Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PURA	61	0	61	0
#2	CDKN2A	47	3	50	200.099
#3	TSC22D3	42	6	48	4034.686
#4	CTBP1	41	4	45	263.291
#5	RB1	40	3	43	2829.151
#6	TAF10	40	3	43	336.975
#7	HOXB7	37	5	42	198.955
#8	NKX3-1	36	2	38	178.015
#9	HNRNPK	36	3	39	298.654
#10	CREB1	34	5	39	349.084
#11	AEBP1	34	4	38	317.697
#12	GTF2I	33	3	36	3378.374
#13	LASS6	32	2	34	732.614
#14	RUNX1	32	12	44	4588.682
#15	ZSCAN18	32	9	41	1242.692
#16	ZEB1	30	11	41	3813.686
#17	CREB3	30	5	35	1797.357
#18	NR1H2	29	9	38	949.305
#19	RBCK1	29	8	37	1176.297
#20	ATF1	27	5	32	666.468
#21	MSRB2	26	7	33	894.767
#22	MEIS2	26	4	30	1560.029
#23	YBX1	26	6	32	1589.448
#24	NFE2L2	26	3	29	206.885
#25	MAFF	25	9	34	2941.781
#26	TCF7L2	24	4	28	2268.277
#27	HEYL	24	6	30	606.269
#28	FOXF2	24	5	29	645.235
#29	NPAS2	23	4	27	1034.35
#30	EDF1	23	9	32	1229.823
#31	STAT6	23	8	31	440.83
#32	MAX	23	11	34	2088.677
#33	TCF25	23	6	29	754.026
#34	ZNF148	22	8	30	1864.327
#35	NFX1	22	1	23	15.3
#36	UBP1	22	3	25	1805.507
#37	ATF5	22	10	32	847.233
#38	IRF1	22	5	27	302.775
#39	HOXB6	22	8	30	421.67
#40	SNAPC2	22	11	33	1796.832
#41	NFYC	22	14	36	3236.059
#42	SP3	22	4	26	379.597
#43	NFKB1	22	6	28	277.511
#44	MEF2A	22	3	25	769.893
#45	IKZF1	21	9	30	7754.57
#46	RELA	21	10	31	1274.273
#47	HOPX	21	7	28	2244.639
#48	EVX1	21	2	23	216.827
#49	RARA	20	9	29	4117.065
#50	DMTF1	20	8	28	2842.642
#51	ZNF24	20	10	30	3024.012
#52	SMAD2	20	8	28	3019.86
#53	MTA1	20	6	26	1052.554
#54	NR2F2	20	6	26	1801.846
#55	NFKB2	19	4	23	415.062
#56	BUD31	19	7	26	2064.697
#57	ZFP36L2	19	9	28	529.058
#58	MLXIPL	19	10	29	5065.054
#59	HNRNPAB	19	7	26	807.536
#60	SPEN	19	9	28	541.326
#61	DRAP1	19	5	24	873.91
#62	TCF4	18	4	22	397.387
#63	ZNF207	18	15	33	6242.244
#64	ZNF394	18	7	25	684.074
#65	FOSL1	18	5	23	653.997
#66	ZKSCAN5	18	6	24	1079.654
#67	RUNX1T1	18	12	30	3590.033
#68	ATF4	18	7	25	479.024
#69	SOX15	18	6	24	574.609
#70	IRF3	18	4	22	1120.043
#71	TGIF1	18	8	26	2339.941
#72	TFE3	18	6	24	694.502
#73	SOX10	17	6	23	1779.139
#74	CSRNP2	17	6	23	1590.559
#75	WNT5A	17	12	29	2790.473
#76	HOXC8	17	5	22	677.875
#77	PITX1	17	5	22	1183.645
#78	SCAND1	17	7	24	237.351
#79	IRF7	17	6	23	756.478
#80	TADA3	17	10	27	2368.473
#81	HMGB1	17	10	27	2047.343
#82	TEAD1	17	8	25	3227.523
#83	NKX6-1	17	2	19	313.139
#84	RBPJ	17	11	28	898.482
#85	ZNF217	17	12	29	856.733
#86	JUND	17	11	28	1491.516
#87	MYC	17	6	23	636.928
#88	SALL2	17	10	27	1224.612
#89	TCF12	16	10	26	1209.777
#90	KDM5B	16	12	28	1861.548
#91	RCAN1	16	10	26	949.08
#92	NFIB	16	11	27	4082.328
#93	RCOR1	16	11	27	1629.731
#94	MYBL2	16	11	27	2727.072
#95	ZNF444	16	8	24	1399.235
#96	ZHX2	16	11	27	3264.771
#97	TAF12	16	10	26	4111.432
#98	HMG20B	16	8	24	1963.496
#99	YY1	16	12	28	2045.239
#100	NFAT5	16	7	23	302.171
#101	SLC2A4RG	16	7	23	655.467
#102	BTG2	16	8	24	3135.055
#103	NR2C1	16	13	29	932.645
#104	ZNF277	15	10	25	1048.854
#105	HOXB5	15	4	19	537.811
#106	HMGA1	15	10	25	1315.07
#107	TARDBP	15	12	27	5098.515
#108	KLF9	15	10	25	1536.594
#109	FOXK2	15	9	24	737.144
#110	TCEAL1	15	8	23	623.394
#111	RELB	15	6	21	673.846
#112	ZFHX3	15	8	23	2746.759
#113	TBP	15	5	20	393.961
#114	FOXO4	15	11	26	3254.913
#115	TSC22D4	15	12	27	1830.181
#116	HMGB2	15	9	24	598.802
#117	HSF1	15	7	22	509.48
#118	KLF3	15	7	22	1066.418
#119	PFDN1	15	5	20	579.294
#120	MAF	15	13	28	1686.445
#121	HCFC1	14	12	26	2284.056
#122	BHLHE40	14	8	22	1567.73
#123	FOXO1	14	7	21	713.273
#124	ZBTB38	14	6	20	178.018
#125	PBX1	14	15	29	2742.286
#126	MSC	14	6	20	468.338
#127	MITF	14	5	19	901.875
#128	ELK3	14	9	23	918.187
#129	RXRB	14	11	25	302.171
#130	ZHX3	14	6	20	465.593
#131	SOLH	14	10	24	1945.888
#132	RORA	14	6	20	1982.013
#133	AFF1	14	14	28	2016.799
#134	CBFB	14	10	24	942.743
#135	TRIM28	14	6	20	222.454
#136	GATA2	14	15	29	3200.352
#137	CNBP	14	13	27	3963.385
#138	XBP1	14	10	24	1041.001
#139	EGR4	14	7	21	3719.152
#140	CEBPB	14	9	23	3977.493
#141	ADNP2	14	8	22	2747.85
#142	ESRRA	14	9	23	2469.987
#143	STRN3	14	8	22	564.176
#144	SCMH1	14	12	26	4130.206
#145	REXO4	14	10	24	550.893
#146	ESR1	14	10	24	6113.894
#147	CCRN4L	14	9	23	3961.377
#148	IRF2	13	10	23	2458.169
#149	FOXN3	13	7	20	1896.624
#150	FOXL1	13	8	21	456.704
#151	NR2F1	13	14	27	3018.85
#152	NR3C1	13	12	25	902.04
#153	FOXD1	13	14	27	1139.3
#154	IRF9	13	7	20	1219.758
#155	HMGA2	13	11	24	1217.629
#156	SLC30A9	13	7	20	695.042
#157	ZNF80	13	6	19	1676.869
#158	SMAD4	13	16	29	4756.264
#159	ELK1	13	10	23	639.306
#160	TEAD4	13	8	21	933.024
#161	TBX5	13	10	23	3144.636
#162	PLAG1	13	11	24	3278.46
#163	HDAC2	13	8	21	1472.528
#164	CREB3L1	13	11	24	2897.941
#165	NFE2L1	13	8	21	259.486
#166	FOXO3	12	12	24	1226.431
#167	HMG20A	12	9	21	2043.096
#168	ZEB2	12	13	25	890.9
#169	MMP14	12	12	24	846.559
#170	PBX3	12	11	23	3809.339
#171	NFYB	12	6	18	634.413
#172	NFIC	12	11	23	2039.27
#173	TFCP2	12	12	24	5076.874
#174	PBX2	12	16	28	1301.923
#175	CITED2	12	10	22	2339.318
#176	CUX1	12	12	24	1915.469
#177	GTF2H4	12	9	21	1567.592
#178	POU2F2	12	13	25	2222.989
#179	E2F3	11	10	21	1896.135
#180	SREBF2	11	9	20	826.017
#181	HIF1A	11	15	26	3090.679
#182	ZGPAT	11	11	22	2504.178
#183	PCGF2	11	14	25	2229.205
#184	AHR	11	11	22	557.414
#185	PTTG1	11	8	19	620.604
#186	ENO1	11	11	22	2417.535
#187	ZNF83	11	9	20	1608.627
#188	TAF7	11	13	24	2440.229
#189	HMX1	11	6	17	522.816
#190	HOXA1	11	11	22	5537.996
#191	SPDEF	11	10	21	1347.896
#192	ZNF232	11	8	19	3033.392
#193	LASS2	11	7	18	1632.668
#194	CSDA	11	8	19	714.279
#195	TFDP1	11	6	17	1153.319
#196	NR4A3	11	9	20	664.019
#197	ETV4	11	12	23	2425.698
#198	GTF2H3	11	9	20	2633.88
#199	PLSCR1	11	7	18	337.97
#200	NFIX	11	11	22	2063.73
#201	USF2	11	8	19	903.014
#202	TFAP4	11	7	18	501.035
#203	WT1	10	8	18	2642.683
#204	ZNF287	10	6	16	805.187
#205	CEBPD	10	11	21	1992.612
#206	HHEX	10	18	28	5129.63
#207	MLX	10	10	20	831.814
#208	CNOT7	10	13	23	2993.424
#209	SOX4	10	14	24	1476.492
#210	GLI2	10	11	21	2032.501
#211	ETV7	10	15	25	1929.451
#212	GCFC1	10	10	20	3518.406
#213	AHCTF1	10	5	15	700.495
#214	ZKSCAN1	10	12	22	1205.883
#215	CTNNB1	10	13	23	2860.727
#216	NFATC1	10	13	23	1821.308
#217	E2F1	10	7	17	381.065
#218	POU1F1	10	3	13	492.854
#219	HOXA4	10	16	26	2645.359
#220	MECOM	10	17	27	2360.27
#221	SMAD3	10	14	24	1033.073
#222	ADNP	10	10	20	3490.167
#223	SATB1	9	9	18	1438.89
#224	MEIS1	9	14	23	2086.222
#225	BACH1	9	12	21	503.109
#226	GLI3	9	11	20	1169.677
#227	STAT2	9	9	18	1179.368
#228	ARNTL2	9	6	15	1659.409
#229	STAT1	9	14	23	1418.618
#230	BCL3	9	10	19	715.491
#231	BATF3	9	11	20	2540.627
#232	SCML1	9	13	22	1545.741
#233	GTF2IRD1	9	10	19	541.407
#234	DDIT3	9	18	27	2019.57
#235	AATF	9	10	19	1183.008
#236	ZNF434	9	5	14	87.13
#237	NR4A2	9	13	22	4371.769
#238	ARNTL	9	11	20	475.346
#239	MEOX2	9	13	22	3709.778
#240	BLZF1	9	16	25	11128.831
#241	LEF1	9	6	15	3409.754
#242	NOLC1	9	11	20	2338.803
#243	MEF2C	9	7	16	2259.962
#244	TAF5L	9	13	22	1082.704
#245	TSC22D2	9	6	15	775.398
#246	MEF2D	9	10	19	1995.118
#247	LZTR1	9	12	21	2441.801
#248	DBP	9	12	21	1901.387
#249	EPAS1	9	7	16	2400.539
#250	HNF1B	8	7	15	3993.738
#251	TRIM29	8	6	14	2027.775
#252	SMAD1	8	14	22	1358.579
#253	SCML2	8	10	18	1857.456
#254	SCAND2	8	6	14	461.89
#255	TCF7L1	8	16	24	1084.633
#256	HSF2	8	12	20	3181.73
#257	ECSIT	8	13	21	425.386
#258	RFXANK	8	5	13	228.87
#259	GATAD2A	8	17	25	2958.024
#260	ZFP36L1	8	18	26	2380.737
#261	SUPT4H1	8	10	18	1354.513
#262	RFX5	8	17	25	969.854
#263	CTCF	8	12	20	1369.34
#264	CREBBP	8	12	20	1215.878
#265	PAX8	8	8	16	2057.306
#266	ERF	8	8	16	979.206
#267	NPAS1	8	12	20	2090.988
#268	FOSL2	8	16	24	3776.75
#269	TBX3	8	12	20	2779.495
#270	TAF6	8	10	18	1355.759
#271	PPARG	8	17	25	3765.356
#272	MYOG	8	9	17	1412.444
#273	FOXP3	8	7	15	230.117
#274	PRDM1	7	9	16	673.591
#275	SOX12	7	11	18	1746.396
#276	RARG	7	11	18	2578.341
#277	ATF3	7	11	18	1140.592
#278	C2orf3	7	10	17	2340.088
#279	MZF1	7	12	19	792.566
#280	HSF4	7	12	19	1022.502
#281	ETV2	7	10	17	1429.105
#282	ZFPM2	7	16	23	2118.303
#283	ZNF175	7	7	14	662.549
#284	SMAD6	7	14	21	1659.127
#285	TSC22D1	7	13	20	1535.525
#286	TCFL5	7	14	21	1713.099
#287	MYOD1	7	6	13	4389.897
#288	RUNX3	7	9	16	2955.362
#289	STAT3	7	12	19	2315.638
#290	SP1	7	7	14	1457.837
#291	ZNF281	7	15	22	601.913
#292	HOXA2	7	8	15	2109.797
#293	ATF2	7	7	14	289.282
#294	KLF10	7	14	21	1073.376
#295	FOXJ3	7	10	17	593.297
#296	TRIM25	7	13	20	5260.424
#297	MLLT10	6	12	18	3015.588
#298	KDM5A	6	9	15	619.207
#299	KLF11	6	15	21	661.079
#300	PITX2	6	13	19	1638.442
#301	FOXH1	6	4	10	1010.402
#302	ETV5	6	10	16	322.942
#303	FOXG1	6	14	20	1915.104
#304	FOXF1	6	14	20	1674.901
#305	ZNF131	6	14	20	2029.296
#306	ZNF3	6	13	19	1629.435
#307	RERE	6	8	14	277.409
#308	CNOT8	6	14	20	815.144
#309	GATAD1	6	15	21	2430.158
#310	TCF21	6	17	23	902.113
#311	ZBTB17	6	10	16	645.773
#312	HOXC4	6	9	15	147.381
#313	PA2G4	6	12	18	995.937
#314	CREBZF	6	11	17	1187.912
#315	NR1D2	6	16	22	2833.192
#316	RAX	6	7	13	535.803
#317	ZNF174	6	8	14	1830.795
#318	HOXA5	6	18	24	3475.071
#319	NOTCH1	6	12	18	1389.178
#320	TAF1B	6	13	19	1585.333
#321	NFYA	6	15	21	2362.947
#322	TFAP2A	6	14	20	903.302
#323	PKNOX2	6	8	14	514.461
#324	MAFB	6	12	18	645.673
#325	ZNF202	6	5	11	862.792
#326	LZTS1	6	4	10	214.108
#327	ZNF446	6	8	14	1355.113
#328	REST	6	12	18	2922.875
#329	CEBPE	6	10	16	1350.478
#330	DLX2	6	5	11	2043.061
#331	ELF1	6	11	17	485.669
#332	NFIL3	6	10	16	530.323
#333	PLAGL2	6	16	22	1683.302
#334	MLL	6	10	16	531.329
#335	FUBP1	6	9	15	303.615
#336	HDAC1	5	17	22	1550.723
#337	LHX3	5	13	18	3561.249
#338	CLOCK	5	8	13	737.689
#339	THRA	5	15	20	2027.971
#340	RXRA	5	10	15	350.432
#341	ELF2	5	11	16	1545.046
#342	STAT5B	5	14	19	2211.36
#343	ZSCAN12	5	7	12	1272.14
#344	VTN	5	6	11	283.075
#345	SMAD5	5	15	20	1065.491
#346	ATF6B	5	7	12	2579.233
#347	NFATC4	5	14	19	1857.503
#348	MTF1	5	15	20	687.213
#349	E4F1	5	12	17	885.482
#350	NR4A1	5	15	20	944.139
#351	KLF5	5	17	22	1792.832
#352	ETV1	5	11	16	1444.663
#353	TBX2	5	14	19	727.645
#354	MYNN	5	15	20	1798.351
#355	TGIF2	5	12	17	318.009
#356	YEATS4	5	12	17	980.365
#357	ZNF45	5	8	13	1229.081
#358	HEY1	5	15	20	862.694
#359	TFDP2	5	10	15	565.641
#360	MSX2	5	18	23	3585.471
#361	RNF4	5	10	15	589.587
#362	CIR1	5	4	9	273.834
#363	TBX1	5	9	14	470.819
#364	VDR	5	18	23	1769.608
#365	TFEB	5	9	14	1468.074
#366	MEOX1	5	10	15	1476.863
#367	SOX13	5	13	18	4329.367
#368	MAFK	5	14	19	1339.062
#369	MNT	5	12	17	2053.421
#370	PRRX1	4	25	29	1001.142
#371	TULP4	4	13	17	910.317
#372	PHF1	4	15	19	711.469
#373	TAF13	4	12	16	1085.115
#374	HOXC5	4	10	14	851.306
#375	SNAI2	4	13	17	512.798
#376	NFE2L3	4	10	14	878.441
#377	CREM	4	17	21	3791.3
#378	ZNF323	4	11	15	761.492
#379	KLF6	4	17	21	1150.931
#380	ALX3	4	7	11	725.315
#381	ATF6	4	13	17	1319.503
#382	ZNF134	4	10	14	1164.806
#383	NPAT	4	5	9	763.825
#384	KLF2	4	10	14	2527.448
#385	HR	4	15	19	2162.429
#386	ZNF189	4	11	15	393.796
#387	SNAPC5	4	12	16	201.077
#388	PITX3	4	10	14	1097.01
#389	ETS1	4	8	12	952.682
#390	LMO4	4	12	16	201.783
#391	IRF5	4	6	10	862.965
#392	KLF4	4	16	20	1762.158
#393	SOX9	4	18	22	609.531
#394	IRF6	3	5	8	720.541
#395	POU2F1	3	4	7	272.028
#396	PRRX2	3	15	18	342.518
#397	EGR2	3	10	13	867.736
#398	POU6F1	3	13	16	776.77
#399	MAFG	3	11	14	987.711
#400	ARNT	3	11	14	623.752
#401	ZKSCAN4	3	16	19	356.287
#402	TCF20	3	15	18	957.255
#403	NR2F6	3	14	17	169.433
#404	ELF4	3	12	15	425.788
#405	BTAF1	3	12	15	649.5
#406	STAT5A	3	11	14	448.82
#407	EGR1	3	15	18	1492.557
#408	ZNF263	3	10	13	1527.483
#409	HINFP	3	10	13	1732.566
#410	TCF15	3	6	9	173.794
#411	FOXJ2	3	13	16	1628.891
#412	ZNF274	3	12	15	433.889
#413	ARID3A	3	13	16	660.148
#414	HIC1	3	11	14	1514.076
#415	ETS2	3	16	19	932.244
#416	SIX1	3	15	18	524.078
#417	TEAD3	3	13	16	589.087
#418	ZNF219	3	11	14	346.794
#419	BHLHE41	3	21	24	1858.957
#420	TAF5	3	5	8	833.616
#421	CDX2	3	9	12	165.303
#422	HES1	3	5	8	2150.849
#423	ZNF236	3	11	14	921.859
#424	POU5F1B	3	8	11	1347.735
#425	ZSCAN5A	3	8	11	722.165
#426	HOXB2	3	15	18	1000.515
#427	TP53	3	13	16	127.177
#428	FLI1	3	10	13	3586.707
#429	ZNF140	3	10	13	893.253
#430	JUNB	3	12	15	1427.44
#431	ZNF91	3	8	11	1535.98
#432	TWIST1	3	15	18	1551.513
#433	JUN	3	14	17	479.383
#434	NR1I2	3	6	9	284.697
#435	CREB3L2	3	16	19	1004.098
#436	MSX1	3	12	15	793.757
#437	HIRA	3	11	14	977.779
#438	NFATC3	3	8	11	90.933
#439	NR1H3	3	14	17	240.121
#440	ZBTB48	3	14	17	513.45
#441	TRIM22	3	13	16	4583.604
#442	SRF	2	14	16	419.832
#443	SIX2	2	7	9	96.578
#444	GAS7	2	18	20	1014.281
#445	AR	2	18	20	894.841
#446	FOXC2	2	8	10	1598.378
#447	TCF7	2	11	13	1147.484
#448	ZNF35	2	8	10	106.829
#449	GATA6	2	14	16	324.993
#450	CREBL2	2	18	20	2944.823
#451	TAF4	2	14	16	311.069
#452	ZXDC	2	8	10	430.44
#453	ARNT2	2	19	21	195.867
#454	SALL1	2	17	19	487.453
#455	MBD1	2	10	12	222.47
#456	EGR3	2	12	14	434.906
#457	ZNF187	2	10	12	1505.378
#458	UBN1	2	12	14	268.753
#459	PPARD	2	14	16	184.996
#460	CREB5	2	8	10	128.695
#461	PPARA	2	12	14	162.33
#462	ARID4A	2	8	10	116.895
#463	TCF3	2	11	13	191.925
#464	PHTF1	2	10	12	107.536
#465	BCL6	2	11	13	106.434
#466	MEIS3P1	2	12	14	318.612
#467	FOXC1	2	15	17	2766.797
#468	ZFHX4	2	18	20	362.644
#469	E2F6	2	11	13	1612.324
#470	ETV6	2	12	14	737.188
#471	FOS	2	8	10	288.474
#472	TFAM	2	13	15	632.66
#473	C11orf9	2	8	10	71.788
#474	SMAD9	2	6	8	2554.788
#475	SREBF1	2	7	9	2219.212
#476	ZNF500	2	12	14	197.332
#477	FBXW7	2	15	17	264.739
#478	KLF7	2	17	19	358.284
#479	SUPT6H	1	16	17	633.834
#480	ZNF93	1	4	5	574.421
#481	NCOR1	1	13	14	238.486
#482	HOXC13	1	5	6	56.073
#483	FOXM1	1	7	8	131.911
#484	CBFA2T2	1	10	11	25.783
#485	TRPS1	1	14	15	1182.392
#486	ZNF238	1	19	20	998.752
#487	BRD8	1	17	18	158.685
#488	MSL3	1	15	16	121.128
#489	ELF3	1	16	17	67.981
#490	FOXJ1	1	5	6	826.039
#491	GABPB1	1	11	12	269.893
#492	SNAPC4	1	17	18	326.906
#493	MYCL1	1	7	8	310.597
#494	SATB2	0	16	16	0
#495	PRDM2	0	14	14	0
#496	HMBOX1	0	18	18	0
#497	PKNOX1	0	13	13	0
#498	HLF	0	9	9	0
#499	ZNF133	0	14	14	0
#500	HOXB3	0	12	12	0