Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	LHX5	65	1	66	24.527
#2	CREBL2	58	8	66	314.853
#3	TEAD4	57	1	58	404.084
#4	REST	54	4	58	652.931
#5	PITX3	54	3	57	178.289
#6	ZEB1	53	1	54	59.548
#7	HMX1	53	2	55	5738.222
#8	MECOM	50	9	59	2379.4
#9	FUBP1	49	8	57	389.192
#10	POU3F1	46	6	52	96.9
#11	TRIM22	46	6	52	928.688
#12	ADNP	46	9	55	3151.026
#13	C11orf9	46	8	54	1203.63
#14	DLX2	46	4	50	137.76
#15	STAT6	45	8	53	1040.222
#16	NFATC1	42	7	49	1673.815
#17	EMX1	41	7	48	304.621
#18	NOLC1	41	5	46	1042.232
#19	EVX1	41	7	48	1832.201
#20	TBX10	41	12	53	20342.928
#21	RAX	40	4	44	50.575
#22	LEF1	39	9	48	2734.986
#23	MEF2D	36	8	44	722.9
#24	SNAI2	35	8	43	2070.716
#25	NR3C2	35	6	41	428.142
#26	PRRX2	34	11	45	261.044
#27	BTAF1	34	9	43	365.828
#28	PKNOX2	34	5	39	128.542
#29	AHR	33	12	45	1904.889
#30	ZNF219	33	12	45	912.761
#31	TSC22D4	33	8	41	252.031
#32	ESRRA	33	15	48	1258.411
#33	LASS6	33	13	46	2496.596
#34	EPAS1	32	7	39	861.941
#35	E2F4	32	8	40	346.842
#36	LZTS1	32	5	37	157.333
#37	RBPJ	32	13	45	1692.165
#38	DMTF1	32	7	39	870.322
#39	YEATS4	31	12	43	444.35
#40	USF2	31	11	42	312.979
#41	MYOG	31	7	38	1674.905
#42	CEBPB	31	9	40	1119.441
#43	SALL2	31	14	45	2080.704
#44	ZNF148	31	7	38	1381.417
#45	SNAPC2	31	10	41	1029.433
#46	CNOT8	31	11	42	579.257
#47	TAF4	30	10	40	1061.854
#48	ELK3	30	6	36	1784.589
#49	MYBL2	30	12	42	1468.199
#50	FOXN3	30	15	45	9688.707
#51	TCF7L1	30	8	38	1068.231
#52	HSF2	30	16	46	1805.037
#53	ZNF444	29	9	38	139.55
#54	TCF12	29	11	40	647.6
#55	STRN3	29	12	41	1569.205
#56	HSF4	29	9	38	191.724
#57	ZNF167	29	14	43	1250.539
#58	FLI1	29	6	35	976.247
#59	TCF15	28	9	37	114.223
#60	ELF3	28	10	38	2095.208
#61	NPAS1	28	10	38	151.988
#62	CREBZF	28	15	43	679.189
#63	SOX10	28	6	34	178.691
#64	ZNF274	28	12	40	616.736
#65	ISL1	27	17	44	3890.528
#66	GATA3	27	4	31	157.538
#67	GCFC1	27	17	44	1027.183
#68	KDM5B	27	18	45	3908.728
#69	GABPB1	27	12	39	963.016
#70	ZNF207	27	7	34	1961.141
#71	TRIM28	27	9	36	2266.969
#72	RARG	26	4	30	42.766
#73	NFYB	26	13	39	847.004
#74	CREB3L1	26	9	35	364.879
#75	PRRX1	25	8	33	326.944
#76	MSX2	25	13	38	3520.052
#77	ELF2	25	13	38	1196.304
#78	SOX15	25	5	30	134.757
#79	CREBBP	25	10	35	839.172
#80	SPEN	24	2	26	211.357
#81	IRF1	24	12	36	1641.924
#82	ATF1	24	8	32	1524.91
#83	GTF2H4	24	17	41	2056.812
#84	KLF2	24	8	32	831.785
#85	NFYC	24	10	34	739.975
#86	BCL6	24	14	38	3283.937
#87	HEY1	24	13	37	2305.211
#88	NR1H2	24	14	38	562.409
#89	CREM	24	12	36	937.852
#90	NFIL3	24	14	38	1707.622
#91	NR3C1	23	17	40	2721.595
#92	HNF1B	23	14	37	1114.235
#93	HES1	23	13	36	1710.719
#94	ZNF277	23	17	40	446.558
#95	ENO1	23	7	30	2537.474
#96	ECSIT	23	13	36	1832.048
#97	NFAT5	23	4	27	323.602
#98	SOX21	23	10	33	1723.917
#99	E2F6	23	17	40	1600.453
#100	NR2F6	23	10	33	605.706
#101	HCLS1	23	2	25	228.525
#102	TGIF1	22	15	37	18375.799
#103	KLF9	22	17	39	978.856
#104	GTF2I	22	15	37	1704.917
#105	ZNF281	22	9	31	281.194
#106	DLX4	22	16	38	4053.5
#107	ZNF202	22	12	34	3739.833
#108	E2F5	22	16	38	1222.138
#109	GATA2	22	9	31	1049.503
#110	KLF10	22	8	30	534.274
#111	IRF2	22	17	39	2042.284
#112	TFAP2C	22	14	36	901.178
#113	ZEB2	22	12	34	981.31
#114	RXRA	22	17	39	1765.357
#115	MLXIPL	22	13	35	353.675
#116	VDR	22	15	37	3278.581
#117	FOXF1	22	9	31	1590.226
#118	ZNF236	21	8	29	128.525
#119	ARNTL	21	11	32	337.639
#120	SLC30A9	21	18	39	2604.988
#121	PURA	21	19	40	2259.959
#122	NFIB	21	10	31	1248.298
#123	MEF2A	21	11	32	556.07
#124	GTF2IRD1	21	20	41	1952.504
#125	RARB	20	17	37	2870.283
#126	SMAD2	20	13	33	538.614
#127	MLLT10	20	15	35	1950.106
#128	SNAPC4	20	11	31	932.084
#129	TAF5	20	17	37	1338.467
#130	ZNF75D	20	16	36	793.411
#131	AEBP1	20	12	32	1296.858
#132	ZBTB17	20	13	33	252.071
#133	EHF	20	16	36	1798.605
#134	NFATC4	20	11	31	138.255
#135	NR2F1	20	6	26	865.839
#136	SOX9	19	10	29	1080.463
#137	TCF25	19	11	30	1093.849
#138	SPI1	19	19	38	1173.935
#139	RUNX1	19	12	31	1154.246
#140	HDAC2	19	10	29	1094.786
#141	CTNNB1	19	16	35	1174.717
#142	ELF4	19	10	29	655.596
#143	PEG3	19	13	32	4120.904
#144	MTF1	19	15	34	1210.548
#145	LASS2	19	19	38	2832.755
#146	ZNF238	19	19	38	2064.315
#147	YY1	19	8	27	1031.978
#148	POU2F2	19	13	32	196.728
#149	ZNF133	19	11	30	1867.908
#150	SP3	18	7	25	366.73
#151	MXD1	18	13	31	2150.746
#152	TFAP4	18	8	26	137.662
#153	MYC	18	10	28	950.333
#154	SOX4	18	13	31	3090.939
#155	PRDM1	18	14	32	1171.75
#156	FOXO1	18	13	31	1134.347
#157	MEF2C	18	9	27	1448.883
#158	ETV4	18	17	35	1249.122
#159	DBP	18	9	27	80.461
#160	SPDEF	18	13	31	1259.649
#161	PLSCR1	18	12	30	735.596
#162	ZNF268	18	13	31	768.975
#163	ZNF3	18	12	30	563.071
#164	CBFB	18	6	24	3931.153
#165	SIX2	18	13	31	627.725
#166	GLI3	18	12	30	476.907
#167	TCF20	18	18	36	1111.931
#168	ELK1	18	9	27	289.818
#169	TEAD1	17	12	29	889.12
#170	NR4A3	17	14	31	1103.661
#171	PLAGL2	17	10	27	568.583
#172	MAX	17	8	25	959.694
#173	FOXO4	17	6	23	126.56
#174	GATA6	17	23	40	2117.783
#175	IRX4	17	15	32	1777.351
#176	AHCTF1	17	17	34	1135.453
#177	FOXC1	17	12	29	929.64
#178	TSC22D3	17	12	29	740.618
#179	ETV7	17	13	30	897.785
#180	ERG	17	6	23	107.371
#181	TCFL5	17	16	33	1101.477
#182	MNX1	17	12	29	453.06
#183	NR2C1	17	13	30	564.242
#184	ATF2	17	18	35	1206.021
#185	KLF4	17	13	30	1276.359
#186	BACH1	17	17	34	938.948
#187	MLL	17	7	24	279.445
#188	NFE2L3	16	12	28	2711.384
#189	NPAT	16	17	33	1826.239
#190	JUND	16	16	32	2894.617
#191	TAF10	16	20	36	1170.103
#192	HOXC8	16	11	27	124.989
#193	MGA	16	14	30	4846.53
#194	IRF3	16	10	26	298.341
#195	FOXJ2	16	11	27	2525.208
#196	ZBTB38	16	7	23	377.571
#197	TFAM	16	10	26	1074.193
#198	TSC22D2	16	20	36	1243.021
#199	RCAN1	16	16	32	1110.876
#200	TGIF2	16	15	31	4363.296
#201	TRPS1	16	18	34	2510.275
#202	HSF1	16	15	31	902.547
#203	YBX1	16	9	25	1970.599
#204	HMGA1	16	14	30	1269.818
#205	BLZF1	16	18	34	1364.111
#206	NFKB2	16	14	30	792.991
#207	ATF6	15	14	29	1419.351
#208	ZNF323	15	18	33	1765.676
#209	CREB1	15	9	24	367.808
#210	TFDP1	15	14	29	1485.953
#211	SCML1	15	20	35	4082.629
#212	NOTCH1	15	12	27	627.538
#213	TFCP2	15	17	32	1229.804
#214	ZFHX4	15	15	30	1931.681
#215	MTA1	15	16	31	844.083
#216	ZKSCAN5	15	13	28	660.946
#217	TSHZ2	15	12	27	2098.305
#218	NFE2L2	15	23	38	1715.417
#219	SOX13	15	16	31	1634.113
#220	ARID3A	15	15	30	1636.635
#221	PRDM2	14	11	25	892.912
#222	NR1I2	14	20	34	1108.576
#223	CDX2	14	19	33	433.186
#224	HOXA11	14	10	24	2227.337
#225	REL	14	13	27	1252.085
#226	ZNF189	14	18	32	1502.686
#227	HMGB2	14	12	26	2094.027
#228	CSDA	14	21	35	3686.45
#229	LMO4	14	24	38	1274.524
#230	ARNT2	14	13	27	1737.56
#231	TCF4	14	14	28	849.238
#232	HMG20A	14	14	28	570.444
#233	FOXM1	14	10	24	802.984
#234	ZGPAT	14	8	22	442.554
#235	SMAD5	14	8	22	1570.057
#236	MSX1	14	20	34	2477.828
#237	EGR3	14	14	28	554.685
#238	KLF5	14	17	31	881.031
#239	TAF12	13	18	31	1240.113
#240	HOXB13	13	12	25	504.071
#241	RB1	13	13	26	927.849
#242	KLF6	13	13	26	1125.504
#243	ETV1	13	16	29	956.319
#244	RUNX1T1	13	7	20	479.675
#245	AATF	13	14	27	2985.136
#246	IRF9	13	10	23	476.047
#247	SIX3	13	12	25	2165.669
#248	SMAD4	13	15	28	1006.159
#249	NCOR1	13	18	31	1586.914
#250	MYCN	13	18	31	2153.337
#251	BATF3	13	13	26	1306.127
#252	PHF1	13	19	32	798.485
#253	NFE2	13	12	25	1919.278
#254	SUPT6H	13	19	32	1310.283
#255	PTTG1	13	23	36	1339.688
#256	PBX2	13	17	30	2317.656
#257	STAT5A	12	17	29	1364.477
#258	STAT1	12	13	25	761.401
#259	PPARG	12	16	28	650.455
#260	SMAD1	12	16	28	1809.742
#261	RELB	12	16	28	701.482
#262	HOXD11	12	14	26	2782.362
#263	FOXO3	12	15	27	773.409
#264	UBN1	12	5	17	626.766
#265	TAF6	12	19	31	1328.529
#266	BACH2	12	16	28	832.976
#267	ZFP36L2	12	13	25	726.831
#268	ZNF217	12	14	26	2613.964
#269	CBFA2T2	12	18	30	1329.53
#270	TFE3	12	18	30	1095.054
#271	FOXH1	12	11	23	330.94
#272	POU5F1B	12	12	24	541.375
#273	ZBTB48	12	17	29	1083.069
#274	TARDBP	12	19	31	2456.01
#275	PLAG1	12	19	31	820.94
#276	PCGF2	11	17	28	1885.909
#277	GATA4	11	14	25	649.111
#278	RCOR1	11	17	28	947.809
#279	DRAP1	11	24	35	1063.613
#280	CSRNP2	11	18	29	483.852
#281	ZSCAN16	11	17	28	1193.081
#282	TAF1B	11	17	28	1110.048
#283	MITF	11	18	29	845.454
#284	EGR2	11	19	30	1522.303
#285	SMAD6	11	13	24	600.486
#286	STAT4	11	15	26	904.699
#287	FOXJ3	11	14	25	434.379
#288	SOX12	11	22	33	849.806
#289	ZNF33B	11	19	30	1226.422
#290	ZNF83	11	15	26	1756.239
#291	CREB3L2	11	19	30	3259.516
#292	BCL3	11	14	25	919.416
#293	PROX1	11	17	28	1456.793
#294	BHLHE40	10	15	25	944.863
#295	FOSL1	10	21	31	1265.109
#296	THRA	10	24	34	4024.964
#297	HOXA10	10	9	19	629.7
#298	E2F3	10	17	27	956.248
#299	HR	10	17	27	1377.812
#300	CIR1	10	17	27	263.424
#301	HMGA2	10	25	35	844.463
#302	PHTF1	10	16	26	1183.86
#303	MAFB	10	16	26	493.093
#304	ASCL1	10	9	19	1020.71
#305	HOXD10	10	16	26	1327.495
#306	TCEAL1	10	19	29	834.823
#307	SCAND1	10	21	31	738.293
#308	HOXB6	10	15	25	1609.542
#309	ZSCAN5A	10	18	28	780.827
#310	ZFHX3	10	10	20	512.106
#311	ZFPM2	10	16	26	2442.332
#312	PAX8	10	8	18	808.637
#313	PBX1	9	23	32	2031.275
#314	ZNF165	9	18	27	697.133
#315	NR1D2	9	8	17	175.809
#316	GATAD1	9	16	25	1841.264
#317	IRF7	9	16	25	378.591
#318	MEIS3P1	9	24	33	1680.502
#319	RFX5	9	24	33	1509.317
#320	SATB2	9	18	27	930.911
#321	HMBOX1	9	18	27	424.773
#322	HIF3A	9	5	14	1711.238
#323	TAL1	9	10	19	221.856
#324	FEV	9	20	29	1581.802
#325	TCF7L2	9	14	23	405.802
#326	FOXA1	9	14	23	274.09
#327	SREBF1	9	20	29	723.868
#328	ERF	9	20	29	1671.861
#329	MEIS2	9	21	30	719.018
#330	CEBPA	9	20	29	883.697
#331	CITED2	9	20	29	921.18
#332	FOS	9	19	28	880.422
#333	ST18	9	11	20	1826.9
#334	BATF	9	13	22	247.801
#335	JUN	9	21	30	858.246
#336	CUX1	9	17	26	1282.974
#337	NR2F2	9	19	28	599.133
#338	ELF1	9	12	21	299.315
#339	BCL11B	9	20	29	1766.487
#340	FOXF2	8	13	21	733.06
#341	NR1H3	8	21	29	2660.043
#342	ZKSCAN1	8	18	26	1055.401
#343	TFEB	8	22	30	1012.579
#344	ATF5	8	26	34	1526.701
#345	SMAD3	8	23	31	1663.796
#346	ARNTL2	8	22	30	698.292
#347	IRF6	8	18	26	1614.039
#348	KLF11	8	18	26	1998.407
#349	ZSCAN18	8	27	35	1845.548
#350	HOXB7	8	18	26	566.494
#351	ADNP2	8	17	25	414.736
#352	TFAP2A	8	14	22	2041.106
#353	MZF1	8	13	21	383.035
#354	JUNB	8	18	26	1032.71
#355	WNT5A	8	19	27	541.144
#356	KLF7	8	20	28	1264.426
#357	MAFF	8	26	34	825.088
#358	NFATC3	8	19	27	292.706
#359	FBXW7	8	20	28	753.806
#360	MMP14	8	16	24	545.251
#361	HOXB5	8	21	29	585.633
#362	SLC2A4RG	8	20	28	538.595
#363	RERE	8	13	21	472.121
#364	MLX	8	23	31	836.834
#365	IRF8	8	22	30	802.516
#366	STAT2	7	18	25	1078.432
#367	PBX3	7	19	26	1342.729
#368	HOXD1	7	20	27	922.163
#369	MYNN	7	18	25	544.88
#370	ZNF93	7	18	25	779.153
#371	TWIST1	7	14	21	577.023
#372	ZNF85	7	19	26	430.633
#373	GRHL2	7	19	26	853.385
#374	HOXD4	7	19	26	691
#375	BUD31	7	20	27	1919.186
#376	TEAD3	7	17	24	536.336
#377	MEIS1	7	22	29	998.296
#378	NEUROD1	7	8	15	1490.827
#379	NR5A2	7	17	24	520.666
#380	TCF21	7	14	21	569.968
#381	PITX2	7	15	22	1290.875
#382	ZNF193	7	18	25	1453.265
#383	NFX1	7	17	24	950.743
#384	NKX3-1	7	20	27	1313.424
#385	IRF4	6	14	20	407.3
#386	PPARD	6	22	28	1801.743
#387	SOX11	6	18	24	958.189
#388	ZNF134	6	20	26	656.181
#389	TCF3	6	25	31	1279.806
#390	ZIC1	6	18	24	846.381
#391	TULP4	6	28	34	816.449
#392	VTN	6	24	30	827.3
#393	RFXANK	6	19	25	1051.695
#394	HOPX	6	17	23	444.466
#395	TSC22D1	6	19	25	632.621
#396	LHX6	6	15	21	606.019
#397	GABPA	6	16	22	665.239
#398	SOLH	6	21	27	574.376
#399	TFCP2L1	6	22	28	900.556
#400	TADA3	6	14	20	415.967
#401	TBX3	6	23	29	2065.475
#402	SLC26A3	6	21	27	1186.797
#403	ZNF140	6	20	26	456.735
#404	HMGB1	6	16	22	311.98
#405	CNOT7	6	21	27	1121.766
#406	ZNF131	6	17	23	339.288
#407	WT1	6	14	20	477.364
#408	HMG20B	6	22	28	589.12
#409	DDIT3	6	10	16	148.378
#410	IKZF1	6	13	19	857.254
#411	HOXA9	6	21	27	2227.428
#412	TFEC	6	15	21	279.543
#413	FOXG1	5	15	20	255.524
#414	ZNF91	5	20	25	868.886
#415	HOXA1	5	23	28	538.604
#416	NR1H4	5	12	17	531.474
#417	E2F8	5	19	24	208.702
#418	ETS2	5	27	32	1948.747
#419	PITX1	5	19	24	685.783
#420	SIM2	5	20	25	844.509
#421	FOSL2	5	20	25	815.247
#422	ZNF24	5	9	14	215.914
#423	SOX2	5	14	19	927.714
#424	TBX2	5	17	22	371.25
#425	ZNF45	5	20	25	223.951
#426	HOXC11	5	19	24	148.607
#427	SUPT4H1	5	20	25	538.054
#428	ELF5	5	17	22	878.649
#429	MSRB2	5	18	23	314.322
#430	CEBPD	5	21	26	2207.676
#431	GAS7	5	24	29	1232.443
#432	PA2G4	5	22	27	498.71
#433	STAT3	5	24	29	3495.715
#434	SNAPC5	5	18	23	626.707
#435	MAFG	5	15	20	759.563
#436	SP140	5	10	15	624.996
#437	BARX1	5	19	24	491.164
#438	ZNF394	5	19	24	1276.601
#439	KDM5A	5	16	21	250.872
#440	FOXD1	4	21	25	538.099
#441	SATB1	4	19	23	551.358
#442	ZNF175	4	18	22	169.867
#443	FOXA2	4	22	26	603.823
#444	RARA	4	24	28	1071.028
#445	SPIB	4	17	21	291.487
#446	HHEX	4	23	27	1168.286
#447	IRF5	4	14	18	34.902
#448	NR4A2	4	23	27	240.682
#449	C2orf3	4	15	19	194.452
#450	HOXA5	4	18	22	347.251
#451	ZNF232	4	23	27	272.492
#452	MYCL1	4	25	29	1138.004
#453	TRIM29	4	31	35	2152.36
#454	FOSB	4	13	17	616.04
#455	MBD1	4	19	23	844.237
#456	HNF4G	4	21	25	976.654
#457	IRX5	4	15	19	1014.031
#458	NFYA	4	31	35	1183.358
#459	RORA	4	24	28	225.179
#460	HLF	3	15	18	352.208
#461	SIX1	3	16	19	627.378
#462	FOXJ1	3	16	19	66.652
#463	ESRRG	3	21	24	677.738
#464	NFIC	3	19	22	182.812
#465	BTG2	3	13	16	270.059
#466	GTF2H3	3	20	23	318.502
#467	ONECUT2	3	24	27	301.245
#468	SALL1	3	15	18	614.596
#469	PAX6	3	24	27	280.3
#470	HOXB2	3	17	20	1085.873
#471	ZFP36L1	3	23	26	288.932
#472	ETV5	3	23	26	303.891
#473	TFDP2	3	23	26	300.821
#474	MEOX1	3	21	24	681.558
#475	ATF3	3	21	24	835.947
#476	TP53	3	20	23	1060.51
#477	ZNF117	3	21	24	456.214
#478	CTBP1	3	22	25	529.13
#479	NANOG	3	21	24	613.014
#480	ZHX2	3	25	28	1007.841
#481	TCF7	3	22	25	438.307
#482	RBCK1	2	19	21	229.166
#483	HOXC10	2	25	27	627.586
#484	GATAD2A	2	21	23	187.498
#485	CLOCK	2	17	19	212.695
#486	BHLHE41	2	29	31	272.081
#487	CDKN2A	2	31	33	780.84
#488	NPAS2	2	24	26	225.998
#489	TP63	2	18	20	957.771
#490	SREBF2	2	23	25	251.479
#491	HIRA	2	26	28	239.446
#492	NR4A1	2	19	21	471.287
#493	EGR1	1	25	26	315.528
#494	RUNX3	1	26	27	100.796
#495	TAF7	1	18	19	53.2
#496	HOXC4	1	16	17	119.802
#497	CREB3	1	26	27	536.829
#498	MAF	1	26	27	268.572
#499	XBP1	1	22	23	186.918
#500	NKX2-1	0	17	17	0