Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	LHX5	55	2	57	73.086
#2	HMX1	53	4	57	2049.279
#3	DLX2	51	3	54	37.631
#4	FUBP1	49	5	54	307.572
#5	CREBL2	49	6	55	290.979
#6	PITX3	47	5	52	1701.397
#7	ZEB1	45	0	45	0
#8	REST	44	7	51	2334.66
#9	C11orf9	44	8	52	1632.465
#10	MECOM	43	6	49	2041.919
#11	EVX1	41	6	47	1179.666
#12	TBX10	41	8	49	18654.834
#13	MEF2D	41	6	47	258.838
#14	POU3F1	40	3	43	83.843
#15	LEF1	39	7	46	1259.997
#16	ADNP	37	9	46	1811.712
#17	NFATC1	37	7	44	1062.364
#18	STAT6	37	8	45	1855.92
#19	PKNOX2	37	5	42	105.839
#20	NR3C2	36	8	44	1850.236
#21	CREB3L1	36	6	42	928.954
#22	ELK3	36	2	38	66.801
#23	TEAD4	35	5	40	508.021
#24	NOLC1	35	8	43	1211.945
#25	GABPB1	34	6	40	364.477
#26	RAX	34	5	39	1227.682
#27	TRIM22	33	10	43	2426.047
#28	MLLT10	33	14	47	1565.014
#29	ZNF207	33	4	37	488.29
#30	ZNF167	33	12	45	1202.256
#31	RARG	32	3	35	49.115
#32	STRN3	32	5	37	388.133
#33	HSF2	32	13	45	1465.432
#34	MYBL2	32	9	41	1132.423
#35	SNAI2	31	6	37	464.99
#36	GTF2IRD1	31	19	50	6341.484
#37	TCF15	31	8	39	132.115
#38	E2F4	30	6	36	150.816
#39	MYOG	30	6	36	1066.236
#40	YEATS4	30	12	42	497.098
#41	EMX1	30	9	39	627.146
#42	HSF4	30	9	39	215.817
#43	ELF3	30	10	40	2845.243
#44	ZNF444	30	6	36	106.754
#45	TAF4	30	7	37	622.672
#46	DMTF1	29	9	38	1037.899
#47	EPAS1	28	13	41	1994.376
#48	CREM	28	11	39	2262.491
#49	FOXN3	28	16	44	2946.151
#50	IRF1	28	7	35	1157.221
#51	SALL2	28	14	42	2186.504
#52	RBPJ	28	10	38	937.418
#53	CNOT8	28	12	40	601.857
#54	TFAP4	27	6	33	170.079
#55	FLI1	27	7	34	723.729
#56	PRRX2	27	11	38	383.347
#57	GCFC1	27	9	36	788.536
#58	NPAS1	27	10	37	666.233
#59	SNAPC2	26	12	38	905.06
#60	TRIM25	26	10	36	298.134
#61	RXRA	26	13	39	692.835
#62	ZNF236	26	8	34	201.786
#63	FOXF1	26	6	32	1759.617
#64	SOX10	26	4	30	325.194
#65	NR1H2	26	10	36	289.109
#66	ZNF281	25	11	36	501.217
#67	E2F6	25	10	35	1439.881
#68	ENO1	25	9	34	2267.309
#69	SP3	25	4	29	514.928
#70	ATF1	25	12	37	2883.69
#71	SPEN	25	1	26	108.012
#72	GTF2H4	25	13	38	2782.333
#73	YY1	25	3	28	967.631
#74	TSC22D4	25	13	38	324.763
#75	HOXC8	25	10	35	504.978
#76	LASS6	25	16	41	2650.868
#77	NFYB	25	15	40	1861.813
#78	USF2	24	13	37	644.811
#79	ZBTB17	24	11	35	202.355
#80	SPI1	24	19	43	2184.517
#81	ESRRA	24	15	39	1728.791
#82	HNF1B	24	15	39	1147.073
#83	SOX21	24	11	35	1895.479
#84	ISL1	23	18	41	3874.285
#85	MLXIPL	23	11	34	1000.688
#86	HEY1	23	12	35	1207.025
#87	BACH1	23	16	39	1651.638
#88	CEBPB	22	11	33	1456.092
#89	MAX	22	9	31	983.196
#90	NR2F6	22	13	35	601.362
#91	ZNF148	22	11	33	956.718
#92	NFIB	22	14	36	2034.868
#93	DLX4	22	16	38	3799.451
#94	ZNF133	22	11	33	3204.151
#95	ECSIT	22	10	32	502.32
#96	CREBBP	22	12	34	499.605
#97	GATA6	22	22	44	3869.85
#98	KLF5	22	14	36	1549.302
#99	BTAF1	22	10	32	600.709
#100	KLF4	22	10	32	964.224
#101	PEG3	22	7	29	1483.903
#102	CSRNP2	21	13	34	1017.004
#103	TAF5	21	17	38	1722.828
#104	AEBP1	21	13	34	881.357
#105	RUNX1	21	14	35	1579.553
#106	ZEB2	21	13	34	534.118
#107	ELF2	21	13	34	2250.78
#108	ZNF274	21	17	38	1226.445
#109	SOX15	21	8	29	87.471
#110	KLF9	21	12	33	1781.484
#111	TRIM28	21	10	31	1045.276
#112	VDR	21	20	41	2318.844
#113	NFIL3	21	17	38	2150.457
#114	ETV4	21	18	39	1941.105
#115	TCF7L1	21	15	36	1359.903
#116	TFCP2	20	14	34	1806.142
#117	HMG20A	20	8	28	265.506
#118	NFKB2	20	9	29	230.926
#119	TCFL5	20	16	36	1188.78
#120	NR2F1	20	7	27	578.159
#121	KLF2	20	8	28	329.724
#122	CREBZF	20	12	32	379.172
#123	POU2F2	20	13	33	286.653
#124	NR3C1	20	15	35	1707.952
#125	ATF2	20	17	37	1573.851
#126	SOX11	20	12	32	2785.024
#127	ZNF277	20	16	36	497.815
#128	ARNTL	20	14	34	2125.523
#129	MGA	19	16	35	3710.936
#130	AHR	19	12	31	1668.959
#131	TFAP2C	19	15	34	2052.466
#132	ZNF3	19	12	31	867.585
#133	DBP	19	9	28	265.779
#134	ZNF238	19	21	40	3249.777
#135	SNAPC4	19	12	31	753.833
#136	ZNF219	18	11	29	670.56
#137	E2F5	18	15	33	1075.959
#138	E2F1	18	10	28	580.214
#139	GATA2	18	15	33	1923.539
#140	KLF10	18	7	25	1008.181
#141	TCF4	18	6	24	674.063
#142	PRRX1	18	8	26	327.755
#143	BLZF1	18	21	39	2617.28
#144	IRF3	18	7	25	788.628
#145	HSF1	18	17	35	2497.698
#146	SMAD4	18	12	30	464.266
#147	ATF6	18	14	32	2697.816
#148	TCF25	18	12	30	1217.303
#149	ZNF75D	18	16	34	1543.382
#150	TRPS1	18	15	33	1806.484
#151	PURA	18	13	31	1139.318
#152	MNX1	18	12	30	242.32
#153	CTNNB1	18	13	31	1546.206
#154	EHF	18	16	34	2275.597
#155	MSX2	17	21	38	4314.051
#156	BCL3	17	9	26	1198.471
#157	NPAT	17	15	32	2273.472
#158	SCAND1	17	18	35	1238.925
#159	AHCTF1	17	17	34	1210.399
#160	HOXD11	17	12	29	1620.259
#161	NFYC	17	10	27	315.863
#162	JUND	17	12	29	1209.481
#163	NFE2L2	17	19	36	1858.72
#164	TSC22D3	17	14	31	1268.571
#165	HMGB2	17	10	27	967.696
#166	KDM5B	17	22	39	3022.488
#167	NFATC4	17	10	27	470.647
#168	ELK1	17	10	27	454.647
#169	HIF3A	16	4	20	2563.479
#170	ETV7	16	10	26	528.708
#171	BCL6	16	16	32	861.367
#172	SMAD6	16	12	28	775.973
#173	GTF2I	16	12	28	880.438
#174	GLI3	16	9	25	213.024
#175	SLC30A9	16	13	29	1062.084
#176	CSDA	16	23	39	1321.586
#177	RB1	16	11	27	1153.927
#178	MLL	16	6	22	767.021
#179	GATA3	16	6	22	384.412
#180	HDAC2	16	10	26	1111.492
#181	IRF2	16	16	32	601.907
#182	BATF	16	13	29	782.549
#183	TCEAL1	16	15	31	1287.067
#184	SPDEF	16	9	25	449.909
#185	TSC22D2	16	17	33	1413.843
#186	FOXO4	16	7	23	119.1
#187	RCAN1	16	17	33	1924.81
#188	HCLS1	16	6	22	758.615
#189	PHF1	16	15	31	1447.583
#190	NOTCH1	15	9	24	556.339
#191	SUPT6H	15	16	31	1268.417
#192	MSX1	15	17	32	1659.049
#193	HMGA1	15	12	27	2237.067
#194	ZNF193	15	14	29	512.746
#195	RUNX1T1	15	8	23	978.084
#196	TARDBP	15	17	32	2585.593
#197	STAT1	15	13	28	1048.178
#198	ZNF85	15	14	29	596.955
#199	PROX1	15	8	23	524.426
#200	TGIF1	15	17	32	14573.376
#201	SOX4	15	15	30	5121.716
#202	NFAT5	15	7	22	423.733
#203	SMAD2	15	17	32	1520.063
#204	TULP4	15	20	35	2500.35
#205	ZNF202	15	16	31	2405.137
#206	NR2C1	15	14	29	2199.309
#207	MTA1	15	18	33	859.161
#208	ZNF189	15	16	31	970.352
#209	ZFPM2	15	13	28	980.395
#210	SIX2	15	15	30	849.276
#211	CREB1	15	6	21	216.606
#212	FOXM1	15	7	22	605.08
#213	MYCN	14	17	31	2389.257
#214	MEF2C	14	8	22	563.244
#215	KLF3	14	18	32	2170.469
#216	REL	14	13	27	699.206
#217	ZNF217	14	13	27	1182.535
#218	ZNF268	14	15	29	649.553
#219	PAX8	14	10	24	1348.208
#220	SOX9	14	14	28	1438.975
#221	NR1I2	14	21	35	1143.449
#222	AATF	14	13	27	2302.034
#223	MXD1	14	13	27	1746.742
#224	ZKSCAN5	14	10	24	2160.676
#225	C2orf3	14	16	30	489.069
#226	NR4A3	14	14	28	2435.429
#227	LMO4	14	18	32	1231.915
#228	POU5F1B	14	15	29	414.076
#229	FOXJ2	14	11	25	1743.079
#230	BHLHE40	14	16	30	1934.755
#231	ARNT2	14	12	26	1039.793
#232	MYC	14	18	32	1330.657
#233	TEAD1	13	15	28	1552.559
#234	ETV1	13	12	25	1390.223
#235	SOX12	13	14	27	1371.725
#236	ZNF83	13	14	27	1230.926
#237	SMAD5	13	6	19	1164.543
#238	YBX1	13	13	26	1580.531
#239	TFDP1	13	14	27	1035.52
#240	TAF12	13	18	31	1347.82
#241	HR	13	16	29	783.192
#242	NFE2L3	13	13	26	1560.852
#243	TAL1	13	10	23	707.389
#244	FOXK2	13	16	29	1790.975
#245	PRDM2	13	8	21	1010.659
#246	CBFA2T2	13	18	31	2319.298
#247	HES1	13	22	35	1064.212
#248	THRA	13	16	29	2200.38
#249	HMGA2	13	22	35	1452.254
#250	CBFB	13	7	20	4960.415
#251	ZFP36L2	13	13	26	723.813
#252	RERE	13	14	27	929.633
#253	ARID3A	13	19	32	1279.492
#254	TAF6	13	22	35	2456.136
#255	IRX4	13	15	28	2879.916
#256	TCF12	12	20	32	941.85
#257	MTF1	12	17	29	703.931
#258	HOXA10	12	11	23	1697.176
#259	ASCL1	12	9	21	1518.177
#260	ELF1	12	8	20	329.694
#261	FOSL1	12	16	28	1954.881
#262	KLF6	12	14	26	755.307
#263	ERG	12	9	21	274.376
#264	FOXO1	12	11	23	856.291
#265	HIF1A	12	11	23	980.7
#266	PTTG1	12	18	30	1651.502
#267	ZSCAN16	12	17	29	609.616
#268	UBN1	12	6	18	381.094
#269	IRF6	12	18	30	2206.667
#270	PPARD	12	15	27	1274.626
#271	PBX2	12	17	29	1440.842
#272	STAT4	12	15	27	2166.929
#273	JUNB	12	12	24	742.86
#274	ZFHX4	12	16	28	1445.797
#275	TADA3	12	16	28	1293.432
#276	CREB3L2	11	16	27	1468.602
#277	FEV	11	17	28	1308.998
#278	BATF3	11	14	25	953.261
#279	RARB	11	17	28	931.39
#280	HOXA11	11	15	26	999.04
#281	SOX13	11	19	30	1156.99
#282	IRF9	11	12	23	706.107
#283	TFAM	11	9	20	598.285
#284	TAF4B	11	12	23	415.395
#285	BARX1	11	14	25	2275.899
#286	JUN	11	16	27	767.896
#287	MZF1	11	14	25	1157.52
#288	ZBTB48	11	15	26	1261.684
#289	ZBTB38	11	9	20	387.217
#290	PCGF2	11	18	29	819.813
#291	SUPT4H1	11	16	27	4957.416
#292	CIR1	11	14	25	330.913
#293	WNT5A	11	14	25	601.839
#294	ELF4	11	11	22	347.615
#295	HOXB13	11	16	27	376.88
#296	HMG20B	11	20	31	774.168
#297	TCF21	10	13	23	712.95
#298	EGR2	10	20	30	1963.445
#299	PLAG1	10	17	27	1569.594
#300	PHTF1	10	11	21	144.573
#301	GABPA	10	19	29	1024.944
#302	PPARG	10	26	36	2117.222
#303	TAF10	10	23	33	547.813
#304	CREB3	10	20	30	1631.067
#305	IKZF1	10	13	23	1104.846
#306	CITED2	10	20	30	556.901
#307	ZNF165	10	18	28	674.935
#308	LASS2	10	22	32	1873.132
#309	TSHZ2	10	17	27	1383.341
#310	BUD31	10	18	28	631.823
#311	SIX1	10	16	26	2815.452
#312	MEF2A	10	18	28	862.3
#313	FOXO3	10	21	31	638.031
#314	KLF11	10	16	26	1254.104
#315	TAF1B	10	21	31	1920.981
#316	PLAGL2	10	12	22	896.146
#317	DRAP1	10	21	31	1956.726
#318	ZNF140	10	21	31	1175.867
#319	FOXH1	10	9	19	109.247
#320	ZNF24	9	9	18	170.782
#321	ADNP2	9	12	21	527.797
#322	SIX3	9	15	24	1302.584
#323	CDX2	9	18	27	438.111
#324	ZFHX3	9	13	22	1020.503
#325	E2F3	9	16	25	819.342
#326	KLF7	9	18	27	758.712
#327	FOXC1	9	15	24	853.23
#328	MITF	9	16	25	1095.269
#329	EGR3	9	20	29	385.18
#330	TFEB	9	21	30	417.247
#331	ZGPAT	9	17	26	1257.047
#332	NFE2	9	14	23	1009.774
#333	ZSCAN5A	9	19	28	1751.671
#334	SP140	9	7	16	181.969
#335	SOLH	9	20	29	818.907
#336	E2F8	9	15	24	1040.92
#337	SATB1	9	17	26	1182.45
#338	TCF7L2	9	13	22	583.263
#339	NR1D2	9	9	18	307.788
#340	TEAD3	9	16	25	1569.809
#341	ERF	9	16	25	1558.173
#342	SREBF1	9	15	24	536.145
#343	SATB2	9	19	28	1532.315
#344	LZTR1	9	15	24	922.811
#345	VAV1	9	12	21	992.251
#346	HOXD10	9	13	22	1658.154
#347	MAFB	8	14	22	1541.813
#348	ARNTL2	8	25	33	1212.474
#349	MAFF	8	27	35	558.891
#350	SCML1	8	23	31	3613.93
#351	SMAD1	8	9	17	332.29
#352	RELB	8	11	19	522.751
#353	MLX	8	24	32	663.193
#354	TFEC	8	12	20	925.393
#355	ZNF131	8	17	25	602.054
#356	CEBPD	8	15	23	729.313
#357	ZNF93	8	17	25	470.81
#358	GRHL2	8	22	30	719.192
#359	PA2G4	8	18	26	293.496
#360	PLSCR1	8	22	30	1162
#361	NFX1	8	16	24	1298.743
#362	SREBF2	8	15	23	402.741
#363	MEIS3P1	8	21	29	858.471
#364	RCOR1	8	23	31	1309.15
#365	NR2F2	8	20	28	388.522
#366	IRF7	8	15	23	410.093
#367	NEUROD1	8	6	14	1244.58
#368	HOXA9	8	17	25	2573.855
#369	GATAD1	8	13	21	766.679
#370	ZNF33B	8	20	28	925.649
#371	HOXB5	8	14	22	480.406
#372	SLC26A3	7	17	24	1095.931
#373	GATA4	7	19	26	825.379
#374	PBX1	7	25	32	1740.833
#375	TFAP2A	7	18	25	927.039
#376	ZKSCAN1	7	19	26	1703.999
#377	FOXF2	7	14	21	281.021
#378	IRF4	7	14	21	650.699
#379	IRF8	7	17	24	478.322
#380	TFCP2L1	7	18	25	639.268
#381	FOXA1	7	16	23	333.145
#382	MMP14	7	21	28	1098.657
#383	MSRB2	7	19	26	810.969
#384	ST18	7	9	16	494.222
#385	RFX5	7	25	32	759.917
#386	ZNF323	7	19	26	722.044
#387	NFATC3	7	22	29	409.028
#388	ATF5	7	15	22	428.247
#389	HMBOX1	7	17	24	449.781
#390	TSC22D1	7	19	26	1227.421
#391	TCF20	7	17	24	722.565
#392	ZNF134	7	18	25	745.135
#393	MYCL1	7	14	21	330.785
#394	TCF7	6	20	26	656.222
#395	BACH2	6	20	26	792.525
#396	DDIT3	6	14	20	487.43
#397	KDM5A	6	16	22	871.483
#398	TCF3	6	19	25	982.894
#399	ZIC1	6	16	22	972.821
#400	LHX6	6	16	22	346.547
#401	ZNF394	6	16	22	1130.74
#402	CEBPA	6	19	25	1044.428
#403	TGIF2	6	19	25	993.633
#404	NKX3-1	6	21	27	1081.841
#405	HNF4G	6	15	21	948.171
#406	HOXB6	6	16	22	1069.224
#407	FOXA2	6	22	28	1107.801
#408	SALL1	6	17	23	673.841
#409	MAFG	6	14	20	1180.62
#410	TBX2	5	18	23	987.383
#411	RFXANK	5	20	25	628.012
#412	HOXA1	5	21	26	630.088
#413	TWIST1	5	19	24	1064.832
#414	TRIM29	5	31	36	3299.515
#415	VTN	5	24	29	1590.199
#416	RARA	5	15	20	880.169
#417	FOSB	5	8	13	793.025
#418	NR1H3	5	24	29	622.612
#419	SMAD3	5	17	22	823.646
#420	ONECUT2	5	20	25	1602.807
#421	FOXJ1	5	19	24	102.166
#422	NFIC	5	21	26	508.094
#423	FBXW7	5	21	26	505.549
#424	CUX1	5	17	22	601.116
#425	CITED1	5	14	19	972.697
#426	PAX6	5	17	22	180.206
#427	FOS	5	14	19	675.181
#428	SLC2A4RG	5	19	24	741.037
#429	BCL11B	5	26	31	1171.73
#430	HOPX	5	19	24	498.565
#431	NCOR1	5	22	27	380.433
#432	NR4A1	5	19	24	784.467
#433	PITX2	5	17	22	552.624
#434	TBX3	5	25	30	1648.142
#435	UBP1	5	14	19	923.778
#436	ZSCAN18	5	19	24	539.468
#437	TFDP2	5	20	25	1242.023
#438	PITX1	4	28	32	368.312
#439	STAT2	4	20	24	803.719
#440	MBD1	4	18	22	524.296
#441	NFYA	4	25	29	2256.824
#442	SIM2	4	19	23	306.608
#443	HOXA5	4	19	23	1298.242
#444	HOXC11	4	17	21	234.671
#445	GTF2H3	4	14	18	918.696
#446	NR5A2	4	19	23	321.84
#447	BTG2	4	17	21	1088.185
#448	CNOT7	4	23	27	1064.239
#449	ZNF117	4	19	23	266.593
#450	PBX3	4	15	19	623.881
#451	HOXC4	4	16	20	1758.408
#452	ZHX2	4	21	25	777.376
#453	FOXD1	4	20	24	415.366
#454	SNAPC5	4	18	22	1974.279
#455	ETS2	4	21	25	877.561
#456	HOXD1	4	17	21	254.666
#457	HMGB1	4	18	22	513.966
#458	IRF5	4	14	18	177.775
#459	ETV5	4	18	22	326.657
#460	RUNX3	3	23	26	398.228
#461	RBCK1	3	17	20	370.351
#462	XBP1	3	16	19	237.934
#463	GAS7	3	23	26	1596.941
#464	STAT3	3	19	22	215.261
#465	ELF5	3	15	18	1601.402
#466	ZNF232	3	24	27	520.177
#467	ZNF45	3	22	25	203.325
#468	NPAS2	3	27	30	447.777
#469	ZFP36L1	3	24	27	343.594
#470	NR1H4	3	13	16	249.084
#471	ATF3	3	19	22	438.896
#472	HIRA	3	20	23	849.247
#473	MEIS1	3	21	24	218.573
#474	HHEX	3	18	21	842.204
#475	HOXB7	3	15	18	713.813
#476	CTBP1	3	22	25	356.213
#477	HOXC10	3	27	30	1150.262
#478	TP63	2	15	17	340.498
#479	ZNF175	2	19	21	108.609
#480	SPIB	2	14	16	186.481
#481	ESRRG	2	23	25	138.439
#482	SOX2	2	16	18	305.523
#483	CDKN2A	2	18	20	275.369
#484	HOXD4	2	21	23	109.884
#485	HLF	2	13	15	106.781
#486	MEIS2	2	21	23	754.625
#487	RORA	2	23	25	70.626
#488	NR4A2	2	16	18	86.31
#489	MEOX1	2	15	17	179.993
#490	HOXB2	2	22	24	198.054
#491	BHLHE41	2	25	27	513.507
#492	FOXG1	2	18	20	119.668
#493	FOSL2	2	19	21	343.953
#494	CLOCK	1	22	23	685.949
#495	GATAD2A	1	23	24	224.678
#496	TP53	1	20	21	84.969
#497	ZNF91	1	22	23	37.609
#498	MAF	1	21	22	304.085
#499	IRX5	0	18	18	0
#500	EGR1	0	22	22	0