Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SPDEF	68	0	68	0
#2	FOXA1	58	2	60	41.287
#3	FOXM1	57	7	64	982.694
#4	FOXC1	56	4	60	91.101
#5	TAF4B	50	5	55	1987.631
#6	JUND	48	1	49	65.354
#7	RUNX1T1	47	3	50	2648.352
#8	FLI1	46	2	48	98.811
#9	PTTG1	44	5	49	639.565
#10	XBP1	41	17	58	2088.537
#11	RXRB	41	3	44	148.084
#12	TFAP2B	39	7	46	282.183
#13	L3MBTL4	39	3	42	1359.141
#14	TSHZ3	38	1	39	52.521
#15	CREB3L4	38	6	44	1068.65
#16	STAT2	37	10	47	6265.904
#17	IKZF1	37	0	37	0
#18	SP1	37	2	39	156.884
#19	FOXO1	36	9	45	2628.198
#20	RCAN1	36	12	48	1462.595
#21	AEBP1	36	4	40	440.479
#22	C5orf41	36	3	39	655.868
#23	CREB1	35	4	39	1148.931
#24	IRF1	35	7	42	3551.587
#25	EN1	34	12	46	3387.682
#26	NFKB2	34	3	37	169.777
#27	EBF1	34	8	42	1052.037
#28	NR3C1	34	3	37	229.502
#29	ZNF367	34	4	38	549.849
#30	E2F7	33	4	37	213.322
#31	TFCP2L1	33	10	43	2277.391
#32	IRF8	33	5	38	821.318
#33	TRIM22	32	6	38	176.888
#34	RELA	32	2	34	849.198
#35	ZEB1	32	15	47	1274.189
#36	NFAT5	31	2	33	122.572
#37	NFYC	31	4	35	3731.871
#38	AR	31	8	39	647.854
#39	HMG20B	31	6	37	474.397
#40	HOXD8	30	8	38	2564.283
#41	RUNX1	30	9	39	1294.997
#42	PRRX1	30	7	37	750.295
#43	HIC1	30	13	43	1764.368
#44	TFAP2A	30	12	42	1178.92
#45	HES1	29	14	43	4199.672
#46	ZNF207	29	7	36	391.831
#47	E2F2	29	9	38	539.648
#48	SP140	29	1	30	3.713
#49	RUNX3	29	17	46	865.798
#50	CNOT7	28	3	31	186.524
#51	ENO1	28	9	37	787.742
#52	ZFP90	28	6	34	153.081
#53	LEF1	28	7	35	444.922
#54	SMAD4	28	9	37	891.043
#55	BTG2	27	9	36	996.552
#56	SPI1	27	6	33	791.84
#57	NR2F6	27	8	35	1548.81
#58	DLX6	27	13	40	1343.655
#59	ZNF397	27	5	32	268.764
#60	ZFP36L2	27	7	34	1406.186
#61	TSC22D3	26	11	37	1569.859
#62	TCF19	26	11	37	1271.703
#63	FOXP1	25	13	38	2089.199
#64	HMGB1	25	8	33	2184.193
#65	IRX1	25	15	40	1036.591
#66	ZBTB38	25	5	30	111.159
#67	FOXO3	25	10	35	4047.711
#68	EPAS1	25	12	37	5353.431
#69	TAF12	25	7	32	199.71
#70	FOXF2	25	10	35	1277.944
#71	KDM5A	25	11	36	1724.458
#72	ZNF165	25	14	39	1691.657
#73	ANKRD30A	25	9	34	348.377
#74	HSF2	25	8	33	966.122
#75	MLL	25	3	28	1120.56
#76	TCF7L1	25	14	39	4134.625
#77	SUPT4H1	24	14	38	1418.033
#78	ZSCAN2	24	12	36	1330.397
#79	CREBL2	24	11	35	549.236
#80	KLF2	24	12	36	945.684
#81	RELB	24	7	31	370.212
#82	MAX	24	12	36	1110.646
#83	NFYB	24	10	34	375.58
#84	RB1	24	10	34	810.482
#85	HCLS1	24	7	31	609.206
#86	ZEB2	23	8	31	360.008
#87	RARA	23	16	39	1015.322
#88	SPEN	23	3	26	987.881
#89	MYBL2	23	12	35	816.341
#90	GTF2H4	23	7	30	466.424
#91	HSF1	23	7	30	1910.611
#92	MYC	23	9	32	1313.154
#93	ZSCAN21	23	13	36	3990.998
#94	SOX8	22	17	39	3527.732
#95	VAV1	22	4	26	57.084
#96	RUNX2	22	6	28	257.244
#97	ZNF135	22	14	36	1823.521
#98	NR1H3	22	8	30	2275.7
#99	ATF3	22	14	36	1768.088
#100	ERG	22	7	29	4585.629
#101	ALX1	22	15	37	1882.426
#102	ZFPM2	22	5	27	2297.352
#103	HOXB2	22	7	29	454.456
#104	PCGF2	22	18	40	3054.407
#105	CREB3L1	21	14	35	3020.191
#106	HMGA2	21	14	35	1706.107
#107	MEOX2	21	10	31	1038.692
#108	ZNF148	21	9	30	176.479
#109	TCF3	21	14	35	705.473
#110	PRDM1	21	13	34	921.265
#111	SPIB	21	12	33	1066.249
#112	ZNF174	21	13	34	1231.638
#113	TCF12	21	3	24	274.162
#114	HOXB6	21	11	32	3007.896
#115	TWIST1	21	11	32	364.425
#116	GATAD1	21	11	32	1550.056
#117	MLLT10	21	9	30	988.347
#118	TFE3	21	6	27	399.432
#119	HOXA7	20	7	27	2671.352
#120	PGBD1	20	13	33	1788.281
#121	NFIX	20	20	40	2048.247
#122	UBN1	20	8	28	486.274
#123	C2orf3	20	12	32	491.138
#124	ETV1	20	12	32	1155.938
#125	TAF5	20	15	35	1227.704
#126	GATA2	20	17	37	5628.76
#127	NFATC3	20	14	34	1353.85
#128	PITX2	20	16	36	3089.451
#129	GAS7	20	10	30	1932.303
#130	MGA	20	5	25	1332.306
#131	CITED2	20	8	28	455.676
#132	BACH2	20	13	33	2630.939
#133	RORA	20	17	37	1623.025
#134	IRF7	20	10	30	835.305
#135	STAT4	20	4	24	782.692
#136	TULP4	20	9	29	896.317
#137	ETV7	20	11	31	2271.345
#138	GLIS2	20	7	27	247.025
#139	NR4A3	20	10	30	1521.556
#140	GATAD2B	20	10	30	945.431
#141	SOX6	19	13	32	829.357
#142	HOXC10	19	12	31	414.879
#143	ELK3	19	8	27	377.942
#144	ZNF639	19	9	28	2255.061
#145	DRAP1	19	13	32	738.665
#146	MEF2C	19	9	28	1350.766
#147	NFIL3	19	11	30	558.06
#148	SNAI2	19	15	34	823.566
#149	ATF6	19	15	34	1185.371
#150	ZIC1	19	17	36	976.61
#151	HMGB2	19	10	29	1275.481
#152	MAF	19	15	34	3530.242
#153	PPARA	19	10	29	1463.751
#154	NFIA	19	17	36	1028.608
#155	CSDA	19	7	26	601.464
#156	HHEX	19	13	32	1128.279
#157	HEY1	18	21	39	5509.301
#158	PLSCR1	18	14	32	1146.892
#159	YBX1	18	10	28	1478.106
#160	CBFA2T2	18	12	30	995.256
#161	E2F8	18	12	30	436.816
#162	EDF1	18	11	29	560.78
#163	SOX17	18	12	30	4348.978
#164	EOMES	18	9	27	1169.319
#165	TFAP2C	18	17	35	951.901
#166	BATF	18	8	26	1284.568
#167	BCL3	18	18	36	1332.847
#168	NR2F1	18	12	30	1167.257
#169	GATA3	18	23	41	4131.165
#170	BHLHE40	18	15	33	342.52
#171	KLF6	18	13	31	488.422
#172	TCF4	18	15	33	1874.982
#173	TBX10	18	11	29	1031.16
#174	STAT1	17	19	36	1731.494
#175	HOPX	17	16	33	1839.702
#176	EGR3	17	13	30	943.317
#177	BATF2	17	9	26	670.115
#178	ETV5	17	21	38	1769.214
#179	ZNF217	17	15	32	1161.332
#180	KLF9	17	17	34	977.22
#181	NFATC2	17	9	26	888.304
#182	AFF4	17	9	26	789.517
#183	ZNF138	17	15	32	1758.699
#184	ELF4	17	23	40	1137.337
#185	ELF1	17	13	30	1263.441
#186	SP3	16	11	27	243.631
#187	ZNF83	16	13	29	665.557
#188	CREM	16	13	29	683.094
#189	TCFL5	16	19	35	1422.631
#190	JUN	16	19	35	3109.953
#191	EGR2	16	16	32	1680.135
#192	SOX9	16	18	34	768.958
#193	KLF10	16	11	27	989.393
#194	HOXD10	16	15	31	1051.376
#195	E2F3	16	15	31	1131.313
#196	ARNTL2	16	14	30	783.756
#197	CREBZF	16	14	30	1137.61
#198	SLC2A4RG	16	24	40	1880.112
#199	LASS6	16	16	32	803.845
#200	ZNF232	16	18	34	1783.833
#201	STAT3	16	11	27	533.557
#202	ZFHX3	16	11	27	726.241
#203	LHX2	16	17	33	2273.534
#204	HOXA5	16	8	24	529.461
#205	CBL	15	7	22	6038.759
#206	NFATC1	15	15	30	1417.952
#207	ARNT2	15	22	37	2186.724
#208	SMAD2	15	15	30	1383.5
#209	BCL6	15	17	32	840.898
#210	ATF7	15	13	28	827.013
#211	TFCP2	15	23	38	3663.878
#212	TGIF2	15	13	28	569.567
#213	KLF5	15	9	24	382.419
#214	CLOCK	15	22	37	5973.526
#215	MNX1	15	16	31	850.083
#216	NR2F2	15	17	32	2000.312
#217	TFEC	15	8	23	104.673
#218	MEF2A	14	18	32	1296.588
#219	CUX1	14	22	36	1213.059
#220	ADNP	14	14	28	1220.429
#221	ZKSCAN1	14	11	25	1358.232
#222	MMP14	14	15	29	1091.828
#223	MTA1	14	19	33	1264.872
#224	GTF2I	14	14	28	1174.059
#225	ASCL2	14	20	34	1201.682
#226	TCF7L2	14	13	27	459.079
#227	AHR	14	18	32	1079.39
#228	RORC	14	15	29	691.056
#229	HOXA9	14	10	24	3665.068
#230	NPAS2	14	20	34	2933.641
#231	FUBP1	14	17	31	1889.878
#232	ZFHX4	14	18	32	734.602
#233	GCFC1	14	20	34	1301.206
#234	SOX13	14	18	32	2613.108
#235	PAX7	13	14	27	1543.097
#236	DMRT2	13	18	31	1721.038
#237	ZNF131	13	13	26	854.806
#238	GLI3	13	20	33	1459.82
#239	E2F5	13	22	35	1361.264
#240	ZNF92	13	15	28	1116.358
#241	SOX4	13	19	32	1008.309
#242	ZNF281	13	20	33	2776.723
#243	NOLC1	13	14	27	2102.683
#244	NR1D2	13	11	24	350.22
#245	CSRNP3	13	14	27	2088.523
#246	FOXQ1	13	21	34	1597.301
#247	RFX5	13	13	26	549.539
#248	PBX3	13	18	31	1962.119
#249	MEOX1	13	14	27	1538.995
#250	KLF12	13	12	25	1340.385
#251	ATF2	12	8	20	155.328
#252	NFE2L3	12	18	30	680.726
#253	ZHX1	12	20	32	1835.062
#254	SMAD5	12	6	18	173.417
#255	TBX22	12	3	15	156.921
#256	TSHZ2	12	24	36	1439.783
#257	TFEB	12	15	27	1653.085
#258	AHCTF1	12	23	35	1070.114
#259	TAF5L	12	17	29	531.95
#260	MEIS1	12	19	31	2140.881
#261	IRF6	12	25	37	785.067
#262	GTF2H2	12	7	19	260.326
#263	MSRB2	12	13	25	633.905
#264	KLF7	12	17	29	562.883
#265	MSX2	12	16	28	602.598
#266	HES6	12	17	29	1184.504
#267	TEAD2	12	12	24	333.671
#268	MSL3	12	19	31	869.766
#269	SOX10	12	14	26	265.239
#270	GABPA	12	17	29	1582.502
#271	TCEAL1	12	18	30	1010.164
#272	TEAD4	12	9	21	655.819
#273	STRN3	12	21	33	1983.126
#274	C1orf85	11	23	34	1124.989
#275	FOXP4	11	24	35	1439.317
#276	FOSL1	11	20	31	2371.863
#277	NFX1	11	12	23	558.232
#278	PBX1	11	19	30	1188.115
#279	NFATC4	11	13	24	600.194
#280	ARNT	11	22	33	1601.696
#281	HOXC9	11	14	25	694.544
#282	THRB	11	20	31	1101.735
#283	SATB2	11	14	25	2400.336
#284	ETS2	11	13	24	1449.257
#285	HOXB5	11	10	21	811.291
#286	TRIM29	11	25	36	1077.777
#287	IRX2	11	22	33	1200.778
#288	ZSCAN18	11	16	27	1403.699
#289	SCML2	11	17	28	525.633
#290	IRF9	11	8	19	630.51
#291	SOLH	11	16	27	897.768
#292	TFDP1	11	17	28	2221.033
#293	ATF1	10	21	31	1654.883
#294	ARNTL	10	16	26	736.342
#295	HOXA10	10	14	24	769.402
#296	ISL1	10	13	23	902.936
#297	TRERF1	10	20	30	648.817
#298	LMO4	10	22	32	1525.015
#299	FOSB	10	3	13	249.986
#300	FOSL2	10	23	33	2235.128
#301	NFIB	10	23	33	1245.383
#302	MSX1	10	12	22	336.529
#303	UHRF1	10	8	18	246.615
#304	NR3C2	10	23	33	1901.387
#305	VAX2	10	14	24	2002.635
#306	PITX1	10	24	34	1662.273
#307	HOXA3	10	8	18	1726.972
#308	FOS	10	8	18	1259.83
#309	TFAM	10	11	21	186.972
#310	PURB	10	17	27	576.404
#311	NFYA	10	16	26	711.088
#312	TP53	10	16	26	511.926
#313	EGR1	10	19	29	699.03
#314	ATF5	10	19	29	638.129
#315	REL	10	15	25	509.931
#316	ZSCAN16	9	16	25	1239.548
#317	BNC1	9	18	27	1531.439
#318	CEBPD	9	20	29	1534.036
#319	ZNF140	9	17	26	1028.843
#320	MITF	9	21	30	1013.943
#321	THRA	9	17	26	945.487
#322	EHF	9	29	38	1155.97
#323	MESP1	9	18	27	2721.468
#324	GLI2	9	18	27	501.643
#325	SOX18	9	16	25	1323.715
#326	HOXB7	9	9	18	983.991
#327	MEIS2	9	19	28	756.405
#328	SUPT6H	9	20	29	1001.844
#329	CBFA2T3	9	15	24	523.244
#330	ZNF91	9	15	24	745.601
#331	TWIST2	9	15	24	638.729
#332	HDAC2	9	17	26	493.263
#333	PROX1	9	19	28	890.346
#334	ERF	9	15	24	853.108
#335	ZNF24	9	12	21	140.285
#336	ZHX2	9	18	27	1756.402
#337	PEG3	9	31	40	4854.961
#338	MAFF	9	25	34	787.801
#339	IRF4	9	10	19	265.274
#340	ZSCAN5A	9	22	31	478.985
#341	SLC26A3	9	12	21	1184.096
#342	LZTS1	9	18	27	2089.981
#343	POU2F2	9	10	19	191.073
#344	BCL11B	9	22	31	1056.592
#345	HOXA11	9	9	18	1508.795
#346	BHLHE41	8	21	29	1319.074
#347	ZFP36L1	8	9	17	227.137
#348	TEAD3	8	18	26	576.348
#349	CEBPA	8	24	32	1459.598
#350	MECOM	8	23	31	692.483
#351	NKX3-1	8	22	30	1040.667
#352	SREBF1	8	20	28	1698.914
#353	PPARG	8	20	28	1684.874
#354	HOXB13	8	13	21	1610.799
#355	POU4F1	8	20	28	1426.032
#356	FOXJ3	8	15	23	277.875
#357	GLIS3	8	10	18	300.974
#358	HOXC13	8	19	27	390.373
#359	SOX7	8	27	35	1439.676
#360	FOXK2	8	20	28	512.502
#361	FOXO6	8	21	29	992.731
#362	HOXA1	8	8	16	1197.71
#363	HMGA1	8	15	23	835.049
#364	ETV4	8	16	24	589.699
#365	TSHZ1	8	21	29	459.667
#366	HOXB3	8	10	18	201.299
#367	EN2	8	15	23	793.93
#368	GRHL2	8	21	29	1532.884
#369	TEAD1	8	22	30	1426.388
#370	DMRT1	8	21	29	2921.626
#371	FOXC2	8	18	26	1162.484
#372	TARDBP	8	16	24	773.933
#373	MTA3	8	16	24	365.046
#374	SALL1	8	13	21	1424.444
#375	ELF5	8	19	27	380.569
#376	SMAD9	8	20	28	381.444
#377	TFDP2	8	18	26	1347.686
#378	CREB5	7	23	30	1019.034
#379	PHF5A	7	16	23	931.956
#380	KDM5B	7	19	26	1388.165
#381	ISX	7	12	19	297.531
#382	NR2C2	7	20	27	847.03
#383	ZNF238	7	27	34	1949.973
#384	NOTCH1	7	20	27	489.081
#385	FOXP2	7	23	30	1333.918
#386	DBP	7	16	23	1557.08
#387	HNF4G	7	21	28	870.024
#388	HEYL	7	14	21	2342.783
#389	ZIC3	7	9	16	630.046
#390	PGR	7	18	25	916.363
#391	ZNF193	7	15	22	518.409
#392	SIM1	7	21	28	1764.677
#393	ZFP37	7	19	26	926.896
#394	SIX4	7	17	24	1106.896
#395	HSF5	7	7	14	137.543
#396	ZNF167	7	23	30	837.862
#397	NR4A1	7	9	16	248.155
#398	MKX	7	21	28	1163.013
#399	ZNF93	7	20	27	1128.839
#400	SLC30A9	7	26	33	1019.155
#401	SOX30	7	13	20	875.06
#402	YY1	7	24	31	5568.969
#403	ESR1	7	18	25	559.933
#404	MYNN	7	24	31	1524.371
#405	CCRN4L	7	21	28	1364.258
#406	VDR	7	22	29	2731.204
#407	ZNF70	7	17	24	906.638
#408	RFXAP	7	21	28	1244.967
#409	SATB1	7	22	29	412.315
#410	POU2F3	6	24	30	966.515
#411	LHX6	6	16	22	300.772
#412	ZNF45	6	16	22	345.756
#413	HR	6	20	26	722.656
#414	RBCK1	6	21	27	479.577
#415	CREB3L2	6	20	26	2835.92
#416	RARB	6	20	26	1145.739
#417	ZNF117	6	16	22	406.486
#418	NFIC	6	16	22	741.412
#419	ZIC2	6	15	21	612.442
#420	GATAD2A	6	17	23	517.714
#421	MYCN	6	18	24	380.578
#422	TP63	6	23	29	1228.504
#423	IRX5	6	18	24	977.435
#424	DLX1	6	18	24	1486.884
#425	SCML1	6	21	27	458.921
#426	HOXA2	6	13	19	1044.377
#427	HOXD1	6	15	21	346.163
#428	ETS1	6	18	24	758.653
#429	NFE2L2	6	18	24	347.933
#430	ZNF277	6	25	31	771.806
#431	ELF3	6	23	29	1377.069
#432	ZNF256	6	20	26	722.711
#433	HDX	5	21	26	717.042
#434	DLX2	5	14	19	412.938
#435	TSC22D1	5	14	19	918.735
#436	HEY2	5	25	30	4228.864
#437	TRPS1	5	22	27	554.126
#438	PAX6	5	25	30	590.957
#439	CTNNB1	5	27	32	783.216
#440	GRHL3	5	23	28	334.534
#441	OVOL1	5	24	29	2665.98
#442	ARX	5	18	23	809.974
#443	SOX2	5	23	28	1073.441
#444	YEATS4	5	18	23	372.862
#445	FOXA3	5	15	20	765.012
#446	C11orf9	5	13	18	783.185
#447	SIX2	5	24	29	855.609
#448	ZNF85	5	16	21	248.025
#449	NR2E1	4	15	19	334.797
#450	FBXW7	4	24	28	611.639
#451	ZNF643	4	28	32	418.842
#452	MEIS3P1	4	24	28	907.545
#453	HLF	4	26	30	1386.738
#454	ESRRG	4	24	28	1495.789
#455	IRX3	4	17	21	808.741
#456	FOXL2	4	17	21	904.66
#457	FOXD1	4	20	24	381.418
#458	KLF3	4	14	18	370.087
#459	MYCL1	4	19	23	734.505
#460	TBX1	4	26	30	495.824
#461	KLF4	4	22	26	1122.435
#462	RERE	4	23	27	3536.577
#463	CUX2	4	8	12	712.265
#464	PPARD	4	17	21	839.431
#465	CTBP1	4	26	30	970.84
#466	BARX1	4	22	26	568.449
#467	SIX1	3	22	25	1385.065
#468	MXD1	3	18	21	704.225
#469	PAX3	3	13	16	464.134
#470	LHX8	3	13	16	89.993
#471	HOXD4	3	21	24	494.353
#472	FOXG1	3	24	27	1534.959
#473	PLAG1	3	18	21	289.397
#474	WT1	3	25	28	454.435
#475	ZNF268	3	22	25	95.177
#476	NR4A2	3	26	29	545.543
#477	ONECUT2	2	22	24	990.676
#478	SCAND3	2	17	19	294.923
#479	SALL2	2	24	26	279.761
#480	TGIF1	2	20	22	209.128
#481	TBX3	2	32	34	539.275
#482	TLX1	2	18	20	564.311
#483	CDKN2A	2	28	30	162.157
#484	SMAD6	2	20	22	87.612
#485	GATA6	2	25	27	535.207
#486	HMBOX1	2	19	21	183.935
#487	SOX11	2	37	39	430.772
#488	ZFP42	2	20	22	151.94
#489	SOX15	2	19	21	118.496
#490	ETV6	2	22	24	315.348
#491	ZNF323	2	20	22	389.287
#492	SIX3	2	26	28	268.74
#493	PHTF1	1	25	26	235.065
#494	SIM2	1	24	25	141.002
#495	LASS2	1	19	20	116.733
#496	FOXI1	1	24	25	171.718
#497	SMAD1	1	20	21	120.105
#498	IRX4	1	28	29	296.641
#499	WNT5A	0	23	23	0
#500	IRF5	0	24	24	0