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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HCFC1	45	7	52	12925.17
#2	RARG	39	1	40	525.432
#3	ELK1	36	4	40	295.034
#4	LZTR1	36	4	40	5850.018
#5	TEAD4	34	8	42	2124.958
#6	E2F4	34	6	40	1134.582
#7	KLF4	33	5	38	1252.054
#8	REST	32	8	40	588.018
#9	SOX15	32	1	33	22.373
#10	ADNP	32	4	36	618.363
#11	NR2F6	31	8	39	1084.889
#12	HMX1	30	2	32	3419.393
#13	E4F1	30	5	35	1502.339
#14	CREBZF	30	9	39	2687.248
#15	ETV1	28	9	37	3002.065
#16	ZNF444	28	7	35	1822.969
#17	DLX2	28	6	34	113.448
#18	TFDP1	28	11	39	991.967
#19	STAT1	27	6	33	937.673
#20	HMGA1	27	2	29	268.202
#21	GTF2IRD1	27	7	34	1319.29
#22	TAF10	27	2	29	956.027
#23	NKX3-1	26	7	33	220.845
#24	CNOT8	26	11	37	2030.404
#25	MMP14	26	10	36	1743.693
#26	MZF1	26	5	31	852.451
#27	MYOG	25	7	32	241.362
#28	ZNF217	25	7	32	2357.295
#29	EVX1	25	4	29	443.326
#30	BACH1	25	10	35	17548.404
#31	CDX2	25	4	29	552.397
#32	CBFB	25	10	35	1324.804
#33	TCF7	24	10	34	851.419
#34	PTTG1	24	7	31	4604.607
#35	STRN3	24	5	29	139.85
#36	EDF1	24	11	35	1736.036
#37	CNBP	24	5	29	1436.338
#38	TFCP2L1	24	6	30	1249.179
#39	TRIM25	23	7	30	452.501
#40	TULP4	23	6	29	585.428
#41	POU5F1B	23	10	33	16623.932
#42	HSF4	23	4	27	117.434
#43	SNAPC2	23	3	26	27.45
#44	MAF	23	2	25	124.946
#45	SNAPC4	23	7	30	795.669
#46	HSF2	22	5	27	123.11
#47	ARNTL2	22	12	34	5062.699
#48	HCLS1	22	5	27	323.22
#49	DMTF1	22	6	28	659.741
#50	E2F5	22	10	32	2826.628
#51	SALL2	21	10	31	488.424
#52	GLI3	21	3	24	3907.74
#53	RELA	21	8	29	563.354
#54	PRRX2	21	13	34	3566.58
#55	ZNF446	21	6	27	632.166
#56	TCF15	21	3	24	27.498
#57	ZGPAT	21	10	31	2993.427
#58	ZEB1	21	10	31	1218.441
#59	HSF1	21	8	29	1694.625
#60	NFATC4	21	13	34	692.358
#61	LHX3	20	6	26	618.846
#62	FEV	20	6	26	255.082
#63	TFEB	20	21	41	6005.616
#64	PKNOX2	20	7	27	560.283
#65	MEIS1	20	10	30	3618.102
#66	ZNF219	20	9	29	412.938
#67	NFE2L3	20	11	31	3425.31
#68	PA2G4	20	5	25	759.41
#69	ATF1	20	13	33	2739.655
#70	RFXANK	19	12	31	1456.74
#71	SCAND1	19	9	28	949.317
#72	USF2	19	7	26	366.04
#73	MYC	19	10	29	1161.93
#74	TGIF2	19	12	31	1273.459
#75	E2F1	19	8	27	23947.145
#76	ZEB2	19	4	23	2012.203
#77	HOXD1	19	5	24	1515.007
#78	IRF6	19	6	25	1059.53
#79	MAFB	19	11	30	2142.888
#80	HNF1B	19	7	26	376.763
#81	SNAI2	18	5	23	325.451
#82	SOX13	18	12	30	5060.375
#83	FLI1	18	3	21	92.948
#84	ZNF75D	18	10	28	1799.262
#85	NR5A2	18	8	26	2197.79
#86	POU6F1	18	12	30	579.88
#87	NFYB	18	8	26	667.197
#88	TSC22D4	18	4	22	4718.273
#89	HOXC11	18	14	32	1826.28
#90	SOX10	18	5	23	74.937
#91	MYNN	18	10	28	1869.943
#92	MYBL2	17	7	24	565.123
#93	ZBTB38	17	9	26	1462.099
#94	MAFF	17	18	35	3989.573
#95	NR3C1	17	13	30	2065.391
#96	ZNF131	17	13	30	730.639
#97	HOXA5	17	10	27	1771.348
#98	ESR1	17	10	27	1474.819
#99	STAT6	17	11	28	14723.555
#100	BRD8	17	8	25	1108.144
#101	IRF5	17	4	21	99.232
#102	C2orf3	17	12	29	1062.089
#103	NR1D2	17	12	29	1298.272
#104	YEATS4	17	10	27	581.771
#105	CIR1	17	14	31	1099.397
#106	MEF2A	16	8	24	3098.719
#107	HOXB1	16	5	21	706.697
#108	ELF1	16	18	34	1525.433
#109	ENO1	16	11	27	1965.525
#110	TRIM28	16	12	28	1340.557
#111	FOXJ2	16	5	21	813.487
#112	TSC22D2	16	9	25	332.33
#113	GCFC1	16	15	31	1140.674
#114	CREB1	16	13	29	1574.416
#115	ADNP2	16	12	28	1452.397
#116	IRF3	16	11	27	5034.834
#117	HOXA10	16	14	30	2578.357
#118	NR3C2	16	12	28	1642.31
#119	TAF12	16	7	23	1541.589
#120	TFAP2A	15	14	29	1172.224
#121	MNX1	15	8	23	941.192
#122	SP3	15	8	23	656.385
#123	AHCTF1	15	12	27	1934.804
#124	PLAGL2	15	9	24	701.016
#125	POU3F1	15	4	19	200.694
#126	TBP	15	14	29	1022.934
#127	POU2F2	15	7	22	371.331
#128	ZBTB48	15	9	24	2141.107
#129	MNT	15	10	25	594.2
#130	NR2C1	15	12	27	1614.25
#131	ESRRA	15	13	28	477.503
#132	CEBPD	15	14	29	3017.581
#133	KDM5B	15	14	29	3069.028
#134	SOX9	14	17	31	6700.698
#135	ECSIT	14	12	26	3341.827
#136	SUPT4H1	14	9	23	1240.377
#137	FOXO1	14	14	28	2246.589
#138	CEBPB	14	7	21	1141.726
#139	BTG2	14	17	31	2656.638
#140	SOLH	14	7	21	2684.332
#141	HNRNPAB	14	18	32	3190.579
#142	NFIL3	14	13	27	2028.381
#143	ELK3	14	13	27	1844.717
#144	AHR	14	13	27	1920.854
#145	TAF1B	14	13	27	1101.557
#146	ELK4	14	11	25	3729.772
#147	E2F6	14	10	24	673.335
#148	RCOR1	14	19	33	1710.934
#149	SPIB	14	14	28	2360.611
#150	ZNF148	14	12	26	1939.505
#151	CREBL2	14	15	29	1208.028
#152	HNF1A	14	17	31	2652.687
#153	TCF21	14	11	25	1330.436
#154	BUD31	14	15	29	1594.743
#155	TWIST1	14	7	21	628.454
#156	RXRB	14	9	23	722.341
#157	ELF2	14	18	32	2675.386
#158	PLSCR1	14	12	26	1242.681
#159	CBFA2T3	14	6	20	582.544
#160	TFEC	13	4	17	114.463
#161	PBX2	13	7	20	629.465
#162	ZNF263	13	9	22	707.087
#163	TCF4	13	13	26	898.64
#164	FOXO3	13	11	24	1498.173
#165	SUPT6H	13	11	24	2840.07
#166	RBCK1	13	14	27	2005.199
#167	C11orf9	13	13	26	1149.466
#168	BACH2	13	6	19	919.396
#169	FOXC1	13	15	28	1818.067
#170	HOXA2	13	10	23	2047.911
#171	FOXK2	13	14	27	2844.606
#172	IRF1	13	14	27	1644.45
#173	HOXD4	13	10	23	1338.101
#174	ZFPM2	13	4	17	1215.772
#175	SMAD1	13	6	19	217.074
#176	GABPB1	13	9	22	1606.749
#177	HHEX	13	10	23	805.72
#178	TFAM	13	12	25	1416.018
#179	ZKSCAN5	13	7	20	998.974
#180	MLXIPL	13	6	19	811.174
#181	ETV7	13	13	26	971.277
#182	NR2F1	13	16	29	1038.618
#183	PHF1	13	12	25	445.707
#184	MEIS2	13	17	30	1357.288
#185	KLF15	13	9	22	472.093
#186	ATF6B	13	12	25	14449.934
#187	HOXA4	13	10	23	2772.981
#188	PURA	13	14	27	1367.656
#189	KLF7	13	8	21	1239.943
#190	FOXJ1	12	7	19	125.222
#191	SATB2	12	15	27	4308.569
#192	FOSB	12	9	21	1165.688
#193	TAF4	12	12	24	1914.97
#194	WNT5A	12	13	25	498.094
#195	HMG20A	12	6	18	102.761
#196	SMAD2	12	24	36	2190.824
#197	TCF3	12	15	27	1374.984
#198	KLF11	12	13	25	944.5
#199	ZNF207	12	9	21	2050.633
#200	ZSCAN16	12	12	24	1496.517
#201	LMO4	12	12	24	1718.012
#202	ST18	12	9	21	2359.569
#203	ERG	12	8	20	833.699
#204	NFATC1	12	11	23	975.623
#205	GTF2H4	12	11	23	849.026
#206	STAT4	12	8	20	1028.627
#207	NOTCH1	12	5	17	531.217
#208	RNF4	12	14	26	1577.417
#209	THRA	12	9	21	862.664
#210	UBP1	12	13	25	1486.397
#211	PRDM2	12	14	26	2467.019
#212	SLC26A3	12	21	33	4845.748
#213	TFAP4	12	10	22	130.319
#214	HMBOX1	12	10	22	514.218
#215	RUNX1T1	12	13	25	1208.306
#216	REXO4	11	12	23	1463.398
#217	AATF	11	15	26	1438.863
#218	MEOX1	11	6	17	403.114
#219	NFIC	11	10	21	11866.822
#220	ZNF24	11	10	21	409.923
#221	TRPS1	11	11	22	1150.176
#222	KLF2	11	13	24	1709.93
#223	FOXF2	11	12	23	1559.997
#224	IRF7	11	9	20	982.464
#225	UBN1	11	12	23	609.259
#226	SMAD4	11	11	22	897.768
#227	YBX1	11	16	27	1033.757
#228	NFATC3	11	10	21	1888.53
#229	MEF2D	11	6	17	192.056
#230	TAF6	11	13	24	475.721
#231	GATAD2A	11	11	22	3974.102
#232	JUND	11	9	20	1330.935
#233	HOXD11	11	12	23	5630.678
#234	MECOM	11	14	25	1207.089
#235	ATF4	11	9	20	533.405
#236	ATF5	11	13	24	559.289
#237	TCF20	11	10	21	2105.458
#238	STAT5A	11	11	22	1322.865
#239	CBFA2T2	11	11	22	1236.227
#240	CEBPE	11	8	19	549.222
#241	ZNF140	11	15	26	851.523
#242	PITX2	11	9	20	1631.396
#243	CREB3	11	10	21	1427.121
#244	DDIT3	11	12	23	448.44
#245	PEG3	11	7	18	579.184
#246	PITX1	10	10	20	942.751
#247	ZNF277	10	17	27	1053.069
#248	SOX4	10	17	27	2129.686
#249	TAF5L	10	10	20	386.706
#250	FOXJ3	10	14	24	998.219
#251	E2F3	10	16	26	2858.752
#252	HOXB5	10	10	20	1594.577
#253	TCEAL1	10	10	20	1092.825
#254	TCFL5	10	17	27	1448.431
#255	TSC22D3	10	13	23	750.096
#256	ONECUT2	10	9	19	1008.811
#257	NRL	10	10	20	561.45
#258	NFE2L2	10	17	27	1200.37
#259	MEF2C	10	14	24	752.119
#260	ETV4	10	12	22	771.281
#261	HDAC2	10	10	20	646.145
#262	CTBP1	10	14	24	1732.547
#263	HMGB2	10	12	22	1040.8
#264	MGA	10	14	24	1446.532
#265	TARDBP	10	7	17	620.372
#266	SREBF2	10	8	18	540.436
#267	NR2F2	10	12	22	1105.813
#268	NR4A1	10	12	22	827.195
#269	FOS	10	13	23	1334.128
#270	SCML1	10	12	22	1406.569
#271	PBX3	10	18	28	1125.198
#272	RCAN1	10	23	33	2652.295
#273	TFE3	10	12	22	2779.518
#274	MTA1	10	13	23	728.946
#275	CSRNP2	10	10	20	639.136
#276	SPDEF	10	20	30	2007.115
#277	RARA	9	9	18	532.27
#278	RBPJ	9	17	26	1173.524
#279	PLAG1	9	22	31	1757.303
#280	AEBP1	9	11	20	617.21
#281	TCF7L1	9	16	25	1210.329
#282	NFE2L1	9	18	27	2409.876
#283	MEIS3P1	9	13	22	622.429
#284	HNRNPK	9	14	23	618.093
#285	GTF2H3	9	14	23	1452.729
#286	ZBTB17	9	12	21	503.579
#287	TBX3	9	14	23	1126.919
#288	PAX8	9	12	21	564.833
#289	PPARD	9	14	23	12224.769
#290	NOLC1	9	15	24	1414.637
#291	FOXF1	9	12	21	655.964
#292	LASS6	9	15	24	1123.46
#293	ATF2	9	12	21	668.022
#294	CEBPA	9	14	23	1561.312
#295	PHTF1	9	11	20	653.442
#296	CREBBP	9	14	23	1131.691
#297	RUNX1	9	20	29	2733.382
#298	CREB3L1	9	10	19	1211.587
#299	CTCF	9	12	21	914.417
#300	FOXD1	9	13	22	1449.41
#301	EPAS1	9	18	27	3054.486
#302	SREBF1	9	11	20	979.984
#303	NR4A2	9	16	25	792.594
#304	ZFP36L1	9	14	23	2258.145
#305	FOXM1	9	12	21	801.57
#306	KLF10	8	9	17	721.472
#307	HOPX	8	11	19	794.908
#308	HOXC4	8	10	18	884.437
#309	ZNF45	8	13	21	734.266
#310	KDM5A	8	14	22	1028.066
#311	SPEN	8	12	20	688.778
#312	HOXB9	8	9	17	515.721
#313	FOXP3	8	9	17	1145.301
#314	SP140	8	7	15	488.109
#315	IRF8	8	15	23	3120.767
#316	AFF1	8	17	25	1638.732
#317	NFKB1	8	10	18	857.994
#318	ZNF232	8	16	24	1261.657
#319	BATF	8	14	22	676.541
#320	RB1	8	10	18	543.596
#321	RXRA	8	16	24	860.296
#322	GAS7	8	11	19	786.237
#323	ZXDC	8	13	21	2213.045
#324	ZNF238	8	13	21	1015.036
#325	CNOT7	8	14	22	2426.842
#326	EHF	8	12	20	2496.333
#327	ZNF274	8	19	27	1681.842
#328	HEY1	8	15	23	1121.394
#329	FOXO4	8	8	16	161.978
#330	VENTX	8	13	21	1092.146
#331	TCF7L2	8	22	30	1198.278
#332	ATF3	8	14	22	1749.934
#333	HAND2	8	6	14	65.809
#334	NR1I2	8	18	26	1766.955
#335	FOXH1	8	7	15	657.235
#336	ZNF323	7	14	21	900.599
#337	RFX5	7	12	19	2003.217
#338	ZNF193	7	12	19	608.231
#339	TAF7	7	19	26	1767.627
#340	HMGB1	7	16	23	1695.557
#341	NR1H4	7	8	15	945.009
#342	ZNF134	7	9	16	337.189
#343	NPAT	7	14	21	1181.386
#344	HLF	7	8	15	344.969
#345	KLF5	7	9	16	407.079
#346	CUX1	7	14	21	1935.42
#347	BATF3	7	7	14	363.128
#348	PBX1	7	18	25	1822.613
#349	MBD1	7	15	22	1643.701
#350	HOXA9	7	12	19	925.663
#351	MSX1	7	12	19	806.284
#352	TCF12	7	16	23	758.667
#353	ZNF236	7	10	17	560.863
#354	ZNF83	7	14	21	958.746
#355	SRF	7	10	17	1704.969
#356	FUBP1	7	13	20	2184.429
#357	FOXN3	7	17	24	1446.349
#358	LEF1	7	19	26	2823.725
#359	TADA3	7	8	15	517.478
#360	HOXC8	7	7	14	69.223
#361	BARX1	7	5	12	1109.639
#362	STAT3	7	13	20	531.431
#363	NR4A3	6	14	20	1882.116
#364	CREM	6	7	13	174.437
#365	PFDN1	6	10	16	440.239
#366	ZNF268	6	13	19	856.682
#367	HOXB13	6	13	19	1176.405
#368	HOXA7	6	5	11	166.918
#369	BCL3	6	16	22	815.679
#370	VDR	6	15	21	841.225
#371	ZNF167	6	16	22	678.585
#372	EGR2	6	14	20	418.276
#373	ZNF165	6	17	23	1834.417
#374	TAF5	6	12	18	841.842
#375	SMAD6	6	16	22	1148.862
#376	NKX2-1	6	11	17	4418.445
#377	SCMH1	6	12	18	702.006
#378	HIF3A	6	11	17	871.468
#379	CITED1	6	11	17	492.927
#380	CSDA	6	13	19	677.721
#381	EGR3	6	15	21	748.494
#382	NPAS2	6	15	21	564.846
#383	ZNF93	6	14	20	627.171
#384	ZNF174	6	12	18	1323.143
#385	STAT5B	6	11	17	1253.587
#386	ISL1	6	18	24	1125.498
#387	YY1	6	13	19	826.772
#388	MSL3	6	9	15	212.574
#389	HINFP	6	11	17	782.1
#390	SOX21	6	9	15	224.704
#391	ESRRG	6	11	17	1412.315
#392	HOXD3	6	12	18	1182.514
#393	TFCP2	6	13	19	756.273
#394	EGR1	6	18	24	3884.981
#395	HOXA3	6	9	15	92.563
#396	HMG20B	6	14	20	559.902
#397	ZNF91	6	14	20	846.801
#398	HMGA2	6	15	21	1369.801
#399	FOSL1	6	16	22	848.818
#400	NFYA	6	14	20	504.352
#401	ETV5	6	12	18	1032.399
#402	FBXW7	6	9	15	155.986
#403	ZSCAN18	6	23	29	1813.818
#404	KLF12	5	15	20	987.991
#405	ELF3	5	20	25	1025.659
#406	SNAPC5	5	12	17	815.6
#407	PKNOX1	5	10	15	364.344
#408	JUN	5	20	25	1156.968
#409	FOXA2	5	16	21	1144.279
#410	HOXA1	5	14	19	1355.303
#411	ETS2	5	14	19	1037.522
#412	JUNB	5	12	17	399.653
#413	NFIB	5	16	21	1509.115
#414	TSC22D1	5	11	16	371.131
#415	FOXG1	5	6	11	352.248
#416	TFDP2	5	18	23	676.088
#417	WT1	5	23	28	2011.801
#418	KLF9	5	12	17	553.282
#419	E2F8	5	18	23	659.118
#420	HIF1A	5	12	17	694.958
#421	SLC2A4RG	5	10	15	329.849
#422	ZNF33B	5	14	19	837.618
#423	NCOR1	5	11	16	1173.057
#424	HAND1	5	10	15	828.586
#425	ZNF202	5	13	18	519.871
#426	ZHX2	5	12	17	652.677
#427	TGIF1	5	16	21	739.385
#428	SIM2	5	12	17	502.736
#429	TCF25	5	15	20	2592.564
#430	MLLT10	5	12	17	945.068
#431	HOXD9	5	11	16	1045.264
#432	HOXB6	5	14	19	701.869
#433	ZNF133	5	16	21	602.196
#434	MSRB2	5	16	21	1061.134
#435	IRF4	4	13	17	272.822
#436	HIRA	4	11	15	318.379
#437	HES1	4	12	16	1167.686
#438	BHLHE41	4	21	25	1819.789
#439	HOXA11	4	9	13	747.018
#440	SCML2	4	9	13	270.875
#441	ZNF85	4	12	16	265.38
#442	PPARG	4	17	21	480.927
#443	ZHX3	4	11	15	483.56
#444	CDKN2A	4	22	26	1344.029
#445	NFYC	4	12	16	456.435
#446	XBP1	4	17	21	662.843
#447	LASS2	4	14	18	459.563
#448	TRIM29	4	20	24	1086.123
#449	TP53	4	15	19	605.046
#450	FOSL2	4	15	19	977.658
#451	GATAD1	4	11	15	407.986
#452	ZFP36L2	4	12	16	764.143
#453	SLC30A9	4	15	19	291.065
#454	KLF6	4	13	17	1055.465
#455	SIX2	4	8	12	306.883
#456	ARNT2	4	11	15	205.017
#457	RERE	4	17	21	807.988
#458	IRF2	4	10	14	148.943
#459	BTAF1	4	14	18	864.087
#460	SMAD3	4	15	19	446.141
#461	ZIC1	4	10	14	255.93
#462	ELF5	3	15	18	481.131
#463	BCL6	3	14	17	320.257
#464	GATA2	3	16	19	325.693
#465	ZNF3	3	18	21	260.811
#466	GRHL2	3	15	18	598.722
#467	HR	3	11	14	165.207
#468	DRAP1	3	15	18	426.738
#469	NFAT5	3	11	14	203.11
#470	RUNX3	3	21	24	691.016
#471	HOXB7	3	15	18	390.214
#472	SATB1	3	22	25	1575.545
#473	RORA	3	13	16	134.144
#474	MSX2	3	17	20	1382.434
#475	MLX	3	13	16	565.595
#476	GATA6	3	16	19	290.195
#477	FOXA1	3	19	22	519.906
#478	EGR4	3	9	12	383.758
#479	MAX	3	14	17	1580.345
#480	BHLHE40	3	17	20	1182.713
#481	ZNF189	3	13	16	442.34
#482	CTNNB1	2	17	19	198.909
#483	VAV1	2	12	14	143.512
#484	PCGF2	2	17	19	319.91
#485	NFX1	2	10	12	271.001
#486	CREB3L2	2	20	22	360.737
#487	KLF3	2	12	14	558.666
#488	TFAP2C	2	14	16	661.754
#489	HOXB2	2	19	21	595.977
#490	NR1H3	2	13	15	268.121
#491	DMRT1	2	9	11	132.48
#492	MYCL1	1	13	14	57.431
#493	ZNF215	1	14	15	150.711
#494	BCL11B	1	13	14	605.458
#495	ELF4	1	19	20	665.198
#496	POU2F3	1	14	15	110.055
#497	IRF9	1	15	16	249.711
#498	TRIM22	1	18	19	243.494
#499	TSHZ2	1	12	13	47.694
#500	HDAC1	1	14	15	67.115