Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	IRF4	40	7	47	1901.624
#2	KLF15	35	2	37	297.073
#3	HOXC12	35	6	41	7398.806
#4	ETV1	35	3	38	2625.895
#5	SOLH	35	4	39	1336.817
#6	SATB1	35	2	37	76.057
#7	IKZF3	34	4	38	1925.161
#8	DLX6	32	7	39	642.418
#9	MSX2	32	8	40	811.236
#10	NR1D2	32	4	36	128.005
#11	NR1H4	32	3	35	110.068
#12	TFEC	32	0	32	0
#13	MTF1	31	6	37	2866.661
#14	SIX3	31	1	32	46.858
#15	NKX2-1	31	7	38	3497.761
#16	ZIC5	30	3	33	111.655
#17	POU4F3	30	8	38	1968.384
#18	HOXD12	30	4	34	166.75
#19	MEOX1	29	6	35	1996.075
#20	STAT5B	29	7	36	8008.87
#21	E2F8	29	7	36	1478.85
#22	SNAPC4	28	7	35	1203.853
#23	MTA1	28	2	30	728.954
#24	HOXD1	28	5	33	2282.843
#25	VDR	28	7	35	912.171
#26	ZNF33A	27	11	38	805.198
#27	IRX1	27	11	38	4059.589
#28	BARHL2	27	12	39	4061.37
#29	CREB3L3	27	3	30	1554.906
#30	TARDBP	27	13	40	5462.843
#31	IRF2	27	4	31	2372.931
#32	NFE2L2	27	5	32	719.709
#33	LASS2	26	5	31	630.706
#34	LHX9	26	17	43	7035.049
#35	STRN3	25	8	33	221.956
#36	FOXC2	25	6	31	3187.611
#37	RELA	25	7	32	1554.889
#38	STAT1	25	6	31	1680.926
#39	SPDEF	25	4	29	688.81
#40	ZNF446	24	6	30	1704.515
#41	ESR1	24	9	33	751.322
#42	AEBP1	24	5	29	4643.928
#43	ZBTB25	23	8	31	1838.822
#44	CEBPA	23	8	31	1045.628
#45	TFE3	23	7	30	177.441
#46	SIM1	23	9	32	3442.165
#47	USF2	23	5	28	941.136
#48	PPARG	23	8	31	286.262
#49	RCOR1	22	8	30	1949.801
#50	STAT4	22	4	26	1444.61
#51	TEAD3	22	4	26	2550.26
#52	HIF3A	22	9	31	581.422
#53	ETV3L	21	9	30	846.298
#54	NKX1-2	21	6	27	4220.755
#55	MSRB2	21	4	25	1075.48
#56	SRF	21	6	27	410.2
#57	ZNF80	21	6	27	150.23
#58	CITED2	20	10	30	1634.624
#59	ZNF483	20	8	28	1662.173
#60	SOX6	20	11	31	6608.281
#61	SCML2	20	11	31	3605.986
#62	HES1	20	7	27	1098.411
#63	ZNF434	20	11	31	2420.249
#64	CEBPD	20	6	26	80.511
#65	NPAT	19	6	25	803.441
#66	SPI1	19	6	25	1923.838
#67	ZNF496	19	4	23	590.342
#68	PLSCR1	19	9	28	2322.534
#69	CDX2	19	8	27	1704.231
#70	ETV4	19	11	30	15391.172
#71	NOTCH1	19	6	25	2378.359
#72	GTF2I	19	11	30	1471.316
#73	MESP1	19	6	25	136.433
#74	GRHL3	19	11	30	3252.467
#75	ELF1	19	15	34	5746.549
#76	MLLT10	19	9	28	682.534
#77	RARB	19	11	30	1516.483
#78	SRY	19	3	22	27.336
#79	SP3	18	7	25	688.203
#80	KLF5	18	11	29	750.985
#81	SOX11	18	2	20	68.683
#82	ATF3	18	4	22	1087.322
#83	HOXB4	18	10	28	3343.099
#84	RBPJ	18	10	28	1022.941
#85	ARNTL2	18	11	29	2677.595
#86	FOXP4	17	7	24	2347.185
#87	MYCN	17	14	31	4581.973
#88	PLAGL2	17	13	30	4144.99
#89	TRIM25	17	8	25	264.96
#90	ZNF396	17	8	25	1377.309
#91	GCM1	17	15	32	4819.414
#92	ESRRG	17	17	34	2832.548
#93	SP4	17	14	31	2209.144
#94	MLL	17	10	27	5692.744
#95	ZIM2	17	13	30	709.441
#96	ADNP2	17	10	27	1446.064
#97	KLF17	17	9	26	9765.81
#98	IRF7	17	8	25	2044.91
#99	CBL	16	13	29	3245.904
#100	IRF5	16	6	22	1149.873
#101	ZNF238	16	7	23	1036.479
#102	RFX5	16	12	28	3042.534
#103	PPARA	16	10	26	2694.728
#104	MSC	16	3	19	1064.044
#105	TBX15	16	7	23	1862.381
#106	ARX	16	9	25	939.538
#107	GTF2IRD1	16	8	24	1926.317
#108	ZSCAN12	16	10	26	767.398
#109	NR2F6	16	2	18	91.927
#110	FOXA1	16	8	24	788.819
#111	CSRNP1	16	1	17	62.537
#112	NFAT5	16	11	27	295.074
#113	TSC22D4	16	13	29	7848.252
#114	CTCF	16	10	26	899.26
#115	TAF13	15	7	22	384.688
#116	BACH1	15	11	26	3166.226
#117	NFATC1	15	11	26	2311.651
#118	ARNT	15	8	23	850.54
#119	BTAF1	15	11	26	3339.89
#120	IKZF1	15	10	25	867.403
#121	KLF4	15	2	17	300.393
#122	SNAPC2	15	10	25	2083.537
#123	ZNF167	15	9	24	666.832
#124	SMAD3	15	4	19	37.944
#125	POU5F1	15	7	22	335.286
#126	HDAC1	15	5	20	2480.898
#127	SCAND3	15	7	22	367.247
#128	ZC3H8	15	1	16	253.585
#129	HOXC6	14	9	23	2377.016
#130	GATA3	14	9	23	4337.802
#131	SMAD1	14	6	20	744.426
#132	TBX21	14	7	21	907.602
#133	NFIX	14	12	26	919.171
#134	TSHZ1	14	13	27	2362.177
#135	ZIC1	14	13	27	1550.818
#136	ZNF287	14	14	28	1594.075
#137	ZNF133	14	14	28	1815.197
#138	PHOX2B	14	12	26	1330.227
#139	ZNF397	14	11	25	3524.094
#140	SMAD4	14	11	25	4016.227
#141	SOX7	14	3	17	483.628
#142	MLXIPL	14	6	20	1839.167
#143	NFKB1	14	10	24	2091.67
#144	ZNF367	14	9	23	351.648
#145	FOXE1	14	4	18	388.834
#146	CREBZF	14	11	25	4282.565
#147	TFCP2	14	13	27	2235.145
#148	CREB3L1	14	3	17	141.417
#149	TFDP2	14	9	23	10307.77
#150	CNBP	14	11	25	2609.206
#151	STAT2	14	10	24	2694.986
#152	FOXA2	14	13	27	472.82
#153	YBX1	14	7	21	251.888
#154	ERF	14	11	25	1150.542
#155	C1orf85	14	7	21	145.35
#156	TFEB	13	12	25	1895.145
#157	TFAM	13	10	23	1256.495
#158	ZNF236	13	14	27	1461.145
#159	TCF4	13	8	21	545.342
#160	ZSCAN18	13	10	23	3233.264
#161	PITX1	13	15	28	3078.792
#162	FOXK1	13	11	24	1541.272
#163	FOXP2	13	14	27	5649.047
#164	NFYA	13	13	26	1354.49
#165	HIRA	13	8	21	4085.184
#166	SLC2A4RG	13	2	15	326.103
#167	ATF5	13	12	25	2165.426
#168	SOX21	13	11	24	1472.989
#169	TULP4	13	9	22	1632.465
#170	YY1	13	7	20	1712.187
#171	MZF1	13	12	25	3643.507
#172	FOSB	13	5	18	343.439
#173	MEOX2	13	15	28	4699.616
#174	UBN1	13	13	26	3523.126
#175	HOXA1	13	8	21	7990.609
#176	NR5A2	12	9	21	1225.841
#177	ESRRA	12	9	21	1390.896
#178	FOXQ1	12	6	18	1204.067
#179	HNF4G	12	5	17	303.724
#180	ZNF24	12	10	22	302.094
#181	HOXB7	12	14	26	2538.808
#182	NKX2-3	12	4	16	417.196
#183	SCRT1	12	10	22	2289.387
#184	AATF	12	6	18	722.109
#185	ZNF90	12	16	28	3568.947
#186	PFDN1	12	6	18	300.332
#187	TCF19	12	15	27	3547.608
#188	NFYC	12	9	21	144.649
#189	TP53	11	14	25	733.731
#190	TCF7	11	6	17	467.415
#191	E4F1	11	13	24	4379.564
#192	AHCTF1	11	11	22	1250.935
#193	ATF4	11	15	26	1661.826
#194	MEIS3	11	6	17	2351.278
#195	IKZF4	11	13	24	3329.807
#196	FOS	11	12	23	3808.084
#197	HOXB9	11	8	19	1833.366
#198	GBX1	11	7	18	974.286
#199	DMTF1	11	12	23	1647
#200	SNAPC5	11	14	25	2185.766
#201	EDF1	11	10	21	2566.533
#202	EVX1	11	12	23	1858.463
#203	PAX7	11	13	24	2015.321
#204	DDIT3	11	12	23	419.521
#205	REXO4	10	8	18	533.468
#206	TEAD1	10	10	20	492.245
#207	GATA5	10	10	20	712.158
#208	MBD1	10	4	14	111.215
#209	CTNNB1	10	3	13	376.088
#210	NR1D1	10	5	15	848.078
#211	NANOGP1	10	10	20	752.061
#212	IRX6	10	6	16	315.381
#213	ANKRD30A	10	10	20	231.294
#214	FOXC1	10	19	29	1876.596
#215	SOX17	10	14	24	1690.11
#216	MAFB	10	8	18	772.509
#217	FOXP3	10	11	21	1542.909
#218	AFF4	10	15	25	2694.444
#219	NPAS2	10	6	16	412.283
#220	GBX2	10	15	25	733.382
#221	GABPB1	10	11	21	498.022
#222	CREBBP	10	5	15	191.924
#223	PLAG1	10	9	19	569.504
#224	KLF12	10	8	18	566.648
#225	ZNF498	10	13	23	368.803
#226	FOXJ3	10	9	19	988.806
#227	TRIM29	10	13	23	2777.796
#228	TCF7L2	9	15	24	1248.428
#229	FOXO4	9	9	18	306.432
#230	USF1	9	6	15	180.294
#231	WNT5A	9	9	18	3910.033
#232	ELK1	9	10	19	511.914
#233	LBX2	9	11	20	4165.578
#234	ELF5	9	5	14	109.525
#235	ARID4A	9	16	25	4608.404
#236	ARNTL	9	4	13	91.003
#237	TP73	9	11	20	1983.421
#238	ESR2	9	14	23	1583.685
#239	GSX1	9	7	16	367.227
#240	NCOR1	9	4	13	180.767
#241	JUN	9	10	19	2105.483
#242	AR	9	5	14	381.314
#243	DBP	9	2	11	40.671
#244	FLI1	9	13	22	935.778
#245	ETV5	9	15	24	4671.792
#246	AFF1	9	15	24	5299.266
#247	TSC22D2	9	16	25	1165.852
#248	KLF11	9	11	20	320.304
#249	EN1	9	10	19	1461.048
#250	ETV6	9	8	17	1177.517
#251	HOXA10	9	8	17	438.941
#252	DLX2	9	13	22	861.882
#253	VAX2	8	13	21	1778.093
#254	SP1	8	6	14	271.827
#255	SCML1	8	13	21	1878.496
#256	TCEAL1	8	7	15	3835.277
#257	NKX6-1	8	6	14	820.043
#258	CREM	8	13	21	2086.782
#259	MAFK	8	14	22	1571.1
#260	MYOG	8	5	13	598.416
#261	ZFP90	8	13	21	1216.397
#262	DLX3	8	5	13	572.691
#263	HNRNPK	8	9	17	1061.238
#264	ZNF215	8	15	23	952.349
#265	PGR	8	21	29	7915.889
#266	NFATC3	8	7	15	2900.099
#267	NR1H2	8	12	20	2031.746
#268	ERG	8	8	16	1554.234
#269	TADA2A	8	4	12	199.377
#270	SPIB	8	6	14	459.673
#271	TFAP2B	8	15	23	1350.355
#272	E2F3	8	14	22	748.827
#273	ZNF197	8	4	12	659.772
#274	TP63	8	14	22	4858.954
#275	SUPT6H	8	5	13	394.399
#276	PA2G4	8	9	17	1297.778
#277	TFAP2A	7	14	21	516.945
#278	CNOT8	7	16	23	2007.417
#279	E2F4	7	12	19	2543.45
#280	IRX3	7	14	21	2451.594
#281	FUBP1	7	14	21	1898.282
#282	CREB5	7	18	25	2819.878
#283	LMX1A	7	11	18	2188.102
#284	NFX1	7	14	21	1118.893
#285	GAS7	7	18	25	1955.833
#286	MECOM	7	12	19	2918.892
#287	MNT	7	7	14	446.073
#288	ZIC2	7	8	15	275.754
#289	FOXJ1	7	15	22	3851.772
#290	GCFC1	7	11	18	616.201
#291	SOX30	7	11	18	532.452
#292	ZNF91	7	7	14	717.996
#293	FOXS1	7	10	17	227.884
#294	ZNF135	7	12	19	1145.154
#295	LCOR	7	9	16	1319.205
#296	FOXF2	7	7	14	229.554
#297	CEBPB	7	19	26	2378.512
#298	NFIB	7	4	11	159.629
#299	NFKB2	7	13	20	849.366
#300	THRA	7	14	21	962.496
#301	TCF7L1	6	11	17	7986.322
#302	MMP14	6	21	27	1155.456
#303	ZKSCAN1	6	9	15	644.417
#304	SPEN	6	15	21	861.206
#305	IRX4	6	11	17	470.413
#306	NFYB	6	12	18	941.391
#307	TAF10	6	9	15	461.744
#308	LHX5	6	16	22	644.765
#309	MYC	6	12	18	874.295
#310	ZFHX4	6	13	19	1529.986
#311	HINFP	6	14	20	520.891
#312	SIM2	6	11	17	488.629
#313	ZNF217	6	9	15	247.244
#314	GATA2	6	12	18	1039.347
#315	ZNF154	6	16	22	1555.876
#316	TBP	6	5	11	105.428
#317	MYT1L	6	18	24	3300.792
#318	TBX3	6	12	18	347.638
#319	HES5	6	14	20	2997.169
#320	MYF6	6	13	19	526.787
#321	ZSCAN29	6	18	24	2968.21
#322	SMAD9	6	15	21	5143.811
#323	PURA	6	16	22	989.674
#324	SOX9	6	6	12	110.898
#325	ZIC3	6	9	15	435.198
#326	ELF4	6	11	17	340.487
#327	NR2F1	6	11	17	499.47
#328	ZFP42	6	3	9	196.623
#329	RELB	6	17	23	1981.385
#330	NFIA	6	17	23	1200.489
#331	MAFF	6	9	15	288.17
#332	TSHZ2	6	6	12	50.059
#333	E2F2	6	6	12	1890.808
#334	MIXL1	6	10	16	305.801
#335	GATAD2B	6	10	16	1650.804
#336	ETV3	6	5	11	273.796
#337	ZNF41	6	14	20	2541.65
#338	PRRX2	6	11	17	708.562
#339	ZNF117	6	12	18	455.061
#340	ZHX3	5	12	17	1313.648
#341	TGIF1	5	14	19	2173.963
#342	FOXO3	5	10	15	2064.178
#343	RORA	5	15	20	947.079
#344	POU1F1	5	9	14	282.749
#345	FOXN2	5	8	13	1888.654
#346	FOSL1	5	11	16	1201.211
#347	TRIM28	5	17	22	2951.862
#348	OLIG2	5	10	15	333.476
#349	HNF1B	5	11	16	933.427
#350	EGR3	5	15	20	1066.158
#351	CUX2	5	18	23	1628.392
#352	ZFHX2	5	11	16	977.177
#353	GTF2H4	5	8	13	525.779
#354	LZTS1	5	4	9	26.547
#355	ATF7	5	18	23	436.617
#356	TEAD2	5	11	16	294.412
#357	RNF4	5	8	13	111.905
#358	ZHX1	5	12	17	557.179
#359	LEUTX	5	8	13	668.594
#360	ALX4	5	14	19	1316.591
#361	RCOR2	5	11	16	1069.272
#362	FOXA3	5	12	17	296.582
#363	ZXDC	5	14	19	767.471
#364	FOXP1	5	9	14	86.532
#365	HNF1A	5	16	21	1224.046
#366	ZNF92	5	10	15	780.114
#367	NFIC	5	17	22	4842.057
#368	IRX2	5	17	22	524.443
#369	SMAD6	5	13	18	1694.282
#370	MEF2A	4	13	17	283.658
#371	LHX6	4	12	16	1259.332
#372	TEAD4	4	15	19	1215.275
#373	ZNF174	4	9	13	391.156
#374	CREB3L2	4	11	15	7991.082
#375	HNF4A	4	16	20	545.771
#376	CRX	4	10	14	261.85
#377	RB1	4	14	18	664.392
#378	KLF3	4	14	18	440.335
#379	PROX1	4	15	19	1651.774
#380	IRF1	4	15	19	653.768
#381	SREBF2	4	9	13	445.715
#382	GRHL2	4	9	13	259.885
#383	ZNF165	4	9	13	2695.265
#384	ZNF187	4	15	19	1103.195
#385	PAX8	4	3	7	107.117
#386	HMGB1	4	14	18	656.793
#387	PURB	4	15	19	1584.054
#388	OTX1	4	14	18	600.735
#389	BCL3	4	17	21	1762.084
#390	PBX3	4	8	12	619.904
#391	GLI2	4	12	16	698.386
#392	SMAD2	4	11	15	59.313
#393	NR3C1	4	10	14	545.706
#394	ETS2	4	14	18	4999.897
#395	FOXE3	4	8	12	495.145
#396	HOXB1	4	16	20	1585.215
#397	ZNF75D	4	4	8	120.407
#398	THRB	4	17	21	1500.866
#399	RXRA	4	7	11	131.917
#400	C12orf28	4	17	21	1938.888
#401	L3MBTL4	4	11	15	11062.448
#402	FOXM1	4	10	14	2137.137
#403	SIX6	4	11	15	373.218
#404	HOXD4	4	13	17	1003.001
#405	FEV	4	15	19	1533.453
#406	ELK4	4	6	10	307.205
#407	DMRT1	4	7	11	349.788
#408	HOXA9	3	15	18	338.616
#409	SOX2	3	5	8	759.083
#410	MAX	3	17	20	1251.558
#411	PBX1	3	16	19	402.955
#412	SOX18	3	17	20	2851.455
#413	OVOL1	3	16	19	1188.411
#414	ZSCAN2	3	12	15	193.223
#415	SOX12	3	12	15	96.903
#416	ELF3	3	7	10	27.146
#417	EMX1	3	20	23	284.249
#418	SCAND2	3	18	21	1377.523
#419	ZNF3	3	14	17	698.833
#420	TGIF2LY	3	11	14	675.948
#421	MEIS2	3	12	15	69.502
#422	E2F1	3	17	20	843.065
#423	ZNF85	3	15	18	1467.577
#424	STAT3	3	10	13	1115.024
#425	ZKSCAN3	3	13	16	450.313
#426	HCFC1	3	17	20	187.023
#427	ATF2	3	21	24	2462.759
#428	ST18	3	15	18	810.882
#429	FOXF1	3	10	13	291.786
#430	RUNX1	3	18	21	614.397
#431	FOXK2	3	18	21	707.198
#432	PHOX2A	3	15	18	1240.665
#433	FOSL2	3	11	14	399.61
#434	TAF5	3	10	13	480.414
#435	PHTF1	3	13	16	4221.729
#436	SNAI2	3	4	7	82.209
#437	HOXB6	3	13	16	532.454
#438	RERE	3	16	19	523.208
#439	ZSCAN10	3	11	14	162.786
#440	MSX1	3	19	22	397.596
#441	PRDM1	3	23	26	1064.56
#442	ESRRB	3	10	13	254.549
#443	ZNF189	3	9	12	3359.745
#444	HOXD13	3	6	9	44.807
#445	PAX5	3	15	18	444.889
#446	KLF10	2	16	18	260.497
#447	MEIS1	2	12	14	2152.043
#448	CSDA	2	7	9	717.238
#449	CDKN2A	2	19	21	572.89
#450	ZBTB17	2	12	14	2395.072
#451	FOXD2	2	13	15	1241.657
#452	CTBP1	2	13	15	811.73
#453	HEY2	2	16	18	381.468
#454	MEF2C	2	13	15	392.74
#455	ISL1	2	17	19	874.411
#456	TCF25	2	17	19	984.452
#457	MITF	2	18	20	156.684
#458	CSRNP2	2	16	18	1044.811
#459	HDX	2	16	18	125.576
#460	LZTR1	2	19	21	138.83
#461	LHX3	2	13	15	695.207
#462	TBX22	2	15	17	2692.968
#463	SCMH1	2	13	15	948.456
#464	TAF7	2	10	12	107.821
#465	NOLC1	2	17	19	217.701
#466	REST	2	10	12	183.563
#467	HMX1	2	18	20	1192.129
#468	ZKSCAN4	2	17	19	339.309
#469	BCL11B	2	12	14	1578.546
#470	SOX8	2	11	13	3108.011
#471	MYPOP	2	15	17	810.779
#472	ZNF202	1	11	12	1523.43
#473	ZRANB2	1	15	16	569.299
#474	KLF2	1	15	16	180.849
#475	CREB1	1	11	12	197.054
#476	ZNF628	1	13	14	1522.653
#477	CBFA2T3	1	14	15	118.656
#478	TBX5	1	15	16	235.941
#479	TFDP1	1	6	7	3862.492
#480	ZNF207	1	17	18	53.841
#481	DLX1	1	18	19	1235.065
#482	ZNF323	1	14	15	131.474
#483	ZNF148	1	12	13	204.972
#484	BLZF1	1	12	13	2817.656
#485	ZNF445	1	9	10	445.268
#486	ZNF449	1	15	16	320.106
#487	HIF1A	1	15	16	494.818
#488	UBP1	1	14	15	506.461
#489	GATAD2A	1	10	11	227.225
#490	TRPS1	1	20	21	623.109
#491	RXRG	1	12	13	101.025
#492	PKNOX2	1	20	21	614.958
#493	ESX1	1	7	8	104.722
#494	MTA2	1	10	11	1547.942
#495	SIN3A	0	16	16	0
#496	HOMEZ	0	18	18	0
#497	GLI3	0	11	11	0
#498	RHOXF1	0	15	15	0
#499	MGA	0	17	17	0
#500	HOXB3	0	15	15	0