Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NR3C1	77	0	77	0
#2	TCF7L2	73	4	77	1257.99
#3	HOXA3	70	1	71	17.556
#4	EBF1	69	2	71	65.188
#5	EPAS1	64	5	69	266.661
#6	PHF1	61	5	66	473.084
#7	FOXO1	61	6	67	158.674
#8	AFF1	59	8	67	882.512
#9	ENO1	55	3	58	840.256
#10	HOXA5	54	6	60	297.996
#11	SCAND1	53	1	54	49.824
#12	YBX1	51	6	57	1332.936
#13	RFXANK	50	7	57	1177.444
#14	LASS2	49	10	59	1204.387
#15	TP63	48	1	49	6.236
#16	HNRNPAB	47	10	57	2184.058
#17	NFYC	47	1	48	4807.645
#18	MEIS2	47	10	57	5276.958
#19	C1orf85	46	8	54	1160.613
#20	IRX1	43	4	47	33.107
#21	STAT3	43	3	46	190.732
#22	LASS6	42	10	52	4524.116
#23	RUNX1T1	42	9	51	1693.861
#24	ZRANB2	41	4	45	775.721
#25	SLC2A4RG	41	14	55	2293.574
#26	NR3C2	40	7	47	1689.939
#27	C5orf41	40	4	44	540.043
#28	MSRB2	38	8	46	1192.19
#29	UHRF1	38	8	46	3233.659
#30	RELA	38	4	42	67.097
#31	HMG20B	38	6	44	275.285
#32	TFDP2	37	11	48	661.767
#33	TAF4	37	9	46	5639.125
#34	SOX10	36	8	44	1509.731
#35	TFDP1	36	11	47	1268.432
#36	CSRNP3	36	7	43	669.603
#37	CSDA	35	13	48	4514.865
#38	TCF7L1	34	16	50	1541.404
#39	SP4	34	9	43	1302.994
#40	E2F5	34	19	53	6461.996
#41	E2F8	34	13	47	1648.157
#42	TSC22D1	34	14	48	3436.032
#43	KDM5B	34	12	46	5481.696
#44	ZEB1	33	5	38	1063.948
#45	MNT	33	13	46	3269.83
#46	RXRB	33	5	38	421.104
#47	TSHZ1	33	8	41	564.706
#48	IRX2	31	10	41	1185.718
#49	HLF	31	10	41	223.424
#50	TRIM28	31	6	37	673.58
#51	SATB1	30	13	43	522.589
#52	IRF3	30	9	39	4115.881
#53	TEAD1	30	14	44	5433.271
#54	MLLT10	30	11	41	663.576
#55	ERG	29	4	33	46.807
#56	CNOT7	28	6	34	294.451
#57	SPDEF	28	10	38	1027.363
#58	NFIB	28	15	43	3186.558
#59	CNOT8	27	9	36	1073.954
#60	TAF10	27	8	35	548.457
#61	HOXA2	27	8	35	1519.315
#62	TFCP2	26	9	35	289.884
#63	CREBBP	26	8	34	334.926
#64	MLX	26	9	35	842.379
#65	IRX3	26	13	39	4366.371
#66	BHLHE41	25	9	34	120.384
#67	TEAD4	25	12	37	834.628
#68	DRAP1	25	10	35	1011.023
#69	GATA3	25	10	35	2298.886
#70	ESR1	25	16	41	4775.926
#71	ZNF367	25	10	35	1031.62
#72	MEOX1	25	9	34	314.186
#73	MITF	25	11	36	909.274
#74	SIX2	25	17	42	2142.771
#75	HSF1	24	11	35	772.72
#76	NFX1	24	11	35	742.719
#77	NR1H2	24	13	37	857.471
#78	SMAD3	24	12	36	573.36
#79	NFIC	24	14	38	6073.111
#80	ZEB2	24	3	27	45.784
#81	ARNT	24	16	40	2410.064
#82	ETV1	24	11	35	949.151
#83	ZFPM2	23	7	30	119.855
#84	ZNF207	23	7	30	1571.245
#85	KLF11	23	10	33	4047.93
#86	PEG3	23	13	36	6037.027
#87	MEOX2	23	9	32	838.821
#88	CREB3L4	23	12	35	1391.702
#89	PTTG1	23	11	34	409.179
#90	HDAC1	22	15	37	2164.66
#91	CSRNP2	22	12	34	1027.287
#92	SALL2	22	10	32	4462.454
#93	FOXO3	22	12	34	2871.016
#94	KLF3	22	10	32	602.706
#95	FLI1	22	6	28	201.929
#96	STAT5A	21	10	31	581.72
#97	FOXM1	21	6	27	455.684
#98	KLF2	21	13	34	1590.722
#99	ADNP	21	9	30	1742.677
#100	CREB3	20	13	33	1073.141
#101	TAF4B	20	11	31	997.333
#102	PITX1	20	17	37	3107.574
#103	SMAD4	20	8	28	1069.747
#104	TFEC	20	10	30	2438.456
#105	TFAP2A	20	7	27	1021.82
#106	STAT5B	20	13	33	6021.75
#107	TEAD2	20	10	30	3254.536
#108	MAX	20	8	28	470.666
#109	XBP1	20	14	34	1058.679
#110	MTA1	20	13	33	1549.447
#111	MEF2C	20	11	31	304.212
#112	TCF4	20	9	29	3828.744
#113	IRF9	20	15	35	966.418
#114	TFAP2C	20	15	35	1613.356
#115	TWIST2	20	8	28	978.362
#116	CSRNP1	19	6	25	517.083
#117	FOXN3	19	13	32	2026.079
#118	TSHZ2	19	14	33	3468.446
#119	SLC30A9	19	13	32	2576.221
#120	EGR1	19	13	32	1216.596
#121	ZFP90	19	14	33	1012.888
#122	PPARG	19	9	28	607.426
#123	NFYA	19	13	32	2109.609
#124	ELK3	19	13	32	596.907
#125	TCF7	19	10	29	1453.428
#126	NFXL1	19	12	31	1713.491
#127	KLF4	19	10	29	996.835
#128	TCF3	19	17	36	2213.52
#129	ZNF148	19	15	34	1501.329
#130	PLSCR1	19	22	41	3306.35
#131	RFX5	18	17	35	3500.324
#132	EGR3	18	7	25	367.963
#133	KLF10	18	13	31	1241.784
#134	BTAF1	18	7	25	411.408
#135	ETV5	18	19	37	1690.315
#136	RORA	18	10	28	1802.45
#137	EDF1	18	12	30	2706.576
#138	FOXN2	18	15	33	551.14
#139	RCAN1	18	15	33	417.894
#140	YEATS4	18	17	35	5781.003
#141	CREBZF	18	9	27	450.696
#142	CEBPA	17	13	30	2971.017
#143	TAF12	17	8	25	742.493
#144	HOXC10	17	18	35	8223.063
#145	JUND	17	9	26	1524.664
#146	TWIST1	17	8	25	321.057
#147	SMAD9	17	14	31	1393.432
#148	GTF2I	17	3	20	229.754
#149	CREM	17	14	31	3563.582
#150	GRHL2	17	14	31	974.38
#151	ZNF397	17	12	29	2521.896
#152	SOLH	17	9	26	273.403
#153	ECSIT	17	16	33	3678.263
#154	NR4A1	16	5	21	1469.732
#155	ETS2	16	13	29	4338.786
#156	ATF2	16	8	24	712.507
#157	RB1	16	12	28	1162.337
#158	ELF5	16	12	28	1883.207
#159	BUD31	16	12	28	201.006
#160	NR2F2	16	11	27	519.244
#161	FOSB	16	1	17	287.596
#162	ATF1	16	10	26	1236.189
#163	NR2F6	16	17	33	1988.554
#164	ZBTB38	16	13	29	3393.414
#165	TP53	15	12	27	6758.808
#166	ZNF394	15	10	25	2726.553
#167	TULP4	15	14	29	2924.451
#168	TBX3	15	15	30	1886.9
#169	ARID4A	15	10	25	2041.642
#170	IRF2	15	13	28	3816.963
#171	CBFA2T2	15	10	25	900.522
#172	MEIS3P1	15	17	32	5293.694
#173	BHLHE40	15	14	29	988.172
#174	LZTS1	15	6	21	45.502
#175	ZNF138	14	14	28	1669.105
#176	TRIM29	14	15	29	1100.994
#177	GAS7	14	13	27	1488.908
#178	TCEAL1	14	12	26	1555.272
#179	HOXA7	14	7	21	68.313
#180	MAFF	14	17	31	754.762
#181	TSHZ3	14	14	28	1476.555
#182	GATAD1	14	13	27	606.792
#183	SOX4	14	15	29	3316.004
#184	TBX15	14	10	24	1503.073
#185	FOXA1	14	8	22	574.019
#186	ZNF217	14	11	25	681.239
#187	IRX5	13	11	24	767.887
#188	EGR2	13	16	29	1247.267
#189	NFIA	13	16	29	1462.643
#190	KLF9	13	15	28	2734.118
#191	ZFHX4	13	10	23	901.336
#192	FOXC1	13	21	34	2852.169
#193	RCOR1	13	16	29	1691.661
#194	HOXB2	13	12	25	1079.102
#195	MYC	13	24	37	2875.632
#196	JUN	13	7	20	1793.763
#197	L3MBTL4	13	13	26	314.796
#198	MLL	13	18	31	1823.392
#199	FOXP1	13	6	19	127.598
#200	ATF3	13	9	22	422.451
#201	RERE	13	9	22	546.171
#202	HCLS1	13	11	24	1442.354
#203	CREBL2	12	12	24	207.718
#204	FOXO6	12	14	26	2109.926
#205	FBXW7	12	13	25	1315.011
#206	ZNF70	12	13	25	1093.832
#207	ZNF33A	12	18	30	1066.562
#208	ZFHX3	12	17	29	4357.016
#209	DMTF1	12	11	23	484.806
#210	BACH1	12	16	28	1598.389
#211	KLF5	12	13	25	174.049
#212	NOLC1	12	15	27	689.863
#213	PBX1	12	15	27	1865.702
#214	TADA3	12	9	21	216.951
#215	MGA	12	12	24	1351.071
#216	ZNF83	12	10	22	737.59
#217	STAT1	12	18	30	1057.02
#218	SMAD2	12	14	26	604.376
#219	CTNNB1	12	11	23	1815.757
#220	ZNF140	11	22	33	6921.931
#221	HMGA1	11	16	27	490.035
#222	ZNF639	11	16	27	1068.863
#223	E4F1	11	20	31	2710.341
#224	TRERF1	11	16	27	2121.517
#225	REL	11	17	28	268.318
#226	BCL6	11	16	27	3961.823
#227	CREB3L1	11	17	28	792.948
#228	FOXP2	11	9	20	818.212
#229	HIC1	11	14	25	652.646
#230	BLZF1	11	12	23	1852.321
#231	FOXK1	11	21	32	2480.178
#232	HOPX	11	21	32	2751.422
#233	GTF2H4	11	17	28	884.776
#234	CITED2	11	15	26	759.581
#235	HOXA9	11	12	23	1298.675
#236	CREB1	11	13	24	1361.808
#237	MTA3	11	16	27	1345.095
#238	MEF2D	11	23	34	4472.997
#239	RBCK1	11	14	25	392.206
#240	ZC3H8	11	15	26	3047.751
#241	GTF2H3	11	12	23	1238.965
#242	SIX4	10	16	26	3906.13
#243	SMAD5	10	19	29	1416.329
#244	ZNF277	10	9	19	1250.656
#245	JDP2	10	13	23	1206.149
#246	RFXAP	10	10	20	788.501
#247	ZSCAN29	10	19	29	3234.046
#248	RBPJ	10	21	31	2349.039
#249	CDKN2A	10	9	19	507.955
#250	GLI3	10	21	31	1030.249
#251	HMGB2	10	17	27	5883.453
#252	SOX7	10	13	23	292.431
#253	ZNF281	10	13	23	654.987
#254	SP1	10	11	21	625.797
#255	NFAT5	10	16	26	1778.225
#256	MYBL2	10	14	24	645.702
#257	THRB	10	17	27	2611.487
#258	GTF2H2	10	11	21	872.744
#259	PCGF2	10	14	24	601.917
#260	TFE3	10	13	23	6381.539
#261	TCFL5	9	17	26	3436.043
#262	HOXD8	9	12	21	353.854
#263	SOX6	9	16	25	777.73
#264	LMO4	9	21	30	3684.396
#265	ZNF274	9	11	20	2210.45
#266	AR	9	15	24	2754.986
#267	JUNB	9	7	16	1527.589
#268	FOSL2	9	14	23	1438.474
#269	ZSCAN18	9	30	39	1456.6
#270	ETV6	9	16	25	3417.54
#271	AHCTF1	9	13	22	986.185
#272	IRF6	9	18	27	8653.841
#273	ELF4	9	13	22	655.321
#274	ARNT2	9	24	33	1128.815
#275	PA2G4	9	17	26	1535.562
#276	STAT2	9	12	21	1998.162
#277	SIX1	8	21	29	2169.745
#278	FOXQ1	8	16	24	723.302
#279	NR2C1	8	17	25	1993.472
#280	IRF7	8	14	22	1022.166
#281	HOXB13	8	14	22	624.123
#282	FOXD1	8	8	16	1068.935
#283	NFKB2	8	12	20	990.214
#284	TAF7	8	25	33	4492.042
#285	EHF	8	18	26	3653.316
#286	ZNF45	8	16	24	1169.071
#287	ZXDC	8	6	14	403.412
#288	AEBP1	8	14	22	2520.403
#289	SCML1	8	28	36	4753.187
#290	NR1H3	8	16	24	1635.537
#291	GATAD2B	8	15	23	382.525
#292	TFAM	8	13	21	1956.9
#293	MSX2	8	17	25	854.195
#294	MAFB	8	13	21	2931.701
#295	NFYB	8	11	19	772.057
#296	TCF12	8	10	18	146.844
#297	HES6	8	15	23	1850.09
#298	SUPT6H	8	11	19	3757.615
#299	ZHX3	7	15	22	1589.052
#300	LEF1	7	22	29	627.544
#301	FOS	7	12	19	330.633
#302	TFAP2B	7	25	32	3279.001
#303	HSF2	7	14	21	6474.656
#304	ASCL2	7	11	18	113.27
#305	TSC22D2	7	16	23	1714.109
#306	RUNX2	7	15	22	1240.8
#307	HIF1A	7	25	32	3042.92
#308	RARB	7	17	24	955.802
#309	NFE2L2	7	14	21	257.407
#310	MXD1	7	18	25	507.453
#311	HOXB7	7	20	27	825.878
#312	STAT6	7	9	16	498.807
#313	ZNF91	7	25	32	1249.083
#314	STRN3	7	16	23	2865.132
#315	HOXB6	7	16	23	1103.247
#316	NFATC4	7	19	26	1044.034
#317	GLIS2	7	14	21	2420.728
#318	GLI2	7	18	25	1293.717
#319	CEBPB	7	20	27	4071.67
#320	IKZF1	6	11	17	565.355
#321	ZKSCAN1	6	22	28	730.386
#322	TRIM22	6	17	23	489.744
#323	NFE2L3	6	19	25	1223.736
#324	ZNF37A	6	13	19	611.577
#325	RUNX1	6	20	26	1105.27
#326	AFF4	6	9	15	962.579
#327	ZNF131	6	17	23	1267.803
#328	RELB	6	14	20	129.785
#329	TRPS1	6	17	23	793.813
#330	SMAD1	6	22	28	1072.623
#331	PURA	6	21	27	922.516
#332	FUBP1	6	15	21	1063.645
#333	TFCP2L1	6	15	21	1269.588
#334	SOX9	6	19	25	2137.258
#335	ZGPAT	6	16	22	1284.079
#336	ATF7	6	16	22	723.129
#337	ETS1	6	16	22	4533.175
#338	MAFK	6	14	20	499.541
#339	SOX12	6	17	23	2952.526
#340	CTBP1	6	14	20	471.805
#341	HOXD4	6	20	26	1082.68
#342	CEBPD	6	13	19	898.714
#343	IRF8	6	14	20	1271.884
#344	ELF1	6	18	24	6075.671
#345	HEY2	6	12	18	282.806
#346	HHEX	6	16	22	1909.123
#347	POU2F3	6	13	19	1606.98
#348	ELF3	6	14	20	1211.604
#349	NKX3-1	5	15	20	1601.368
#350	LHX6	5	13	18	2684.243
#351	NFIX	5	17	22	1010.701
#352	TARDBP	5	20	25	1974.48
#353	ESRRG	5	24	29	1564.537
#354	PRRX1	5	13	18	3065.719
#355	TCF25	5	19	24	3360.17
#356	PGR	5	22	27	2748.103
#357	KLF12	5	18	23	777.674
#358	KLF15	5	15	20	1147.507
#359	GCFC1	5	13	18	1555.132
#360	FOXF2	5	12	17	565.281
#361	RORC	5	14	19	2763.265
#362	GABPA	5	13	18	744.686
#363	RARA	5	18	23	797.439
#364	OVOL1	5	15	20	220.779
#365	ZNF165	5	24	29	1999.372
#366	SNAI2	5	18	23	408.554
#367	ZFP36L2	5	13	18	140.323
#368	NR4A3	5	10	15	1445.222
#369	CUX1	5	20	25	334.557
#370	NFIL3	5	10	15	1022.589
#371	SPEN	5	19	24	1082.665
#372	HOXB3	5	19	24	535.151
#373	ZNF92	5	15	20	910.853
#374	PRDM1	4	13	17	1666.75
#375	NR2F1	4	22	26	3824.278
#376	ZNF238	4	21	25	800.384
#377	BCL11B	4	18	22	961.19
#378	SOX11	4	13	17	243.944
#379	ZFP36L1	4	22	26	1804.415
#380	SOX17	4	9	13	288.326
#381	MMP14	4	15	19	623.146
#382	HES1	4	18	22	282.603
#383	TEF	4	15	19	101.079
#384	PURB	4	16	20	953.78
#385	HOXA10	4	19	23	930.908
#386	ZIC2	4	13	17	273.982
#387	NFATC1	4	11	15	210.563
#388	IRF1	4	16	20	281.526
#389	ZHX1	4	22	26	4134.385
#390	KDM5A	4	8	12	1118.04
#391	SMAD6	4	10	14	61.269
#392	SP3	4	17	21	1660.175
#393	SIN3A	4	23	27	1166.426
#394	TCF15	4	13	17	3873.789
#395	SOX13	4	14	18	2410.421
#396	FOSL1	4	13	17	1053.091
#397	BATF2	4	17	21	560.461
#398	KLF16	4	12	16	862.321
#399	SIM2	4	22	26	770.708
#400	ZNF628	4	9	13	2988.288
#401	ARNTL2	4	17	21	245.115
#402	SCML2	4	18	22	1991.238
#403	TBX5	4	14	18	2507.65
#404	SOX5	4	14	18	631.561
#405	CNBP	4	11	15	27.576
#406	BATF	4	20	24	122.195
#407	HMGB1	4	18	22	2323.493
#408	NANOG	4	18	22	652.018
#409	NCOR1	4	13	17	817.997
#410	TAL1	4	14	18	1216.927
#411	TCF19	4	18	22	620.831
#412	SRF	3	16	19	714.341
#413	HEY1	3	17	20	105.995
#414	PPARA	3	18	21	802.663
#415	FOXK2	3	15	18	468.589
#416	SOX2	3	20	23	703.3
#417	ERF	3	16	19	1024.548
#418	TSC22D3	3	13	16	744.023
#419	NFATC2	3	19	22	839.129
#420	VDR	3	19	22	2949.003
#421	ATF5	3	16	19	1379.982
#422	GATA2	3	19	22	545.842
#423	FOXI1	3	17	20	744.701
#424	BTG2	3	12	15	132.293
#425	SREBF2	3	14	17	99.388
#426	ATF6	3	24	27	3293.592
#427	AHR	3	23	26	1775.94
#428	ZNF445	3	23	26	1297.712
#429	HIF3A	3	13	16	59.193
#430	FOXP4	3	16	19	492.957
#431	ETV4	3	14	17	289.1
#432	ZNF33B	3	13	16	929.579
#433	ZNF3	3	16	19	1436.303
#434	DLX1	3	9	12	65.587
#435	BACH2	3	17	20	157.445
#436	ZNF268	3	11	14	541.731
#437	KLF6	3	11	14	356.81
#438	TBX2	3	14	17	246.082
#439	GATAD2A	3	14	17	1090.3
#440	EOMES	3	13	16	1227.886
#441	SREBF1	3	17	20	89.361
#442	MEIS1	3	14	17	63.241
#443	MESP1	3	16	19	531.351
#444	SOX8	3	15	18	170.298
#445	REST	3	12	15	163.958
#446	NFATC3	3	19	22	431.495
#447	SOX15	3	11	14	344.501
#448	PBX3	2	17	19	1307.144
#449	HIRA	2	16	18	1186.006
#450	KLF7	2	15	17	89.353
#451	ZNF232	2	22	24	2008.805
#452	NR4A2	2	13	15	1159.869
#453	TGIF1	2	13	15	121.022
#454	HOXD10	2	19	21	644.857
#455	PBX2	2	15	17	1027.207
#456	WT1	2	18	20	902.9
#457	TBX10	2	10	12	59.766
#458	LCOR	2	15	17	97.349
#459	ZNF117	2	19	21	453.205
#460	PROX1	2	14	16	108.118
#461	TAF5	2	14	16	70.968
#462	MSX1	2	9	11	68.163
#463	IRX4	2	13	15	1183.521
#464	MAF	2	21	23	654.073
#465	SLC26A3	2	21	23	110.053
#466	GABPB1	2	17	19	326.532
#467	SOX18	2	17	19	960.443
#468	WNT5A	2	18	20	2504.91
#469	MLXIPL	2	13	15	153.532
#470	HOXC9	2	16	18	363.75
#471	ZNF167	2	16	18	591.988
#472	E2F3	2	21	23	336.351
#473	DLX2	1	15	16	1067.434
#474	BCL3	1	22	23	181.615
#475	ZIC1	1	22	23	862.124
#476	TGIF2	1	25	26	362.913
#477	EN1	1	16	17	121.894
#478	CITED1	1	20	21	43.34
#479	CREB5	1	13	14	520.059
#480	SPI1	1	18	19	113.162
#481	MKX	1	14	15	1733.888
#482	SATB2	1	26	27	97.447
#483	ARNTL	1	17	18	16.912
#484	FOXG1	1	6	7	4.016
#485	FOXA3	1	17	18	44.567
#486	CBL	1	18	19	448.754
#487	NR1D2	1	17	18	31.032
#488	ANKRD30A	1	21	22	398.317
#489	ZNF323	0	19	19	0
#490	NPAS2	0	24	24	0
#491	FOXC2	0	16	16	0
#492	ARX	0	13	13	0
#493	ASCL1	0	9	9	0
#494	IRF5	0	14	14	0
#495	SIM1	0	16	16	0
#496	HMBOX1	0	15	15	0
#497	RUNX3	0	17	17	0
#498	GATA6	0	16	16	0
#499	CUX2	0	12	12	0
#500	MECOM	0	17	17	0