Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NFE2L2	53	6	59	1083.437
#2	E2F7	51	5	56	643.628
#3	NKX2-1	49	9	58	1754.325
#4	RORC	49	3	52	264.908
#5	SNAI2	46	6	52	820.647
#6	HOPX	38	5	43	429.865
#7	TRIM29	38	12	50	1716.746
#8	TP63	38	5	43	1789.477
#9	CREB3L1	37	12	49	2053.208
#10	HNF1B	37	14	51	1334.864
#11	ZNF639	37	8	45	406.672
#12	SOX2	36	14	50	1528.491
#13	RUNX1T1	36	5	41	966.125
#14	MYBL2	35	4	39	95.811
#15	C5orf41	35	3	38	196.403
#16	BNC1	34	4	38	306.535
#17	WNT5A	33	9	42	324.849
#18	FOXD1	33	10	43	1224.926
#19	FOXE1	33	11	44	674.463
#20	GLI2	33	5	38	438.459
#21	TCF19	32	4	36	765.371
#22	ZNF75D	31	10	41	976.596
#23	GRHL3	31	5	36	264.736
#24	GABPA	31	8	39	635.661
#25	IRF6	31	7	38	174.908
#26	TGIF2	31	13	44	1794.703
#27	CBFB	30	5	35	153.695
#28	FOXA3	30	8	38	1658.63
#29	SMAD9	30	10	40	1613.943
#30	UHRF1	30	2	32	72.239
#31	DMRT2	30	10	40	1161.702
#32	TCF4	29	11	40	666.23
#33	ZNF131	29	5	34	545.65
#34	CSRNP1	29	5	34	443.764
#35	GAS7	29	8	37	353.492
#36	CBFA2T2	28	3	31	332.432
#37	PRRX1	28	9	37	1435.483
#38	MEF2C	28	5	33	683.197
#39	ZNF367	28	3	31	352.196
#40	TBX5	27	6	33	382.063
#41	MYNN	27	11	38	2294.354
#42	NR3C2	27	18	45	1636.383
#43	TCF21	27	8	35	517.027
#44	FLI1	26	10	36	703.936
#45	TWIST1	26	13	39	2812.217
#46	IRX5	26	13	39	1688.188
#47	IKZF1	25	2	27	594.901
#48	ARNTL2	25	16	41	963.765
#49	FOS	25	12	37	2220.315
#50	MEOX2	25	5	30	379.8
#51	SP1	25	7	32	1548.413
#52	DLX6	25	15	40	345.327
#53	HOXA1	25	15	40	1217.46
#54	MBD1	25	13	38	846.662
#55	FOXA2	24	15	39	2534.484
#56	NFIX	24	15	39	1688.635
#57	ZSCAN2	24	10	34	1532.732
#58	E2F5	24	16	40	1324.845
#59	PROX1	24	10	34	1215.894
#60	PEG3	24	8	32	2290.669
#61	PRDM2	23	12	35	1726.925
#62	ZNF33A	23	15	38	1571.949
#63	VDR	23	17	40	764.523
#64	EN1	23	6	29	2473.718
#65	PITX1	23	12	35	360.195
#66	TBX2	23	10	33	615.651
#67	RCAN1	23	19	42	1951.577
#68	IRX3	23	15	38	926.634
#69	NR2F1	23	10	33	2184.461
#70	ERF	23	14	37	1922.742
#71	FOSL1	23	11	34	3000.67
#72	HMGA1	22	9	31	237.972
#73	GATAD2B	22	11	33	1459.04
#74	MSX1	22	15	37	2267.373
#75	ATF6	22	6	28	404.24
#76	RUNX3	22	7	29	2007.058
#77	IRF8	22	3	25	447.822
#78	XBP1	22	11	33	1031.492
#79	TBX15	22	14	36	1095.323
#80	TARDBP	22	11	33	1613.716
#81	LEF1	22	13	35	1095.219
#82	MAFK	22	14	36	1310.398
#83	E2F3	22	13	35	1129.13
#84	MSC	21	8	29	2092.542
#85	CREBL2	21	9	30	758.827
#86	TCF3	21	14	35	1385.392
#87	ZC3H8	21	16	37	961.771
#88	ARNT	21	11	32	567.599
#89	KLF2	21	14	35	1979.225
#90	PAX6	21	12	33	5639.406
#91	SOX4	20	8	28	986.361
#92	TRIM22	20	6	26	378.662
#93	ZSCAN16	20	14	34	727.387
#94	ZNF3	20	5	25	1183.155
#95	FOSL2	20	17	37	2564.494
#96	ZNF281	20	14	34	847.522
#97	TFEC	20	5	25	354.96
#98	SMAD3	20	18	38	1619.895
#99	PBX3	20	12	32	1921.145
#100	LHX2	20	7	27	357.085
#101	LASS6	20	15	35	1666.837
#102	KLF15	20	11	31	1944.881
#103	MEIS3P1	20	14	34	1196.058
#104	NR4A1	19	9	28	810.184
#105	MAX	19	6	25	243.773
#106	LZTS1	19	17	36	1573.527
#107	HOXD13	19	10	29	1046.83
#108	ZNF93	19	12	31	1407.593
#109	TFAP2A	19	18	37	940.975
#110	FOXN3	19	8	27	1092.573
#111	SMAD4	19	5	24	497.085
#112	CNOT8	19	11	30	1484.975
#113	KLF9	19	9	28	732.645
#114	HHEX	19	15	34	915.129
#115	FOXP4	18	16	34	1132.701
#116	FOXM1	18	7	25	136.226
#117	OVOL1	18	12	30	633.516
#118	TSHZ3	18	9	27	628.595
#119	CCRN4L	18	11	29	1798.557
#120	SIX4	18	9	27	465.761
#121	CEBPA	18	14	32	1574.177
#122	MAFG	18	14	32	835.211
#123	HES6	18	14	32	1745.533
#124	ZFP36L2	18	11	29	1797.12
#125	TFCP2L1	18	17	35	1715.317
#126	FOXF1	18	11	29	705.448
#127	ZNF135	18	8	26	1290.408
#128	HOXA5	18	20	38	1424.797
#129	TFDP2	18	18	36	1195.256
#130	HOXC9	18	10	28	1082.828
#131	MECOM	18	17	35	2858.473
#132	IKZF4	18	15	33	2111.014
#133	ZNF397	18	14	32	2324.7
#134	ZKSCAN1	17	14	31	1160.427
#135	TAF4B	17	15	32	2644.945
#136	ZFPM2	17	10	27	693.639
#137	MAFB	17	10	27	534.696
#138	BHLHE40	17	14	31	965.904
#139	SPDEF	17	13	30	943.289
#140	ZNF643	17	12	29	1858.563
#141	BACH2	17	14	31	919.705
#142	ZNF207	17	14	31	1479.161
#143	TCF12	17	8	25	746.344
#144	FOSB	17	7	24	382.907
#145	ASCL1	17	15	32	1035.475
#146	TFEB	17	13	30	1149.568
#147	CTNNB1	17	10	27	1613.35
#148	BCL11B	17	18	35	1104.112
#149	CREB3L4	17	17	34	2137.046
#150	NFYC	17	10	27	497.474
#151	GATA3	17	16	33	3590.042
#152	FOXF2	17	10	27	509.741
#153	ZNF91	17	23	40	3382.716
#154	CITED2	17	11	28	1140.092
#155	TFAP2B	16	10	26	940.457
#156	ECSIT	16	14	30	925.563
#157	BATF3	16	13	29	2007.477
#158	E2F8	16	11	27	456.283
#159	SOX7	16	13	29	1441.061
#160	PGR	16	8	24	1515.688
#161	GABPB1	16	14	30	886.038
#162	HMGA2	16	16	32	1830.092
#163	NFIB	16	20	36	2704.508
#164	SMAD5	16	13	29	1981.768
#165	BATF	16	15	31	2243.838
#166	AEBP1	16	3	19	118.228
#167	MAF	16	14	30	673.492
#168	FOXJ2	16	12	28	1409.371
#169	ZNF238	16	17	33	384.139
#170	TAL1	16	11	27	1395.934
#171	EGR3	15	6	21	228.101
#172	TAF4	15	15	30	1654.852
#173	ETV1	15	20	35	1259.855
#174	ZEB2	15	7	22	662.998
#175	SPIC	15	6	21	786.199
#176	ST18	15	4	19	588.711
#177	PLAGL2	15	13	28	687.515
#178	MYCL1	15	15	30	795.338
#179	HR	15	8	23	109.365
#180	KCNH8	15	8	23	920.385
#181	ZNF236	15	12	27	1531.489
#182	IRF4	15	12	27	822.921
#183	NEUROD1	15	6	21	565.746
#184	GLI3	15	11	26	643.187
#185	RORA	15	15	30	705.219
#186	CREB3	15	10	25	887.85
#187	ZNF138	15	11	26	1598.815
#188	CEBPD	15	16	31	1529.999
#189	RELB	15	11	26	1181.216
#190	GATA2	14	16	30	1604.927
#191	GTF2H4	14	14	28	2284.236
#192	ZBTB25	14	17	31	1753.262
#193	AHR	14	19	33	1711.278
#194	ATF5	14	15	29	1205.086
#195	HOXB3	14	7	21	769.974
#196	SOX11	14	9	23	991.855
#197	ENO1	14	15	29	1039.499
#198	ETV6	14	11	25	1060.078
#199	NFATC1	14	13	27	876.353
#200	TAF13	14	16	30	1743.893
#201	HSF2	14	13	27	1443.102
#202	ATF2	14	18	32	1398.366
#203	IRF1	14	8	22	484.799
#204	ATF1	14	15	29	850.996
#205	NFATC2	14	10	24	825.722
#206	ETS2	13	19	32	1581.915
#207	KLF16	13	11	24	811.43
#208	NFE2	13	6	19	1411.168
#209	CNOT7	13	10	23	1426.712
#210	TEAD4	13	13	26	751.055
#211	FOXL2	13	9	22	293.693
#212	CREM	13	15	28	792.177
#213	CSDA	13	15	28	1159.946
#214	STAT4	13	18	31	997.338
#215	ZNF83	13	21	34	2730.927
#216	POU2F2	13	6	19	683.218
#217	RFXAP	13	16	29	1959.765
#218	VAV1	13	14	27	1168.935
#219	EGR1	13	9	22	354.711
#220	GATA6	13	19	32	1522.683
#221	LHX8	13	4	17	611.202
#222	KLF5	13	12	25	723.239
#223	C1orf85	13	13	26	613.106
#224	KLF4	13	18	31	1646.375
#225	IRF7	13	18	31	1084.927
#226	THRA	13	14	27	2000.467
#227	HOXC11	13	9	22	886.845
#228	NR4A3	13	17	30	1938.621
#229	SREBF2	13	14	27	1340.448
#230	FOXP2	13	18	31	2344.342
#231	HEYL	13	15	28	1542.803
#232	SP140	13	7	20	811.366
#233	HOXB7	13	17	30	1250.756
#234	ZNF70	13	14	27	1077.312
#235	RARB	13	18	31	985.373
#236	PBX1	13	19	32	1732.198
#237	DLX1	13	9	22	1583.047
#238	HCLS1	13	8	21	185.93
#239	MYCN	12	25	37	1909.21
#240	POU3F2	12	9	21	1606.333
#241	SIX2	12	15	27	1003.253
#242	MYC	12	20	32	1088.937
#243	HIF3A	12	15	27	1364.403
#244	BTG2	12	16	28	705.389
#245	L3MBTL4	12	22	34	1608.488
#246	MMP14	12	17	29	1157.969
#247	HOXA3	12	17	29	1401.727
#248	HOXD11	12	8	20	220.288
#249	SLC30A9	12	18	30	1222.808
#250	NR1H3	12	14	26	1341.775
#251	PRDM1	12	13	25	450.045
#252	GLIS2	12	16	28	1086.083
#253	MITF	12	14	26	811.859
#254	KLF6	12	15	27	1315.473
#255	TAF1B	12	19	31	2075.06
#256	ZXDC	12	12	24	511.827
#257	CREB3L2	12	17	29	2057.601
#258	TULP4	12	13	25	1149.365
#259	PLSCR1	12	12	24	1112.469
#260	NR2C1	12	16	28	856.096
#261	PURA	12	11	23	1124.578
#262	ZNF202	12	13	25	1461.867
#263	CUX1	12	15	27	1118.31
#264	HOXC4	12	14	26	1987.103
#265	RORB	12	5	17	258.864
#266	HOXB5	12	6	18	705.791
#267	ZNF498	12	9	21	440.009
#268	ZNF167	11	17	28	1921.739
#269	TWIST2	11	18	29	3070.02
#270	ETS1	11	19	30	1572.006
#271	FOXI1	11	8	19	349.821
#272	HOXC5	11	10	21	975.032
#273	TSHZ2	11	18	29	1117.892
#274	PTTG1	11	11	22	255.998
#275	RXRA	11	13	24	2382.154
#276	TRPS1	11	19	30	1061.383
#277	HOXD1	11	18	29	966.859
#278	SIM1	11	8	19	1189.879
#279	BATF2	11	11	22	1278.263
#280	FOXP1	11	17	28	1127.364
#281	NR2F6	11	17	28	2087.333
#282	HOXA9	11	19	30	2447.049
#283	MSX2	11	15	26	1370.798
#284	TGIF1	11	22	33	1602.283
#285	GRHL2	11	24	35	1368.733
#286	ZNF496	11	17	28	1392.913
#287	HOXA2	11	16	27	1750.548
#288	TBX3	11	15	26	1546.666
#289	MTA3	11	18	29	1239.357
#290	PBX2	11	16	27	821.621
#291	HOXB4	11	11	22	498.44
#292	ZNF117	10	20	30	1531.973
#293	ZNF33B	10	16	26	631.241
#294	GTF2I	10	16	26	580.795
#295	TCFL5	10	14	24	1241.499
#296	TAF5	10	18	28	921.975
#297	ATF7	10	13	23	708.764
#298	WT1	10	20	30	1426.674
#299	TCF7L1	10	22	32	2341.29
#300	MYT1	10	9	19	934.411
#301	LZTR1	10	16	26	1235.29
#302	SALL2	10	16	26	633.912
#303	ARNT2	10	20	30	2981.192
#304	ZGPAT	10	5	15	388.156
#305	SOX13	10	17	27	1287.92
#306	TFAP2C	10	20	30	2044.135
#307	PPARG	10	21	31	1775.593
#308	EBF1	10	16	26	1173.471
#309	FOXA1	10	20	30	1381.893
#310	HOXD8	10	15	25	822.645
#311	ONECUT2	10	16	26	2065.207
#312	HES1	10	18	28	797.307
#313	C2orf3	10	12	22	962.891
#314	GCM1	10	5	15	529.086
#315	ZNF193	10	14	24	840.856
#316	TSC22D3	10	15	25	650.284
#317	EOMES	10	12	22	685.465
#318	ZNF85	10	14	24	807.01
#319	SIX1	10	17	27	1779.717
#320	LMO4	9	11	20	696.422
#321	HOXB2	9	15	24	1711.502
#322	ZFHX3	9	17	26	1026.069
#323	ATF3	9	12	21	468.714
#324	MXD1	9	20	29	960.7
#325	ERG	9	15	24	564.961
#326	ZNF232	9	21	30	1309.681
#327	ZFHX4	9	11	20	940.082
#328	C11orf9	9	14	23	1625.455
#329	NFIC	9	15	24	1576.279
#330	ZBTB38	9	14	23	577.099
#331	FOXC2	9	8	17	1200.946
#332	HOXA10	9	12	21	943.123
#333	RXRB	9	10	19	478.566
#334	PPARD	9	16	25	2087.554
#335	ZNF217	9	12	21	657.182
#336	KLF12	9	15	24	641.414
#337	MESP1	9	22	31	1053.776
#338	SOX9	9	28	37	2225.468
#339	ESR1	9	18	27	522.345
#340	TEAD3	9	17	26	653.702
#341	HOXB6	9	11	20	799.548
#342	TSHZ1	9	20	29	1029.992
#343	EGR2	9	12	21	616.554
#344	NFAT5	9	14	23	487.815
#345	SIX3	9	6	15	599.654
#346	CLOCK	9	14	23	1123.199
#347	RHOXF1	9	7	16	413.713
#348	STAT1	9	14	23	620.226
#349	EPAS1	9	16	25	593.099
#350	ZSCAN18	9	18	27	1303.045
#351	ZEB1	9	17	26	391.681
#352	TP53	9	24	33	1321.568
#353	BHLHE41	9	21	30	561.24
#354	MKX	8	15	23	966.312
#355	HOXC13	8	10	18	537.63
#356	ATF6B	8	19	27	1133.392
#357	HOXA4	8	16	24	635.113
#358	SMAD2	8	15	23	623.26
#359	TBX19	8	17	25	2113.771
#360	ELK3	8	7	15	380.106
#361	ARID3A	8	19	27	1218.501
#362	SP3	8	9	17	479.368
#363	NR2F2	8	20	28	671.953
#364	RERE	8	17	25	1149.856
#365	ZNF133	8	18	26	1123.404
#366	GLIS3	8	22	30	1094.477
#367	ZNF274	8	16	24	477.52
#368	NFX1	8	14	22	984.194
#369	SMAD6	8	17	25	1164.289
#370	GATAD1	8	12	20	946.075
#371	ZSCAN5A	8	16	24	890.078
#372	ZNF19	8	13	21	566.998
#373	ARNTL	8	17	25	443.721
#374	MLLT10	8	13	21	1088.682
#375	BCL3	8	16	24	794.797
#376	AFF4	8	10	18	400.93
#377	OTX2	8	5	13	843.261
#378	TEAD2	8	14	22	1109.245
#379	HEY1	8	19	27	407.414
#380	ZFP37	8	15	23	1387.91
#381	HOXD10	8	11	19	211.933
#382	NFE2L3	8	16	24	1108.926
#383	HOXA7	8	6	14	416.08
#384	NFYA	7	23	30	767.897
#385	TEF	7	16	23	516.154
#386	SMAD1	7	17	24	902.757
#387	SATB1	7	16	23	1217.613
#388	SIM2	7	19	26	672.733
#389	RUNX2	7	15	22	957.844
#390	ALX1	7	10	17	551.442
#391	MGA	7	18	25	1201.463
#392	PRRX2	7	12	19	486.308
#393	ELF3	7	28	35	1040.704
#394	FOXO6	7	21	28	835.336
#395	BARX1	7	18	25	590.109
#396	PPARA	7	15	22	861.583
#397	SLC2A4RG	7	11	18	661.465
#398	AR	7	10	17	406.722
#399	TFAP2D	7	13	20	689.528
#400	EHF	7	23	30	1375.705
#401	SOX8	7	12	19	905.958
#402	ESRRG	7	22	29	1832.509
#403	JDP2	7	15	22	1981.746
#404	HOXC10	7	20	27	1027.621
#405	NR0B1	7	25	32	2960.519
#406	POU4F1	7	14	21	512.597
#407	MEIS2	7	16	23	1393.824
#408	KLF7	6	20	26	1192.414
#409	PGBD1	6	11	17	314.232
#410	TFAM	6	13	19	531.522
#411	HEY2	6	14	20	1190.474
#412	TRERF1	6	16	22	434.846
#413	SOX15	6	18	24	436.878
#414	NR1D2	6	14	20	1339.205
#415	DDIT3	6	12	18	287.577
#416	HLF	6	29	35	941.726
#417	NKX2-3	6	6	12	346.677
#418	NOTCH1	6	18	24	730.148
#419	MEIS1	6	21	27	700.931
#420	THRB	6	19	25	771.721
#421	ZFP42	6	8	14	406.262
#422	FOXO1	6	15	21	1086.51
#423	MLX	6	14	20	805.879
#424	FOXL1	6	6	12	206.207
#425	ZNF256	6	21	27	788.977
#426	BCL6	6	15	21	615.003
#427	IRX4	6	7	13	214.682
#428	HOXD4	6	13	19	654.554
#429	FOXJ1	5	17	22	375.286
#430	TFDP1	5	19	24	325.922
#431	CSRNP3	5	16	21	670.587
#432	KLF3	5	16	21	343.066
#433	ZNF215	5	17	22	614.368
#434	ZIC2	5	23	28	392.253
#435	ZNF165	5	20	25	818.604
#436	NFIA	5	22	27	402.52
#437	CREB5	5	18	23	756.853
#438	IRF9	5	9	14	729.487
#439	TBX1	5	15	20	552.051
#440	NPAS2	5	24	29	785.24
#441	JUN	5	13	18	220.37
#442	PLAG1	5	16	21	1006.12
#443	SCAND3	5	17	22	736.424
#444	LHX6	5	11	16	1120.289
#445	GTF2H2	5	17	22	460.159
#446	ZNF148	5	11	16	196.235
#447	ZIC1	5	18	23	389.384
#448	NR4A2	5	16	21	290.788
#449	RARA	5	18	23	732.964
#450	POU2F3	5	18	23	882.654
#451	FBXW7	5	14	19	466.238
#452	LHX9	5	7	12	275.589
#453	ISL1	4	14	18	789.234
#454	NR5A2	4	15	19	481.438
#455	SOX6	4	23	27	356.597
#456	FOXQ1	4	30	34	1312.316
#457	ASCL2	4	25	29	697.677
#458	FOXG1	4	10	14	257.132
#459	PITX2	4	19	23	396.246
#460	NKX3-1	4	19	23	475.817
#461	CTBP1	4	14	18	714.96
#462	ZNF92	4	18	22	611.231
#463	SATB2	4	22	26	463.592
#464	ETV4	4	15	19	385.449
#465	SREBF1	4	15	19	375.054
#466	ARX	4	26	30	1817.268
#467	HSF1	4	14	18	388.812
#468	ZHX2	4	13	17	454.562
#469	CDKN2A	4	24	28	433.864
#470	MYT1L	4	5	9	277.733
#471	ZNF268	4	15	19	525.076
#472	ZNF323	4	25	29	1747.666
#473	ETV5	3	18	21	223.56
#474	ETV7	3	13	16	513.666
#475	CREBZF	3	14	17	173.099
#476	PURB	3	19	22	402.956
#477	TCF7L2	3	20	23	568.801
#478	MEOX1	3	13	16	372.275
#479	SPIB	3	9	12	368.131
#480	ZNF174	3	15	18	464.918
#481	FOXK2	3	19	22	409.305
#482	NR1H4	3	7	10	222.162
#483	TRIM25	3	19	22	448.347
#484	SCML1	3	20	23	365.522
#485	STRN3	3	15	18	407.609
#486	TAF5L	2	20	22	173.865
#487	ZFP36L1	2	16	18	634.309
#488	IRX2	2	26	28	520.02
#489	DBP	2	16	18	124.175
#490	HMBOX1	2	17	19	381.28
#491	HNF4G	2	22	24	298.094
#492	FOXC1	2	25	27	479.637
#493	MTA1	1	21	22	340.059
#494	MLL	1	19	20	42.111
#495	IRX1	1	15	16	166.958
#496	IRF5	1	19	20	47.569
#497	BLZF1	1	20	21	172.805
#498	PAX7	1	25	26	122.061
#499	TSC22D1	1	24	25	1124.779
#500	ELF5	0	26	26	0