Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	IRF4	47	0	47	0
#2	SUPT6H	45	8	53	8946.639
#3	RELA	42	4	46	146.995
#4	GRHL3	40	2	42	1034.885
#5	E2F2	38	4	42	4219.545
#6	L3MBTL4	38	5	43	420.036
#7	PPARA	33	6	39	218.714
#8	TFDP1	32	6	38	6038.629
#9	AFF4	32	9	41	999.94
#10	THRA	31	3	34	96.651
#11	FOXD1	30	10	40	4054.601
#12	NR0B1	30	5	35	131.885
#13	ZIC5	29	8	37	655.584
#14	FOXL1	29	7	36	1480.934
#15	CREB1	28	6	34	1103.094
#16	TFAP2E	28	4	32	215.225
#17	ZFP36L1	27	3	30	74.451
#18	SMAD4	27	11	38	810.292
#19	SOX8	27	4	31	115.128
#20	ASCL1	26	5	31	498.117
#21	CEBPA	26	11	37	2042.867
#22	IRF5	25	6	31	648.845
#23	ZNF148	25	12	37	967.431
#24	ESRRB	25	11	36	2350.343
#25	NFATC2	25	6	31	260.791
#26	TBX19	25	9	34	749.689
#27	HINFP	24	11	35	1052.247
#28	ZNF643	24	6	30	1874.517
#29	SMAD5	23	14	37	795.864
#30	SNAPC4	23	8	31	2230.987
#31	MMP14	23	5	28	5278.495
#32	FOXA3	23	6	29	676.121
#33	HOXC6	22	9	31	1300.395
#34	FBXW7	22	7	29	2936.363
#35	EMX1	22	5	27	510.295
#36	STAT1	22	8	30	744.581
#37	RNF4	22	10	32	960.782
#38	SOX6	21	2	23	218.247
#39	TSC22D4	21	5	26	1631.372
#40	ETV4	21	6	27	2005.328
#41	THRB	21	11	32	2366.39
#42	STAT6	21	7	28	762.661
#43	ZNF165	20	2	22	314.153
#44	ATF7	20	5	25	375.642
#45	FOXE1	20	13	33	5768.451
#46	TCF4	20	12	32	1527.049
#47	GATAD2B	20	11	31	1976.047
#48	SMAD3	20	9	29	4434.229
#49	SOX12	19	7	26	1097.221
#50	HOXD9	19	14	33	5073.611
#51	SMAD9	19	11	30	2624.986
#52	PGR	19	6	25	847.754
#53	MAFK	19	8	27	1410.166
#54	ZNF219	19	5	24	652.296
#55	TCF20	18	8	26	1765.654
#56	ESX1	18	5	23	921.959
#57	ELK1	18	8	26	1454.009
#58	ETV6	18	14	32	5185.872
#59	TFDP2	18	6	24	1104.841
#60	RHOXF2B	18	11	29	3294.418
#61	ZNF167	18	6	24	342.751
#62	CDKN2A	18	11	29	2113.184
#63	ZSCAN12	18	10	28	1408.519
#64	MYC	18	2	20	378.89
#65	ZNF438	18	10	28	617.397
#66	TBX3	18	15	33	3236.402
#67	TBX5	18	8	26	4360.152
#68	FOXA2	17	9	26	2355.097
#69	PURB	17	7	24	2238.266
#70	BATF3	17	8	25	2285.525
#71	STAT3	17	8	25	3294.293
#72	VDR	17	14	31	1676.025
#73	KLF7	17	5	22	443.231
#74	POU6F2	17	9	26	576.4
#75	ZNF483	16	6	22	106.47
#76	POU3F4	16	9	25	2516.086
#77	ARX	16	9	25	1359.436
#78	DLX3	16	12	28	1149.269
#79	HAND1	16	5	21	2212.803
#80	ZNF500	16	8	24	2138.506
#81	FOXJ3	16	11	27	2412.87
#82	HMBOX1	16	13	29	2026.878
#83	CBFB	16	12	28	510.821
#84	ZNF24	16	12	28	2538.689
#85	LHX6	16	14	30	3048.269
#86	TP73	16	9	25	1418.904
#87	SALL2	16	14	30	1317.092
#88	TCF7L2	16	8	24	527.971
#89	FOXD3	15	13	28	1129.174
#90	HOXB5	15	13	28	1351.035
#91	ELF1	15	11	26	2481.901
#92	MAFA	15	8	23	430.685
#93	SOX17	15	7	22	1126.688
#94	KDM5B	15	14	29	498.21
#95	NOLC1	15	6	21	1500.787
#96	ZSCAN29	15	8	23	902.162
#97	ARNT2	15	14	29	4751.442
#98	ZNF140	15	9	24	3097.512
#99	MECOM	15	4	19	1135.167
#100	JDP2	15	13	28	2981.092
#101	RXRA	15	5	20	2138.286
#102	ERF	15	8	23	831.795
#103	FOXI1	14	6	20	101.009
#104	PAX5	14	10	24	1356.448
#105	IRX1	14	6	20	1587.762
#106	LZTR1	14	12	26	2233.535
#107	NFYA	14	7	21	2521.126
#108	SPIB	14	14	28	3073.713
#109	CREBL2	14	7	21	1902.555
#110	PLAGL2	14	9	23	766.504
#111	HMGA1	14	9	23	669.066
#112	ETS2	14	9	23	2046.704
#113	GTF2I	14	11	25	850.796
#114	OLIG2	14	9	23	462.713
#115	ALX4	14	8	22	1206.061
#116	TLX2	14	3	17	656.037
#117	BCL3	13	12	25	2545.109
#118	RHOXF2	13	13	26	2101.948
#119	ASCL2	13	7	20	252.726
#120	LASS5	13	4	17	112.172
#121	ETV3	13	9	22	1204.617
#122	ELF5	13	7	20	362.369
#123	TSC22D3	13	15	28	1067.413
#124	ZNF81	13	14	27	962.154
#125	ATOH1	13	8	21	1800.391
#126	ZSCAN1	13	8	21	2509.955
#127	ZHX2	13	11	24	1986.9
#128	SMAD2	13	13	26	837.278
#129	NFX1	13	11	24	1655.853
#130	GLI2	13	10	23	883.359
#131	TFAM	13	13	26	522.392
#132	CREB3L1	13	12	25	529.302
#133	ZNF263	13	7	20	478.613
#134	HOXB7	13	7	20	1140.118
#135	SATB2	13	10	23	3177.532
#136	NFATC3	13	12	25	2935.725
#137	RAX	13	9	22	2340.241
#138	IRF1	12	9	21	2854.434
#139	IKZF1	12	12	24	1735.462
#140	TMEM229A	12	15	27	2666.271
#141	RCOR1	12	14	26	289.901
#142	ZFP42	12	10	22	2079.834
#143	TBX4	12	11	23	1974.098
#144	ST18	12	5	17	571.22
#145	ESR1	12	14	26	1945.095
#146	MTA3	12	12	24	742.887
#147	SOX30	12	9	21	1814.099
#148	ZNF256	12	12	24	3746.23
#149	STRN3	12	15	27	1525.35
#150	CREB3L2	12	11	23	1419.941
#151	EGR2	12	15	27	5737.071
#152	ZNF134	12	11	23	1036.239
#153	NKX6-1	12	8	20	443.236
#154	MEIS3P1	12	9	21	1134.427
#155	E2F6	12	4	16	505.295
#156	ZKSCAN1	12	16	28	5151.324
#157	ALX1	12	7	19	2909.49
#158	TFEC	11	6	17	726.514
#159	SOX11	11	9	20	1430.261
#160	PTH	11	11	22	1071.515
#161	PRDM1	11	8	19	949.327
#162	ZNF238	11	9	20	4598.092
#163	OTX1	11	9	20	859.109
#164	CITED2	11	5	16	473.39
#165	CTBP1	11	11	22	1046.623
#166	DRAP1	11	4	15	1252.041
#167	TAL1	11	12	23	1465.869
#168	GATAD2A	11	11	22	1370.403
#169	HESX1	11	8	19	1461.695
#170	MLL	11	8	19	856.281
#171	ATF6B	11	9	20	746.777
#172	TBP	11	11	22	1918.692
#173	HOXD13	11	8	19	788.834
#174	IRX3	11	15	26	2514.016
#175	TP63	11	12	23	3605.797
#176	MYT1L	11	11	22	1992.902
#177	ZNF133	11	5	16	1040.131
#178	ZNF70	11	5	16	314.818
#179	HSF2	11	11	22	9200.611
#180	REST	11	3	14	137.847
#181	OVOL1	11	7	18	1520.935
#182	POU3F2	11	10	21	1090.333
#183	POU2F2	11	7	18	186.484
#184	SIM2	11	16	27	6468.09
#185	ZNF131	11	10	21	7734.585
#186	ZNF193	11	11	22	1415.314
#187	GSC	11	11	22	2124.788
#188	NFYB	11	12	23	1980.858
#189	SP1	10	13	23	2195.251
#190	NKX1-2	10	9	19	1445.877
#191	GATA2	10	10	20	770.026
#192	PFDN1	10	11	21	1567.354
#193	NR2E3	10	14	24	1740.8
#194	HNF1A	10	4	14	288.315
#195	AFF1	10	8	18	269.988
#196	HNRNPK	10	8	18	838.032
#197	ZNF187	10	11	21	1813.595
#198	PPARD	10	13	23	678.091
#199	RUNX2	10	13	23	722.959
#200	ZNF85	10	8	18	1414.604
#201	FOXO4	10	11	21	1448.894
#202	ZEB1	10	14	24	1350.819
#203	GABPB1	10	15	25	1241.188
#204	SCRT2	10	11	21	1144.596
#205	SOX5	10	10	20	1238.026
#206	SCAND3	10	13	23	1141.016
#207	TWIST1	10	5	15	1037.731
#208	FOXP2	10	3	13	239.345
#209	LHX1	10	13	23	2169.424
#210	DLX1	10	12	22	1822.242
#211	MXD1	10	8	18	1099.12
#212	ZBTB48	10	10	20	1040.396
#213	KLF6	10	12	22	2076.606
#214	SIX1	10	10	20	3960.113
#215	RBPJL	10	10	20	2658.04
#216	FOXN4	10	6	16	1302.207
#217	SIN3A	10	14	24	2611.157
#218	NFKB1	10	7	17	695.911
#219	RHOXF1	10	6	16	1012.424
#220	PBX3	10	10	20	1627.667
#221	SIX4	10	3	13	753.308
#222	ZNF236	10	9	19	1155.505
#223	HOXA4	10	9	19	1964.48
#224	E2F4	9	7	16	218.209
#225	HDAC1	9	16	25	1284.657
#226	PHTF1	9	15	24	1126.495
#227	CCRN4L	9	18	27	2982.395
#228	ZNF174	9	12	21	2114.386
#229	FOXP3	9	16	25	698.785
#230	TFAP2A	9	11	20	479.581
#231	SOX4	9	12	21	4584.62
#232	C1orf85	9	13	22	1386.946
#233	NCOR1	9	11	20	889.298
#234	TBX1	9	18	27	2908.656
#235	SP4	9	8	17	364.421
#236	HNF1B	9	11	20	1183.373
#237	ELF3	9	6	15	901.717
#238	FOXD2	9	16	25	3070.157
#239	NRL	9	17	26	1067.887
#240	CREBZF	9	7	16	239.447
#241	HOPX	9	12	21	328.587
#242	EHF	9	10	19	1121.921
#243	CREB3L3	9	4	13	242.551
#244	ELK4	9	9	18	480.851
#245	CLOCK	9	11	20	2264.77
#246	GCFC1	9	8	17	844.882
#247	JUND	9	4	13	430.744
#248	CREB3L4	9	11	20	1107.585
#249	FOXJ1	9	11	20	1204.504
#250	FOXR1	9	10	19	826.859
#251	HIC1	9	10	19	2391.812
#252	NR1H2	9	8	17	1825.958
#253	RARG	9	15	24	1768.56
#254	BATF2	9	10	19	748.967
#255	SREBF1	9	11	20	1704.105
#256	BRD8	9	11	20	2447.106
#257	DLX2	9	9	18	2537.477
#258	ATF3	9	7	16	793.694
#259	PHF1	9	15	24	1331.826
#260	NFAT5	9	9	18	843.295
#261	TULP4	9	10	19	1816.855
#262	RCOR2	8	11	19	704.303
#263	TSHZ3	8	12	20	1114.158
#264	RORA	8	10	18	955.382
#265	KLF4	8	13	21	1723.098
#266	ZNF45	8	10	18	1033.77
#267	ZNF19	8	12	20	279.876
#268	TCF21	8	11	19	1824.111
#269	RERE	8	14	22	3376.449
#270	LHX4	8	7	15	1059.471
#271	ETV3L	8	10	18	2027.156
#272	MNT	8	13	21	2795.617
#273	HOXC8	8	18	26	1019.156
#274	PPARG	8	11	19	2293.765
#275	SP140	8	10	18	740.841
#276	STAT5B	8	8	16	880.098
#277	TSC22D1	8	11	19	1408.415
#278	RORC	8	14	22	1729.687
#279	TSHZ2	8	5	13	973.986
#280	SOX7	8	8	16	1123.797
#281	LCOR	8	12	20	2021.654
#282	ZEB2	8	3	11	164.34
#283	ZNF232	8	8	16	1302.433
#284	ZNF37A	8	14	22	951.028
#285	MLXIPL	8	8	16	758.212
#286	FOXC1	8	13	21	849.831
#287	ZRANB2	8	4	12	907.372
#288	ZNF397	8	10	18	651.636
#289	KLF12	8	10	18	1078.154
#290	LMX1B	8	8	16	1324.848
#291	ZNF175	8	15	23	910.603
#292	ZNF449	8	12	20	1535.142
#293	CNOT8	8	11	19	816.536
#294	FOXJ2	8	15	23	3368.543
#295	TEAD1	8	13	21	2146.927
#296	GATA4	7	8	15	903.549
#297	HOXA9	7	8	15	1189.961
#298	ZNF35	7	15	22	1655.673
#299	PAX3	7	9	16	1306.561
#300	PKNOX2	7	19	26	5298.764
#301	TPRX1	7	9	16	1847.036
#302	PKNOX1	7	13	20	471.314
#303	GLIS3	7	13	20	1510.281
#304	ZBTB38	7	9	16	541.832
#305	TP53	7	8	15	358.468
#306	MEF2D	7	1	8	1618.942
#307	PBX1	7	8	15	743.949
#308	FOXI3	7	7	14	443.854
#309	MNX1	7	12	19	2313.06
#310	FOXP1	7	22	29	3697.252
#311	BACH1	7	9	16	1036.661
#312	RUNX1T1	7	13	20	710.776
#313	TGIF2LY	7	7	14	570.953
#314	SCML1	7	6	13	1855.064
#315	HNRNPAB	7	11	18	804.435
#316	FOXD4	7	8	15	1630.335
#317	ZFPM2	7	11	18	1176.538
#318	DDIT3	7	8	15	1393.671
#319	POU3F1	7	2	9	41.923
#320	HOXA10	7	12	19	951.715
#321	HIF1A	7	6	13	1440.801
#322	KLF3	7	13	20	2129.738
#323	YY1	7	11	18	1691.24
#324	ATF4	7	21	28	6142.223
#325	ZNF445	7	16	23	1872.261
#326	RUNX1	7	14	21	1495.728
#327	TCFL5	7	18	25	1394.641
#328	LHX3	6	13	19	1161.871
#329	BTG2	6	6	12	434.167
#330	SNAPC5	6	15	21	1096.875
#331	HOXC4	6	12	18	702.938
#332	EN2	6	10	16	434.392
#333	NR4A2	6	12	18	878.121
#334	NR3C1	6	11	17	1361.545
#335	AHCTF1	6	6	12	178.396
#336	NFE2	6	5	11	312.616
#337	ZNF213	6	9	15	989.95
#338	NPAS2	6	12	18	579.254
#339	ZNF135	6	17	23	1955.53
#340	NEUROD1	6	14	20	1165.642
#341	RARA	6	10	16	747.742
#342	NFE2L1	6	13	19	1614.388
#343	USF2	6	13	19	487
#344	PHF5A	6	13	19	2200.009
#345	TRIM25	6	7	13	476.939
#346	ZBTB25	6	9	15	602.886
#347	ESR2	6	9	15	680.051
#348	MTA1	6	12	18	553.049
#349	CREM	6	13	19	1952.348
#350	SUPT4H1	6	14	20	369.442
#351	EGR1	6	13	19	1309.513
#352	NFIX	6	14	20	1042.15
#353	MEIS1	6	15	21	856.765
#354	MYCN	6	9	15	385.162
#355	CREBBP	6	11	17	961.482
#356	HMGA2	6	11	17	3129.668
#357	BLZF1	6	7	13	366.489
#358	EVX1	6	10	16	383.505
#359	IRX2	6	15	21	1615.426
#360	SPI1	6	12	18	1263.71
#361	SPDEF	6	14	20	2718.009
#362	HES5	6	6	12	258.342
#363	ADNP2	5	10	15	1220.073
#364	CREB3	5	9	14	1682.062
#365	ATF6	5	8	13	1133.83
#366	FOXO3	5	4	9	896.548
#367	ELF4	5	13	18	1106.506
#368	WNT5A	5	12	17	1122.353
#369	SOLH	5	12	17	761.515
#370	TARDBP	5	8	13	829.296
#371	TEAD2	5	3	8	766.345
#372	ZXDA	5	4	9	313.029
#373	ARNTL	5	12	17	896.383
#374	MSX2	5	14	19	1222.646
#375	NFIB	5	13	18	656.518
#376	NR2F1	5	14	19	1522.96
#377	HCLS1	5	12	17	1176.465
#378	FOXK1	5	12	17	804.262
#379	HMGB1	5	14	19	1281.553
#380	ZKSCAN4	5	9	14	413.222
#381	POU5F2	5	5	10	421.176
#382	ZSCAN2	5	14	19	1482.324
#383	EN1	5	13	18	1868.447
#384	VENTX	5	12	17	1657.846
#385	TSC22D2	5	8	13	598.622
#386	ONECUT2	5	8	13	522.007
#387	FOSL2	5	15	20	1554.89
#388	KLF15	5	16	21	995.79
#389	TBX6	5	14	19	1810.644
#390	E4F1	5	10	15	763.417
#391	NFKB2	5	9	14	1033.026
#392	MITF	5	13	18	1058.241
#393	NKX2-1	5	12	17	1165.47
#394	EOMES	5	9	14	1644.798
#395	CNOT7	5	15	20	1607.995
#396	DMTF1	5	10	15	358.276
#397	LHX5	5	9	14	424.608
#398	PCGF6	5	15	20	2056.441
#399	HAND2	5	8	13	578.811
#400	NFIA	4	18	22	438.04
#401	SIX3	4	13	17	602.875
#402	SMAD1	4	11	15	384.432
#403	GTF2IRD1	4	6	10	336.252
#404	ATF2	4	11	15	478.744
#405	SOX10	4	11	15	719.398
#406	AEBP1	4	4	8	747.775
#407	NOTCH1	4	12	16	746.74
#408	ARNTL2	4	4	8	175.585
#409	HEYL	4	11	15	1700.586
#410	NR4A3	4	12	16	801.803
#411	POU4F2	4	15	19	1784.734
#412	BARX1	4	17	21	1229.127
#413	IRX5	4	11	15	734.178
#414	GTF2H3	4	10	14	960.413
#415	DMRT2	4	15	19	1119.573
#416	ARNT	4	7	11	1520.792
#417	MEIS3	4	13	17	1082.191
#418	SRF	4	17	21	935.011
#419	CEBPB	4	10	14	815.467
#420	ZNF202	4	6	10	221.387
#421	HNF4A	4	9	13	577.513
#422	RBPJ	4	5	9	582.24
#423	TFDP3	4	6	10	452.105
#424	RFXANK	4	9	13	375.725
#425	HOXB3	4	10	14	1154.536
#426	FOXA1	4	15	19	780.385
#427	NFE2L2	4	7	11	404.718
#428	TFCP2	4	13	17	684.462
#429	LHX9	4	14	18	895.946
#430	UHRF1	4	16	20	1566.02
#431	ANKRD30A	4	8	12	297.57
#432	AR	4	9	13	486.332
#433	STAT5A	4	10	14	691.661
#434	NR1D1	4	14	18	1941.625
#435	LMO4	4	15	19	410.196
#436	SCAND2	4	12	16	1821.162
#437	ZSCAN16	4	13	17	280.625
#438	HOXC13	4	8	12	466.817
#439	VAV1	3	9	12	774.93
#440	POU5F1	3	14	17	767.19
#441	ELK3	3	12	15	527.114
#442	FOXN3	3	12	15	694.545
#443	EGR4	3	4	7	320.282
#444	E2F8	3	14	17	1569.709
#445	ZSCAN4	3	16	19	983.101
#446	NFE2L3	3	15	18	392.236
#447	PROX1	3	15	18	710.805
#448	MLLT10	3	8	11	349.595
#449	MYF6	3	13	16	659.134
#450	SOX2	3	13	16	814.511
#451	NR2F6	3	18	21	767.856
#452	TCF7	3	11	14	567.295
#453	TRIM28	3	5	8	478.037
#454	NFIL3	3	9	12	1489.579
#455	FOXM1	3	9	12	181.061
#456	HR	3	22	25	264.037
#457	ZNF189	3	10	13	305.634
#458	MGA	3	13	16	822.976
#459	REL	3	17	20	1268.955
#460	FOSB	3	8	11	351.186
#461	ZNF75D	3	5	8	450.231
#462	NME2	3	15	18	401.217
#463	SIX6	3	8	11	393.99
#464	RELB	3	14	17	1267.235
#465	CRX	3	13	16	753.084
#466	CUX1	3	9	12	280.561
#467	PAX8	3	5	8	259.156
#468	FOSL1	3	14	17	550.968
#469	FOS	2	11	13	1419.464
#470	RORB	2	11	13	330.549
#471	MLX	2	11	13	228.341
#472	SPEN	2	12	14	607.043
#473	MYOG	2	13	15	359.275
#474	ESRRA	2	17	19	862.679
#475	CTCF	2	13	15	227.042
#476	UBN1	2	15	17	329.619
#477	ZIC1	2	12	14	946.159
#478	NFYC	2	14	16	208.152
#479	JUN	2	16	18	534.399
#480	KCNH8	2	13	15	627.282
#481	TEF	2	12	14	284.607
#482	ERG	2	6	8	225.39
#483	ZSCAN10	2	11	13	669.498
#484	RB1	2	14	16	923.472
#485	PITX1	2	12	14	171.781
#486	STAT2	2	9	11	326.761
#487	ZFHX2	2	6	8	187.182
#488	TLX3	1	7	8	1019.401
#489	TRIM29	1	10	11	172.076
#490	ZNF277	1	13	14	697.979
#491	MYPOP	1	11	12	165.444
#492	BTAF1	1	11	12	66.013
#493	BARHL1	1	13	14	141.162
#494	CTNNB1	1	20	21	240.702
#495	ZNF207	1	12	13	232.373
#496	PRRX1	1	18	19	110.322
#497	HOXA11	0	14	14	0
#498	TCF7L1	0	14	14	0
#499	LEF1	0	10	10	0
#500	E2F1	0	18	18	0