Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	GRHL2	76	2	78	443.963
#2	HNF4A	66	1	67	47.288
#3	KLF5	65	3	68	156.245
#4	IKZF1	61	2	63	776.843
#5	ELF3	57	6	63	1210.223
#6	IRF6	49	1	50	6224.448
#7	FOXQ1	48	7	55	198.446
#8	MMP14	45	8	53	2033.468
#9	OVOL1	44	3	47	823.746
#10	TCF3	44	3	47	212.56
#11	SOX10	43	1	44	93.849
#12	TAF4B	42	7	49	2901.603
#13	NR2F2	42	6	48	593.912
#14	NR3C1	40	8	48	1164.598
#15	E2F2	39	9	48	594.346
#16	ZNF165	39	6	45	189.385
#17	IRF4	38	8	46	1967.774
#18	REST	38	8	46	2950.42
#19	KLF3	38	11	49	523.638
#20	FLI1	37	10	47	810.49
#21	HNF1A	37	8	45	2018.42
#22	VAX2	37	11	48	4581.398
#23	HCLS1	37	3	40	1136.425
#24	FOSL2	35	9	44	3336.997
#25	GATA6	35	8	43	495.147
#26	TFAP4	34	11	45	1576.705
#27	TWIST1	33	14	47	4381.197
#28	TEAD1	33	7	40	194.944
#29	TGIF1	33	8	41	314.054
#30	CDX2	32	10	42	3241.691
#31	SOX9	32	8	40	897.077
#32	NFIC	32	9	41	768.642
#33	GLI3	31	9	40	655.082
#34	TCF7L2	31	11	42	921.02
#35	HOXC9	31	6	37	626.345
#36	ZHX2	31	14	45	3197.969
#37	PAX3	31	8	39	530.924
#38	EHF	31	7	38	330.267
#39	FOXF2	31	19	50	5069.202
#40	GTF2IRD1	30	10	40	464.916
#41	HES1	30	7	37	336.185
#42	ALX1	30	7	37	1303.868
#43	HOXC10	30	4	34	599.135
#44	HOXC8	30	2	32	63.694
#45	SNAI2	29	10	39	792.638
#46	FOXD3	29	5	34	404.097
#47	DLX1	29	10	39	564.576
#48	VAV1	28	4	32	343.797
#49	CBFA2T3	28	15	43	1690.397
#50	REL	28	7	35	228.305
#51	SIX1	27	11	38	2501.284
#52	MNT	27	12	39	1012.732
#53	LZTS1	27	11	38	2404.401
#54	CEBPB	27	9	36	768.458
#55	ZEB2	26	8	34	771.761
#56	HOXD3	26	6	32	589.615
#57	HOXB7	26	6	32	457.076
#58	BCL3	26	11	37	2520.648
#59	POU2F2	26	7	33	1216.582
#60	UHRF1	25	9	34	679.302
#61	LASS6	25	11	36	1216.469
#62	HMGB1	25	7	32	1493.169
#63	HOXC13	25	12	37	1628.165
#64	HOXB6	25	5	30	559.553
#65	CBFB	25	8	33	2114.414
#66	KLF9	24	9	33	894.172
#67	ZEB1	24	8	32	267.629
#68	MITF	24	14	38	1877.799
#69	HOXA9	24	13	37	1593.394
#70	PPARG	24	10	34	3334.924
#71	SPIB	24	6	30	155.304
#72	ZNF92	23	7	30	970.371
#73	EPAS1	23	12	35	3580.588
#74	STAT6	23	12	35	1882.939
#75	CITED2	23	19	42	2898.339
#76	ETV5	23	7	30	438.649
#77	ZC3H8	22	8	30	1055.943
#78	IRX3	22	21	43	2840.341
#79	KLF6	22	13	35	1208.711
#80	GABPA	22	10	32	524.89
#81	CTNNB1	22	14	36	2905.853
#82	HSF2	22	8	30	399.478
#83	SOX13	22	11	33	3060.717
#84	SALL2	22	11	33	2475.881
#85	NFE2L1	22	11	33	787.484
#86	FOXD1	21	20	41	7062.182
#87	HOXB13	21	14	35	2129.197
#88	GLI2	21	12	33	1257.337
#89	HOXB5	21	7	28	329.771
#90	SP140	21	11	32	354.095
#91	MAFF	21	12	33	1158.747
#92	NFKB2	20	10	30	1906.577
#93	FOS	20	7	27	1440.348
#94	YEATS4	20	10	30	652.998
#95	IRF9	20	7	27	743.336
#96	HMG20B	20	8	28	189.271
#97	MEIS1	20	12	32	1896.477
#98	PRDM1	20	8	28	1275.152
#99	ZNF85	19	9	28	746.365
#100	E2F5	19	15	34	1266.887
#101	ZBTB38	19	17	36	2411.527
#102	FBXW7	19	10	29	417.184
#103	MEF2B	19	12	31	831.741
#104	CREM	19	11	30	628.59
#105	ELK3	19	17	36	575.36
#106	KLF4	19	10	29	521.712
#107	ZNF134	19	8	27	541.668
#108	CITED1	18	16	34	1432.132
#109	MXD1	18	9	27	553.556
#110	ZSCAN18	18	15	33	7756.101
#111	RUNX3	18	13	31	554.133
#112	ZIC1	18	19	37	3150.324
#113	HOXB8	18	5	23	202.11
#114	TCF15	18	19	37	3179.84
#115	TCF7L1	18	21	39	4236.601
#116	SMAD4	18	13	31	4626.378
#117	NKX3-1	17	11	28	1773.952
#118	TSHZ3	17	17	34	1964.706
#119	PURB	17	13	30	1439.485
#120	EVI1	17	13	30	351.334
#121	HOXC6	17	4	21	447.472
#122	NFKB1	17	7	24	713.458
#123	BCL6	17	21	38	2369.764
#124	ELF1	17	14	31	1628.852
#125	HOXB9	17	11	28	429.246
#126	HIF1A	17	12	29	1143.269
#127	HOXD13	16	13	29	1344.581
#128	POU3F2	16	9	25	2358.063
#129	HOXB1	16	13	29	912.279
#130	ZNF256	16	14	30	2694.696
#131	TSC22D1	16	10	26	951.88
#132	KCNH8	16	12	28	2234.629
#133	IRF1	16	18	34	2290.189
#134	PPARD	16	12	28	1250.312
#135	MYCL1	16	11	27	1671.708
#136	PITX2	16	15	31	616.502
#137	FOXA2	16	14	30	572.449
#138	SP4	16	16	32	672.763
#139	ZNF71	16	14	30	1661.027
#140	PKNOX2	15	10	25	1799.1
#141	SIX5	15	16	31	833.183
#142	SLC2A4RG	15	15	30	676.131
#143	RBCK1	15	13	28	1688.987
#144	PLSCR1	15	16	31	812.811
#145	EBF1	15	16	31	752.807
#146	ZIC5	15	12	27	2235.131
#147	RUNX1	15	13	28	2308.488
#148	STAT5A	15	10	25	696.646
#149	ZFP36L1	14	17	31	932.18
#150	GATA2	14	20	34	1687.083
#151	HOXA13	14	14	28	1054.362
#152	SMAD3	14	15	29	1842.755
#153	CEBPE	14	13	27	1815.221
#154	GAS7	14	4	18	66.435
#155	ETV1	14	13	27	1693.451
#156	CLOCK	14	13	27	603.58
#157	GSC	14	21	35	2761.014
#158	TWIST2	14	13	27	1370.303
#159	TSC22D2	14	19	33	1328.271
#160	AHR	14	15	29	1420.261
#161	SOX15	14	12	26	1335.732
#162	NFATC3	14	9	23	550.012
#163	STAT4	14	16	30	2188.068
#164	SIX3	14	9	23	1114.442
#165	ETV7	14	15	29	1127.074
#166	JUNB	14	12	26	732.884
#167	HOXD10	14	9	23	2710.537
#168	TARDBP	14	11	25	767.676
#169	RARB	14	14	28	861.777
#170	BACH2	14	15	29	960.762
#171	BATF2	14	18	32	1372.89
#172	MSX1	13	18	31	1575.764
#173	IRX4	13	17	30	1641.095
#174	TEAD4	13	13	26	739.213
#175	MSX2	13	21	34	573.034
#176	C1orf85	13	16	29	1262.582
#177	HOXA3	13	21	34	1517.711
#178	PTTG1	13	17	30	2341.157
#179	MYC	13	14	27	4016.397
#180	TBX3	13	23	36	1335.835
#181	DLX6	13	3	16	464.922
#182	SIX4	13	14	27	1575.024
#183	SMAD9	13	15	28	1818.064
#184	ZFHX4	13	18	31	1775.958
#185	ARID3A	13	10	23	442.553
#186	NFXL1	13	16	29	633.872
#187	FOXN4	13	16	29	1681.967
#188	BATF3	13	16	29	854.542
#189	ARNTL2	13	14	27	1116.503
#190	HOXC11	13	11	24	956.073
#191	HEYL	13	15	28	2259.305
#192	HOXD11	13	16	29	2184.623
#193	HMBOX1	13	6	19	590.378
#194	C2orf3	13	9	22	249.956
#195	EOMES	13	10	23	859.115
#196	HMX1	13	18	31	3808.921
#197	ZNF323	13	12	25	1082.086
#198	NKX2-3	13	12	25	1301.029
#199	HOXA7	13	5	18	292.595
#200	ZNF217	13	13	26	1812.05
#201	STAT1	12	17	29	1529.5
#202	LHX2	12	16	28	1669.328
#203	FUBP1	12	13	25	795.594
#204	RELB	12	7	19	997.766
#205	NKX3-2	12	16	28	1645.369
#206	SIM2	12	17	29	446.817
#207	ZNF219	12	12	24	842.408
#208	ESRRA	12	10	22	107.966
#209	NFIL3	12	13	25	1103.047
#210	TFEC	12	13	25	736.745
#211	IRF2	12	15	27	828.41
#212	ETS1	12	14	26	1033.301
#213	FOXJ2	12	17	29	2198.466
#214	PPARA	12	13	25	517.895
#215	TEAD3	12	9	21	227.199
#216	PRRX1	12	16	28	2784.317
#217	IRF7	12	14	26	3043.683
#218	ZNF449	12	15	27	2390.334
#219	PGBD1	12	13	25	731.809
#220	TCF4	12	20	32	627.194
#221	RORC	12	14	26	1110.724
#222	HMGA2	12	20	32	1785.028
#223	HNF4G	12	13	25	818.279
#224	HOXA10	12	7	19	1661.261
#225	ZSCAN16	12	11	23	1101.284
#226	ZSCAN2	12	8	20	1375.19
#227	ZIC2	12	11	23	1071.083
#228	ZFHX3	12	13	25	271.943
#229	C11orf9	12	12	24	810.21
#230	MTA2	11	16	27	549.669
#231	NFATC2	11	17	28	2130.091
#232	CEBPD	11	23	34	1736.076
#233	ETS2	11	13	24	1489.508
#234	TRIM22	11	17	28	842.57
#235	EGR3	11	9	20	593.232
#236	BCL11B	11	22	33	1489.135
#237	MAF	11	16	27	2823.287
#238	SATB2	11	15	26	772.105
#239	ZNF93	11	13	24	1303.87
#240	JUN	11	23	34	760.754
#241	FOXN3	11	12	23	733.343
#242	TCEAL1	11	12	23	675.81
#243	EN1	11	22	33	2818.56
#244	ZNF140	11	8	19	2279.438
#245	E2F8	11	19	30	1541.777
#246	STAT3	11	17	28	1884.509
#247	TFAM	11	13	24	1115.071
#248	MEF2D	11	12	23	299.865
#249	PCGF6	11	17	28	1388.676
#250	RFX5	11	13	24	402.513
#251	NR1H3	11	11	22	269.554
#252	RAX	11	6	17	686.855
#253	TRIM25	11	15	26	710.893
#254	ECSIT	11	13	24	873.88
#255	HOXB3	11	7	18	79.104
#256	PROX1	10	13	23	1360.871
#257	TCF12	10	12	22	742.813
#258	ZNF236	10	9	19	1124.036
#259	ESRRG	10	20	30	3077.087
#260	MYF5	10	11	21	609.098
#261	LHX1	10	21	31	1045.901
#262	RXRG	10	12	22	622.213
#263	WNT5A	10	18	28	2313.465
#264	FOXJ1	10	14	24	1266.689
#265	TBX1	10	19	29	1237.024
#266	TRPS1	10	15	25	825.657
#267	PURA	10	12	22	1418.514
#268	NOLC1	10	12	22	563.816
#269	LCOR	10	15	25	1519.369
#270	ZNF274	10	15	25	564.663
#271	ENO1	10	17	27	1213.767
#272	NR1I2	10	7	17	336.33
#273	HOXB2	10	13	23	1522.533
#274	HMGB2	10	10	20	640.794
#275	MSRB2	10	15	25	950.539
#276	HOXD1	10	18	28	1039.001
#277	FOXG1	10	13	23	1122.011
#278	ZHX3	10	22	32	708.092
#279	PAX4	10	9	19	896.609
#280	THRB	10	19	29	1670.044
#281	ZNF207	10	13	23	649.393
#282	GRHL3	10	15	25	775.266
#283	ARNT2	10	16	26	970.558
#284	NKX2-8	9	16	25	1092.446
#285	TP63	9	11	20	676.369
#286	RCAN1	9	12	21	480.213
#287	FOXC1	9	8	17	133.84
#288	TFDP2	9	7	16	899.796
#289	STAT5B	9	11	20	1965.614
#290	SCML1	9	17	26	492.073
#291	IRF8	9	19	28	869.978
#292	DLX4	9	16	25	1194.261
#293	TSC22D3	9	14	23	926.448
#294	ZNF438	9	17	26	979.426
#295	AEBP1	9	11	20	518.947
#296	DLX2	9	9	18	110.084
#297	PLAGL2	9	10	19	698.568
#298	VDR	9	16	25	1869.243
#299	HMGA1	9	16	25	1232.135
#300	OLIG2	9	10	19	331.629
#301	IRF5	9	13	22	1130.212
#302	NFAT5	9	16	25	1392.588
#303	TBX22	9	6	15	619.397
#304	HEY1	9	18	27	641.059
#305	BACH1	9	18	27	1529.872
#306	TSHZ2	9	14	23	1191.904
#307	TFCP2L1	9	6	15	20.776
#308	STAT2	9	13	22	486.697
#309	EN2	9	10	19	507.622
#310	FOXA1	9	19	28	585.975
#311	MYBL2	9	9	18	394.251
#312	EGR1	9	11	20	911.913
#313	HNF1B	9	17	26	716.999
#314	NR2E1	9	20	29	1408.906
#315	TBX15	9	16	25	1299.833
#316	MYCN	8	23	31	3681.016
#317	PLAG1	8	19	27	1647.871
#318	SALL1	8	14	22	653.538
#319	SREBF1	8	18	26	840.327
#320	BNC1	8	9	17	706.777
#321	SCML2	8	17	25	828.37
#322	BARX1	8	16	24	512.735
#323	LEF1	8	20	28	983.166
#324	SMAD1	8	17	25	587.504
#325	POU2F3	8	18	26	1084.089
#326	TRIM29	8	13	21	397.842
#327	GLIS3	8	17	25	1786.238
#328	JUND	8	14	22	816.404
#329	SOX7	8	13	21	2331.487
#330	TCF7	8	19	27	676.49
#331	RUNX2	8	19	27	1375.566
#332	SOX8	8	11	19	1210.31
#333	NEUROD1	8	10	18	1811.892
#334	ZNF643	8	17	25	796.188
#335	FOXE1	8	22	30	1178.674
#336	SOX2	8	22	30	1482.955
#337	HEY2	8	16	24	359.232
#338	PRRX2	8	26	34	2634.275
#339	ZNF83	8	17	25	1388.65
#340	WT1	8	22	30	2314.77
#341	ERG	8	13	21	1240.795
#342	ZNF167	8	11	19	454.682
#343	CREB3L4	8	13	21	561.754
#344	BATF	8	17	25	1255.137
#345	GTF2H2	8	12	20	236.039
#346	NR1D2	8	15	23	762.09
#347	SMAD2	8	12	20	1656.514
#348	CNOT7	8	13	21	930.039
#349	NRL	8	8	16	914.611
#350	SOX5	8	14	22	878.1
#351	PBX4	7	21	28	856.551
#352	LHX6	7	16	23	1587.419
#353	NFIB	7	16	23	790.979
#354	NR4A1	7	13	20	579.781
#355	MESP1	7	21	28	1989.753
#356	PBX2	7	15	22	580.242
#357	SPIC	7	11	18	527.116
#358	NFE2	7	13	20	1256.508
#359	CREB3L2	7	11	18	326.133
#360	RARA	7	18	25	1012.755
#361	MEIS2	7	24	31	1615.986
#362	CUX1	7	16	23	483.468
#363	PBX1	7	20	27	1037.726
#364	HOXA11	7	9	16	276.701
#365	AR	7	17	24	2889.156
#366	NFATC1	7	19	26	1450.555
#367	TBX5	7	13	20	704.548
#368	HDAC1	7	18	25	1139.041
#369	LHX5	7	7	14	716.732
#370	ZNF281	7	16	23	807.639
#371	TAF1B	7	18	25	918.359
#372	ARNTL	7	13	20	408.698
#373	XBP1	7	15	22	875.767
#374	ATF5	7	15	22	347.904
#375	HOXC5	7	10	17	1301.152
#376	NPAS2	7	21	28	1219.795
#377	E2F3	7	19	26	781.234
#378	ELF5	7	11	18	836.506
#379	RORB	6	15	21	912.126
#380	PBX3	6	12	18	231.589
#381	MAFG	6	11	17	226.696
#382	ZNF135	6	10	16	2001.994
#383	RFXAP	6	11	17	1032.946
#384	FOXO4	6	13	19	690.65
#385	POU4F2	6	8	14	463.905
#386	ISL2	6	17	23	1208.274
#387	TLX2	6	15	21	1462.51
#388	NR1H4	6	15	21	653.949
#389	FOXO3	6	19	25	1142.535
#390	RFX3	6	19	25	1541.024
#391	GCM1	6	10	16	646.536
#392	ZNF117	6	14	20	689.452
#393	NKX2-1	6	17	23	1012.143
#394	RBPJ	6	14	20	386.846
#395	HESX1	6	14	20	443.409
#396	MAFB	6	17	23	664.542
#397	PEG3	6	11	17	757.497
#398	NFIA	6	15	21	893.779
#399	KLF2	6	17	23	511.669
#400	TSHZ1	6	13	19	416.11
#401	TBX21	6	8	14	449.785
#402	MEF2A	6	15	21	773.983
#403	TEAD2	6	14	20	503.19
#404	SMAD5	6	13	19	877.618
#405	NFYB	6	17	23	1291.605
#406	NR2F1	6	21	27	901.633
#407	ZFP42	6	12	18	464.763
#408	TGIF2	6	14	20	702.594
#409	EGR2	6	13	19	434.333
#410	RB1	6	19	25	1993.708
#411	FOXO1	6	16	22	550.887
#412	FOXN2	6	9	15	610.518
#413	RCOR2	6	21	27	1756.186
#414	GATA3	6	25	31	1142.703
#415	FOXL2	6	21	27	762.874
#416	KLF12	6	17	23	507.83
#417	HOXA5	6	11	17	312.901
#418	NANOG	5	17	22	577.643
#419	AFF1	5	18	23	433.069
#420	NR3C2	5	22	27	1242.856
#421	USF1	5	15	20	1591.929
#422	KLF10	5	16	21	1199.193
#423	ZNF268	5	9	14	155.706
#424	PAX6	5	23	28	608.583
#425	NR5A2	5	13	18	570.104
#426	PHTF1	5	15	20	575.464
#427	DMRT1	5	15	20	616.972
#428	NR4A3	5	13	18	316.929
#429	TFDP1	5	12	17	208.56
#430	ESR1	5	17	22	853.598
#431	NFE2L3	5	15	20	833.799
#432	TRERF1	5	20	25	1035.578
#433	ATF3	5	20	25	705.406
#434	CSDA	5	16	21	873.298
#435	ZNF483	5	19	24	996.838
#436	RHOXF2	5	10	15	250.709
#437	KLF17	5	17	22	955.835
#438	ZFPM2	5	16	21	685.925
#439	SOX11	5	18	23	1307.234
#440	MSC	5	17	22	273.279
#441	ATF4	5	16	21	570.982
#442	ZNF70	5	13	18	368.433
#443	GATA4	5	16	21	686.344
#444	SMAD6	5	13	18	153.177
#445	ALX3	5	13	18	1149.809
#446	LMO4	5	14	19	428.99
#447	NOTCH1	5	19	24	780.485
#448	DDIT3	5	12	17	231.146
#449	ZNF397	5	18	23	986.819
#450	TCFL5	4	14	18	676.046
#451	MEOX1	4	15	19	468.323
#452	ONECUT2	4	14	18	1029.843
#453	BTG2	4	19	23	235.364
#454	TFCP2	4	19	23	926.588
#455	MAFK	4	14	18	585.305
#456	MGA	4	17	21	297.22
#457	TP53	4	18	22	968.906
#458	CUX2	4	17	21	493.593
#459	PGR	4	5	9	329.567
#460	ZNF232	4	12	16	354.634
#461	ZNF91	4	14	18	369.745
#462	RUNX1T1	4	11	15	446.551
#463	TSC22D4	4	14	18	667.928
#464	CDKN2A	4	18	22	678.039
#465	POU5F1	4	12	16	254.727
#466	KLF15	3	23	26	368.321
#467	REXO4	3	17	20	750.201
#468	POU4F1	3	14	17	256.972
#469	ZNF175	3	16	19	167.492
#470	FOXF1	3	16	19	176.221
#471	MEOX2	3	17	20	1031.712
#472	ESX1	3	17	20	337.469
#473	SLC26A3	3	14	17	273.763
#474	HOXD4	3	15	18	171.675
#475	HOPX	3	16	19	1034.779
#476	CREBL2	3	19	22	169.433
#477	VTN	3	14	17	329.411
#478	SOX1	3	15	18	566.974
#479	HES6	3	18	21	161.984
#480	NR4A2	3	20	23	559.503
#481	LASS2	3	15	18	465.704
#482	ST18	3	17	20	357.254
#483	CREB3L1	3	26	29	490.453
#484	RERE	3	16	19	381.315
#485	ZNF37A	3	16	19	575.929
#486	FOXP1	3	18	21	329.437
#487	IRX2	2	17	19	316.795
#488	DMRT2	2	21	23	616.749
#489	SOX4	2	21	23	408.206
#490	JDP2	2	20	22	100.715
#491	ZNF215	1	18	19	194.063
#492	SATB1	1	17	18	293.686
#493	CREB5	1	20	21	62.548
#494	ISL1	1	19	20	223.447
#495	ADNP2	1	15	16	115.651
#496	MKX	1	24	25	531.259
#497	RORA	1	18	19	591.582
#498	E2F7	0	17	17	0
#499	MTA3	0	14	14	0
#500	HHEX	0	16	16	0