Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SMAD4	53	0	53	0
#2	ZRANB2	44	4	48	251.388
#3	PURB	43	4	47	154.51
#4	ETS1	41	9	50	779.083
#5	RFX3	40	1	41	31.598
#6	SP3	37	4	41	190.951
#7	NR3C1	37	0	37	0
#8	CNBP	36	7	43	9661.684
#9	ZNF217	36	5	41	499.019
#10	CNOT7	35	1	36	4.111
#11	UBP1	35	4	39	82.219
#12	NFE2L2	33	7	40	2337.848
#13	ELF2	33	6	39	3741.15
#14	MXD1	33	6	39	573.967
#15	ZNF500	33	4	37	553.287
#16	RARA	32	4	36	383.491
#17	HIRA	32	4	36	119.907
#18	HOXC13	31	3	34	229.603
#19	HDAC2	30	5	35	632.039
#20	KLF12	28	7	35	317.407
#21	CREB5	28	7	35	11606.545
#22	MNT	27	5	32	1202.192
#23	NR2E3	27	6	33	140.591
#24	NFIL3	27	1	28	30.101
#25	SPI1	27	5	32	1673.985
#26	FOSL2	26	13	39	3324.103
#27	TFE3	26	6	32	1212.473
#28	IRX1	26	5	31	248.699
#29	ZEB2	26	8	34	992.751
#30	DMRT1	26	3	29	53.348
#31	CREBBP	26	9	35	846.807
#32	SOX2	25	7	32	332.076
#33	FOXN2	25	3	28	1606.524
#34	CREB3	25	5	30	185.287
#35	ARID3A	25	8	33	1519.513
#36	LZTR1	25	4	29	1090.508
#37	ELF1	25	6	31	158.687
#38	FOS	25	8	33	12155.051
#39	NR1D1	24	4	28	134.76
#40	BCL11B	24	3	27	111.935
#41	DMTF1	23	7	30	219.796
#42	NPAT	23	5	28	374.363
#43	STAT3	22	6	28	907.165
#44	CBFB	22	7	29	71.78
#45	CEBPB	22	4	26	905.535
#46	CSDA	21	8	29	4503.387
#47	TRIM28	21	11	32	1146.984
#48	ARNTL	21	5	26	14546.771
#49	PITX1	21	4	25	126.842
#50	SPIC	21	5	26	158.869
#51	TBP	20	8	28	916.007
#52	HDAC1	20	6	26	908.737
#53	JDP2	20	7	27	462.185
#54	RUNX3	20	7	27	682.631
#55	PPARD	19	8	27	2127.131
#56	SNAPC4	19	6	25	844.641
#57	E4F1	19	6	25	932.343
#58	ATF6B	19	7	26	178.764
#59	STAT4	19	10	29	1466.17
#60	RCAN1	19	8	27	276.252
#61	DBP	19	8	27	2836.102
#62	ADNP	18	8	26	949.757
#63	FOXJ3	18	8	26	877.418
#64	PURA	18	10	28	848.834
#65	SLC30A9	18	8	26	415.626
#66	GATA1	18	6	24	192.553
#67	AHR	18	2	20	100.68
#68	BTAF1	18	7	25	1878.068
#69	BCL6	18	6	24	3914.979
#70	POU2F1	18	8	26	356.536
#71	ZNF444	18	11	29	418.511
#72	RFX5	17	8	25	3495.527
#73	PKNOX1	17	8	25	253.498
#74	THRB	17	8	25	2616.422
#75	NOTCH1	17	9	26	666.853
#76	SPEN	17	5	22	596.879
#77	TULP4	17	13	30	650.768
#78	TRIM22	17	11	28	5628.495
#79	RFX1	17	9	26	759.318
#80	NFIC	16	9	25	1476.606
#81	ENO1	16	13	29	1974.121
#82	RORA	16	9	25	8682.643
#83	REXO4	16	9	25	1458.874
#84	STAT2	16	1	17	492.913
#85	MLL	16	6	22	1664.124
#86	ZNF238	16	8	24	332.161
#87	HOXD3	16	9	25	342.766
#88	ZNF263	16	3	19	1389.319
#89	TSHZ1	16	12	28	1649.135
#90	TAF4	16	8	24	431.162
#91	AFF4	16	7	23	285.014
#92	MTF1	15	11	26	5626.705
#93	CBL	15	10	25	419.22
#94	TCF25	15	10	25	1759.044
#95	TCF7	15	5	20	974.385
#96	MTA1	15	6	21	1478.784
#97	ALX3	15	6	21	253.411
#98	TAF7	15	6	21	218.384
#99	CEBPD	14	8	22	912.587
#100	RELA	14	12	26	2653.728
#101	RNF4	14	11	25	741.468
#102	RXRA	14	10	24	2138.359
#103	EDF1	14	16	30	2894.569
#104	ZFPM1	14	11	25	1405.381
#105	ZNF438	14	5	19	6121.498
#106	MYPOP	14	12	26	8299.55
#107	FLI1	14	6	20	196.449
#108	MYC	14	10	24	1506.66
#109	POU5F1	14	10	24	1463.702
#110	UBN1	14	10	24	1198.557
#111	MAFB	14	10	24	2866.086
#112	KLF1	14	9	23	339.089
#113	RAX2	14	11	25	1341.548
#114	SOX30	14	6	20	281.286
#115	PBX2	14	11	25	1654.503
#116	NR1H2	13	9	22	545.318
#117	TFAM	13	9	22	1393.471
#118	SCMH1	13	11	24	926.981
#119	AATF	13	6	19	105.425
#120	ZFP36L1	13	6	19	174.474
#121	TADA3	13	9	22	307.115
#122	ADNP2	13	9	22	1170.878
#123	ZBTB17	13	5	18	233.125
#124	ZHX1	13	9	22	615.852
#125	ZNF281	12	9	21	749.162
#126	IRF1	12	10	22	2183.664
#127	PBX4	12	7	19	573.259
#128	TBX1	12	8	20	270.712
#129	FOXD4L5	12	11	23	202.875
#130	ZNF207	12	10	22	1102.31
#131	TFEB	12	8	20	2571.66
#132	CTNNB1	12	8	20	793.798
#133	CTCF	12	11	23	2321.772
#134	FOXP1	12	8	20	152.062
#135	RELB	11	8	19	428.754
#136	MYCL1	11	4	15	237.445
#137	ZFHX3	11	7	18	3593.631
#138	POU2F2	11	12	23	1763.402
#139	NFATC1	11	7	18	1229.801
#140	BCL3	11	12	23	1129.139
#141	BTG2	11	7	18	1086.536
#142	CLOCK	11	7	18	821.963
#143	HNRNPAB	11	11	22	1347.317
#144	HNRNPK	11	8	19	3420.079
#145	BUD31	11	14	25	2533.528
#146	RBPJ	11	8	19	1130.432
#147	PHTF1	11	7	18	15439.314
#148	SP1	11	6	17	538.042
#149	JUND	11	11	22	9161.22
#150	DRAP1	11	14	25	4001.828
#151	SP4	11	9	20	566.883
#152	CSRNP2	11	12	23	929.897
#153	SP140	10	12	22	1995.313
#154	C11orf9	10	6	16	954.837
#155	ZNF3	10	6	16	498.801
#156	E2F3	10	10	20	1012.132
#157	E2F6	10	10	20	1766.863
#158	ECSIT	10	10	20	831.328
#159	ZNF175	10	13	23	1836.228
#160	ETS2	10	9	19	486.936
#161	ETV6	10	9	19	1319.981
#162	FOXO4	10	8	18	257.745
#163	TSC22D4	10	10	20	2252.824
#164	HCFC1	10	13	23	1955.595
#165	STRN3	10	8	18	95.829
#166	IRF7	10	6	16	5000.158
#167	STAT1	10	11	21	806.814
#168	ZSCAN2	10	15	25	5852.618
#169	LEF1	10	7	17	305.619
#170	MNX1	10	4	14	29.029
#171	SNAPC2	10	8	18	289.397
#172	SCAND1	10	6	16	119.496
#173	NFX1	10	12	22	2899.624
#174	PA2G4	10	9	19	1850.317
#175	PBX1	10	11	21	788.175
#176	IRF9	9	7	16	340.338
#177	SOX13	9	5	14	1798.668
#178	MEF2D	9	17	26	3517.326
#179	SOX12	9	5	14	89.204
#180	MSL3	9	11	20	548.773
#181	FOXO1	9	10	19	373.905
#182	ZNF91	9	9	18	2744.197
#183	ERF	9	10	19	610.204
#184	ELK1	9	9	18	1108.832
#185	ELF5	9	7	16	2701.796
#186	RBCK1	9	15	24	2514.422
#187	DDIT3	9	7	16	577.381
#188	CTBP1	9	11	20	1672.989
#189	CSRNP1	9	11	20	1352.989
#190	ZNF256	9	14	23	858.465
#191	ZNF277	9	11	20	1229.263
#192	CBFA2T2	9	9	18	1189.122
#193	C5orf41	9	10	19	1440.216
#194	KLF9	9	11	20	1011.321
#195	SREBF2	9	10	19	1140.792
#196	SRF	9	9	18	3240.801
#197	SIN3A	8	14	22	3224.237
#198	KLF17	8	5	13	1595.352
#199	TCF3	8	14	22	1164.393
#200	SLC2A4RG	8	11	19	750.538
#201	HHEX	8	9	17	625.361
#202	ATF6	8	12	20	2241.269
#203	BHLHE40	8	10	18	201.407
#204	SOLH	8	11	19	270.059
#205	HDX	8	6	14	262.509
#206	CEBPA	8	16	24	2991.322
#207	PBX3	8	7	15	427.796
#208	GATAD2B	8	12	20	798.399
#209	EBF1	8	6	14	417.193
#210	VAV1	8	10	18	2251.746
#211	NR5A1	8	6	14	32.502
#212	TAF10	8	14	22	1475.783
#213	PRDM1	8	9	17	2828.466
#214	ZBTB48	7	14	21	703.595
#215	ZFP42	7	11	18	2027.534
#216	FOXD4L4	7	8	15	26.974
#217	NEUROD2	7	10	17	1156.537
#218	ESRRA	7	13	20	1579.435
#219	ATF4	7	9	16	565.162
#220	SPIB	7	8	15	774.342
#221	RFXAP	7	8	15	10069.739
#222	E2F2	7	6	13	631.038
#223	ZSCAN16	7	10	17	1768.971
#224	RXRB	7	8	15	1917.707
#225	ZNF35	7	10	17	901.554
#226	IRF3	7	12	19	318.5
#227	TCF12	7	13	20	9440.622
#228	ZNF37A	7	8	15	1457.718
#229	CREBZF	7	9	16	364.389
#230	BATF	7	17	24	3458.245
#231	TRERF1	7	13	20	944.311
#232	GAS7	7	17	24	1377.945
#233	ZXDC	6	9	15	129.232
#234	AHCTF1	6	18	24	1247.212
#235	ARID4A	6	12	18	283.813
#236	BACH2	6	10	16	1137.04
#237	CBFA2T3	6	12	18	324.552
#238	CITED2	6	11	17	1011.046
#239	FBXW7	6	11	17	2561.208
#240	FOXH1	6	7	13	825.245
#241	FOXP3	6	8	14	463.739
#242	HMGB2	6	10	16	434.867
#243	KLF16	6	8	14	2275.315
#244	LCOR	6	8	14	116.952
#245	LMO4	6	17	23	1147.528
#246	MAX	6	12	18	862.537
#247	MZF1	6	10	16	446.471
#248	NFE2	6	11	17	593.404
#249	NFIX	6	8	14	1323.728
#250	NR1H3	6	6	12	12460.869
#251	RERE	6	10	16	183.665
#252	RFXANK	6	13	19	1166.667
#253	SMAD5	6	8	14	252.34
#254	SUPT4H1	6	21	27	1746.888
#255	YY1	6	12	18	11806.255
#256	ZC3H8	6	13	19	380.199
#257	ZKSCAN1	6	10	16	1761.86
#258	ZKSCAN4	6	15	21	778.815
#259	ZNF148	6	15	21	975.015
#260	ZNF434	6	8	14	351.201
#261	ZNF498	6	8	14	3224.805
#262	ATF3	5	7	12	1567.699
#263	CUX1	5	15	20	1052.652
#264	ZNF446	5	11	16	881.705
#265	ZNF189	5	12	17	370.547
#266	PFDN1	5	9	14	1449.072
#267	ZNF133	5	14	19	392.997
#268	EOMES	5	13	18	444.379
#269	RUNX1	5	15	20	2923.395
#270	ZFP90	5	16	21	536.371
#271	PLAGL2	5	11	16	1788.091
#272	FOSB	5	11	16	11410.832
#273	FOXG1	5	8	13	608.942
#274	LHX6	5	11	16	1654.964
#275	STAT5B	5	12	17	719.845
#276	KLF4	5	6	11	611.168
#277	FOXO3	5	11	16	1679.555
#278	TSC22D2	5	9	14	248.57
#279	GTF2IRD1	5	12	17	2045.728
#280	TP53	5	13	18	1059.483
#281	STAT5A	5	15	20	4229.714
#282	TFDP1	5	9	14	4669.477
#283	BLZF1	5	15	20	4112.453
#284	SUPT6H	5	10	15	1043.755
#285	SATB1	5	11	16	1884.644
#286	TCF7L2	5	13	18	3333.713
#287	TCF4	5	9	14	1591.491
#288	HOXC10	5	7	12	341.22
#289	ONECUT2	5	8	13	54.684
#290	EVX1	4	8	12	133.806
#291	ATF5	4	12	16	1927.044
#292	KLF6	4	18	22	1167.225
#293	TRIM25	4	9	13	1400.977
#294	TGIF2	4	13	17	382.999
#295	ZKSCAN5	4	8	12	781.538
#296	HOMEZ	4	17	21	1289.505
#297	CIR1	4	13	17	592.49
#298	HSF2	4	14	18	1323.251
#299	NFYC	4	9	13	172.576
#300	SPDEF	4	9	13	421.776
#301	NR2C2	4	14	18	1284.138
#302	CREB3L2	4	11	15	1403.629
#303	IRF8	4	13	17	514.293
#304	ZNF232	4	8	12	385.907
#305	ZNF213	4	8	12	1364.656
#306	SMAD2	4	11	15	1201.923
#307	SMAD3	4	12	16	521.042
#308	HINFP	4	10	14	842.486
#309	USF2	3	10	13	208.54
#310	NFYA	3	13	16	797.004
#311	NFKB1	3	15	18	2163.696
#312	MTA3	3	14	17	621.071
#313	MTA2	3	16	19	315.638
#314	MEF2C	3	13	16	3526.576
#315	MECOM	3	9	12	20.525
#316	LASS6	3	21	24	3674.654
#317	LASS5	3	14	17	1209.806
#318	ZNF83	3	8	11	44.514
#319	IKZF3	3	15	18	1460.132
#320	TAF1B	3	10	13	256.574
#321	TBX3	3	9	12	167.228
#322	HMG20A	3	8	11	24.696
#323	GTF2H4	3	12	15	663.265
#324	TSC22D1	3	13	16	745
#325	GATAD2A	3	10	13	1117.648
#326	XBP1	3	15	18	388.921
#327	FOXJ2	3	12	15	1971.404
#328	ZBTB25	3	9	12	61.163
#329	ATF2	3	14	17	64.025
#330	ETV7	3	14	17	454.397
#331	ESR2	3	10	13	70.576
#332	ASCL2	3	12	15	1061.987
#333	E2F4	3	10	13	132.429
#334	ZNF274	3	13	16	2084.519
#335	ZNF33B	3	10	13	109.909
#336	ZSCAN21	3	13	16	310.929
#337	BATF3	3	16	19	12385.435
#338	PTTG1	3	12	15	578.579
#339	PRDM2	3	7	10	593.613
#340	HOXA6	2	11	13	1279.461
#341	HOPX	2	16	18	432.298
#342	TAF5	2	10	12	142.994
#343	TAF12	2	15	17	596.953
#344	MEF2A	2	15	17	2156.881
#345	HCLS1	2	19	21	776.374
#346	MLLT10	2	10	12	2997.505
#347	ZHX2	2	12	14	1008.656
#348	ZHX3	2	12	14	688.91
#349	NFE2L1	2	19	21	526.636
#350	SREBF1	2	15	17	311.886
#351	CREBL2	2	7	9	457.332
#352	HOXC4	2	15	17	498.51
#353	MSX2	2	6	8	49.494
#354	ZNF134	2	11	13	830.246
#355	ZNF140	2	7	9	215.492
#356	VENTX	2	13	15	195.508
#357	TGIF1	2	12	14	389.691
#358	ELF4	2	16	18	2018.162
#359	KDM5B	2	18	20	56.71
#360	TAL1	2	9	11	407.581
#361	NME2	2	14	16	863.656
#362	TARDBP	2	9	11	97.13
#363	GATA2	2	12	14	1687.419
#364	KLF2	2	17	19	490.319
#365	TSC22D3	2	12	14	408.226
#366	MAFG	2	10	12	433.582
#367	ZNF187	1	18	19	3005.331
#368	SNAI3	1	13	14	39.047
#369	ZNF193	1	11	12	149.411
#370	EGR1	1	12	13	59.689
#371	NFATC3	1	14	15	109.802
#372	ZNF219	1	8	9	4.615
#373	SCRT1	1	7	8	377.831
#374	GLIS3	1	9	10	786.853
#375	HES6	1	11	12	72.87
#376	NFKB2	1	15	16	114.806
#377	TSHZ2	1	12	13	47.591
#378	TSHZ3	1	19	20	62.298
#379	TBX19	1	14	15	31.697
#380	ZNF394	1	16	17	67.59
#381	IRF5	1	14	15	58.787
#382	ARNT	1	10	11	32.402
#383	TFCP2	1	14	15	615.003
#384	IRF2	1	13	14	192.261
#385	LASS2	1	17	18	885.074
#386	KLF11	1	9	10	37.265
#387	MAF	1	15	16	87.65
#388	IRF4	1	11	12	180.162
#389	SOX8	1	10	11	1265.804
#390	NR2C1	1	12	13	23.678
#391	ETV3	1	11	12	185.398
#392	POU6F1	1	11	12	97.809
#393	RUNX2	1	7	8	9.775
#394	ZKSCAN3	1	10	11	20.246
#395	ZSCAN18	1	13	14	1143.665
#396	TRPS1	1	13	14	1322.881
#397	ARNTL2	1	9	10	335.062
#398	ZNF18	1	9	10	19.108
#399	TFDP2	0	16	16	0
#400	STAT6	0	11	11	0
#401	THRA	0	11	11	0
#402	C1orf85	0	21	21	0
#403	NFXL1	0	7	7	0
#404	GCFC1	0	10	10	0
#405	GATAD1	0	9	9	0
#406	USF1	0	11	11	0
#407	PDX1	0	15	15	0
#408	BARHL2	0	8	8	0
#409	NR2F6	0	12	12	0
#410	MSRB2	0	13	13	0
#411	ZNF174	0	15	15	0
#412	MYBL2	0	8	8	0
#413	PHF1	0	10	10	0
#414	RORC	0	15	15	0
#415	CREB1	0	17	17	0
#416	TAF5L	0	9	9	0
#417	HOXB6	0	9	9	0
#418	CEBPE	0	11	11	0
#419	HOXB2	0	13	13	0
#420	TCF20	0	11	11	0
#421	IKZF1	0	17	17	0
#422	TEF	0	13	13	0
#423	NKX3-1	0	18	18	0
#424	HMBOX1	0	14	14	0