Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	KLF3	93	4	97	1758.464
#2	XBP1	82	7	89	515.231
#3	BCL6	81	6	87	4186.171
#4	GRHL2	71	2	73	106.978
#5	IRF6	70	2	72	28.61
#6	EPAS1	67	5	72	361.658
#7	KLF5	66	6	72	734.006
#8	ETS1	63	7	70	637.488
#9	KDM5B	62	13	75	1236.161
#10	SPDEF	61	4	65	133.082
#11	CREB3L4	59	4	63	189.199
#12	OVOL1	58	1	59	997.548
#13	PAX3	58	1	59	23.385
#14	FOSL2	57	10	67	1821.216
#15	ELK3	56	13	69	1948.506
#16	ZEB2	56	7	63	1065.559
#17	MITF	55	15	70	2528.499
#18	NR2F2	55	5	60	448.387
#19	ZEB1	53	6	59	682.77
#20	NR3C1	53	8	61	738.622
#21	ETV5	52	8	60	2539.888
#22	FOSL1	52	8	60	315.627
#23	HNF4A	52	3	55	88.098
#24	ELF1	49	8	57	2073.796
#25	GATA6	49	13	62	980.898
#26	TRPS1	48	10	58	751.321
#27	SOX13	48	13	61	1495.662
#28	NFIC	47	9	56	1018.983
#29	TCF3	47	7	54	1482.173
#30	AHR	47	10	57	856.029
#31	RXRA	46	13	59	1767.605
#32	FOXA1	45	9	54	1556.398
#33	HOXA9	44	4	48	276.465
#34	SOX10	44	3	47	76.92
#35	LASS6	44	13	57	1418.851
#36	TCF7L2	44	13	57	2179.498
#37	TEAD1	42	13	55	531.234
#38	PLSCR1	42	24	66	2360.038
#39	ELF3	42	5	47	52.452
#40	ZNF165	41	5	46	126.034
#41	HMG20B	41	16	57	1644.074
#42	ZNF274	40	10	50	1278.269
#43	MEIS3P1	39	19	58	2273.486
#44	SOX9	39	15	54	1759.995
#45	IRF8	38	8	46	1395.713
#46	LZTS1	38	6	44	363.047
#47	IKZF1	38	3	41	366.273
#48	GAS7	38	3	41	381.805
#49	PBX1	38	14	52	534.817
#50	MYC	37	7	44	1530.056
#51	IRX5	37	7	44	124.369
#52	ZSCAN16	36	10	46	183.26
#53	ZNF217	36	14	50	1647.27
#54	CREB3L2	36	15	51	1179.786
#55	ASCL2	36	11	47	1235.713
#56	ZNF238	35	16	51	1251.031
#57	RUNX1	35	19	54	2344.058
#58	SMAD4	35	13	48	3715.057
#59	HOXC10	35	7	42	622.618
#60	EHF	34	12	46	375.101
#61	PKNOX2	34	5	39	692.283
#62	SIX1	34	15	49	1084.865
#63	MAFF	33	18	51	1084.63
#64	HMGB2	32	10	42	1536.869
#65	POU3F2	32	17	49	2712.252
#66	TFCP2L1	32	14	46	1128.744
#67	HES6	32	21	53	1631.559
#68	TAF5	32	11	43	1349.868
#69	SREBF2	31	20	51	2044.904
#70	HCLS1	31	8	39	274.689
#71	BCL3	31	13	44	926.195
#72	IRF1	31	16	47	841.915
#73	FOXP4	31	18	49	1573.524
#74	TFAP2A	30	25	55	2181.3
#75	KLF4	30	12	42	401.517
#76	SOX12	30	13	43	489.289
#77	TEAD3	30	12	42	1858.303
#78	ETS2	29	16	45	1115.05
#79	UHRF1	29	10	39	1393.747
#80	ALX1	29	10	39	1052.102
#81	FOXD3	29	7	36	169.865
#82	GATA3	29	16	45	1293.138
#83	FOXQ1	29	15	44	1053.99
#84	E2F7	28	23	51	1535.778
#85	PROX1	28	13	41	1088.991
#86	TWIST2	28	18	46	1330.305
#87	POU2F2	28	12	40	2232.599
#88	CDX2	28	5	33	1023.788
#89	EBF1	28	13	41	1805.835
#90	TCF7	28	8	36	874.634
#91	CSDA	27	23	50	2185.775
#92	HOXA10	27	10	37	781.23
#93	TFAP2C	27	21	48	2060.08
#94	FOXG1	27	13	40	3028.698
#95	TAF4B	27	17	44	1891.717
#96	E2F2	26	20	46	1254.92
#97	CREM	26	18	44	2486.954
#98	ESR1	26	10	36	628.253
#99	HOXA13	26	10	36	326.837
#100	HNF4G	26	8	34	126.074
#101	NR2F6	26	12	38	533.443
#102	SPIB	26	4	30	439.447
#103	BTG2	26	21	47	2086.576
#104	ZHX2	26	21	47	2045.502
#105	IRX3	25	16	41	974.397
#106	TEAD4	25	13	38	600.041
#107	SOX6	25	9	34	493.52
#108	SMAD1	25	15	40	2308.361
#109	CSRNP3	25	13	38	1283.263
#110	SNAI2	25	16	41	908.653
#111	HOXC13	25	9	34	319.996
#112	SATB2	25	18	43	1936.665
#113	TBX3	24	18	42	1807.06
#114	MAFK	24	19	43	1924.681
#115	ZNF134	24	13	37	326.151
#116	AFF1	24	12	36	306.4
#117	CEBPB	24	14	38	1122.426
#118	HMGA2	24	15	39	666.623
#119	KLF11	24	18	42	771.506
#120	TCEAL1	24	12	36	856.35
#121	PITX2	24	18	42	1236.499
#122	ETV1	24	14	38	748.373
#123	HES1	23	16	39	2176.223
#124	HOXB6	23	10	33	533.726
#125	KLF15	23	19	42	1023.311
#126	MEF2C	23	24	47	1292.612
#127	VDR	23	13	36	559.759
#128	HOXD13	23	15	38	2555.194
#129	ZNF138	22	11	33	883.633
#130	NFXL1	22	14	36	1137.205
#131	HOXB5	22	9	31	962.011
#132	REL	22	16	38	977.943
#133	MYCL1	22	20	42	2360.851
#134	CLOCK	22	19	41	1016.891
#135	ZFP37	22	19	41	1701.083
#136	DRAP1	22	14	36	642.093
#137	SOX30	22	10	32	1759.64
#138	NR2F1	22	20	42	963.039
#139	BARX1	21	11	32	1652.715
#140	FOXM1	21	7	28	383.594
#141	ZIC1	21	21	42	938.514
#142	SIX3	21	12	33	1048.463
#143	ESRRG	21	16	37	1676.123
#144	CBL	21	15	36	778.906
#145	TRIM29	21	12	33	359.925
#146	RCAN1	21	22	43	2005.134
#147	CITED2	21	16	37	1015.215
#148	GLIS2	21	24	45	2213.732
#149	RXRG	21	9	30	217.451
#150	BACH2	21	16	37	1326.617
#151	HOXC9	21	20	41	2229.262
#152	FOXO6	21	19	40	2198.216
#153	ARNTL2	21	20	41	549.306
#154	GATAD2B	21	20	41	864.139
#155	SMAD3	21	16	37	857.983
#156	ZFP36L2	21	19	40	800.095
#157	NR0B1	20	15	35	1190.517
#158	TSC22D3	20	22	42	841.627
#159	MSX1	20	20	40	1400.675
#160	DLX1	20	19	39	644.822
#161	TGIF2	20	23	43	1441.86
#162	DDIT3	20	17	37	1340.731
#163	C12orf28	20	16	36	682.576
#164	ETV4	20	19	39	1732.673
#165	BATF3	20	16	36	1154.943
#166	FOXA2	20	15	35	942.634
#167	CUX1	20	18	38	947.546
#168	ZNF643	20	14	34	504.195
#169	ZXDA	20	8	28	618.888
#170	MXD1	20	15	35	452.524
#171	CEBPA	20	18	38	612.44
#172	HOXD8	20	14	34	2059.488
#173	DLX2	20	14	34	183.21
#174	HOXB7	19	13	32	1671.041
#175	GTF2IRD1	19	24	43	2202.512
#176	GLI3	19	16	35	791.412
#177	AEBP1	19	16	35	444.863
#178	ZNF496	19	20	39	1802.646
#179	RUNX1T1	19	15	34	956.404
#180	ZSCAN18	19	14	33	852.046
#181	NOTCH1	19	14	33	2963.828
#182	FOXA3	19	13	32	549.333
#183	SLC2A4RG	18	17	35	1153.133
#184	HOXB8	18	10	28	404.434
#185	ZFHX3	18	18	36	2484.442
#186	IRF4	18	10	28	711.149
#187	SP4	18	22	40	1421.182
#188	ZBTB38	18	19	37	675.881
#189	ZKSCAN1	18	19	37	914.236
#190	HOXA11	18	9	27	230.337
#191	SALL1	18	20	38	1505.77
#192	THRB	18	16	34	789.583
#193	MAF	18	13	31	641.907
#194	MMP14	18	22	40	1046.103
#195	VAV1	18	14	32	623.445
#196	SOX11	18	18	36	3319.289
#197	POU4F1	18	19	37	2810.442
#198	MYBL2	17	11	28	961.384
#199	LEF1	17	25	42	982.584
#200	PPARG	17	23	40	880.061
#201	MSX2	17	19	36	868.286
#202	HOXA7	17	9	26	334.43
#203	NFE2L3	17	21	38	390.425
#204	HOXA3	17	15	32	696.706
#205	RB1	17	20	37	3590.682
#206	FOXC2	17	13	30	1223.388
#207	NFATC1	17	17	34	592.172
#208	RFXAP	17	17	34	1145.76
#209	NFYA	17	20	37	875.305
#210	MGA	17	12	29	726.34
#211	CREBZF	17	20	37	907.887
#212	MEOX1	17	10	27	705.789
#213	PHF1	17	24	41	1635.55
#214	TARDBP	17	23	40	1417.518
#215	LHX2	16	17	33	608.32
#216	PGBD1	16	11	27	327.678
#217	SOX8	16	20	36	902.642
#218	NEUROD1	16	5	21	619.412
#219	HOXA4	16	17	33	1063.731
#220	HMGB1	16	17	33	1458.176
#221	ZNF639	16	17	33	1260.888
#222	TWIST1	16	26	42	1330.984
#223	ARID3A	16	20	36	1394.841
#224	NFKB2	16	21	37	763.013
#225	ANKRD30A	16	9	25	600.361
#226	GLIS3	16	23	39	805.618
#227	SUPT4H1	16	17	33	1037.193
#228	JUNB	16	15	31	556.91
#229	ZNF85	16	12	28	398.511
#230	HOXC4	16	18	34	888.317
#231	PRRX1	16	23	39	1042.216
#232	OLIG2	16	12	28	435.214
#233	C1orf85	16	28	44	3347.821
#234	RORC	16	13	29	3237.43
#235	MEOX2	16	16	32	927.536
#236	PEG3	15	22	37	1721.435
#237	STAT5B	15	26	41	1602.473
#238	HOXB3	15	9	24	120.931
#239	EN2	15	15	30	652.694
#240	MYT1	15	10	25	749.934
#241	FUBP1	15	16	31	790.623
#242	MSRB2	15	27	42	2235.911
#243	SIX4	15	11	26	119.655
#244	PHTF1	15	18	33	426.879
#245	NR4A3	15	15	30	604.129
#246	ELF4	15	16	31	934.933
#247	SIM1	15	14	29	2102.688
#248	SOX4	15	19	34	883.322
#249	RARA	15	15	30	545.322
#250	NPAS2	15	21	36	625.541
#251	HOXA5	14	14	28	659.716
#252	PITX1	14	20	34	1103.924
#253	TFDP2	14	24	38	1595.098
#254	NKX2-1	14	17	31	1256.586
#255	RUNX3	14	20	34	571.655
#256	FOXE1	14	18	32	1129.804
#257	CBFA2T3	14	17	31	771.376
#258	FOXF1	14	13	27	574.165
#259	NFIX	14	20	34	1264.254
#260	MSC	14	17	31	1310.719
#261	STAT6	14	29	43	3050.448
#262	C11orf9	14	15	29	209.297
#263	JUN	14	24	38	1631.235
#264	MEIS2	14	29	43	2253.845
#265	KLF10	14	20	34	872.513
#266	VTN	13	8	21	510.583
#267	JDP2	13	25	38	445.601
#268	NR1D2	13	22	35	766.01
#269	ZNF232	13	27	40	2041.592
#270	SMAD9	13	29	42	1268.141
#271	KLF6	13	15	28	1200.455
#272	ZNF93	13	18	31	878.242
#273	SREBF1	13	16	29	1072.802
#274	GATA4	13	18	31	1027.123
#275	PLAGL2	13	20	33	1256.262
#276	PGR	13	11	24	205.38
#277	GLI2	13	18	31	733.685
#278	KLF7	13	25	38	1805.65
#279	SALL2	13	32	45	1380.261
#280	SPEN	13	17	30	740.641
#281	C2orf3	13	18	31	879.771
#282	RBCK1	13	24	37	930.137
#283	ZNF3	13	14	27	371.573
#284	NFE2L2	12	21	33	958.769
#285	ZNF140	12	17	29	652.134
#286	PRRX2	12	18	30	890.695
#287	GATAD1	12	24	36	1744.115
#288	CREBL2	12	22	34	1809.773
#289	FOXL2	12	22	34	1847.487
#290	ZIC2	12	26	38	1241.27
#291	STAT3	12	19	31	959.055
#292	TFE3	12	30	42	2321.692
#293	ZNF91	12	16	28	706.916
#294	MAFB	12	24	36	1064.642
#295	TRERF1	12	23	35	1537.541
#296	TFCP2	12	26	38	1315.615
#297	E2F8	12	18	30	1212.228
#298	ZNF148	12	24	36	696.185
#299	EN1	12	15	27	891.538
#300	MYCN	12	21	33	1133.281
#301	HOXD4	12	14	26	393.139
#302	SMAD2	12	21	33	1128.243
#303	BHLHE40	11	27	38	777.522
#304	NCOR1	11	10	21	431.383
#305	MEF2A	11	16	27	265.367
#306	RUNX2	11	21	32	596.789
#307	HOXD10	11	20	31	1416.791
#308	MEIS1	11	23	34	1384.33
#309	ELF5	11	15	26	493.311
#310	C5orf41	11	16	27	896.455
#311	ST18	11	8	19	209.52
#312	TFEB	11	15	26	663.277
#313	TBX2	11	16	27	582.259
#314	ZFP36L1	11	36	47	1846.878
#315	HOXA1	11	22	33	1118.041
#316	CEBPD	11	21	32	447.005
#317	MNX1	11	21	32	1022.236
#318	SOX17	11	8	19	379.99
#319	NFIA	11	27	38	825.149
#320	NFIB	11	19	30	399.678
#321	FOXF2	11	23	34	663.722
#322	ZNF71	11	19	30	588.358
#323	HOPX	11	18	29	640.966
#324	ARNT	11	26	37	951.282
#325	HEY2	10	28	38	1131.976
#326	ZNF277	10	18	28	904.736
#327	ADNP2	10	24	34	2013.36
#328	T	10	9	19	772.444
#329	ZFPM2	10	23	33	1167.46
#330	TCF19	10	17	27	489.908
#331	HOXB9	10	16	26	243.004
#332	PCGF2	10	22	32	489.721
#333	E2F1	10	11	21	196.44
#334	DLX6	10	25	35	970.317
#335	IRF9	10	18	28	500.346
#336	RFX5	10	15	25	436.305
#337	CNOT7	10	25	35	759.138
#338	MECOM	10	24	34	1498.404
#339	ZHX1	10	25	35	732.008
#340	STAT4	10	13	23	761.133
#341	STRN3	10	14	24	686.193
#342	DLX4	10	22	32	2535.599
#343	HMX2	10	18	28	829.826
#344	TCF7L1	10	23	33	518.65
#345	HMGA1	10	17	27	560.542
#346	HNF1B	10	23	33	667.979
#347	DBP	10	19	29	653.741
#348	LMO4	10	27	37	1958.503
#349	PRDM2	9	21	30	609.877
#350	SIN3A	9	26	35	1111.367
#351	ETV6	9	33	42	1843.723
#352	ATF7	9	19	28	596.61
#353	KLF9	9	31	40	856.125
#354	FOXC1	9	32	41	879.511
#355	GATA2	9	25	34	679.194
#356	CTNNB1	9	27	36	513.943
#357	SOX2	9	36	45	2372.817
#358	RXRB	9	26	35	1026.697
#359	NFAT5	9	32	41	1567.838
#360	MLL	9	18	27	287.973
#361	PLAG1	9	15	24	419.112
#362	SLC30A9	9	19	28	480.015
#363	SOX7	9	17	26	833.615
#364	MBD1	9	20	29	454.37
#365	HOXB2	9	23	32	766.227
#366	TCF4	9	29	38	1600.979
#367	TSHZ3	9	24	33	1909.034
#368	SCML1	9	25	34	835.286
#369	PBX3	9	22	31	771.117
#370	SOX15	9	15	24	510.96
#371	STAT1	9	17	26	877.71
#372	AR	9	21	30	834.259
#373	BNC1	9	15	24	681.946
#374	ISX	8	10	18	355.963
#375	ASCL1	8	10	18	332.449
#376	PBX2	8	20	28	499.713
#377	BATF	8	16	24	236.669
#378	MEF2D	8	24	32	710.911
#379	ZFHX4	8	18	26	353.332
#380	ARX	8	14	22	352.05
#381	NR4A2	8	19	27	701.533
#382	IRX4	8	16	24	529.43
#383	ARNT2	8	27	35	391.752
#384	BCL11B	8	17	25	211.303
#385	MKX	8	25	33	1257.507
#386	E2F5	8	25	33	1598.035
#387	FLI1	8	15	23	608.852
#388	LHX8	8	12	20	524.199
#389	HEY1	8	25	33	673.748
#390	CITED1	8	20	28	607.123
#391	RARG	8	22	30	729.595
#392	HHEX	8	31	39	1180.379
#393	SCAND1	8	23	31	764.2
#394	FOXL1	8	21	29	948.427
#395	FOXO3	7	22	29	754.071
#396	TFDP1	7	29	36	2340.107
#397	CDKN2A	7	26	33	1777.854
#398	HOXC11	7	16	23	346.277
#399	PAX8	7	7	14	203.071
#400	TEF	7	20	27	761.741
#401	NFIL3	7	24	31	1105.441
#402	NR3C2	7	18	25	650.847
#403	ATF5	7	25	32	612.43
#404	PAX6	7	25	32	489.268
#405	ZGPAT	7	18	25	413.688
#406	FOXD1	7	37	44	982.924
#407	TAF13	7	15	22	646.553
#408	HINFP	7	22	29	489.712
#409	EGR3	7	20	27	550.884
#410	SLC26A3	7	4	11	85.726
#411	IRX2	7	23	30	141.231
#412	ZNF175	7	26	33	840.434
#413	TSHZ1	7	39	46	1127.03
#414	IRF2	7	23	30	736.715
#415	TCFL5	7	22	29	549.695
#416	ZNF45	7	24	31	738.074
#417	CBFA2T2	7	22	29	322.282
#418	KDM5A	6	23	29	522.97
#419	ZNF397	6	26	32	404.51
#420	SMAD5	6	26	32	1801.838
#421	ZFP90	6	22	28	1072.811
#422	TP63	6	25	31	505.832
#423	ZNF117	6	22	28	466.861
#424	PPARA	6	22	28	266.575
#425	ZNF256	6	16	22	487.467
#426	HMBOX1	6	25	31	448.742
#427	TSC22D1	6	30	36	926.898
#428	NR4A1	6	14	20	309.262
#429	NR1H3	6	17	23	316.693
#430	NFE2	6	12	18	324.965
#431	ZNF323	6	31	37	940.608
#432	ISL1	6	20	26	865.36
#433	NR5A2	6	26	32	1795.771
#434	TP53	6	30	36	1369.302
#435	EGR2	6	15	21	573.714
#436	ZNF70	6	26	32	544.532
#437	HSF1	6	29	35	565.742
#438	HOXA2	5	14	19	257.04
#439	SIX2	5	31	36	461.424
#440	CREB5	5	25	30	620.445
#441	KLF12	5	31	36	819.957
#442	ZNF83	5	21	26	392.98
#443	FOXO1	5	34	39	443.157
#444	RELB	5	23	28	387.324
#445	SIM2	5	24	29	1614.663
#446	ZNF207	5	23	28	371.707
#447	HR	5	26	31	989.883
#448	RORA	5	16	21	476.256
#449	TULP4	5	26	31	653.365
#450	PPARD	5	20	25	1457.345
#451	RARB	5	23	28	386.247
#452	EGR1	5	24	29	226.25
#453	SATB1	5	35	40	650.659
#454	RERE	5	24	29	1426.465
#455	NR2E1	5	8	13	222.728
#456	HOXB13	5	28	33	680.386
#457	ZNF215	4	20	24	446.2
#458	BHLHE41	4	34	38	430.825
#459	DMRT2	4	19	23	526.306
#460	KLF2	4	21	25	338.805
#461	NFX1	4	28	32	401.763
#462	ZNF174	4	25	29	361.061
#463	ISL2	4	23	27	363.892
#464	ZNF268	4	21	25	307.553
#465	NFATC2	4	20	24	720.177
#466	FOXN3	4	31	35	914.833
#467	FOXP1	4	29	33	929.956
#468	TEAD2	4	27	31	358.395
#469	FOXP2	4	28	32	1341.547
#470	ZNF133	4	32	36	337.02
#471	ZNF33B	4	23	27	763.697
#472	SMAD6	4	22	26	342.217
#473	ARNTL	3	24	27	236.744
#474	TFEC	3	14	17	159.269
#475	TRIM22	3	25	28	152.586
#476	BACH1	3	28	31	292.169
#477	SUPT6H	3	27	30	422.02
#478	NKX2-5	3	24	27	482.504
#479	WT1	3	30	33	397.585
#480	ZNF131	3	29	32	469.501
#481	ZFP42	3	14	17	283.427
#482	TFAP2B	3	15	18	113.313
#483	MLLT10	3	25	28	223.468
#484	MESP1	3	28	31	600.223
#485	WNT5A	3	37	40	273.832
#486	LHX6	3	27	30	1243.448
#487	IRF7	3	31	34	469.239
#488	ONECUT2	3	25	28	326.938
#489	ATF3	2	26	28	219.495
#490	FOS	2	28	30	81.847
#491	HOXD1	2	19	21	198.723
#492	PURB	2	30	32	135.458
#493	FOXR2	2	16	18	252.889
#494	GRHL3	1	25	26	547.516
#495	TBX1	1	32	33	78.55
#496	NKX3-1	1	31	32	373.455
#497	CTBP1	1	32	33	584.52
#498	PRDM1	1	36	37	33.619
#499	CREB3L1	1	32	33	96.015
#500	TGIF1	0	32	32	0