F1B	1	8	9	230.027
#484	STRN3	1	8	9	70.36
#485	HOXA9	1	7	8	74.885
#486	SOX17	1	13	14	124.16
#487	EGR4	0	10	10	0
#488	EPAS1	0	13	13	0
#489	MYCN	0	7	7	0
#490	IRF5	0	6	6	0
#491	CREB5	0	10	10	0
#492	ARID3A	0	4	4	0
#493	HIF3A	0	8	8	0
#494	TAF4B	0	11	11	0
#495	CTBP1	0	10	10	0
#496	HDAC1	0	12	12	0
#497	NR1H4	0	12	12	0
#498	SREBF1	0	14	14	0
#499	SOX10	0	10	10	0
#500	ETV5	0	14	14	0