Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZEB2	70	1	71	526.723
#2	CNBP	65	4	69	465.247
#3	KLF9	55	7	62	2391.115
#4	FOXF1	52	1	53	7.253
#5	LASS5	51	4	55	1485.351
#6	FOXM1	49	7	56	848.095
#7	USF2	48	11	59	4242.199
#8	ZSCAN16	47	11	58	3301.399
#9	PPARG	47	9	56	4109.908
#10	MECOM	47	11	58	2464.569
#11	AFF4	46	3	49	175.755
#12	RXRA	44	9	53	762.523
#13	NFIX	44	6	50	289.057
#14	ADNP	44	3	47	100.36
#15	MTA2	43	12	55	1286.678
#16	ZFPM1	43	14	57	3652.914
#17	TCEAL1	43	6	49	1784.807
#18	SMAD4	42	5	47	618.749
#19	SP3	42	0	42	0
#20	ZBTB48	41	5	46	606.809
#21	TSHZ3	40	3	43	139.801
#22	TFDP1	40	8	48	466.595
#23	STAT6	40	8	48	861.611
#24	NFIA	40	4	44	146.074
#25	RAX2	40	3	43	108.12
#26	NR2F6	40	14	54	2544.737
#27	MEIS1	39	9	48	1740.6
#28	ZNF3	39	11	50	1502.213
#29	IKZF4	39	5	44	423.296
#30	NFE2L2	39	4	43	127.265
#31	MYCL1	39	11	50	7624.365
#32	TSC22D1	39	10	49	1354.038
#33	SOX4	38	15	53	1296.427
#34	AEBP1	38	6	44	240.16
#35	RNF4	36	3	39	82.212
#36	E2F1	36	5	41	1891.806
#37	NFIB	35	11	46	3504.816
#38	HLF	35	4	39	2053.383
#39	NFIL3	35	14	49	4207.763
#40	STAT5B	34	12	46	763.038
#41	ZHX2	34	13	47	1973.596
#42	ELF1	33	13	46	1067.598
#43	TSC22D3	32	8	40	586.69
#44	RCAN1	32	11	43	1253.524
#45	UHRF1	32	9	41	3021.363
#46	ATF6B	32	7	39	2685.807
#47	ENO1	31	10	41	1472.446
#48	HIRA	31	6	37	1980.855
#49	GATA5	31	5	36	396.163
#50	PA2G4	30	10	40	1043.1
#51	STRN3	30	5	35	921.062
#52	ELF4	30	8	38	804.616
#53	CREB5	30	13	43	3565.963
#54	MZF1	30	1	31	16.575
#55	GAS7	30	9	39	2004.789
#56	MEF2D	29	10	39	1071.959
#57	SMAD3	29	6	35	1028.223
#58	NFATC4	29	6	35	12265.402
#59	HMGB2	29	13	42	2130.579
#60	ZNF444	29	12	41	1079.87
#61	GATA3	29	4	33	176.266
#62	CSRNP1	28	7	35	654.45
#63	HOXB7	28	9	37	845.68
#64	EBF1	28	8	36	441.604
#65	FOXQ1	28	5	33	221.104
#66	E2F2	28	6	34	185.649
#67	LCOR	28	13	41	2239.109
#68	AATF	28	14	42	773.943
#69	TCF4	27	9	36	729.402
#70	STAT3	27	7	34	313.548
#71	IRF8	26	10	36	1221.469
#72	TP63	26	16	42	4098.124
#73	GLI2	26	8	34	642.376
#74	IRF6	26	13	39	4680.468
#75	IRF3	26	6	32	596.933
#76	PURA	26	10	36	1153.258
#77	NPAS2	26	11	37	1007.663
#78	CCRN4L	25	12	37	2134.436
#79	E4F1	25	13	38	1721.518
#80	TCF25	25	10	35	1744.389
#81	PLAGL2	25	14	39	1340.807
#82	POU2F1	25	10	35	2030.094
#83	CREB3L4	25	16	41	4707.043
#84	ZNF165	25	17	42	4084.392
#85	FBXW7	24	10	34	2563.829
#86	TADA3	24	17	41	3625.776
#87	ATF1	24	4	28	46.075
#88	BATF3	24	8	32	773.533
#89	C5orf41	24	11	35	1403.854
#90	BTG2	24	15	39	1512.271
#91	NFXL1	24	9	33	2138.197
#92	PTTG1	24	7	31	569.704
#93	HOXB5	24	6	30	268.055
#94	TWIST1	23	12	35	2211.882
#95	HOXB3	23	10	33	1467.741
#96	PHF5A	23	13	36	1119.694
#97	NPAT	23	11	34	1113.246
#98	FOXA1	23	6	29	1113.748
#99	MEF2C	23	9	32	116.79
#100	GRHL2	22	10	32	806.85
#101	HNRNPK	22	5	27	760.951
#102	HES6	22	18	40	2198.11
#103	TRIM28	22	12	34	1558.51
#104	LZTR1	22	7	29	1947.565
#105	ZNF133	22	9	31	2034.688
#106	GLIS3	22	5	27	1273.927
#107	CNOT8	22	6	28	1025.378
#108	TCF21	22	9	31	1820.475
#109	PFDN1	22	9	31	326.039
#110	DMTF1	21	5	26	466.968
#111	ZFP90	21	19	40	3760.249
#112	HNRNPAB	21	8	29	288.793
#113	KLF2	21	8	29	229.279
#114	NR3C2	21	13	34	512.25
#115	ATF6	21	15	36	1223.77
#116	TAF4	21	10	31	2113.786
#117	RERE	21	8	29	1060.692
#118	BATF	21	16	37	963.747
#119	RORA	20	13	33	4342.5
#120	TGIF1	20	10	30	1502.137
#121	HOXB4	20	11	31	851.709
#122	RUNX3	20	5	25	264.781
#123	PHF1	20	13	33	4308.202
#124	TBX3	20	11	31	710.682
#125	ZNF217	20	6	26	735.346
#126	TBP	19	9	28	260.233
#127	TBX1	19	16	35	843.67
#128	RFX1	19	9	28	511.848
#129	NR1H2	19	13	32	1253.592
#130	SUPT6H	19	16	35	1206.704
#131	CNOT7	19	12	31	1390.025
#132	ELF3	19	9	28	693.05
#133	SOX15	19	13	32	745.795
#134	SNAPC4	19	12	31	1861.032
#135	BHLHE41	19	11	30	935.599
#136	ZNF438	19	12	31	4471.122
#137	ZNF193	19	13	32	1508.647
#138	TRIM29	19	12	31	777.165
#139	HDAC2	18	14	32	1231.237
#140	HOMEZ	18	12	30	997.661
#141	ZEB1	18	7	25	705.789
#142	SMAD6	18	13	31	718.851
#143	BRD8	18	12	30	3955.477
#144	HOXB8	18	5	23	163.509
#145	NFIC	18	13	31	925.973
#146	SCMH1	18	15	33	2970.151
#147	FOS	18	5	23	54.931
#148	CEBPA	18	18	36	1369.225
#149	SRF	18	10	28	4854.303
#150	TSC22D2	18	10	28	2503.946
#151	CEBPB	17	12	29	509.032
#152	TSHZ1	17	15	32	1298.239
#153	SOLH	17	14	31	2396.874
#154	TFAP2C	17	14	31	2886.418
#155	TEAD4	17	18	35	4973.523
#156	TCF12	17	11	28	707.389
#157	TSHZ2	17	16	33	761.678
#158	FOSB	16	4	20	274.335
#159	CEBPD	16	10	26	349.287
#160	STAT4	16	11	27	1215.237
#161	NME2	16	13	29	2220.868
#162	TCF3	16	14	30	2966.113
#163	ESRRA	16	12	28	1525.168
#164	PBX2	16	11	27	931.802
#165	E2F6	16	21	37	5494.626
#166	SNAPC2	16	21	37	6758.728
#167	GTF2H4	16	11	27	1566.356
#168	GABPB1	15	24	39	2191.603
#169	EGR1	15	7	22	92.287
#170	XBP1	15	17	32	1824.157
#171	GTF2H3	15	10	25	1826.701
#172	PRRX1	15	13	28	2052.132
#173	CREBBP	15	14	29	421.786
#174	YEATS4	15	12	27	4213.105
#175	USF1	15	13	28	1134.248
#176	ZNF140	15	10	25	1631.901
#177	HMG20A	15	9	24	1054.713
#178	FOXJ3	15	14	29	707.569
#179	DMRT1	15	8	23	1989.403
#180	RFX5	15	13	28	1689.011
#181	RB1	15	10	25	1504.209
#182	TGIF2	15	15	30	2226.831
#183	EPAS1	15	18	33	583.132
#184	SMAD5	15	12	27	304.822
#185	TAF10	15	16	31	2882.376
#186	CSRNP2	14	14	28	1813.003
#187	BHLHE40	14	12	26	1180.718
#188	E2F7	14	17	31	1539.622
#189	MSC	14	13	27	3830.432
#190	MSRB2	14	12	26	2338.202
#191	HOXC6	14	13	27	2232.727
#192	RARB	14	14	28	1254.488
#193	PURB	14	13	27	1516.171
#194	MEIS2	14	10	24	339.721
#195	SLC2A4RG	14	12	26	904.985
#196	VENTX	14	17	31	1207.236
#197	TRIM22	14	18	32	3333.21
#198	ATF4	14	9	23	479.251
#199	NR2F1	14	12	26	109.085
#200	E2F8	13	14	27	881.319
#201	SPI1	13	11	24	477.939
#202	ZFP36L1	13	14	27	4780.263
#203	NOTCH1	13	21	34	929.948
#204	ZFHX3	13	14	27	2539.691
#205	ZNF500	13	19	32	1391.044
#206	PGBD1	13	18	31	880.377
#207	HOXA5	13	17	30	999.326
#208	E2F5	13	14	27	1358.571
#209	HOXD3	13	16	29	1439.097
#210	PEG3	13	17	30	771.944
#211	FOXD1	13	24	37	5231.151
#212	PBX3	12	16	28	12753.761
#213	MAF	12	17	29	1969.936
#214	STAT5A	12	23	35	2677.499
#215	E2F3	12	17	29	1300.251
#216	TCF7L1	12	10	22	1052.925
#217	GATA2	12	11	23	2076.036
#218	MESP1	12	19	31	1511.023
#219	JUND	12	11	23	515.006
#220	ZNF83	12	16	28	3992.471
#221	HOXB13	12	9	21	1179.524
#222	ZNF91	11	18	29	5505.672
#223	IRX1	11	4	15	397.704
#224	GTF2IRD1	11	20	31	761.896
#225	NFYC	11	13	24	5878.694
#226	SUPT4H1	11	10	21	453.824
#227	ESR1	11	12	23	6107.767
#228	YY1	11	13	24	670.73
#229	TFCP2	11	12	23	731.948
#230	ZXDC	11	10	21	216.821
#231	MKX	11	10	21	216.434
#232	ISL1	11	20	31	2154.885
#233	CDKN2A	11	19	30	715.863
#234	TCF7L2	11	22	33	876.373
#235	FOXD4L4	11	8	19	4602.373
#236	LZTS1	11	19	30	1473.65
#237	RELB	11	10	21	1276.374
#238	STAT2	11	15	26	1193.052
#239	SCAND1	10	12	22	833.373
#240	OTX1	10	16	26	2428.53
#241	GATAD2B	10	15	25	1508.425
#242	MYC	10	16	26	872.63
#243	HOXC13	10	10	20	714.494
#244	TBX2	10	18	28	1868.805
#245	JDP2	10	17	27	4062.89
#246	NR4A1	10	11	21	149.851
#247	MAFB	10	20	30	2108.434
#248	HDAC1	10	24	34	1840.136
#249	KLF11	10	21	31	1054.618
#250	ZRANB2	10	8	18	1719.557
#251	HOXC9	10	14	24	405.774
#252	MLLT10	10	14	24	273.487
#253	IRF4	10	3	13	11.587
#254	KLF6	10	5	15	927.94
#255	PBX1	10	16	26	2718.668
#256	SNAPC5	10	11	21	1295.137
#257	LASS2	10	19	29	1770.336
#258	FOXO1	10	18	28	993.821
#259	MSL3	10	15	25	335.706
#260	GRHL3	10	13	23	2521.811
#261	SP1	10	10	20	2782.473
#262	HEYL	10	12	22	2395.079
#263	ATF5	10	16	26	418.074
#264	EOMES	10	11	21	996.418
#265	SIX4	9	14	23	518.387
#266	MSX2	9	15	24	1425.623
#267	MEOX1	9	12	21	432.661
#268	FOXD2	9	22	31	4122.199
#269	ETV5	9	21	30	2120.11
#270	HIF1A	9	12	21	466.902
#271	REL	9	8	17	1828.078
#272	HOXB6	9	10	19	472.436
#273	HOXC8	9	21	30	866.823
#274	MAFF	9	9	18	1220.778
#275	ZNF69	9	17	26	1544.125
#276	ZFHX4	9	14	23	257.428
#277	SP4	9	14	23	1127.186
#278	ZNF33B	9	14	23	527.328
#279	HOXB2	9	13	22	925.019
#280	ELF5	9	14	23	3901.915
#281	HOXC4	9	15	24	1067.055
#282	ZNF85	9	11	20	439.982
#283	CREBZF	9	16	25	433.007
#284	ZNF274	9	11	20	615.697
#285	HOXD4	9	12	21	767.094
#286	HOXA13	9	10	19	7822.938
#287	KDM5B	9	18	27	9197.902
#288	BUD31	9	13	22	657.097
#289	MYNN	9	16	25	1988.932
#290	MTF1	9	17	26	1823.13
#291	ECSIT	9	21	30	1390.303
#292	RARA	9	13	22	891.009
#293	IKZF3	8	13	21	517.07
#294	ZFPM2	8	14	22	327.855
#295	DLX3	8	19	27	1064.415
#296	BTAF1	8	13	21	423.185
#297	ELK1	8	13	21	1749.967
#298	ETV6	8	19	27	718.618
#299	IRF9	8	15	23	1688.54
#300	TAF7	8	15	23	163.151
#301	RORB	8	11	19	257.866
#302	SOX17	8	13	21	768.093
#303	REXO4	8	13	21	1126.471
#304	FOXJ2	8	15	23	2603.091
#305	EHF	8	20	28	1141.599
#306	FOXD4L1	8	16	24	2710.844
#307	SIX5	8	19	27	2035.856
#308	TULP4	8	21	29	424.156
#309	JUN	8	9	17	531.755
#310	POU2F2	8	22	30	2352.488
#311	TAF4B	8	13	21	2165.653
#312	IRX3	8	16	24	736.474
#313	HES1	8	11	19	351.209
#314	ZIC2	8	20	28	3654.891
#315	RBCK1	8	12	20	414.606
#316	CBFB	8	21	29	1642.683
#317	SNAI2	8	13	21	231.7
#318	TEF	8	12	20	537.922
#319	ZHX3	8	14	22	1081.456
#320	ETS1	8	15	23	1513.026
#321	LHX2	8	23	31	3686.113
#322	PLSCR1	8	12	20	2302.396
#323	ASCL2	8	23	31	2060.263
#324	ETS2	8	15	23	925.873
#325	GATAD2A	8	20	28	1499.477
#326	ZNF277	8	13	21	830.738
#327	KLF12	7	14	21	1137.948
#328	SATB1	7	19	26	3830.271
#329	FOSL1	7	12	19	1666.11
#330	PRDM1	7	16	23	1125.473
#331	SOX13	7	25	32	2915.611
#332	ZNF135	7	18	25	1715.396
#333	CTNNB1	7	11	18	1919.562
#334	FOXA3	7	15	22	2222.674
#335	SNAI3	7	14	21	860.258
#336	TRERF1	7	15	22	571.929
#337	KLF5	7	9	16	497.791
#338	HES5	7	12	19	1021.442
#339	HOXD1	7	14	21	1737.649
#340	HOXA2	7	15	22	1024.675
#341	STAT1	7	9	16	767.691
#342	FOSL2	7	18	25	1249.794
#343	POU3F1	7	20	27	924.648
#344	EGR2	7	12	19	1901.567
#345	RUNX2	7	19	26	731.06
#346	TFCP2L1	7	16	23	6100.509
#347	ZSCAN4	7	18	25	3551.88
#348	MNX1	7	20	27	5116.077
#349	NFKB2	7	15	22	2792.788
#350	RORC	7	20	27	2018.668
#351	PCGF6	6	18	24	2418.188
#352	NFE2L1	6	24	30	4514.383
#353	MLL	6	17	23	1038.436
#354	RELA	6	13	19	375.129
#355	ARID3A	6	24	30	1666.943
#356	CDX2	6	20	26	3986.151
#357	HOXD10	6	9	15	156.899
#358	RUNX1	6	21	27	1042.983
#359	NPAS1	6	18	24	1956.615
#360	ZKSCAN1	6	13	19	320.965
#361	SREBF2	6	20	26	199.143
#362	PHTF1	6	18	24	1939.413
#363	CSDA	6	23	29	1030.653
#364	ZNF256	6	25	31	1172.8
#365	HOXD11	6	12	18	391.647
#366	TSC22D4	6	22	28	1683.16
#367	TFAP2A	6	18	24	1942.722
#368	HOXA9	6	13	19	1169.819
#369	LEF1	6	19	25	2794.903
#370	GLI3	6	25	31	2154.15
#371	LASS6	6	14	20	436.99
#372	FOXP1	6	11	17	125.925
#373	FLI1	6	14	20	1435.753
#374	TP53	5	19	24	856.821
#375	VTN	5	21	26	8943.627
#376	BATF2	5	18	23	1469.964
#377	NFE2L3	5	24	29	461.936
#378	PBX4	5	16	21	695.237
#379	BCL3	5	18	23	2594.475
#380	ZNF219	5	19	24	1030.608
#381	IRX5	5	13	18	1474.913
#382	ZFP42	5	17	22	517.253
#383	ZC3H8	5	15	20	1024.023
#384	C1orf85	5	18	23	4708.945
#385	SIM2	5	14	19	916.567
#386	OVOL1	5	14	19	658.926
#387	ERF	5	15	20	663.011
#388	HMX2	5	13	18	1819.838
#389	MTA1	5	12	17	90.495
#390	HOXA11	5	9	14	233.048
#391	SIX2	5	20	25	767.074
#392	POU4F1	5	16	21	1198.736
#393	NOLC1	5	14	19	1831.759
#394	TEAD2	4	29	33	2341.258
#395	WNT5A	4	23	27	378.101
#396	NR1H4	4	14	18	2086.687
#397	ARNT2	4	22	26	859.202
#398	ZNF397	4	14	18	114.12
#399	KLF4	4	12	16	672.536
#400	ZNF18	4	14	18	151.716
#401	ASCL1	4	11	15	253.842
#402	ZHX1	4	13	17	231.043
#403	IRF7	4	16	20	314.326
#404	POU3F2	4	6	10	217.945
#405	SOX8	4	22	26	1191.059
#406	HOXD9	4	11	15	473.518
#407	POU5F1	4	22	26	1049.157
#408	MXD1	4	21	25	1203.485
#409	ETV4	4	17	21	356.499
#410	ZNF175	4	22	26	362.902
#411	DRAP1	4	17	21	1185.016
#412	SPIB	4	9	13	1262.196
#413	LMO4	4	21	25	6586.921
#414	BARX1	4	14	18	1010.238
#415	HOXA4	4	18	22	593.11
#416	MSX1	4	21	25	357.346
#417	ZSCAN18	4	20	24	1589.623
#418	CREB1	4	13	17	154.715
#419	EN1	4	14	18	3306.496
#420	ETV3	4	15	19	320.351
#421	RBPJ	4	17	21	1508.757
#422	TAF1B	4	21	25	1259.428
#423	PKNOX2	4	15	19	714.568
#424	KLF15	4	18	22	1467.349
#425	FOXN2	4	16	20	239.811
#426	HOPX	4	24	28	333.695
#427	FOXO4	4	22	26	777.39
#428	NR4A2	4	13	17	1136.006
#429	MYCN	4	14	18	287.279
#430	PROX1	4	19	23	512.428
#431	TBX15	4	21	25	2008.508
#432	SOX10	4	10	14	117.178
#433	SOX18	3	13	16	593.136
#434	TEAD3	3	15	18	621.101
#435	SOX9	3	24	27	893.669
#436	NR2C2	3	12	15	685.601
#437	HHEX	3	19	22	625.381
#438	HOXA10	3	14	17	189.028
#439	IRF1	3	20	23	3000.744
#440	SMAD9	3	13	16	674.775
#441	NKX3-1	3	19	22	446.592
#442	SOX21	3	24	27	3106.556
#443	GABPA	3	16	19	109.492
#444	CLOCK	3	11	14	504.788
#445	ARNT	3	21	24	439.759
#446	FOXN4	3	22	25	2760.308
#447	PCGF2	3	26	29	1197.191
#448	FOXF2	3	25	28	608.79
#449	AR	3	20	23	1242.843
#450	PRRX2	3	16	19	286.717
#451	NR2F2	3	24	27	1582.812
#452	SOX7	3	20	23	1350.791
#453	NR4A3	3	11	14	1040.655
#454	TFEB	3	22	25	1347.727
#455	MMP14	3	15	18	418.232
#456	BLZF1	3	20	23	257.643
#457	CREB3L2	3	13	16	221.585
#458	CITED2	2	18	20	74.877
#459	ONECUT2	2	20	22	1045.084
#460	CIR1	2	18	20	254.674
#461	TAF13	2	18	20	168.362
#462	NKX2-1	2	12	14	605.947
#463	BCL11B	2	30	32	504.941
#464	FOXC1	2	19	21	794.917
#465	IKZF1	2	14	16	57.755
#466	RCOR2	2	16	18	335.665
#467	PITX1	2	16	18	500.349
#468	HOXB9	2	13	15	56.104
#469	SALL2	2	25	27	434.583
#470	NR1H3	2	25	27	1234.895
#471	MEIS3	2	22	24	328.726
#472	NKX3-2	2	20	22	2092.597
#473	TFAP2B	2	11	13	1234.113
#474	SREBF1	2	20	22	574.905
#475	HCLS1	2	24	26	1657.833
#476	FOXS1	2	18	20	352.472
#477	SIX1	2	15	17	722.684
#478	SCML1	1	20	21	93.564
#479	PRDM2	1	23	24	237.638
#480	HMBOX1	1	21	22	140.82
#481	ZFP37	1	19	20	529.36
#482	ZNF323	1	25	26	1148.077
#483	DDIT3	1	17	18	33.992
#484	TARDBP	1	17	18	117.148
#485	HOXD8	1	18	19	96.088
#486	TCFL5	1	20	21	62.032
#487	FOXJ1	1	26	27	484.86
#488	HEY1	1	26	27	49.858
#489	NFE2	1	22	23	360.53
#490	HAND1	1	12	13	52.852
#491	HOXA6	1	19	20	40.583
#492	SATB2	1	25	26	130.878
#493	IRX4	1	18	19	17.6
#494	HSF4	0	16	16	0
#495	IRX2	0	18	18	0
#496	PAX8	0	17	17	0
#497	DMBX1	0	32	32	0
#498	MYT1	0	25	25	0
#499	TFAM	0	21	21	0
#500	IRF5	0	20	20	0