Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TBX5	107	15	122	564.954
#2	SNAPC2	105	1	106	1.526
#3	HNF4A	104	17	121	336.272
#4	ZNF500	103	12	115	82.347
#5	SOX15	102	2	104	2.527
#6	IRF8	101	18	119	169.145
#7	ZNF81	98	7	105	34.789
#8	CREBZF	96	8	104	35.122
#9	NPAS1	93	0	93	0
#10	ZBTB17	91	4	95	11.516
#11	PAX8	89	15	104	67.492
#12	ZNF35	88	13	101	2068.634
#13	HOXB9	87	7	94	28.051
#14	E4F1	87	24	111	329.38
#15	NEUROG1	87	6	93	13.695
#16	KLF12	86	13	99	967.441
#17	E2F4	85	28	113	382.725
#18	TBX2	83	11	94	299.003
#19	OVOL1	81	22	103	106.616
#20	HR	80	15	95	6364.344
#21	FOSB	78	12	90	976.021
#22	ZBTB38	77	24	101	2677.067
#23	ZNF140	75	23	98	222.753
#24	NFIC	75	24	99	543.463
#25	NFKB1	75	24	99	814.344
#26	NR6A1	75	8	83	253.639
#27	EMX1	74	9	83	16.632
#28	MNT	73	28	101	1340.563
#29	NFATC1	73	13	86	1504.363
#30	HOXC8	70	23	93	305.676
#31	ZNF236	70	25	95	1032.546
#32	NR2E1	70	11	81	1000.197
#33	GAS7	69	24	93	162.247
#34	CIR1	69	27	96	741.535
#35	FUBP1	68	19	87	253.777
#36	ASCL2	68	3	71	3.44
#37	FOS	68	10	78	522.198
#38	THRA	67	19	86	210.277
#39	ZNF268	67	16	83	665.666
#40	TFAP2B	67	13	80	14597.485
#41	ZNF263	67	22	89	719.717
#42	TRIM25	66	9	75	99.616
#43	CREB1	66	23	89	392.386
#44	NR2C1	65	24	89	353.493
#45	TLX2	65	32	97	289.672
#46	IKZF1	64	19	83	2377.682
#47	CCRN4L	64	23	87	523.458
#48	ELK1	64	21	85	17764.508
#49	NFATC4	62	21	83	107.482
#50	ZNF446	61	26	87	568.871
#51	LMX1B	61	12	73	44.702
#52	MZF1	60	22	82	874.755
#53	ZNF148	60	11	71	91.745
#54	PCGF2	59	25	84	439.47
#55	TCF20	59	21	80	208.366
#56	NKX3-1	59	5	64	3.696
#57	TEF	59	27	86	762.15
#58	GCFC1	58	18	76	1946.423
#59	MLX	58	36	94	744.591
#60	MGA	58	28	86	778.834
#61	DLX2	58	9	67	430.202
#62	ZHX2	58	22	80	1836.951
#63	SCAND2	58	22	80	84.44
#64	MYCL1	57	19	76	2693.976
#65	POU6F2	56	27	83	163.474
#66	NRL	56	20	76	347.083
#67	TFAP4	55	24	79	8628.731
#68	STRN3	54	24	78	4460.974
#69	HOXB13	54	36	90	322.967
#70	ZNF133	54	29	83	704.803
#71	MTF1	54	38	92	572.776
#72	GLI2	54	28	82	463.11
#73	TFAM	53	26	79	614.889
#74	NR4A1	52	15	67	1482.084
#75	ALX1	52	11	63	726.117
#76	GTF2I	51	10	61	731.008
#77	ZNF639	51	36	87	1648.415
#78	E2F6	51	25	76	1000.022
#79	SOX5	51	26	77	173.68
#80	MYOD1	50	20	70	1305.444
#81	FBXW7	50	25	75	3685.427
#82	GRHL2	50	15	65	478.791
#83	NR4A2	50	17	67	2350.318
#84	TFE3	50	42	92	500.085
#85	FOXF1	49	10	59	682.9
#86	E2F3	49	28	77	362.641
#87	ZSCAN16	49	29	78	1936.165
#88	CREBBP	48	34	82	399.443
#89	DMTF1	48	32	80	696.426
#90	RFXANK	48	25	73	1404.276
#91	ZNF274	48	30	78	863.312
#92	MYT1	48	19	67	80.628
#93	CTCF	48	29	77	814.594
#94	ELK4	48	23	71	376.414
#95	ATF3	47	24	71	1117.562
#96	ZNF281	47	21	68	966.326
#97	HOXA4	47	31	78	721.055
#98	ZNF83	46	15	61	369.35
#99	UBP1	46	33	79	491.758
#100	TCF12	46	30	76	1115.368
#101	GATA6	45	15	60	817.171
#102	ZNF45	45	25	70	693.453
#103	BLZF1	45	33	78	628.287
#104	MMP14	45	20	65	88.12
#105	RXRB	45	17	62	327.858
#106	IRF6	45	17	62	686.756
#107	UBN1	45	27	72	561.316
#108	YBX1	45	26	71	436.959
#109	ELF1	45	35	80	561.513
#110	BATF	45	41	86	26047.813
#111	TLX3	45	34	79	263.243
#112	RFX5	45	20	65	290.449
#113	LHX3	44	35	79	811.247
#114	IKZF4	44	26	70	184.982
#115	ZKSCAN1	44	27	71	1720.342
#116	ATF1	43	37	80	773.325
#117	FOXJ3	42	29	71	19064.882
#118	ATF5	42	19	61	1161.289
#119	CEBPA	42	14	56	434.73
#120	RFX1	42	18	60	614.354
#121	STAT5B	42	24	66	797.368
#122	SP3	42	31	73	815.78
#123	IRX4	41	8	49	251.329
#124	FOXN3	41	22	63	3021.726
#125	GATAD1	41	16	57	194.344
#126	SIX3	41	33	74	3222.104
#127	MEOX1	41	5	46	616.746
#128	VDR	41	26	67	667.962
#129	USF2	41	35	76	912.11
#130	PLAGL2	41	31	72	2678.219
#131	NFKB2	40	32	72	643.469
#132	ATF6	40	24	64	1217.932
#133	HAND1	40	33	73	3929.22
#134	MAFF	40	22	62	784.278
#135	HMG20A	40	30	70	552.527
#136	TEAD3	40	23	63	600.468
#137	ADNP2	40	24	64	3489.956
#138	ZNF93	39	34	73	246.515
#139	MYCN	39	26	65	754.305
#140	NR1H2	39	28	67	1319.77
#141	PKNOX2	39	26	65	254.639
#142	BCL6	39	25	64	677.872
#143	BRD8	39	39	78	427.576
#144	HES1	39	20	59	364.677
#145	MEF2A	39	40	79	1506.352
#146	MLXIPL	39	30	69	344.031
#147	C2orf3	39	31	70	871.726
#148	ESR2	38	11	49	15.41
#149	KDM5A	38	40	78	431.436
#150	MEIS2	38	31	69	1153.809
#151	PKNOX1	38	33	71	976.014
#152	SOX11	38	6	44	952.414
#153	PAX3	38	36	74	549.551
#154	HSF2	38	22	60	174.914
#155	TAF4B	37	34	71	173.482
#156	HOXD13	37	16	53	364.087
#157	HOXB6	37	21	58	810.433
#158	SIX2	37	28	65	3101.648
#159	ZNF238	36	20	56	389.102
#160	ZNF215	36	31	67	481.804
#161	MEIS1	36	13	49	775.884
#162	RCAN1	36	19	55	1133.178
#163	HSF4	36	37	73	21020.434
#164	ASCL1	36	7	43	3248.857
#165	IRF9	36	20	56	724.873
#166	ZNF277	36	39	75	493.454
#167	TSC22D4	36	22	58	404.747
#168	CTNNB1	36	36	72	676.858
#169	ZNF232	36	23	59	322.569
#170	MEF2C	35	23	58	2485.385
#171	KLF3	35	27	62	1674.18
#172	TP63	35	22	57	672.716
#173	ZNF394	35	32	67	2127.964
#174	REL	34	24	58	1007.923
#175	ATF2	34	36	70	534.733
#176	MSL3	34	33	67	821.356
#177	EGR3	34	18	52	7447.102
#178	RARA	34	35	69	428.194
#179	PHF1	34	30	64	497.755
#180	TBX3	34	20	54	772.503
#181	DRAP1	34	34	68	530.65
#182	RUNX1T1	34	15	49	2646.485
#183	TCF7	33	25	58	371.649
#184	ZIC1	33	20	53	706.668
#185	HOXC11	33	26	59	251.424
#186	PEG3	33	19	52	785.538
#187	EDF1	33	25	58	1216.165
#188	TFAP2C	33	31	64	796.091
#189	ECSIT	32	26	58	634.89
#190	TCF7L2	32	30	62	568.566
#191	TRIM29	32	30	62	5533.814
#192	PBX2	32	44	76	1027.524
#193	HOXD4	32	16	48	441.508
#194	ZNF217	32	37	69	507.224
#195	BTG2	32	20	52	728.168
#196	T	31	21	52	14799.079
#197	IRF2	31	27	58	503.918
#198	NPAS2	31	33	64	1365.277
#199	TCF4	31	21	52	796.752
#200	CUX1	31	46	77	2366.557
#201	HIRA	31	41	72	2302.243
#202	ZNF91	31	40	71	609.685
#203	PAX6	31	31	62	1191.891
#204	STAT3	31	41	72	1544.634
#205	MAFG	31	28	59	1000.095
#206	RUNX1	31	38	69	1020.674
#207	HOXB5	31	22	53	440.592
#208	AHCTF1	31	28	59	417.732
#209	SMAD4	30	20	50	1877.222
#210	SMAD6	30	33	63	686.112
#211	SPI1	30	23	53	88.085
#212	NFYA	30	25	55	613.679
#213	CLOCK	30	34	64	811.034
#214	HNRNPK	30	28	58	391.521
#215	SOX13	30	24	54	1378.471
#216	LZTS1	30	34	64	177.05
#217	E2F8	29	35	64	991.159
#218	KLF7	29	38	67	816.612
#219	BATF3	29	21	50	1034.112
#220	MBD1	29	34	63	658.176
#221	RCOR1	29	37	66	758.217
#222	FOXF2	29	31	60	1085.532
#223	RARG	29	37	66	3869.383
#224	LHX6	29	27	56	536.958
#225	NFYC	29	32	61	1022.614
#226	MSX1	29	42	71	1580.076
#227	RARB	29	30	59	1456.003
#228	BTAF1	29	37	66	770.458
#229	POU5F1B	28	34	62	358.937
#230	FOXO1	28	16	44	676.752
#231	ST18	28	16	44	262.56
#232	RXRA	28	34	62	585.018
#233	ZNF207	28	37	65	1030.191
#234	PFDN1	28	31	59	818.545
#235	TFDP3	28	33	61	6089.087
#236	TAF4	28	20	48	1432.689
#237	HOXA9	28	20	48	1199.798
#238	TRPS1	27	34	61	5045.088
#239	HMG20B	27	42	69	922.706
#240	ETV3	27	47	74	601.963
#241	LHX2	27	28	55	607.763
#242	ZFPM2	27	16	43	528.167
#243	NFIB	27	43	70	891.772
#244	HOXA2	27	32	59	907.927
#245	SPEN	27	34	61	723.057
#246	MLLT10	27	28	55	373.407
#247	PRRX2	27	14	41	2446.903
#248	MECOM	27	25	52	664.899
#249	SCMH1	27	26	53	598.226
#250	FOXJ1	27	15	42	365.327
#251	ZKSCAN5	27	35	62	989.975
#252	SRF	27	34	61	1006.242
#253	ZNF193	26	36	62	1317.972
#254	ZNF117	26	22	48	1034.852
#255	VTN	26	37	63	1268.206
#256	PHTF1	26	36	62	1038.265
#257	SREBF2	26	45	71	1719.423
#258	CREM	26	38	64	1176.686
#259	NR2F6	26	38	64	4594.937
#260	ZNF187	26	23	49	264.105
#261	HDAC2	26	41	67	1234.053
#262	VAX2	26	40	66	612.155
#263	MAX	26	41	67	877.579
#264	FOSL1	25	26	51	648.731
#265	NOTCH1	25	31	56	915.132
#266	NFIL3	25	34	59	438.154
#267	ELF3	25	19	44	592.466
#268	ATF4	25	43	68	545.572
#269	GTF2IRD1	25	40	65	1103.52
#270	ZNF24	25	35	60	750.048
#271	IRF7	25	26	51	543.91
#272	HOPX	25	23	48	2693.501
#273	TARDBP	25	46	71	540.842
#274	TFEB	25	42	67	487.848
#275	NCOR1	25	37	62	769.253
#276	TCF7L1	25	27	52	759.769
#277	CNOT7	25	52	77	2487.994
#278	REST	25	36	61	1092.423
#279	SOX2	25	26	51	2065.968
#280	HOXD1	25	29	54	1648.742
#281	PAX7	25	35	60	253.71
#282	MYBL2	25	32	57	253.604
#283	HOXB2	25	41	66	988.339
#284	KLF5	25	36	61	576.766
#285	NFE2L1	24	46	70	739.033
#286	ARNTL	24	33	57	2268.282
#287	KLF2	24	35	59	613.704
#288	TSHZ2	24	31	55	191.148
#289	RERE	24	36	60	446.193
#290	ZHX3	24	32	56	563.617
#291	MLL	24	40	64	485.157
#292	ZEB1	24	21	45	631.257
#293	TAF5L	24	40	64	3264.221
#294	NFYB	24	28	52	1231.898
#295	ADNP	24	40	64	710.722
#296	SNAPC4	24	33	57	334.029
#297	GATAD2A	24	30	54	635.1
#298	HOXD10	24	36	60	504.99
#299	NOLC1	24	47	71	766.839
#300	KDM5B	23	40	63	1191.761
#301	PLSCR1	23	32	55	1154.659
#302	YEATS4	23	40	63	484.724
#303	ELK3	23	47	70	1341.014
#304	TRIM22	23	44	67	1227.168
#305	STAT6	23	48	71	487.356
#306	FOXO3	23	30	53	440.741
#307	JUN	23	32	55	663.677
#308	TAF7	23	49	72	1557.728
#309	ETS2	23	32	55	443.152
#310	IRF4	23	37	60	2945.219
#311	HCLS1	23	27	50	733.333
#312	HMGB1	22	36	58	588.62
#313	STAT5A	22	26	48	391.553
#314	HSF1	22	40	62	928.783
#315	FOXE1	22	24	46	355.864
#316	ZNF323	22	34	56	571.199
#317	SOLH	22	29	51	596.936
#318	LASS6	22	31	53	343.553
#319	HOXA5	22	31	53	1117.405
#320	HOXA11	22	28	50	360.912
#321	E2F1	22	34	56	158.142
#322	HMX1	21	29	50	159.529
#323	TAF12	21	37	58	1337.328
#324	MNX1	21	37	58	815.806
#325	FOXC1	21	46	67	992.909
#326	NFX1	21	39	60	294.303
#327	EHF	21	30	51	1725.388
#328	TCF25	21	40	61	1481.142
#329	PAX4	21	38	59	756.237
#330	XBP1	21	26	47	335.616
#331	TFDP1	20	35	55	872.074
#332	GLI3	20	40	60	577.423
#333	TFCP2	20	41	61	929.573
#334	TULP4	20	44	64	899
#335	TADA3	20	26	46	462.239
#336	HMBOX1	20	44	64	598.709
#337	ARNTL2	20	39	59	1319.429
#338	HNF1B	20	33	53	1017.579
#339	PHOX2A	20	44	64	967.407
#340	ZSCAN18	20	34	54	590.886
#341	TADA2A	20	22	42	450.513
#342	E2F5	20	40	60	552.054
#343	SOX9	20	46	66	1252.01
#344	SOX10	20	40	60	548.338
#345	ARID3A	20	27	47	591.009
#346	HEY1	19	42	61	2166.97
#347	KLF6	19	39	58	495.307
#348	CREB5	19	34	53	246.676
#349	MEIS3P1	19	31	50	620.643
#350	SLC30A9	19	35	54	364.823
#351	ETV1	19	32	51	664.177
#352	BACH1	19	29	48	1074.421
#353	PITX1	19	37	56	712.012
#354	GATA3	19	28	47	739.164
#355	FOXK2	19	41	60	984.159
#356	ZKSCAN4	19	39	58	1709.399
#357	TCFL5	19	45	64	607.54
#358	GTF2H4	18	40	58	545.433
#359	TFDP2	18	40	58	808.573
#360	MSX2	18	41	59	1045.622
#361	BHLHE40	18	43	61	742.703
#362	HOXA1	18	25	43	347.523
#363	TAF6	18	45	63	670.831
#364	NR0B1	18	31	49	2898.394
#365	TGIF2	18	37	55	1280.978
#366	SNAPC5	18	48	66	736.971
#367	ARNT2	18	32	50	639.533
#368	CSRNP2	18	26	44	137.939
#369	NR1H3	18	32	50	493.005
#370	ZFHX3	18	34	52	3011.892
#371	SHOX	17	47	64	608.653
#372	ZNF444	17	43	60	2064.61
#373	TSC22D3	17	28	45	585.314
#374	CEBPB	17	36	53	548.604
#375	TSC22D1	17	44	61	473.082
#376	HOXA10	16	47	63	1757.247
#377	GTF2H3	16	30	46	374.363
#378	HNF1A	16	37	53	397.69
#379	JUNB	16	33	49	713.93
#380	FOXG1	16	30	46	375.758
#381	SCML1	16	34	50	353.77
#382	ZNF165	16	32	48	1100.824
#383	PPARG	16	40	56	792.935
#384	LASS2	16	36	52	1121.551
#385	FOXA1	16	36	52	494.979
#386	BHLHE41	16	30	46	746.29
#387	FOXD1	16	40	56	616.646
#388	AHR	16	39	55	1521.27
#389	EGR1	16	38	54	418.695
#390	SCML2	16	36	52	416.299
#391	TCF3	16	49	65	549.253
#392	NFE2L2	16	35	51	1768.672
#393	ZNF85	16	31	47	1904.935
#394	KLF9	16	40	56	800.657
#395	SPDEF	15	42	57	1055.728
#396	MYC	15	48	63	752.098
#397	NR2F1	15	41	56	264.758
#398	TP53	15	36	51	267.074
#399	SMAD2	15	30	45	482.724
#400	SMAD3	15	42	57	721.488
#401	PBX1	15	49	64	803.244
#402	PPARD	15	29	44	356.283
#403	NPAT	15	42	57	812.869
#404	LZTR1	15	39	54	1253.209
#405	ELF5	15	41	56	2055.787
#406	IRF1	15	45	60	712.423
#407	FOSL2	15	31	46	579.79
#408	KLF11	15	36	51	539.095
#409	SATB2	15	37	52	357.964
#410	TWIST1	14	34	48	496.353
#411	CBFB	14	41	55	1284.724
#412	ZNF219	14	41	55	1008.725
#413	JUND	14	43	57	1203.204
#414	ZFP36L1	14	48	62	1570.088
#415	ETV4	13	34	47	325.461
#416	REXO4	13	38	51	104.602
#417	RNF4	13	46	59	500.974
#418	AATF	13	44	57	559.696
#419	HOXB3	13	40	53	569.539
#420	CREB3L1	13	44	57	387.392
#421	HMGA1	13	39	52	601.663
#422	MSRB2	13	48	61	572.56
#423	PBX3	12	36	48	1359.145
#424	MAFB	12	42	54	607.896
#425	HDAC1	12	45	57	1004.382
#426	IRX5	12	45	57	1692.276
#427	NKX2-1	12	40	52	597.954
#428	GATA2	12	43	55	428.798
#429	CNOT8	12	43	55	988.746
#430	HMGA2	12	41	53	876.54
#431	HOXB7	12	28	40	276.989
#432	CSDA	12	45	57	551.532
#433	HOXC10	12	43	55	725.378
#434	SALL2	12	34	46	386.349
#435	KLF10	12	42	54	428.135
#436	BCL3	11	43	54	448.387
#437	PTTG1	11	48	59	468.007
#438	ZNF131	11	49	60	292.673
#439	PURA	11	49	60	1628.947
#440	PLAG1	11	41	52	377.943
#441	RB1	11	43	54	329.061
#442	FOXD3	11	25	36	77.576
#443	RUNX3	11	36	47	366.121
#444	DBP	11	40	51	485.049
#445	HCFC1	11	54	65	1373.141
#446	AFF1	10	53	63	353.94
#447	ELF4	10	44	54	383.795
#448	YY1	10	44	54	292.833
#449	SLC2A4RG	10	43	53	515.452
#450	GABPB1	10	37	47	420.457
#451	CITED2	10	47	57	399.038
#452	TFAP2A	10	38	48	382.648
#453	CREBL2	10	39	49	257.522
#454	FOXA2	10	31	41	124.957
#455	BUD31	9	42	51	352.621
#456	CREB3	9	49	58	561.68
#457	SUPT4H1	9	40	49	545.278
#458	TCEAL1	9	37	46	182.065
#459	TSC22D2	9	47	56	527.953
#460	RELA	9	50	59	406.93
#461	MITF	9	50	59	412.63
#462	LMO4	9	56	65	1834.257
#463	C11orf9	9	29	38	357.787
#464	NR3C1	9	35	44	172.121
#465	ZFP36L2	9	37	46	592.385
#466	CEBPD	9	47	56	304.94
#467	SCAND1	9	47	56	599.006
#468	RBCK1	9	42	51	233.487
#469	TEAD4	8	47	55	1391.228
#470	SMAD1	8	49	57	685.676
#471	TGIF1	8	46	54	372.977
#472	PA2G4	8	36	44	291.485
#473	CTBP1	7	49	56	492.234
#474	CREB3L2	7	45	52	319.22
#475	NR2F2	7	53	60	215.976
#476	MTA1	7	48	55	775.283
#477	SOX4	7	48	55	451.746
#478	TRIM28	6	47	53	1155.561
#479	RBPJ	6	42	48	925.515
#480	ETV5	6	50	56	374.551
#481	HNRNPAB	6	47	53	198.703
#482	SUPT6H	6	51	57	493.658
#483	WNT5A	6	44	50	226.367
#484	SNAI2	6	43	49	293.16
#485	NFE2L3	6	46	52	220.258
#486	SOX12	5	54	59	242.287
#487	KLF4	5	44	49	190.705
#488	HMGB2	5	45	50	185.752
#489	IRF3	4	50	54	265.953
#490	SATB1	4	41	45	109.496
#491	CNBP	4	47	51	340.158
#492	SREBF1	4	50	54	393.957
#493	TAF10	3	51	54	381.559
#494	FOXM1	3	50	53	82.1
#495	EPAS1	3	53	56	137.122
#496	STAT1	2	59	61	84.673
#497	ENO1	2	55	57	164.778
#498	DDIT3	1	52	53	51.567
#499	HIF1A	1	49	50	40.475
#500	CDKN2A	1	48	49	33.177