Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZIC2	79	6	85	2231.789
#2	TFAP2A	67	6	73	4420.553
#3	PLSCR1	55	5	60	2117.334
#4	EPAS1	54	5	59	972.054
#5	CREM	49	7	56	3662.596
#6	DLX1	49	6	55	1885.285
#7	GATA6	46	7	53	1361.107
#8	DRAP1	45	3	48	1717.629
#9	TCF4	44	13	57	5809.934
#10	FOXN3	42	10	52	3680.174
#11	MTA3	38	5	43	1488.548
#12	FOXP1	38	13	51	4227.871
#13	CSDA	37	10	47	2310.512
#14	TFAP2C	37	10	47	5506.384
#15	NR2F1	37	3	40	1266.938
#16	PPARD	36	5	41	343.742
#17	GCFC1	36	6	42	3004.069
#18	HOXA10	36	7	43	2335.045
#19	LHX2	34	10	44	2416.767
#20	ELK3	34	5	39	998.667
#21	NR4A2	33	5	38	2470.713
#22	CDKN2A	33	7	40	1792.461
#23	DLX2	32	7	39	1025.179
#24	NR2F2	32	9	41	2773.914
#25	MYC	32	8	40	1847.483
#26	HMG20B	31	8	39	1036.309
#27	TSC22D3	31	14	45	5859.08
#28	MITF	31	10	41	3345.747
#29	HOXA5	31	11	42	5920.245
#30	ISL1	30	10	40	3353.994
#31	ETS2	30	10	40	1007.97
#32	ETV1	30	12	42	2928.027
#33	FOXL2	30	9	39	1977.358
#34	HEY1	30	6	36	456.285
#35	MEIS3P1	29	7	36	1521.84
#36	HOXA3	29	10	39	6321.215
#37	MEIS1	29	7	36	477.613
#38	MSX2	29	14	43	2747.894
#39	GLI3	28	8	36	1016.669
#40	HOXC13	28	4	32	1067.099
#41	ARNTL2	28	8	36	2011.515
#42	FOXO1	28	11	39	3316.888
#43	BARX1	27	8	35	1481.236
#44	HOXB3	27	13	40	5123.78
#45	PBX2	27	11	38	1363.786
#46	FOXF2	26	12	38	2969.431
#47	HMGA2	25	8	33	1025.518
#48	PPARG	25	12	37	3788.46
#49	TEAD2	24	9	33	4898.867
#50	SP4	24	4	28	622.583
#51	KLF5	24	11	35	1476.423
#52	ZSCAN16	24	11	35	1528.669
#53	ZNF496	24	6	30	383.309
#54	PBX1	24	9	33	1532.078
#55	POU4F1	24	7	31	830.227
#56	TWIST2	23	10	33	2508.488
#57	SOX7	23	13	36	2945.368
#58	RORA	23	6	29	2737.439
#59	ZNF232	22	17	39	3996.671
#60	SATB2	22	9	31	2301.112
#61	SOX4	22	11	33	2285.904
#62	NR0B1	22	5	27	1037.618
#63	BCL3	22	11	33	1512.105
#64	AHR	22	11	33	1760.884
#65	ZNF138	22	12	34	6209.507
#66	BTG2	21	10	31	882.523
#67	PGBD1	21	7	28	1174.942
#68	HOXA9	21	8	29	2789.785
#69	IRX2	21	16	37	2713.338
#70	TSC22D1	21	8	29	1164.802
#71	TWIST1	20	11	31	3836.947
#72	SOX12	20	10	30	2135.154
#73	KLF12	20	10	30	1145.601
#74	SOX2	20	9	29	916.223
#75	IRF9	20	4	24	444.691
#76	FOSL1	20	10	30	955.88
#77	SOX9	20	12	32	733.173
#78	E2F1	20	10	30	686.988
#79	FOXQ1	19	10	29	2355.856
#80	FOXF1	19	8	27	1300.742
#81	ZNF71	19	12	31	2092.226
#82	C11orf9	19	11	30	4353.78
#83	ZNF18	19	16	35	3057.102
#84	JDP2	19	13	32	3483.127
#85	TEAD3	19	10	29	663.776
#86	MEF2D	19	7	26	468.28
#87	ZHX1	19	12	31	3190.607
#88	CREB3L2	19	12	31	1842.135
#89	ETV5	19	9	28	820.605
#90	LEF1	18	11	29	3451.723
#91	PBX3	18	5	23	391.582
#92	ZBTB38	18	4	22	278.684
#93	LHX6	18	7	25	980.176
#94	TFDP1	18	10	28	1779.721
#95	E2F2	17	9	26	1628.666
#96	ALX1	17	9	26	1035.192
#97	PEG3	17	4	21	128.031
#98	PRRX2	17	8	25	522.957
#99	HIRA	17	12	29	3459.899
#100	TSHZ1	17	13	30	3905.141
#101	FOXE1	17	12	29	2522.628
#102	MEIS2	17	12	29	1122.623
#103	UHRF1	17	8	25	2364.387
#104	ZNF202	16	5	21	874.725
#105	FOXM1	16	9	25	1572.612
#106	NPAS2	16	11	27	1411.883
#107	MECOM	16	11	27	1125.495
#108	SMAD9	16	13	29	1235.499
#109	SIX5	15	7	22	837.116
#110	C2orf3	15	10	25	929.245
#111	GRHL2	15	3	18	108.128
#112	RUNX3	15	6	21	636.254
#113	NFIA	15	7	22	1564.204
#114	ATF1	15	12	27	1648.735
#115	CREB3L4	15	11	26	595.973
#116	SLC30A9	15	14	29	3152.115
#117	WNT5A	15	12	27	3580.23
#118	NKX3-1	15	18	33	1418.048
#119	RUNX2	15	15	30	3023.804
#120	CITED2	14	14	28	3791.723
#121	TFCP2L1	14	9	23	766.082
#122	HOXA7	14	6	20	782.98
#123	HOXD10	14	7	21	720.347
#124	C1orf85	14	15	29	1740.898
#125	EHF	14	9	23	747.72
#126	SIX1	13	10	23	1726.76
#127	ZEB1	13	11	24	1339.83
#128	SMAD3	13	10	23	561.594
#129	TCF19	13	7	20	334.276
#130	HOXC9	13	14	27	4756.364
#131	HES1	13	10	23	1037.395
#132	TSC22D2	13	13	26	3890.471
#133	PITX2	13	12	25	2499.791
#134	ZNF268	13	12	25	973.618
#135	FOS	13	12	25	1468.203
#136	ZNF35	13	7	20	1559.185
#137	ARNT	13	11	24	915.98
#138	TRPS1	13	9	22	226.881
#139	FOXP2	13	2	15	44.932
#140	HSF2	12	16	28	3088.845
#141	HOXB6	12	11	23	1536.951
#142	GLIS3	12	15	27	3284.124
#143	ZNF91	12	11	23	1190.254
#144	MEF2C	12	12	24	2923.473
#145	ZKSCAN5	12	8	20	433.597
#146	NR4A1	12	10	22	600.203
#147	MYBL2	12	14	26	2462.833
#148	ZNF165	12	12	24	1113.647
#149	TBX1	12	10	22	4161.463
#150	DLX6	12	10	22	578.278
#151	LZTR1	12	11	23	981.425
#152	TFDP2	12	9	21	1542.75
#153	JUNB	12	13	25	1756.293
#154	ATF6	12	11	23	1076.807
#155	MAFK	12	8	20	2953.948
#156	ZNF449	12	10	22	1451.725
#157	BATF3	12	8	20	1531.816
#158	IRF1	11	10	21	1257.972
#159	POU3F2	11	5	16	701.333
#160	REL	11	10	21	1149.991
#161	TRIM29	11	10	21	894.501
#162	ZEB2	11	7	18	1397.326
#163	ZNF639	11	12	23	1489.716
#164	HOXA2	11	15	26	2595.777
#165	ZNF256	11	15	26	1854.158
#166	NR3C1	11	10	21	423.511
#167	ZNF70	11	8	19	160.792
#168	SLC2A4RG	11	13	24	886.768
#169	CSRNP3	11	7	18	426.763
#170	GATAD2B	11	8	19	363.352
#171	BHLHE41	11	14	25	2003.965
#172	SALL2	11	15	26	1828.046
#173	RXRA	11	8	19	426.487
#174	CTBP1	11	12	23	685.189
#175	ZHX2	11	7	18	358.825
#176	SNAI2	11	14	25	2469.317
#177	MSX1	11	10	21	1087.478
#178	FOXC1	10	15	25	1001.864
#179	ZNF92	10	9	19	1884.207
#180	CREB3L1	10	15	25	1424.884
#181	PRDM1	10	9	19	894.047
#182	ZNF217	10	8	18	302.034
#183	RERE	10	15	25	1211.461
#184	IRX3	10	19	29	1108.185
#185	PITX1	10	7	17	627.789
#186	GLIS2	10	10	20	745.169
#187	ZSCAN18	10	10	20	399.704
#188	TSHZ3	10	6	16	759.81
#189	PAX6	10	6	16	1076.924
#190	HOXA1	10	9	19	724.163
#191	TAF5	10	10	20	2353.55
#192	HINFP	10	13	23	1524.788
#193	FOXJ2	10	9	19	916.375
#194	RARB	10	14	24	2593.973
#195	SALL1	9	12	21	391.93
#196	ETS1	9	16	25	636.362
#197	BHLHE40	9	11	20	668.846
#198	FOXO3	9	10	19	1230.815
#199	ZNF175	9	10	19	386.856
#200	HES6	9	13	22	1302.793
#201	MYCN	9	11	20	570.889
#202	HDX	9	11	20	2392.842
#203	HR	9	9	18	1241.694
#204	HOXB2	9	17	26	4326.609
#205	PROX1	9	5	14	1469.766
#206	STAT4	9	10	19	1693.742
#207	MLLT10	9	13	22	2885.556
#208	ISL2	9	12	21	1582.201
#209	PKNOX1	9	11	20	742.404
#210	DBP	9	13	22	2934.638
#211	PLAGL2	9	7	16	275.409
#212	IRF6	9	9	18	372.155
#213	ELF3	9	11	20	1150.622
#214	MBD1	9	16	25	4734.538
#215	GATA3	9	16	25	1429.529
#216	PCGF2	9	11	20	767.551
#217	NR1D2	9	11	20	4303.873
#218	NFIB	9	17	26	2206.062
#219	NKX2-5	9	10	19	724.02
#220	VAV1	9	8	17	653.726
#221	STAT6	9	9	18	974.783
#222	KLF9	8	18	26	2449.872
#223	FOXD1	8	18	26	3499.642
#224	MNX1	8	12	20	2686.744
#225	ZSCAN12	8	11	19	735.005
#226	THRA	8	6	14	477.104
#227	FOXA1	8	7	15	2028.382
#228	ZNF83	8	11	19	2674.825
#229	EGR1	8	13	21	1965.499
#230	AEBP1	8	11	19	1265.265
#231	NR4A3	8	14	22	880.416
#232	ST18	8	8	16	1558.163
#233	NFE2L3	8	12	20	458.379
#234	HHEX	8	11	19	1025.214
#235	OVOL1	8	4	12	254.741
#236	PAX8	8	8	16	590.741
#237	FOXO6	8	13	21	949.95
#238	TRIM22	8	14	22	2277.371
#239	HOXD11	8	11	19	1271.276
#240	CSRNP1	8	10	18	1073.552
#241	ONECUT2	8	15	23	986.421
#242	ZGPAT	8	9	17	1424.154
#243	FOSB	8	13	21	3644.685
#244	SRF	8	13	21	1100.915
#245	HNF1B	7	6	13	437.23
#246	CEBPB	7	10	17	3687.003
#247	STAT1	7	15	22	1625.108
#248	ZFHX4	7	8	15	358.85
#249	FOXA2	7	15	22	2017.235
#250	ARNTL	7	7	14	419.183
#251	TBX3	7	12	19	639.982
#252	JUN	7	13	20	2026.698
#253	GAS7	7	7	14	292.183
#254	LMO4	7	11	18	1587.342
#255	MLL	7	16	23	6307.388
#256	CEBPD	7	14	21	813.629
#257	NR1H2	7	13	20	438.194
#258	NFIC	7	8	15	341.386
#259	THRB	7	15	22	1407.038
#260	AR	7	4	11	363.93
#261	GRHL3	7	11	18	912.242
#262	VTN	7	12	19	2588.316
#263	HOXA11	7	7	14	197.718
#264	ZNF238	7	11	18	682.802
#265	HOXC10	7	12	19	994.125
#266	ATF7	7	9	16	253.474
#267	RELB	7	11	18	435.821
#268	ZNF85	7	9	16	1085.803
#269	TFEB	7	13	20	366.585
#270	SMAD2	7	12	19	2504.306
#271	FUBP1	7	14	21	1964.368
#272	SIX2	7	17	24	2152.958
#273	CREBZF	7	12	19	571.188
#274	MSRB2	7	12	19	298.445
#275	GATA4	6	8	14	296.909
#276	PRRX1	6	7	13	124.538
#277	FLI1	6	5	11	278.269
#278	SIX3	6	4	10	259.943
#279	ARNT2	6	18	24	1711.957
#280	SMAD6	6	18	24	3706.167
#281	ZIC3	6	5	11	531.833
#282	WT1	6	16	22	1026.701
#283	KLF4	6	15	21	1912.919
#284	CREB5	6	14	20	1287.538
#285	FOXL1	6	14	20	1398.828
#286	ZNF207	6	18	24	6149.573
#287	FOSL2	6	13	19	1261.991
#288	IRF2	6	14	20	1945.728
#289	BNC1	6	6	12	1085.022
#290	SIM2	6	9	15	501.796
#291	TFE3	6	13	19	556.83
#292	ZFPM1	6	12	18	618.124
#293	TFEC	6	8	14	665.021
#294	TARDBP	6	9	15	156.832
#295	TGIF2	6	14	20	989.53
#296	TCF7L1	6	16	22	2131.773
#297	NR2F6	6	11	17	298.8
#298	HOXA4	6	4	10	218.066
#299	DDIT3	6	13	19	3866.959
#300	PGR	6	3	9	161.631
#301	ZFHX3	6	8	14	539.634
#302	STAT2	6	14	20	778.58
#303	SP1	6	13	19	593.621
#304	TCFL5	6	11	17	504.001
#305	ZNF24	6	8	14	503.861
#306	CUX1	6	13	19	407.491
#307	TRIM25	6	14	20	1695.335
#308	RFX5	6	14	20	593.633
#309	ZIC5	5	5	10	172.24
#310	NFYA	5	8	13	436.779
#311	ZNF117	5	8	13	194.889
#312	HOXD3	5	5	10	1008.318
#313	ZNF45	5	11	16	372.472
#314	RCAN1	5	16	21	883.163
#315	KCNH8	5	6	11	899.109
#316	SCML1	5	19	24	779.128
#317	SOX30	5	10	15	810.518
#318	AHCTF1	5	11	16	1738.723
#319	MAF	5	4	9	32.676
#320	MYT1L	5	7	12	1667.262
#321	MMP14	5	11	16	715.095
#322	ELF1	5	15	20	749.902
#323	TP53	5	13	18	800.629
#324	NR3C2	5	6	11	1274.487
#325	HCLS1	5	6	11	277.616
#326	KLF2	5	13	18	1286.662
#327	ZNF93	5	12	17	788.143
#328	SOLH	5	12	17	687.647
#329	MEIS3	5	5	10	510.395
#330	PLAG1	5	12	17	731.746
#331	MAFB	5	4	9	400.375
#332	HEY2	5	9	14	1092.622
#333	SIX4	5	7	12	644.722
#334	HOXB9	5	14	19	490.005
#335	HOXD1	5	8	13	528.547
#336	RFXAP	5	11	16	494.242
#337	EBF1	5	10	15	769.751
#338	NR5A2	5	7	12	686.394
#339	DMRT2	5	3	8	251.739
#340	SOX13	5	16	21	810.862
#341	ZNF397	5	11	16	270.263
#342	ETV4	5	17	22	1104.948
#343	ZXDC	5	14	19	3620.292
#344	ZKSCAN4	5	11	16	1138.654
#345	VDR	5	13	18	637.322
#346	GABPA	5	13	18	2153.876
#347	ZXDA	4	13	17	605.631
#348	FOXJ3	4	8	12	105.44
#349	T	4	2	6	81.255
#350	MXD1	4	10	14	215.808
#351	GLI2	4	16	20	1266.224
#352	TCF7L2	4	12	16	388.471
#353	LHX9	4	5	9	519.53
#354	LASS6	4	17	21	759.176
#355	LHX8	4	4	8	60.889
#356	TFAP2B	4	5	9	2997.167
#357	ZNF167	4	5	9	56.52
#358	CLOCK	4	9	13	234.416
#359	HOXB7	4	15	19	516.361
#360	NFIX	4	8	12	128.328
#361	PAX3	4	8	12	838.082
#362	IRF7	4	11	15	890.016
#363	GATAD1	4	15	19	1842.105
#364	RUNX1	4	13	17	564.211
#365	MESP1	4	16	20	963.278
#366	MAFF	4	11	15	557.958
#367	ZFPM2	4	4	8	161.43
#368	ZNF41	4	14	18	854.93
#369	GTF2H4	4	13	17	1038.886
#370	RBCK1	4	15	19	571.318
#371	SATB1	4	12	16	1747.625
#372	ZIC1	4	6	10	354.48
#373	ELF4	4	15	19	291.237
#374	ZNF133	4	14	18	863.271
#375	HEYL	4	12	16	5095.373
#376	SOX11	4	6	10	1186.01
#377	ZFP36L2	4	8	12	504.394
#378	TBX2	4	8	12	362.977
#379	HOPX	4	5	9	2815.133
#380	E2F7	3	9	12	2155.363
#381	PAX7	3	6	9	241.299
#382	TCF3	3	11	14	223.674
#383	TEF	3	10	13	1066.766
#384	CITED1	3	9	12	597.815
#385	ZNF277	3	15	18	1413.991
#386	ASCL1	3	4	7	100.448
#387	PPARA	3	11	14	264.666
#388	NFAT5	3	12	15	413.731
#389	SCAND1	3	10	13	217.905
#390	NFX1	3	12	15	294.825
#391	HMGA1	3	12	15	415.123
#392	TRERF1	3	18	21	911.654
#393	ATF5	3	18	21	1096.225
#394	ZNF174	3	12	15	824.785
#395	ZNF148	3	13	16	210.43
#396	GTF2I	3	15	18	1175.235
#397	FOXK2	3	9	12	311.766
#398	IRX4	3	12	15	198.169
#399	NFKB2	3	15	18	208.518
#400	KLF11	3	10	13	1414.549
#401	SOX6	3	7	10	236.128
#402	CEBPA	3	13	16	611.014
#403	ARID3A	3	7	10	107.628
#404	HMBOX1	3	19	22	253.673
#405	SNAPC4	3	14	17	1802.7
#406	FOXR1	3	6	9	124.778
#407	KLF6	3	15	18	407.635
#408	HOXD8	3	13	16	819.498
#409	LZTS1	3	5	8	140.096
#410	GATA5	3	6	9	1618.425
#411	POU2F2	3	7	10	722.268
#412	RB1	3	17	20	4977.43
#413	HMX2	3	13	16	723.096
#414	ZFP37	3	13	16	370.851
#415	TADA2A	3	9	12	344.424
#416	RARG	2	16	18	69.237
#417	SCAND3	2	13	15	76.563
#418	HOXD13	2	7	9	332.575
#419	FOXG1	2	14	16	1046.707
#420	FOXA3	2	12	14	1634.772
#421	C5orf41	2	14	16	374.592
#422	KLF7	2	11	13	182.211
#423	MKX	2	6	8	80.695
#424	ZNF215	2	17	19	209.366
#425	ESR1	2	7	9	154.229
#426	RELA	2	12	14	99.482
#427	SMAD4	2	12	14	140.018
#428	POU4F2	2	4	6	3.88
#429	NR1H3	2	15	17	161.487
#430	SOX15	2	15	17	257.552
#431	XBP1	2	16	18	173.239
#432	SUPT6H	2	14	16	852.685
#433	ZNF187	2	14	16	91.041
#434	ZBTB48	2	12	14	61.976
#435	NFATC1	2	10	12	605.535
#436	TULP4	2	12	14	84.026
#437	HOXB5	2	14	16	1156.334
#438	STAT5B	2	13	15	377.423
#439	TCF21	2	7	9	12.276
#440	DLX4	2	9	11	1172.775
#441	ZNF131	2	15	17	1775.324
#442	ZKSCAN2	2	18	20	550.898
#443	PHF1	2	14	16	68.285
#444	ZKSCAN3	2	10	12	106.36
#445	ZNF193	2	8	10	30.78
#446	PRDM2	2	9	11	45.64
#447	SREBF1	2	12	14	107.962
#448	HIC1	2	10	12	260.207
#449	CBFB	2	18	20	141.182
#450	NFE2L2	2	8	10	338.977
#451	TEAD1	2	19	21	856.572
#452	FOXC2	2	17	19	1205.71
#453	ZFP42	1	11	12	32.912
#454	MGA	1	12	13	35.425
#455	HNF4A	1	8	9	34.384
#456	TP63	1	13	14	220.137
#457	CTNNB1	1	13	14	165.274
#458	ZNF628	1	11	12	55.786
#459	AFF4	1	11	12	1561.002
#460	ZFP36L1	1	7	8	90.74
#461	HOXC4	1	12	13	196.61
#462	ZNF140	1	11	12	120.312
#463	RORB	1	7	8	300.063
#464	FOXP4	1	16	17	1433.565
#465	CCRN4L	1	13	14	558.576
#466	TGIF1	1	10	11	729.597
#467	IRX5	1	15	16	164.895
#468	SPEN	1	17	18	96.107
#469	ZSCAN5A	1	14	15	546.024
#470	NPAS1	1	11	12	53.856
#471	ZNF323	1	15	16	169.721
#472	ARX	1	7	8	49.828
#473	PBX4	1	7	8	20.84
#474	HOXB4	1	16	17	79.977
#475	ZNF3	1	12	13	22.096
#476	MYT1	1	6	7	35.288
#477	PHTF1	1	11	12	52.788
#478	RARA	1	9	10	29.688
#479	ZNF643	1	12	13	87.857
#480	E2F8	1	11	12	877.3
#481	TAF13	1	14	15	92.192
#482	SOX8	1	6	7	852.541
#483	SP140	1	4	5	19.377
#484	HOXB8	1	10	11	630.09
#485	CBFA2T2	0	11	11	0
#486	RHOXF1	0	11	11	0
#487	NR2E1	0	6	6	0
#488	PURB	0	10	10	0
#489	BATF2	0	12	12	0
#490	BCL6	0	8	8	0
#491	EN1	0	7	7	0
#492	GATA2	0	18	18	0
#493	HNF4G	0	12	12	0
#494	HSF1	0	22	22	0
#495	BACH2	0	12	12	0
#496	ETV6	0	20	20	0
#497	ATF3	0	18	18	0
#498	NFATC2	0	12	12	0
#499	CBL	0	16	16	0
#500	TCF12	0	12	12	0